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Aging and disease    2020, Vol. 11 Issue (1) : 108-117     DOI: 10.14336/AD.2019.0405
Orginal Article |
Type 2 Myocardial Infarction: A Geriatric Population-based Model of Pathogenesis
Alain Putot1,4,*, Melanie Jeanmichel2, Frederic Chague2, Patrick Manckoundia1,3, Yves Cottin2,4, Marianne Zeller4
1Geriatric Department, University Hospital of Dijon Bourgogne, France.
2Cardiology Department, University Hospital of Dijon Bourgogne, France.
3INSERM U1093 Cognition Action Plasticite, Universite de Bourgogne Franche Comte, France.
4Physiopathologie et Epidémiologie Cerebro-Cardiovasculaires (PEC2), Universite de Bourgogne Franche Comte, France.
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Distinction between type 2 myocardial infarction (T2MI), defined as an imbalance between oxygen supply and demand without atherothrombosis, and type 1 myocardial infarction (T1MI), due to plaque disruption, is often a clinical challenge in frail elderly patients. We aimed to identify the characteristics and underlying causes of T2MI using a comprehensive geriatric approach. From a multicentre population-based prospective study in coronary care units, we adjudicated 4572 consecutive patients hospitalized for an acute T1MI or T2MI, according to the 3rd universal definition and a prespecified geriatric model of T2MI pathogenesis. In total, 3710 (81%) had T1MI and 862 (19%) T2MI. Patients with T2MI were 10 y older (77 vs 67 y, p<0.001), more frequently female (44 vs 26%, p<0.001) and had more frequent comorbidities. In multivariate analysis, acute heart failure, tachycardia and C-reactive protein elevation at admission were associated with a higher risk of T2MI vs T1MI, whereas chest pain, troponin I peak > 10 µg/L and ST-segment elevation were associated with a lower risk. Underlying mechanisms leading to T2MI highlighted 3 main patterns: 1) Age-related physiological cardiovascular decline 2) chronic predisposing factors including chronic anaemia (10%) and severe aortic stenosis (7%), 3) acute triggering factors, the most common being acute infection (39%), mainly respiratory tract infection, followed by tachyarrhythmia (13%) and acute heart failure (10%). 122 (14%) patients had combined predisposing and triggering conditions for T2MI. In our large population-based survey of T2MI, chronic anaemia and severe aortic stenosis increased predisposition to T2MI and acute respiratory infection was by far the most frequent trigger. Our data shed new light on the age-related pathophysiological basis for discrepancies in oxygen supply and demand leading to MI.

Keywords type 2 myocardial infarction      anemia      respiratory tract infection      aortic stenosis      tachyarrhythmia pathophysiology     
Corresponding Authors: Alain Putot   
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These authors contributed equally to this work.

Just Accepted Date: 08 May 2019   Issue Date: 15 January 2020
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Alain Putot
Melanie Jeanmichel
Frederic Chague
Patrick Manckoundia
Yves Cottin
Marianne Zeller
Cite this article:   
Alain Putot,Melanie Jeanmichel,Frederic Chague, et al. Type 2 Myocardial Infarction: A Geriatric Population-based Model of Pathogenesis[J]. Aging and disease, 2020, 11(1): 108-117.
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Figure 1.  Flow chart.
Figure 2.  Geriatric model applied to type 2 myocardial infarction pathogenesis.
Figure 3.  Multivariate analysis of factors associated with type 2 myocardial infarction. CRP: C-reactive protein; HF: heart failure; MI: myocardial infarction, SBPL systolic blood pressure; STEMI: ST-segment elevation myocardial infarction; Trpo I peak: cardiac troponin I peak.
Figure 4.  Predisposing and precipitating factors for type 2 myocardial infarction.
Figure 5.  Main combinations of etiologic factors for type 2 acute myocardial infarction. (A) Combination of acute factors. (B and C) Combinations of acute and chronic factors. (D) Acute and chronic factors combined with infection. (E) Acute and chronic factors combined with tachyarrhythmia. F. Acute and chronic factors combined with acute heart failure.
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