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Aging and Disease    2015, Vol. 6 Issue (1) : 1-5     DOI: 10.14336/AD.2014.1210
The Critical Need to Promote Research of Aging and Aging-related Diseases to Improve Health and Longevity of the Elderly Population
Kunlin Jin1, 2, James W. Simpkins1, 3, Xunming Ji1, 4, Miriam Leis1, 5, Ilia Stambler1, 6
1Executive Committee, International Society on Aging and Disease (ISOAD), Fort Worth, TX76137, USA
2Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX76137, USA.
3Center for Basic and Translational Stroke Research, West Virginia University, West Virginia, USA.
4Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
5Fraunhofer Society for the Advancement of Applied Research, Munich, Germany.
6Department of Science, Technology and Society, Bar Ilan University, Ramat Gan, Israel.
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Due to the aging of the global population and the derivative increase in aging-related non-communicable diseases and their economic burden, there is an urgent need to promote research on aging and aging-related diseases as a way to improve healthy and productive longevity for the elderly population. To accomplish this goal, we advocate the following policies: 1) Increasing funding for research and development specifically directed to ameliorate degenerative aging processes and to extend healthy and productive lifespan for the population; 2) Providing a set of incentives for commercial, academic, public and governmental organizations to foster engagement in such research and development; and 3) Establishing and expanding coordination and consultation structures, programs and institutions involved in aging-related research, development and education in academia, industry, public policy agencies and at governmental and supra-governmental levels.

Keywords aging      aging-related diseases      health      longevity      elderly      population     
Corresponding Authors: Ilia Stambler   
Issue Date: 01 February 2015
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Kunlin Jin
James W. Simpkins
Xunming Ji
Miriam Leis
Ilia Stambler
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Kunlin Jin,James W. Simpkins,Xunming Ji, et al. The Critical Need to Promote Research of Aging and Aging-related Diseases to Improve Health and Longevity of the Elderly Population[J]. Aging and Disease, 2015, 6(1): 1-5.
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[1] World Health Organization2014). World Health Statistics – Large Gains in Life ExpectancyAccessed December 2014. Retrieved from:
[2] Human Mortality DatabaseAccessed December 2014. Retrieved from:
[3] United Nations Department of Economic and Social Affairs, Population Division2011). World Population Prospects: The 2010 Revision, CD-ROM EditionAccessed December 2014. Retrieved from:
[4] World Health Organization2013). Draft Twelfth General Programme of WorkAccessed December 2014. Retrieved from:
[5] World Health Organization2014). Ageing and Life CourseAccessed December 2014. Retrieved from:
[6] United Nations Department of Economic and Social Affairs, Population Division2013). World Population Aging ReportAccessed December 2014. Retrieved from:
[7] The International Longevity Center Global Alliance2010). Global Aging Report. Threats to Longevity. A Call to ActionAccessed December 2014. Retrieved from:
[8] Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V(2012). Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet, 380:2095-2128
[9] Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H(2012). A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010 a systematic analysis for the Global Burden of Disease Study 2010. Lancet, 380:2224-2260
[10] Kennedy BK, Berger SL, Brunet A, Campisi J, Cuervo AM, Epel ES(2014). Geroscience: linking aging to chronic disease. Cell, 59:709-713
[11] Healthspan Campaign2013). NIH Geroscience Interest Group (GSIG) Releases Recommendations from the October 2013 Advances in Geroscience SummitAccessed December 2014. Retrieved from:
[12] Fahy GM, West MD, Coles LS, Harris SB The Future of Aging: Pathways to Human Life ExtensionNew YorkSpringer2010
[13] Fontana L, Kennedy BK, Longo VD, Seals D, Melov S(2014). Medical research: treat ageing. Nature, 511:405-407
[14] López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G(2013). The hallmarks of aging. Cell, 153:1194-1217
[15] De Grey ADNJ, Rae M Ending Aging. The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our LifetimeNew YorkSt. Martin’s Press2007
[16] Goldman DP, Cutler D, Rowe JW, Michaud PC, Sullivan J, Peneva D, Olshansky SJ(2013). Substantial health and economic returns from delayed aging may warrant a new focus for medical research. Health Aff, 10:1698-1705
[17] Rae MJ, Butler RN, Campisi J, de Grey ADNJ, Finch CE, Gough M(2010). The demographic and biomedical case for late-life interventions in aging. Sci Transl Med, 2:40cm21
[18] Kanfi Y, Naiman S, Amir G, Peshti V, Zinman G, Nahum L(2012). The sirtuin SIRT6 regulates lifespan in male mice. Nature, 483:218-221
[19] Atala A Extending life using tissue and organ replacement. 2008). Curr Aging Sci, 1:73-83
[20] Baati T, Bourasset F, Gharbi N, Njim L, Abderrabba M, Kerkeni A(2012). The prolongation of the lifespan of rats by repeated oral administration of [60] fullerene. Biomaterials, 33:4936-4946
[21] Kheir JN, Scharp LA, Borden MA, Swanson EJ, Loxley A, Reese JH(2012). Oxygen gas-filled microparticles provide intravenous oxygen delivery. Sci Transl Med, 4:140ra88
[22] Shawn M, Douglas SM, Bachelet I, Church GM(2012). A logic-gated nanorobot for targeted transport of molecular payloads. Science, 335:831-834
[23] Kennedy BK, Pennypacker JK(2014). Drugs that modulate aging: the promising yet difficult path ahead. Transl Res, 163:456-465
[24] Chung HY, Cesari M, Anton S, Marzetti E, Giovannini S, Seo AY(2009). Molecular inflammation: Underpinnings of aging and age-related diseases. Ageing Res Rev, 8:18-30
[25] Lunn JS, Sakowski SA, Hur J, Feldman EL(2011). Stem cell technology for neurodegenerative diseases. Ann Neurol, 70:353-361
[26] Baylis D, Bartlett DB, Patel HP, Roberts HC(2014). Understanding how we age: insights into inflammaging. Longev Healthspan, 3:6
[27] Dai DF, Chiao YA, Marcinek DJ, Szeto HH, Rabinovitch PS(2014). Mitochondrial oxidative stress in aging and healthspan. Longev Healthspan, 3:6
[28] Zieman S, Kass D(2004). Advanced glycation end product cross-linking: Pathophysiologic role and therapeutic target in cardiovascular disease. Congest Heart Fail, 10:144-149
[29] Bredenkamp N, Nowell CS, Blackburn CC(2014). Regeneration of the aged thymus by a single transcription factor. Development, 141:1627-1637
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