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Aging and Disease    2011, Vol. 2 Issue (6) : 449-465     DOI:
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NF-κB in Aging and Disease
Jeremy S. Tilstra1, Cheryl L. Clauson1, Laura J. Niedernhofer1, 2, Paul D. Robbins1, *
1Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
2University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
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Abstract  

Stochastic damage to cellular macromolecules and organelles is thought to be a driving force behind aging and associated degenerative changes. However, stress response pathways activated by this damage may also contribute to aging. The IKK/NF-κB signaling pathway has been proposed to be one of the key mediators of aging. It is activated by genotoxic, oxidative, and inflammatory stresses and regulates expression of cytokines, growth factors, and genes that regulate apoptosis, cell cycle progression, cell senescence, and inflammation. Transcriptional activity of NF-κB is increased in a variety of tissues with aging and is associated with numerous age-related degenerative diseases including Alzheimer’s, diabetes and osteoporosis. In mouse models, inhibition of NF-κB leads to delayed onset of age-related symptoms and pathologies. In addition, NF-κB activation is linked with many of the known lifespan regulators including insulin/IGF-1, FOXO, SIRT, mTOR, and DNA damage. Thus NF-κB represents a possible therapeutic target for extending mammalian healthspan.

Keywords Aging      NF-κB      Inflammation      Senescence     
Corresponding Authors: Paul D. Robbins   
Issue Date: 01 June 2011
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Jeremy S. Tilstra
Cheryl L. Clauson
Laura J. Niedernhofer
Paul D. Robbins
Cite this article:   
Jeremy S. Tilstra,Cheryl L. Clauson,Laura J. Niedernhofer, et al. NF-κB in Aging and Disease[J]. Aging and Disease, 2011, 2(6): 449-465.
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http://www.aginganddisease.org/EN/     OR     http://www.aginganddisease.org/EN/Y2011/V2/I6/449
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