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Aging and Disease    2014, Vol. 5 Issue (3) : 170-176     DOI: 10.14336/AD.2014.0500170
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Raised Serum Proinflammatory Cytokines in Alzheimer’s Disease with Depression
Vineet Kumar Khemka1, Anirban Ganguly1, Debajit Bagchi1, Arindam Ghosh1, Aritri Bir1, Atanu Biswas2, Sita Chattopadhyay3, Sasanka Chakrabarti1, *
1Department of Biochemistry, Institute of Post Graduate Medical Education and Research, Kolkata, India.
2Department of Neuromedicine, Bangur Institute of Neurosciences, Kolkata, India.
3Department of Community Medicine, Institute of Post Graduate Medical Education and Research, Kolkata, India.
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Abstract  

The purpose of the present study was to identify the changes in the levels of proinflammatory cytokines like IL-1β, IL-6 and TNF-α in peripheral circulation in Alzheimer’s disease (AD) subjects and to correlate these with associated depression and cognitive deficit. Fifty five AD subjects and thirty seven age and sex matched controls were included in the study. The AD patients were grouped as AD with depression (n= 31) and AD without depression (n= 24). The serum levels of IL-1β, IL-6 and TNF-α were determined by immunoassay by commercially available kits. The serum levels of IL-6 and TNF-α were elevated in AD patients with depression compared to control (p<0.001) or AD without depression (p<0.001). The serum level of IL-1β was higher in AD patients with or without depression as compared to controls. Furthermore, a strong inverse correlation was observed between the MMSE scores and serum levels of IL-6 or TNF-α in AD subjects with depression. The study highlights the important role of peripheral IL-6 and TNF-α in AD associated depression and cognitive deficits.

Keywords Alzheimer’s disease      IL-6      IL-1β      TNF-α      Depression      Cognitive deficit     
Corresponding Authors: Sasanka Chakrabarti   
Issue Date: 10 May 2014
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Vineet Kumar Khemka
Anirban Ganguly
Debajit Bagchi
Arindam Ghosh
Aritri Bir
Atanu Biswas
Sita Chattopadhyay
Sasanka Chakrabarti
Cite this article:   
Vineet Kumar Khemka,Anirban Ganguly,Debajit Bagchi, et al. Raised Serum Proinflammatory Cytokines in Alzheimer’s Disease with Depression[J]. Aging and Disease, 2014, 5(3): 170-176.
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http://www.aginganddisease.org/EN/10.14336/AD.2014.0500170     OR     http://www.aginganddisease.org/EN/Y2014/V5/I3/170
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