Please wait a minute...
 Home  About the Journal Editorial Board Aims & Scope Peer Review Policy Subscription Contact us
 
Early Edition  //  Current Issue  //  Open Special Issues  //  Archives  //  Most Read  //  Most Downloaded  //  Most Cited
Aging and disease    2016, Vol. 7 Issue (3) : 278-284     DOI: 10.14336/AD.2015.1025
Original Article |
Levels and Rates of Physical Activity in Older Adults with Multiple Sclerosis
Klaren Rachel E., Sebastiao Emerson, Chiu Chung-Yi, Kinnett-Hopkins Dominique, McAuley Edward, Motl Robert W.*
Department of Kinesiology & Community Health, University of Illinois at Urbana-Champaign, USA.
Download: PDF(760 KB)   HTML
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks    
Abstract  

There is much evidence supporting the safety and benefits of physical activity in adults with multiple sclerosis (MS) and recent evidence of beneficial effects on physical function in older adults with MS. However, there is very little known about physical activity participation in older adults with conditions such as MS. This study compared levels of physical activity (i.e., sedentary behavior, light physical activity (LPA), and moderate-to-vigorous physical activity (MVPA)) and rates of meeting public health guidelines for MVPA (i.e., ≥30 min/day) among young (i.e., ages 20-39 years), middle-aged (i.e., ages 40-59 years) and older adults (i.e., ages ≥60 years) with MS. The sample included 963 persons with MS who provided demographic and clinical information and wore an accelerometer for a 7-day period. The primary analysis involved a between-subjects ANOVA on accelerometer variables (i.e., accelerometer wear time; number of valid days; sedentary behavior in min/day; LPA in min/day; and MVPA in min/day). Collectively, our data indicated that older adults with MS engaged in less MVPA and more sedentary behavior than middle-aged and young adults with MS. Such results highlight the importance of developing physical activity interventions as an effective means for managing the progression and consequences of MS in older adults.

Keywords accelerometry      physical activity      older adults      multiple sclerosis     
Corresponding Authors: Motl Robert W.   
About author:

These authors equally contribute this work

Issue Date: 09 January 2016
Service
E-mail this article
E-mail Alert
RSS
Articles by authors
Klaren Rachel E.
Sebastiao Emerson
Chiu Chung-Yi
Kinnett-Hopkins Dominique
McAuley Edward
Motl Robert W.
Cite this article:   
Klaren Rachel E.,Sebastiao Emerson,Chiu Chung-Yi, et al. Levels and Rates of Physical Activity in Older Adults with Multiple Sclerosis[J]. Aging and disease, 2016, 7(3): 278-284.
URL:  
http://www.aginganddisease.org/EN/10.14336/AD.2015.1025     OR     http://www.aginganddisease.org/EN/Y2016/V7/I3/278
VariableAge Groups
p-value
Young (n=194)Middle-aged (n=662)Older (n=107)
Age, years33.1 (4.7)49.6 (5.4)63.0 (3.6)0.001*
Sex, % female82.285.577.60.09
Race, % Caucasian91.294.296.30.20
BMI, kg/m227.6 (6.8)27.1 (6.8)27.6 (7.4)0.24
Education, % college graduate66.059.658.90.26
Income, % >$40K/year60.173.363.60.001*
Type of MS, %RRMS96.992.082.20.01*
Disease duration, years6.3 (5.0)10.8 (7.2)16.5 (9.2)0.001*
PDDS score (mdn, IQR)1.0 (3.0)2.0 (2.0)3.0 (3.0)0.001*
Table 1  Demographic and clinical characteristics in 963 persons with MS by years of age (i.e., 20-39, 40-59, and ≥60)
VariableAge Groups
F-valuep-value
Young
(n=194)
Middle-aged
(n=662)
Older
(n=107)
Wear time, min/day823.4 (70.8)838.9 (86.1)840.2 (70.8)2.90.057
Number of valid days5.8 (1.3)6.0 (1.3)6.5 (1.0)11.10.001*
Sedentary behavior, min/day509.6 (83.7)532.8 (100.4)554.1 (89.9)8.00.001*
LPA, min/day289.4 (75.0)287.7 (85.2)275.0 (84.2)1.20.302
MVPA, min/day24.5 (20.1)19.3 (20.2)12.6 (16.7)12.60.001*
Table 2  Accelerometer variables in 963 persons with MS by years of age (i.e., 20-39, 40-59, and ≥60)
Figure 1.  Minutes per day of moderate-to-vigorous physical activity (MVPA) among age groups of people with MS

† = p < .05 for Young vs. Middle-aged groups; ‡ = p < .05 for Young vs. Older age groups; ‽ = p < .05 for Middle-aged vs. Older age groups; Young = age of 20-39 years; Middle-aged = age of 40-59 years; Older = ages ≥60 years. Values represent mean score and standard error of the mean.

[1] Minden SL, Marder WD, Harrold LN, Dor A, editors. Multiple sclerosis - A statistical portrait: A compendium of data on demographics, disability, and health service utilization in the United States. Cambridge: ABT Associates Inc; 1993.
[2] Marrie RA, Yu N, Blanchard J, Leung S, Elliott L (2010). The rising prevalence and changing age distribution of multiple sclerosis in Manitoba. Neurology, 74:465-471.
[3] Awad A, Stüve O (2010). Multiple sclerosis in the elderly patient. Drugs Aging, 27:283-294.
[4] Stern M, Sorkin L, Milton K, Sperber K (2010). Aging with multiple sclerosis. Phys Med Rehabil Clin N Am, 21:403-417.
[5] Bove R, Musallam A, Healy BC, Houtchens M, Glanz BI, Khoury S, et al. (2010). No sex-specific difference in disease trajectory in multiple sclerosis patients before and after age 50. BMC Neurol, 13:73.
[6] DiLorenzo T, Halper J, Picone MA (2003). Reliability and validity of the Multiple Sclerosis Quality of Life Inventory in older individuals. Disabil Rehabil, 25:891-897.
[7] Finlayson M (2004). Concerns about the future among older adults with multiple sclerosis. AJOT, 58:54-63.
[8] FinlaysonM & van DenendT (2003). Experiencing the loss of mobility: Perspectives of older adults. Disabil Rehabil, 25:1168-1180.
[9] Finlayson M, Shevil E, Cho CC (2009). Perceptions of cognitive symptoms among people aging with multiple sclerosis and their caregivers. AJOT, 63:151-159.
[10] Jones KH, Ford DV, Jones PA, John A, Middleton RM, Lockhart-Jones H, et al. (2013). How people with multiple sclerosis rate their quality of life: An EQ-5D survey via the UK MS Register. PLoS One, 8(6):e65640.
[11] Trojano M, Liguori M, Bosco Zimatore G, Bugarini R, Avolio C, Paolicelli D, et al. (2002). Age-related disability in multiple sclerosis. Ann Neurol, 51:475-480.
[12] Confavreux C, Vukusic S (2006). Age at disability milestones in multiple sclerosis. Brain, 129:595-605.
[13] Multiple Sclerosis Coalition. The use of disease-modifying therapies in multiple sclerosis: Principles and current evidence. 2014, 2015 updates. www.nationalmssociety.org/NationalMSSociety/media/MSNationalFiles/Brochures/DMT_Consensus_MS_Coalition.pdf
[14] Shirani A, Zhao Y, Petkau J, Gustafson P, Karim ME, Evans C, et al. (2015). Multiple sclerosis in older adults: The clinical profile and impact of interferon beta treatment. BioMed Res Int, 2015:451912.
[15] Ford CC, Bove RM (2015). Effects of aging on the disease course and management of multiple sclerosis. The Science of MS Management, 4:1-13.
[16] Pilutti LA, Platta ME, Motl RW, Latimer-Cheung AE (2014). The safety of exercise training in multiple sclerosis: a systematic review. J Neurol Sci, 343:3-7.
[17] Motl RW, Pilutti LA (2012). The benefits of exercise training in multiple sclerosis. Nat Rev Neurol, 8:487-97.
[18] McAuley E, Wojcicki TR, Learmonth YC, Roberts SA, Hubbard EA, Kinnett-Hopkins D, et al. (2015). Effects of a DVD-delivered exercise intervention on physical function in older adults with multiple sclerosis: A pilot randomized controlled trial. Mult Scler, 1:1-9.
[19] Keysor JJ (2003). Does late-life physical activity or exercise prevent or minimize disablement? A critical review of scientific evidence. Prev Med, 25:129-36.
[20] Latimer-Cheung AE, Pilutti LA, Hicks AL, Martin Ginis KA, Fenuta AM, MacKibbon KA, et al. (2013). Effects of exercise training on fitness, mobility, fatigue, and health related quality of life among adults with multiple sclerosis: a systematic review to inform guideline development. Arch Phys Med Rehabil, 94:1800-28.
[21] Dalgas U, Stenager E (2012). Exercise and disease progression in multiple sclerosis: can exercise slow down the progression of multiple sclerosis? Ther Adv Neurol Disord, 5:81-95.
[22] Motl RW, McAuley E (2010). Physical activity, disability, and quality of life in older adults. Phys Med Rehabil Clin N Am, 21:299-308.
[23] Klaren RE, Motl RW, Dlugonski D, Sandroff BM, Pilutti LA (2013). Objectively quantified physical activity in persons with multiple sclerosis. Arch Phys Med Rehabil, 94:2342-8.
[24] Motl RW, McAuley E, Sandroff BM, Hubbard EA. (2015). Descriptive epidemiology of physical activity rates in multiple sclerosis. Acta Neurol Scand, 131:422-35.
[25] Evenson KR, Buchner DM, Morland KB (2012). Objective measurement of physical activity and sedentary behavior among US adults aged 60 years or older. Prev Chronic Dis, 9:E26.
[26] Hart TL, Swartz AM, Cashin SE, Strath SJ (2011). How many days of monitoring predict physical activity and sedentary behaviour in older adults? Int J Behav Nutr Phys Act, 8:62.
[27] Motl RW, Zhu W, Park Y, McAuley E, Scott JA, Snook EM (2007). Reliability of scores from physical activity monitors in adults with multiple sclerosis. Adapt Phys Activ Q, 24:245-53.
[28] Sandroff BM, Motl RW, Suh Y (2012). Accelerometer output and its association with energy expenditure in persons with multiple sclerosis. J Rehabil Res Dev, 49:467-75.
[29] Learmonth YC, Motl RW, Sandroff BM, Pula JH, Cadavid D (2013). Validation of patient determined disease steps (PDDS) scale scores in persons with multiple sclerosis. BMC Neurol, 13:37.
[30] Cohen J, Editor. Statistical power analysis for the behavioral sciences. 2nd ed. Hillsdale: Lawrence Erlbaum; 1988.
[31] Freedman VA, Martin LG, Schoeni RF (2002). Recent trends in disability and functioning among older adults in the United States: a systematic review. JAMA, 288:3137-46.
[32] Amato MP, Ponziani G, Rossi F, Liedl CL, Stefanile C, Rossi L (2001). Quality of life in multiple sclerosis: the impact of depression, fatigue and disability. Mult Scler, 7:340-4.
[1] Michael G. Flynn,Melissa M. Markofski,Andres E. Carrillo. Elevated Inflammatory Status and Increased Risk of Chronic Disease in Chronological Aging: Inflamm-aging or Inflamm-inactivity?[J]. Aging and disease, 2019, 10(1): 147-156.
[2] Kleipool Emma EF., Hoogendijk Emiel O., Trappenburg Marijke C., Handoko M. Louis, Huisman Martijn, Peters Mike JL., Muller Majon. Frailty in Older Adults with Cardiovascular Disease: Cause, Effect or Both?[J]. Aging and disease, 2018, 9(3): 489-497.
[3] Shen Ting, You Yuyi, Joseph Chitra, Mirzaei Mehdi, Klistorner Alexander, Graham Stuart L., Gupta Vivek. BDNF Polymorphism: A Review of Its Diagnostic and Clinical Relevance in Neurodegenerative Disorders[J]. Aging and disease, 2018, 9(3): 523-536.
[4] Lana Alberto, Valdés-Bécares Ana, Buño Antonio, Rodríguez-Artalejo Fernando, Lopez-Garcia Esther. Serum Leptin Concentration is Associated with Incident Frailty in Older Adults[J]. Aging and disease, 2017, 8(2): 240-249.
[5] Rachel E. Ward,Paolo Caserotti,Jane A. Cauley,Robert M. Boudreau,Bret H. Goodpaster,Aaron I. Vinik,Anne B. Newman,Elsa S. Strotmeyer. Mobility-Related Consequences of Reduced Lower-Extremity Peripheral Nerve Function with Age: A Systematic Review[J]. A&D, 2016, 7(4): 466-478.
[6] XinQi Dong,E-Shien Chang,Ping Zeng,Melissa A. Simon. Suicide in the Global Chinese Aging Population: A Review of Risk and Protective Factors, Consequences, and Interventions[J]. A&D, 2015, 6(2): 121-130.
[7] Martin Burtscher. Effects of Living at Higher Altitudes on Mortality: A Narrative Review[J]. Aging and Disease, 2014, 5(4): 274-280.
[8] Mark Mapstone, Tiffany N. Hilton, Hongmei Yang, Joseph J. Guido, Amneris E. Luque, William J. Hall, Stephen Dewhurst, Krupa Shah. Poor Aerobic Fitness May Contribute to Cognitive Decline in HIV-infected Older Adults[J]. Aging and Disease, 2013, 4(6): 311-319.
[9] Courtenay R. Bruce. A Review of Ethical Considerations for Ventricular Assist Device Placement in Older Adults[J]. Aging and Disease, 2013, 4(2): 100-112.
[10] Patricia Griffin,Joshua J. Michel,Kristy Huysman,Alison J. Logar,Abbe N. Vallejo. Integration of Immunity with Physical and Cognitive Function in Definitions of Successful Aging[J]. Aging and Disease, 2012, 3(1): 34-50.
Viewed
Full text


Abstract

Cited

  Shared   
Copyright © 2014 Aging and Disease, All Rights Reserved.
Address: Aging and Disease Editorial Office 3400 Camp Bowie Boulevard Fort Worth, TX76106 USA
Fax: (817) 735-0408 E-mail: editorial@aginganddisease.org
Powered by Beijing Magtech Co. Ltd