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Aging and Disease    2014, Vol. 5 Issue (4) : 226-237     DOI: 10.14336/AD.2014.0500226
Managing Sarcopenia and Its Related-Fractures to Improve Quality of Life in Geriatric Populations
Tetsuro Hida1, *, Atsushi Harada2, Shiro Imagama1, Naoki Ishiguro1
1Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine
2Department of Orthopedic Surgery, National Center for Geriatrics and Gerontology
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Sarcopenia, an aging-induced generalized decrease in muscle mass, strength, and function, is known to affect elderly individuals by decreasing mobile function and increasing frailty and imbalance that lead to falls and fragile fractures. Sarcopenia is a known risk factor for osteoporotic fractures, infections, and early death in some specific situations. The number of patients with sarcopenia is estimated to increase to 500 million people in the year 2050. Sarcopenia is believed to be caused by multiple factors such as disuse, malnutrition, age-related cellular changes, apoptosis, and genetic predisposition; however, this remains to be determined. Various methods have been developed, but no safe or effective treatment has been found to date. This paper is a review on the association between sarcopenia and its related-fractures and their diagnoses and management methods to prevent fractures.

Keywords sarcopenia      sarcopenia-related fracture      osteoporosis      diagnosis      muscle mass      treatment      pathogenesis     
Corresponding Authors: Tetsuro Hida   
Issue Date: 04 November 2014
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Tetsuro Hida
Atsushi Harada
Shiro Imagama
Naoki Ishiguro
Cite this article:   
Tetsuro Hida,Atsushi Harada,Shiro Imagama, et al. Managing Sarcopenia and Its Related-Fractures to Improve Quality of Life in Geriatric Populations[J]. Aging and Disease, 2014, 5(4): 226-237.
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Figure 1.  Recommended algorithm for diagnosing sarcopenia from EWGSOP (ref.8, partly modified from original)
Figure 2.  80 year-old woman with a hip fracture lying on operation table. Coexisting severe sarcopenia was pointed out.
Figure 3.  Relationship between sarcopenia, osteoporosis and fracture
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