Aging and disease

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Table of Content

01 January 2011. VOL 2, ISSUE 1 Previous Issue Next Issue

Acute Seizures in Old Age Leads to a Greater Loss of CA1 Pyramidal Neurons, an Increased Propensity for Developing Chronic TLE and Severe Cognitive Dysfunction
Bharathi Hattiangady, Ramkumar Kuruba, Ashok K. Shetty

2011, 2 (1): 1-18

PDF (1557KB)
Endogenously EGFP-Labeled Mouse Embryonic Stem Cells
Junli Zhang, Rammohan V. Rao, Patricia Spilman, Julie Mangada, Lin Xie, Cathy Vitelli, Olivia F. Gorostiza, David T. Madden, Xianmin Zeng, Kunlin Jin, Matthew J. Hart, Dale E. Bredesen, Veronica Galvan

2011, 2 (1): 18-29

PDF (979KB)
Functional Dedifferentiation and Altered Connectivity in Older Adults: Neural Accounts of Cognitive Aging
Joshua O. S. Goh

2011, 2 (1): 30-48

PDF (512KB)
Aging of the Subventricular Zone Neural Stem Cell Niche
Joanne C. Conover, Brett A. Shook

2011, 2 (1): 49-63

PDF (1008KB)
Brain Aging and Regeneration after Injuries: an Organismal approach
Ana-Maria Buga, Raluca Vintilescu, Oltin Tiberiu Pop, Aurel Popa–Wagner

2011, 2 (1): 64-79

PDF (623KB)
Aging and Stress: Past Hypotheses, Present Approaches and Perspectives
Pedro Garrido

2011, 2 (1): 80-99

PDF (751KB)

Cover Illustration

01 January 2011. Vol.2 No.1
The persistence of an active subventricular zone neural stem cell niche in the adult mammalian forebrain supports its continued role in the production of new neurons and in generating cells to function in repair through adulthood. Unfortunately, with increasing age the niche begins to deteriorate, compromising these functions. The reasons for this decline are not clear. Studies are beginning to define the molecular and physiologic changes in the microenvironment of the aging subventricular zone niche. New revelations from aging studies will allow for a more thorough understanding of which reparative functions are lost in the aged brain, the progression of niche demise and the possibility for therauptic intervention to improve aging brain function.

[Detail]

Cover Illustration

The persistence of an active subventricular zone neural stem cell niche in the adult mammalian forebrain supports its continued role in the production of new neurons and in generating cells to function in repair through adulthood. Unfortunately, with increasing age the niche begins to deteriorate, compromising these functions. The reasons for this decline are not clear. Studies are beginning to define the molecular and physiologic changes in the microenvironment of the aging subventricular zone niche. New revelations from aging studies will allow for a more thorough understanding of which reparative functions are lost in the aged brain, the progression of niche demise and the possibility for therauptic intervention to improve aging brain function.