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Aging and Disease    2010, Vol. 1 Issue (1) : 37-59     DOI:
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Alzheimer’s Disease: Fatty Acids We Eat may be Linked to a Specific Protection via Low-dose Aspirin
Massimo F. L. Pomponi1, Giovanni Gambassi2, Massimiliano Pomponi3, Carlo Masullo4, *
1Istituto di Biochimica e Biochimica clinica, Università Cattolica del S. Cuore (UCSC), Largo F. Vito, 1, 00168 Rome, Italy
2 Centro Medicina Invecchiamento, UCSC, Largo A. Gemelli, 8, 00168 Rome
3Istituto di Psichiatria, UCSC; Largo F. Vito, 1, 00168 Rome
4Istituto di Neurologia, UCSC, Largo A. Gemelli, 8, 00168 Rome
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Abstract  

It has been suggested that cognitive decline in aging is the consequence of a growing vulnerability to an asymptomatic state of neuroinflammation. Moreover, it is becoming more evident that inflammation occurs in the brain of Alzheimer’s disease (AD) patients and that the classical mediators of inflammation, eicosanoids and cytokines, may contribute to the neurodegeneration. In agreement with this observation, aspirin (ASA) - a non-steroidal anti-inflammatory drug - may protect against AD and/or vascular dementia. However, both the time of prescription and the dose of ASA may be critical. A major indication for low-dose ASA is in combination with docosahexaenoic acid (DHA). DHA plays an essential role in neural function and its anti-inflammatory properties are associated with the well-known ability of this fatty acid to inhibit the production of various pro-inflammatory mediators, including eicosanoids and cytokines. Higher DHA intake is inversely correlated with relative risk of AD and DHA+ASA supplement may further decrease cognitive decline in healthy elderly adults. Although low-dose ASA may be insufficient for any anti-inflammatory action the concomitant presence of DHA favours a neuroprotective role for ASA. This depends on the allosteric effects of ASA on cyclooxygenase-2 and following production - from DHA - of specific lipid mediators (resolvins, protectins, and electrophilic oxo-derivatives). ASA and DHA might protect against AD, although controlled trials are warranted.

Keywords Cytokines      docosahexaenoic acid (DHA)      aspirin (ASA)      resolvins      neuroprotectin D1 (NPD1)      nonsteroidal anti-inflammatory drugs (NSAIDs)      primary prevention     
Corresponding Authors: Carlo Masullo   
Issue Date: 01 January 2010
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Massimo F. L. Pomponi
Giovanni Gambassi
Massimiliano Pomponi
Carlo Masullo
Cite this article:   
Massimo F. L. Pomponi,Giovanni Gambassi,Massimiliano Pomponi, et al. Alzheimer’s Disease: Fatty Acids We Eat may be Linked to a Specific Protection via Low-dose Aspirin[J]. Aging and Disease, 2010, 1(1): 37-59.
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http://www.aginganddisease.org/EN/     OR     http://www.aginganddisease.org/EN/Y2010/V1/I1/37
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