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Aging and disease    2019, Vol. 10 Issue (4) : 901-907     DOI: 10.14336/AD.2018.1025
Mini-review |
The role of CD2AP in the Pathogenesis of Alzheimer's Disease
Qing-Qing Tao, Yu-Chao Chen, Zhi-Ying Wu*
Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China.
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Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by irreversible decline in cognition with unclear pathogenesis. Recently, accumulating evidence has revealed that CD2 associated protein (CD2AP), a scaffolding molecule regulates signal transduction and cytoskeletal molecules, is implicated in AD pathogenesis. Several single nucleotide polymorphisms (SNPs) in CD2AP gene are associated with higher risk for AD and mRNA levels of CD2AP are decreased in peripheral lymphocytes of sporadic AD patients. Furthermore, CD2AP loss of function is linked to enhanced Aβ production, Tau-induced neurotoxicity, abnormal neurite structure modulation and reduced blood-brain barrier integrity. This review is to summarize the recent discoveries about the genetics and known functions of CD2AP. The recent evidence concerning the roles of CD2AP in the AD pathogenesis is summarized and CD2AP can be a promising therapeutic target for AD.

Keywords Alzheimer’s disease      CD2AP      pathogenesis      genetics     
Corresponding Authors: Wu Zhi-Ying   
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These authors contributed equally to this work.

Just Accepted Date: 08 December 2018   Issue Date: 01 August 2019
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Qing-Qing Tao
Yu-Chao Chen
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Qing-Qing Tao,Yu-Chao Chen,Zhi-Ying Wu. The role of CD2AP in the Pathogenesis of Alzheimer's Disease[J]. Aging and disease, 2019, 10(4): 901-907.
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Figure 1.  The chromosome location and schematic representation of the structural domains of <i>CD2AP</i>

A) CD2AP is located on chromosome 6 (6p12.3). B) The protein has three consecutive SH3 domains at the amino terminus. The middle region is a proline-rich sequence. The carboxy terminus contains a duplex helical structural region where has a binding site for the actin cytoskeleton.

YearSNP IDSourcePopulationCases/ControlsP valueORAssociationReference
2011rs9349407USAAfrican American513/4960.8600.98NegativeLogue et al. [38]
2011rs9349407Mayo2American and European ancestry2,521/4,0550.5600.97NegativeCarrasquillo et al. [29]
2011rs9349407ADGC combined
analysis (Stage 1+2)
European ancestry11840/109311.00E-061.12PositiveNaj et al. [15]
2011rs9349407GERAD+ consortiaEuropean ancestry6283/71658.00E-041.11PositiveHollingworth et al. [13]
2011rs9296559GERAD+ consortiaEuropean ancestry6283/71651.50E-031.1PositiveHollingworth et al. [13]
2013rs9349407North ChinaEast Asian612/6120.8501.024NegativeTan et al. [30]
2013rs9349407JapanEast Asian891/8440.3800.94NegativeMiyashita et al. [39]
2013rs10948363Four Consortia
combined analysis (Stage 1+2)*
European ancestry25580/484665.20E-111.1PositiveLambert et al. [34]
2013rs9349407AmericaAmerican725/6510.029NGPositiveShulman et al. [37]
2015rs116754410TorontoCaucasian330/333,705.33E-08NGPositiveVardarajan et al. [35]
2015rs9349407South ChinaHan Chinese229/3180.0481.368PositiveJiao et al. [36]
2015rs10948363South ChinaHan Chinese229/3180.3951.138NegativeJiao et al. [36]
2017rs9349407Southeast China (Stage 1)Han Chinese422/14354.6E-102.11PositiveTao et al. [14]
2017rs9296559Southeast China (Stage 1+2)Han Chinese647/2,1387.69E-091.773PositiveTao et al. [14]
Table 1  Associations between CD2AP and sporadic AD.
Figure 2.  Possible mechanisms underlying CD2AP loss of function in the pathogenesis of sporadic AD

CD2AP loss of function is linked to enhanced Aβ metabolism, Tau-induced neurotoxicity, abnormal neurite structure modulation and reduced blood-brain barrier integrity.

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