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Aging and Disease    2014, Vol. 5 Issue (4) : 226-237     DOI: 10.14336/AD.2014.0500226
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Managing Sarcopenia and Its Related-Fractures to Improve Quality of Life in Geriatric Populations
Tetsuro Hida1, *, Atsushi Harada2, Shiro Imagama1, Naoki Ishiguro1
1Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine
2Department of Orthopedic Surgery, National Center for Geriatrics and Gerontology
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Abstract  

Sarcopenia, an aging-induced generalized decrease in muscle mass, strength, and function, is known to affect elderly individuals by decreasing mobile function and increasing frailty and imbalance that lead to falls and fragile fractures. Sarcopenia is a known risk factor for osteoporotic fractures, infections, and early death in some specific situations. The number of patients with sarcopenia is estimated to increase to 500 million people in the year 2050. Sarcopenia is believed to be caused by multiple factors such as disuse, malnutrition, age-related cellular changes, apoptosis, and genetic predisposition; however, this remains to be determined. Various methods have been developed, but no safe or effective treatment has been found to date. This paper is a review on the association between sarcopenia and its related-fractures and their diagnoses and management methods to prevent fractures.

Keywords sarcopenia      sarcopenia-related fracture      osteoporosis      diagnosis      muscle mass      treatment      pathogenesis     
Corresponding Authors: Tetsuro Hida   
Issue Date: 10 July 2014
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Tetsuro Hida
Atsushi Harada
Shiro Imagama
Naoki Ishiguro
Cite this article:   
Tetsuro Hida,Atsushi Harada,Shiro Imagama, et al. Managing Sarcopenia and Its Related-Fractures to Improve Quality of Life in Geriatric Populations[J]. Aging and Disease, 2014, 5(4): 226-237.
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http://www.aginganddisease.org/EN/10.14336/AD.2014.0500226     OR     http://www.aginganddisease.org/EN/Y2014/V5/I4/226
[1] Kanda K, Sugama K, Hayashida H, Sakuma J, Kawakami Y, Miura S(2013). Eccentric exercise-induced delayed-onset muscle soreness and changes in markers of muscle damage and inflammation. Exerc Immunol Rev, 19:72-85
[2] Lang T, Cauley JA, Tylavsky F, Bauer D, Cummings S, Harris TB(2010). Computed tomographic measurements of thigh muscle cross-sectional area and attenuation coefficient predict hip fracture: the health, aging, and body composition study. J Bone Miner Res, 25:513-519
[3] Akhmetshina A, Palumbo K, Dees C, Bergmann C, Venalis P, Zerr P(2012). Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis. Nat Commun, 3:735
[4] Joe AWB, Yi L, Natarajan A, Le Grand F, So L, Wang J(2010). Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis. Nat Cell Biol, 12:153-163
[5] Waters DL, Hale L, Grant AM, Herbison P, Goulding A(2010). Osteoporosis and gait and balance disturbances in older sarcopenic obese New Zealanders. Osteoporos Int, 21:351-357
[6] Berg HE, Larsson L, Tesch PA(1997). Lower limb skeletal muscle function after 6 wk of bed rest. J Appl Physiol, 82:182-188
[7] Coker RH, Wolfe RR(2012). Bedrest and sarcopenia. Curr Opin Clin Nutr Metab Care, 15:7
[8] Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F(2010). Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing, 39:412-423
[9] Rosenberg I(1989). Summary comments. Am J Clin Nutr, 50:1231-1233
[10] Fielding RA, Vellas B, Evans WJ, Bhasin S, Morley JE, Newman AB(2011). Sarcopenia: An Undiagnosed Condition in Older Adults. Current Consensus Definition: Prevalence, Etiology, and Consequences International Working Group on Sarcopenia. J Am Med Dir Assoc, 12:249-256
[11] Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, Ross RR(1998). Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol, 147:755-763
[12] Fantin F, Di Francesco V, Fontana G, Zivelonghi A, Bissoli L, Zoico E(2007). Longitudinal body composition changes in old men and women: interrelationships with worsening disability. J Gerontol A Biol Sci Med Sci, 62:1375-1381
[13] Sanada K, Miyachi M, Tanimoto M, Yamamoto K, Murakami H, Okumura S(2010). A cross-sectional study of sarcopenia in Japanese men and women: reference values and association with cardiovascular risk factors. Eur J Appl Physiol, 110:57-65
[14] Baumgartner RN, Waters DL, Gallagher D, Morley JE, Garry PJ(1999). Predictors of skeletal muscle mass in elderly men and women. Mech Ageing Dev, 107:123-136
[15] Janssen I, Heymsfield SB, Baumgartner RN, Ross R(2000). Estimation of skeletal muscle mass by bioelectrical impedance analysis. J Appl Physiol, 89:465-471
[16] Delmonico MJ, Harris TB, Visser M, Park SW, Conroy MB, Velasquez-Mieyer P(2009). Longitudinal study of muscle strength, quality, and adipose tissue infiltration. Am J Clin Nutr, 90:1579-1585
[17] Hansen RD, Williamson DA, Finnegan TP, Lloyd BD, Grady JN, Diamond TH(2007). Estimation of thigh muscle cross-sectional area by dual-energy X-ray absorptiometry in frail elderly patients. Am J Clin Nutr, 86:952-958
[18] Kato A, Ishida J, Endo Y, Takita T, Furuhashi M, Maruyama Y(2011). Association of abdominal visceral adiposity and thigh sarcopenia with changes of arteriosclerosis in haemodialysis patients. Nephrol Dial Transplant, 26:1967-1976
[19] Newman AB, Kupelian V, Visser M, Simonsick EM, Goodpaster BH, Kritchevsky SB(2006). Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort. J Gerontol A Biol Sci Med Sci, 61:72-77
[20] Visser M, Kritchevsky SB, Goodpaster BH, Newman AB, Nevitt M, Stamm E(2002). Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: the health, aging and body composition study. J Am Geriatr Soc, 50:897-904
[21] Harimoto N, Shirabe K, Yamashita YI, Ikegami T, Yoshizumi T, Soejima Y(2013). Sarcopenia as a predictor of prognosis in patients following hepatectomy for hepatocellular carcinoma. Br J Surg, 100:1523-1530
[22] Pezaro C, Mukherji D, Tunariu N, Cassidy AM, Omlin A, Bianchini D(2013). Sarcopenia and change in body composition following maximal androgen suppression with abiraterone in men with castration-resistant prostate cancer. Br J Cancer, 109:325-331
[23] Martin L, Birdsell L, Macdonald N, Reiman T, Clandinin MT, McCargar LJ(2013). Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index. J Clin Oncol, 31:1539-1547
[24] Nuti R, Martini G(1992). Measurements of bone mineral density by DXA total body absorptiometry in different skeletal sites in postmenopausal osteoporosis. Bone, 13:173-178
[25] Wang ZM, Visser M, Ma R, Baumgartner RN, Kotler D, Gallagher D(1996). Skeletal muscle mass: evaluation of neutron activation and dual-energy X-ray absorptiometry methods. J Appl Physiol, 80:824-831
[26] Baumgartner RN, Stauber PM, McHugh D, Koehler KM, Garry PJ(1995). Cross-sectional age differences in body composition in persons 60+ years of age. J Gerontol A Biol Sci Med Sci, 50:M307-316
[27] Kyle UG, Genton L, Hans D, Karsegard VL, Michel JP, Slosman DO(2001). Total body mass, fat mass, fat-free mass, and skeletal muscle in older people: cross-sectional differences in 60-year-old persons. J Am Geriatr Soc, 49:1633-1640
[28] Hoffer EC, Meador CK, Simpson DC(1969). Correlation of whole-body impedance with total body water volume. J Appl Physiol, 27:531-534
[29] National Institutes of Health1996). Bioelectrical impedance analysis in body composition measurement: National Institutes of Health Technology Assessment Conference Statement. Am J Clin Nutr, 64:524S-532S
[30] Roubenoff R, Baumgartner RN, Harris TB, Dallal GE, Hannan MT, Economos CD(1997). Application of bioelectrical impedance analysis to elderly populations. J Gerontol A Biol Sci Med Sci, 52:M129-136
[31] Roubenoff R(1996). Applications of bioelectrical impedance analysis for body composition to epidemiologic studies. Am J Clin Nutr, 64:459S-462S
[32] Chien MY, Huang TY, Wu YT(2008). Prevalence of Sarcopenia Estimated Using a Bioelectrical Impedance Analysis Prediction Equation in Community-Dwelling Elderly People in Taiwan. J Am Geriatr Soc, 56:1710-1715
[33] Tanimoto Y, Watanabe M, Sun W, Hirota C, Sugiura Y, Kono R(2012). Association between muscle mass and disability in performing instrumental activities of daily living (IADL) in community-dwelling elderly in Japan. Arch Gerontol Geriatr, 54:e230-e233
[34] Tanimoto Y, Watanabe M, Sun W, Sugiura Y, Tsuda Y, Kimura M(2012). Association between sarcopenia and higher-level functional capacity in daily living in community-dwelling elderly subjects in Japan. Arch Gerontol Geriatr, 55:e9-e13
[35] Rosenberg JG, Ryan ED, Sobolewski EJ, Scharville MJ, Thompson BJ, King GE(2013). Reliability of panoramic ultrasound imaging to simultaneously examine muscle size and quality of the medial gastrocnemius. Muscle NerveEpub ahead of print
[36] Watanabe Y, Yamada Y, Fukumoto Y, Ishihara T, Yokoyama K, Yoshida T(2013). Echo intensity obtained from ultrasonography images reflecting muscle strength in elderly men. Clin Interv Aging, 8:993-998
[37] Radaelli R, Bottaro M, Wilhelm EN, Wagner DR, Pinto RS(2012). Time course of strength and echo intensity recovery after resistance exercise in women. J Strength Cond Res, 26:2577-2584
[38] Fukumoto Y, Ikezoe T, Yamada Y, Tsukagoshi R, Nakamura M, Mori N(2012). Skeletal muscle quality assessed from echo intensity is associated with muscle strength of middle-aged and elderly persons. Eur J Appl Physiol, 112:1519-1525
[39] Cadore EL, Izquierdo M, Conceicao M, Radaelli R, Pinto RS, Baroni BM(2012). Echo intensity is associated with skeletal muscle power and cardiovascular performance in elderly men. Exp Gerontol, 47:473-478
[40] Rolland Y, Lauwers-Cances V, Cournot M, Nourhashemi F, Reynish W, Riviere D(2003). Sarcopenia, calf circumference, and physical function of elderly women: a cross-sectional study. J Am Geriatr Soc, 51:1120-1124
[41] Di Monaco M, Vallero F, Di Monaco R, Tappero R, Cavanna A(2007). Skeletal muscle mass, fat mass, and hip bone mineral density in elderly women with hip fracture. J Bone Miner Metab, 25:237-242
[42] Janssen I, Heymsfield SB, Ross R(2002). Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc, 50:889-896
[43] Hida T, Ishiguro N, Shimokata H, Sakai Y, Matsui Y, Takemura M(2013). High prevalence of sarcopenia and reduced leg muscle mass in Japanese patients immediately after a hip fracture. Geriatr Gerontol Int, 13:413-420
[44] Hirano K, Imagama S, Hasegawa Y, Ito Z, Muramoto A, Ishiguro N(2013). The influence of locomotive syndrome on health-related quality of life in a community-living population. Mod Rheumatol, 23:939-944
[45] Hirano K, Imagama S, Hasegawa Y, Wakao N, Muramoto A, Ishiguro N(2012). Effect of back muscle strength and sagittal spinal imbalance on locomotive syndrome in Japanese men. Orthopedics, 35:e1073-1078
[46] Nakamura K(2011). The concept and treatment of locomotive syndrome: its acceptance and spread in Japan. J Orthop Sci, 16:489-491
[47] Muramoto A, Imagama S, Ito Z, Hirano K, Ishiguro N, Hasegawa Y(2012). Physical performance tests are useful for evaluating and monitoring the severity of locomotive syndrome. J Orthop Sci, 17:782-788
[48] Muramoto A, Imagama S, Ito Z, Hirano K, Tauchi R, Ishiguro N(2013). Threshold values of physical performance tests for locomotive syndrome. J Orthop Sci, 18:618-626
[49] Hida T, Sakai Y, Harada A, Imagama S, Ishiguro N(2011). The impact of sarcopenia, the muscle decreasing disease, in cervical compressive myelopathy diagnosed by dual energy X-ray absorptiometry. World Spinal Column J, 2:148
[50] Michikawa T, Nishiwaki Y, Takebayashi T, Toyama Y(2009). One-leg standing test for elderly populations. J Orthop Sci, 14:675-685
[51] Hida T, Harada A(2013). Fall Risk and Fracture. Diagnosing sarcopenia and sarcopenic leg to prevent fall and fracture : its difficulty and pit falls. Clin Calcium, 23:707-712
[52] Pfisterer MH, Griffiths DJ, Schaefer W, Resnick NM(2006). The effect of age on lower urinary tract function: a study in women. J Am Geriatr Soc, 54:405-412
[53] Dutta C, Hadley EC, Lexell J(1997). Sarcopenia and physical performance in old age: overview. Muscle Nerve Suppl, 5:S5-9
[54] Chen HI, Kuo CS(1989). Relationship between respiratory muscle function and age, sex, and other factors. J Appl Physiol, 66:943-948
[55] Kim J, Davenport P, Sapienza C(2009). Effect of expiratory muscle strength training on elderly cough function. Arch Gerontol Geriatr, 48:361-366
[56] Ney DM, Weiss JM, Kind AJ, Robbins J(2009). Senescent swallowing: impact, strategies, and interventions. Nutr Clin Pract, 24:395-413
[57] Buehring B, Hind J, Fidler E, Krueger D, Binkley N, Robbins J(2013). Tongue Strength Is Associated with Jumping Mechanography Performance and Handgrip Strength but Not with Classic Functional Tests in Older Adults. J Am Geriatr Soc, 61:418-422
[58] Kuroda Y, Kuroda R(2012). Relationship between thinness and swallowing function in Japanese older adults: implications for sarcopenic dysphagia. J Am Geriatr Soc, 60:1785-1786
[59] Nogueira Reis(2013). Swallowing disorders in nursing home residents: how can the problem be explained?. Clin Interv Aging, 8:221-227
[60] Park YH, Han HR, Oh BM, Lee J, Park JA, Yu SJ(2013). Prevalence and associated factors of dysphagia in nursing home residents. Geriatric Nursing, 34:212-217
[61] Cosqueric G, Sebag A, Ducolombier C, Thomas C, Piette F, Weill-Engerer S(2006). Sarcopenia is predictive of nosocomial infection in care of the elderly. Br J Nutr, 96:895-901
[62] Kim TN, Park MS, Yang SJ, Yoo HJ, Kang HJ, Song W(2010). Prevalence and determinant factors of sarcopenia in patients with type 2 diabetes: the Korean Sarcopenic Obesity Study (KSOS)Diabetes Care, 33:1497-1499
[63] Levine ME, Crimmins EM(2012). The impact of insulin resistance and inflammation on the association between sarcopenic obesity and physical functioning. Obesity (Silver Spring)20:2101-2106
[64] Srikanthan P, Hevener AL, Karlamangla AS(2010). Sarcopenia exacerbates obesity-associated insulin resistance and dysglycemia: findings from the National Health and Nutrition Examination Survey III. PLoS ONE, 5:e10805
[65] Bijlsma AY, Meskers CG, van Heemst D, Westendorp RG, de Craen AJ, Maier AB(2013). Diagnostic criteria for sarcopenia relate differently to insulin resistance. Age (Dordr)Epub ahead of print
[66] Aubertin-Leheudre M, Lord C, Goulet ED, Khalil A, Dionne IJ(2006). Effect of sarcopenia on cardiovascular disease risk factors in obese postmenopausal women. Obesity (Silver Spring)14:2277-2283
[67] Montano–Loza AJ, Meza–Junco J, Prado CMM, Lieffers JR, Baracos VE, Bain VG(2012). Muscle Wasting Is Associated With Mortality in Patients With Cirrhosis. Clinical Gastroenterology and Hepatology, 10:166-173e161
[68] Meza-Junco J, Montano-Loza AJ, Baracos VE, Prado CM, Bain VG, Beaumont C(2013). Sarcopenia as a Prognostic Index of Nutritional Status in Concurrent Cirrhosis and Hepatocellular Carcinoma. J Clin GastroenterolEpub ahead of print
[69] Baracos V, Kazemi-Bajestani SM(2013). Clinical outcomes related to muscle mass in humans with cancer and catabolic illnesses. Int J Biochem Cell Biol, 45:2302-2308
[70] Kilgour RD, Vigano A, Trutschnigg B, Lucar E, Borod M, Morais JA(2013). Handgrip strength predicts survival and is associated with markers of clinical and functional outcomes in advanced cancer patients. Support Care CancerEpub ahead of print
[71] Moisey LL, Mourtzakis M, Cotton BA, Premji T, Heyland DK, Wade CE(2013). Skeletal muscle predicts ventilator-free days, ICU-free days, and mortality in elderly ICU patients. Crit Care, 17:R206
[72] Landi F, Liperoti R, Fusco D, Mastropaolo S, Quattrociocchi D, Proia A(2012). Sarcopenia and Mortality among Older Nursing Home Residents. J Am Med Dir Assoc, 13:121-126
[73] Coin A, Perissinotto E, Enzi G, Zamboni M, Inelmen EM, Frigo AC(2008). Predictors of low bone mineral density in the elderly: the role of dietary intake, nutritional status and sarcopenia. Eur J Clin Nutr, 62:802-809
[74] Wu C-H, Yang KC, Chang HH, Yen JF, Tsai KS, Huang K-C(2013). Sarcopenia is Related to Increased Risk for Low Bone Mineral Density. J Clin Densitom, 16:98-103
[75] Walsh MC, Hunter GR, Livingstone MB(2006). Sarcopenia in premenopausal and postmenopausal women with osteopenia, osteoporosis and normal bone mineral density. Osteoporos Int, 17:61-67
[76] Harada A, Mizuno M, Takemura M, Tokuda H, Okuizumi H, Niino N(2001). Hip fracture prevention trial using hip protectors in Japanese nursing homes. Osteoporos Int, 12:215-221
[77] Harada A, Matsuyama Y, Nakano T, Deguchi M, Kuratsu S, Sueyoshi Y(2010). Nationwide survey of current medical practices for hospitalized elderly with spine fractures in Japan. J Orthop Sci, 15:79-85
[78] Johnell O, Kanis JA(2006). An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int, 17:1726-1733
[79] Dolan P, Torgerson D(1998). The cost of treating osteoporotic fractures in the United Kingdom female population. Osteoporos Int, 8:611-617
[80] Visser M, Kiel DP, Langlois J, Hannan MT, Felson DT, Wilson PW(1998). Muscle mass and fat mass in relation to bone mineral density in very old men and women: the Framingham Heart Study. Appl Radiat Isot, 49:745-747
[81] Capozza RF, Cure-Cure C, Cointry GR, Meta M, Cure P, Rittweger J(2008). Association between low lean body mass and osteoporotic fractures after menopause. Menopause, 15:905-913
[82] Di Monaco M, Vallero F, Di Monaco R, Tappero R(2011). Prevalence of sarcopenia and its association with osteoporosis in 313 older women following a hip fracture. Arch Gerontol Geriatr, 52:71-74
[83] Hida T, Ishiguro N, Sakai Y, Ito K, Harada A(2012). Sarcopenia as a Potential Risk Factor for Osteoporotic Vertebral Compression Fracture in Japanese Elderly Individuals. J Spine Res, 3:357
[84] Vanitallie TB(2003). Frailty in the elderly: contributions of sarcopenia and visceral protein depletion. Metabolism, 52:22-26
[85] Barr R, Macdonald H, Stewart A, McGuigan F, Rogers A, Eastell R(2010). Association between vitamin D receptor gene polymorphisms, falls, balance and muscle power: results from two independent studies (APOSS and OPUS)Osteoporos Int, 21:457-466
[86] Evans WJ(2010). Skeletal muscle loss: cachexia, sarcopenia, and inactivity. Am J Clin Nutr, 91:1123S-1127S
[87] Covinsky KE, Pierluissi E, Johnston CB(2011). Hospitalization-associated disability. JAMA, 306:1782-1793
[88] Yuki A, Otsuka R, Kozakai R, Kitamura I, Okura T, Ando F(2013). Relationship between Low Free Testosterone Levels and Loss of Muscle Mass. Sci Rep, 3:1818
[89] Sipila S, Narici M, Kjaer M, Pollanen E, Atkinson RA, Hansen M(2013). Sex hormones and skeletal muscle weakness. Biogerontology, 14:231-245
[90] Hwang AC, Liu LK, Lee WJ, Lin MH, Peng LN, Won CW(2013). Association of Androgen with Skeletal Muscle Mass and Muscle Function among Men and Women Age 50 Years and Older in Taiwan: Results from I-Lan Longitudinal Aging Study. Rejuvenation ResEpub ahead of print
[91] Messier V, Rabasa-Lhoret R, Barbat-Artigas S, Elisha B, Karelis AD, Aubertin-Leheudre M(2011). Menopause and sarcopenia: A potential role for sex hormones. Maturitas, 68:331-336
[92] Sorensen MB, Rosenfalck AM, Hojgaard L, Ottesen B(2001). Obesity and sarcopenia after menopause are reversed by sex hormone replacement therapy. Obes Res, 9:622-626
[93] Roubenoff R, Parise H, Payette HA, Abad LW, D’Agostino R, Jacques PF(2003). Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study. Am J Med, 115:429-435
[94] Zoico E, Corzato F, Bambace C, Rossi AP, Micciolo R, Cinti S(2013). Myosteatosis and myofibrosis: Relationship with aging, inflammation and insulin resistance. Arch Gerontol Geriatr, 57:411-416
[95] Armand AS, Laziz I, Djeghloul D, Lecolle S, Bertrand AT, Biondi O(2011). Apoptosis-inducing factor regulates skeletal muscle progenitor cell number and muscle phenotype. PLoS ONE, 6:e27283
[96] Leeuwenburgh C(2003). Role of apoptosis in sarcopenia. J Gerontol A Biol Sci Med Sci, 58:999-1001
[97] Michaud M, Balardy L, Moulis G, Gaudin C, Peyrot C, Vellas B(2013). Proinflammatory Cytokines, Aging, and Age-Related Diseases. J Am Med Dir AssocEpub ahead of print
[98] Nourhashemi F, Andrieu S, Gillette-Guyonnet S, Reynish E, Albarede JL, Grandjean H(2002). Is there a relationship between fat-free soft tissue mass and low cognitive function? Results from a study of 7,105 women. J Am Geriatr Soc, 50:1796-1801
[99] Larsson L, Sjodin B, Karlsson J(1978). Histochemical and biochemical changes in human skeletal muscle with age in sedentary males, age 22–65 years. Acta Physiol Scand, 103:31-39
[100] Bodine SC, Stitt TN, Gonzalez M, Kline WO, Stover GL, Bauerlein R(2001). Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol, 3:1014-1019
[101] Conboy IM(2003). Notch-Mediated Restoration of Regenerative Potential to Aged Muscle. Science, 302:1575-1577
[102] Bray SJ(2006). Notch signalling: a simple pathway becomes complex. Nature Reviews Molecular Cell Biology, 7:678-689
[103] Brack AS, Conboy MJ, Roy S, Lee M, Kuo CJ, Keller C(2007). Increased Wnt Signaling During Aging Alters Muscle Stem Cell Fate and Increases Fibrosis. Science, 317:807-810
[104] Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A(2012). Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes. Cell, 149:1298-1313
[105] Zhang W, Drake MT(2011). Potential Role for Therapies Targeting DKK1, LRP5, and Serotonin in the Treatment of Osteoporosis. Current Osteoporosis Reports, 10:93-100
[106] Butler JS, Murray DW, Hurson CJ, O’Brien J, Doran PP, O’Byrne JM(2011). The role of Dkk1 in bone mass regulation: Correlating serum Dkk1 expression with bone mineral density. Journal of Orthopaedic Research, 29:414-418
[107] Li X, Ominsky MS, Warmington KS, Morony S, Gong J, Cao J(2009). Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis. J Bone Miner Res, 24:578-588
[108] Nelson ME, Fiatarone MA, Morganti CM, Trice I, Greenberg RA, Evans WJ(1994). Effects of high-intensity strength training on multiple risk factors for osteoporotic fractures. A randomized controlled trial. JAMA, 272:1909-1914
[109] Peterson MD, Sen A, Gordon PM(2011). Influence of Resistance Exercise on Lean Body Mass in Aging Adults. Med Sci Sports Exerc, 43:249-258
[110] Russo CR, Ricca M, Ferrucci L(2000). True osteoporosis and frailty-related osteopenia: two different clinical entities. J Am Geriatr Soc, 48:1738-1739
[111] Terabe Y, Harada A, Tokuda H, Okuizumi H, Nagaya M, Shimokata H(2012). Vitamin D Deficiency in Elderly Women in Nursing Homes: Investigation with Consideration of Decreased Activation Function from the Kidneys. J Am Geriatr Soc, 60:251-255
[112] Boucher BJ(2012). The problems of vitamin d insufficiency in older people. Aging Dis, 3:313-329
[113] Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B(2005). Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA, 293:2257-2264
[114] Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC, Staehelin HB, Bazemore MG, Zee RY(2004). Effect of Vitamin D on falls: a meta-analysis. JAMA, 291:1999-2006
[115] Bischoff HA, Stahelin HB, Dick W, Akos R, Knecht M, Salis C(2003). Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res, 18:343-351
[116] Kim HK, Suzuki T, Saito K, Yoshida H, Kobayashi H, Kato H(2012). Effects of Exercise and Amino Acid Supplementation on Body Composition and Physical Function in Community-Dwelling Elderly Japanese Sarcopenic Women: A Randomized Controlled Trial. J Am Geriatr Soc, 60:16-23
[117] Bonnefoy M, Cornu C, Normand S, Boutitie F, Bugnard F, Rahmani A(2003). The effects of exercise and protein-energy supplements on body composition and muscle function in frail elderly individuals: a long-term controlled randomised study. Br J Nutr, 89:731-739
[118] Basaria S, Coviello AD, Travison TG, Storer TW, Farwell WR, Jette AM(2010). Adverse events associated with testosterone administration. N Engl J Med, 363:109-122
[119] Ryall JG, Gregorevic P, Plant DR, Sillence MN, Lynch GS(2002). Beta 2-agonist fenoterol has greater effects on contractile function of rat skeletal muscles than clenbuterol. Am J Physiol Regul Integr Comp Physiol, 283:R1386-1394
[120] Kamalakkannan G, Petrilli CM, George I, LaManca J, McLaughlin BT, Shane E(2008). Clenbuterol Increases Lean Muscle Mass but Not Endurance in Patients With Chronic Heart Failure. The Journal of Heart and Lung Transplantation, 27:457-461
[121] Vestergaard P(2007). Fracture Risk in Patients With Chronic Lung Diseases Treated With Bronchodilator Drugs and Inhaled and Oral Corticosteroids. Chest, 132:1599
[122] Lang CC, Struthers AD(2013). Targeting the reninangiotensin-aldosterone system in heart failure. Nat Rev Cardiol, 10:125-134
[123] Verbeke F, Lindley E, Van Bortel L, Vanholder R, London G, Cochat P(2013). A European Renal Best Practice (ERBP) position statement on the Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for the Management of Blood Pressure in Non-dialysis-dependent Chronic Kidney Disease: an endorsement with some caveats for real-life application. Nephrol Dial TransplantEpub ahead of print
[124] Morales MG, Cabrera D, Cespedes C, Vio CP, Vazquez Y, Brandan E(2013). Inhibition of the angiotensin-converting enzyme decreases skeletal muscle fibrosis in dystrophic mice by a diminution in the expression and activity of connective tissue growth factor (CTGF/CCN-2)Cell Tissue ResEpub ahead of print
[125] Sumukadas D, Witham MD, Struthers AD, McMurdo MET(2007). Effect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trial. CMAJ, 177:867-874
[126] Schellenbaum GD, Smith NL, Heckbert SR, Lumley T, Rea TD, Furberg CD(2005). Weight Loss, Muscle Strength, and Angiotensin-Converting Enzyme Inhibitors in Older Adults with Congestive Heart Failure or Hypertension. J Am Geriatr Soc, 53:1996-2000
[127] Burks TN, Andres-Mateos E, Marx R, Mejias R, Van Erp C, Simmers JL(2011). Losartan Restores Skeletal Muscle Remodeling and Protects Against Disuse Atrophy in Sarcopenia. Sci Transl Med, 3:82ra37
[128] Bunout D, Barrera G, de la Maza MP, Leiva L, Backhouse C, Hirsch S(2009). Effects of enalapril or nifedipine on muscle strength or functional capacity in elderly subjects. A double blind trial. J Renin Angiotensin Aldosterone Syst, 10:77-84
[129] Papadakis MA, Grady D, Black D, Tierney MJ, Gooding G, Schambelan M(1996). Growth hormone replacement in healthy older men improves body composition but not functional ability. Ann Intern Med, 124:708
[130] Thompson J, Butterfield G, Gylfadottir U, Yesavage J, Marcus R, Hintz R(1998). Effects of human growth hormone, insulin-like growth factor I, and diet and exercise on body composition of obese postmenopausal women. J Clin Endocrinol Metab, 83:1477-1484
[131] Aubertin-Leheudre M, Audet M, Goulet ED, Dionne IJ(2005). HRT provides no additional beneficial effect on sarcopenia in physically active postmenopausal women: a cross-sectional, observational study. Maturitas, 51:140-145
[132] Kenny AM, Dawson L, Kleppinger A, Iannuzzi-Sucich M, Judge JO(2003). Prevalence of sarcopenia and predictors of skeletal muscle mass in nonobese women who are long-term users of estrogen-replacement therapy. J Gerontol A Biol Sci Med Sci, 58:M436-440
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