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Aging and disease    2020, Vol. 11 Issue (6) : 1345-1351     DOI: 10.14336/AD.2020.1014
Commentary Article |
COVID-19 and Acute Sarcopenia
Carly Welch1,2,3,*, Carolyn Greig2,4,5, Tahir Masud2,6,7, Daisy Wilson1,3, Thomas A Jackson1,2,3
1Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
2MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, University of Birmingham and University of Nottingham, UK.
3University Hospitals Birmingham NHS Trust, Birmingham, B15 2GW, UK.
4School of Sport, Exercise, and Rehabilitation Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
5Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
6University of Nottingham, Nottingham, UK.
7Nottingham University Hospitals NHS Trust, Nottingham, UK.
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Abstract  

The COVID-19 pandemic has had a devastating global impact, with older adults being most at risk of death from the disease. However, acute sarcopenia occurs in survivors of COVID-19; older adults and the most critically unwell patients are the most at risk. Acute sarcopenia is an under-recognised condition of acute muscle insufficiency, defined by declines in muscle function and/or quantity within six months, usually following a stressor event. This commentary reviews definition and mechanisms of acute sarcopenia in COVID-19 and suggests recommendations for research and clinical practice. Research should now focus on the longer-term consequences of acute sarcopenia in patients who have suffered from COVID-19. At the same time, clinicians need to be increasingly aware of the condition, and measurements of muscle strength, quantity, and physical performance should be embedded into clinical practice. Clinicians should consider the risks of acute sarcopenia when weighing up the risks and benefits of treatment (e.g. dexamethasone), and instigate multidisciplinary treatment including dietetics input.

Keywords COVID-19      sarcopenia      acute     
Corresponding Authors: Welch Carly   
About author:

These authors contributed equally to this work.

Just Accepted Date: 19 October 2020   Issue Date: 19 November 2020
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Welch Carly
Greig Carolyn
Masud Tahir
Wilson Daisy
Jackson Thomas A
Cite this article:   
Welch Carly,Greig Carolyn,Masud Tahir, et al. COVID-19 and Acute Sarcopenia[J]. Aging and disease, 2020, 11(6): 1345-1351.
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http://www.aginganddisease.org/EN/10.14336/AD.2020.1014     OR
Figure 1.  Mechanisms of acute sarcopenia development with COVID-19. Precipitating factors for acute sarcopenia with COVID-19 are demonstrated by pathways and predisposing factors are shown separately. MPB = Muscle Protein Breakdown; MPS = Muscle Protein Synthesis
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