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Aging and disease    2015, Vol. 6 Issue (3) : 168-173     DOI: 10.14336/AD.2014.0925
OriginalArticle |
Plasma Epidermal Growth Factor Decreased in the Early Stage of Parkinson’s Disease
Jiang Qian-Wen, Wang Cheng, Zhou Yi, Hou Miao-Miao, Wang Xi, Tang Hui-Dong, Wu Yi-Wen, Ma Jian-Fang*(), Chen Sheng-Di*()
Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to ShanghaiJiao Tong University School of Medicine, Shanghai, 200025, China
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Epidermal growth factor (EGF) is a neurotrophic factor that plays an important role in Parkinson’s disease (PD). We measured plasma EGF level in PD, essential tremor (ET) and normal controls toinvestigate whether it changes in PD and whether it is associated with motor and non-motor symptoms of PD. 100 patients with PD, 40 patients with ET as disease control and 76 healthy persons were enrolled in the present study. Motor and non-motor symptoms were assessed by different scales. Plasma EGF levels of three groups were measured by enzyme-linked immunosorbent assay kit. Spearman test and linear logistics regression model were used to test the correlation of EGF with motor and non-motor symptoms of PD. Plasma EGF level was significantly decreased in early PD patients compared with normal control, butnot in advanced PD patients. Interestingly, plasma EGF level was significantly increased in advanced PD and total PD patients compared with ET patients, but not in early PD patients. In addition, plasma EGF level was correlated with UPDRS-III scores in PD. Also plasma EGF level was correlated with UPDRS-III scores and NMS scores in early PD.Our results suggested that plasma EGF decreased in the early stage of PD and increased later on in the PD disease course. Also, plasma EGF level was increased significantly in PD compared with ET patients and correlated with motor and non-motor symptoms in early PD.

Keywords epidermal growth factor      Parkinson’s disease      essential tremor     
Corresponding Authors: Ma Jian-Fang,Chen Sheng-Di     E-mail:;
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present address: Kunming Biomed International, Kunming, Yunnan, 650500, China

Issue Date: 01 June 2015
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Jiang Qian-Wen
Wang Cheng
Zhou Yi
Hou Miao-Miao
Wang Xi
Tang Hui-Dong
Wu Yi-Wen
Ma Jian-Fang
Chen Sheng-Di
Cite this article:   
Jiang Qian-Wen,Wang Cheng,Zhou Yi, et al. Plasma Epidermal Growth Factor Decreased in the Early Stage of Parkinson’s Disease[J]. Aging and disease, 2015, 6(3): 168-173.
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Table 1  Demographic features and EGF level of PD, ET and controls
Table 2  Demographic features, clinical characteristics and serum EGF level in PD patients and control
Figure 1.  Correlation of plasma EGF with motor and non-motor symptoms of PD.A. Plasma EGF correlated with UPDRS-III scores in PD patients. B. Plasma EGF correlated with UPDRS-III scores in early PD. C. Plasma EGF correlated with NMS scores in early PD.
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