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Aging and disease    2015, Vol. 6 Issue (6) : 499-503     DOI: 10.14336/AD.2014.1201
Review Article |
Cell Therapy for Parkinson’s Disease: New Hope from Reprogramming Technologies
Chen Zhiguo1,2,3,*()
1 Cell Therapy Center, Xuanwu Hospital, Capital Medical University, and Key Laboratory of Neurodegeneration, Ministry of Education, Beijing, 100053, China
2 Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
3 Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing, China
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Parkinson’s disease (PD) is a neurodegenerative disease with the major pathology being the progressive loss of dopaminergic (DA) midbrain neurons in the substantia nigra. As early as in the 1980s, open-label clinical trials employing fetal ventral mesencephalon (fVM) tissues have demonstrated significant efficacy for PD treatment, which led to two NIH-sponsored double-blind placebo-controlled clinical trials. However, both trials showed only mild outcome. Retrospective analysis revealed several possible reasons that include patient selection, heterogeneity of grafts, immune recognition of grafts, lack of standardization of transplantation procedure and uneven distribution of grafts. Recent years have seen advances in reprogramming technologies which may provide solutions to the problems associated with fVM tissues. Induced pluripotent stem cells (iPSCs) and induced neural stem cells (iNSCs) hold promise for generating clinical grade DA neural cells that are safe, homogeneous, scalable and standardizable. These new technologies may bring back clinical trials using cell therapy for PD treatment in the future.

Keywords cell therapy      Parkinson’s disease      reprogramming      dopaminergic neurons      clinical trials     
Corresponding Authors: Chen Zhiguo     E-mail:
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present address: Kunming Biomed International, Kunming, Yunnan, 650500, China

Issue Date: 01 December 2015
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Chen Zhiguo. Cell Therapy for Parkinson’s Disease: New Hope from Reprogramming Technologies[J]. Aging and disease, 2015, 6(6): 499-503.
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