Aging and disease

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01 April 2011. VOL 2, ISSUE 4 Previous Issue Next Issue

From Bench to Bedside: Unique Challenges of Treating Epilepsy in the Aging Brain
Lee A. Shapiro

2011, 2 (4): 275-277

PDF (244KB)
Pathophysiological Considerations of Seizures, Epilepsy, and Status Epilepticus in the Elderly
Rebecca M. Verellen, Jose E. Cavazos

2011, 2 (4): 278-285

PDF (400KB)
Seizure-induced Increased Neurogenesis Occurs in the Dentate Gyrus of Aged Sprague-Dawley Rats
Lee A. Shapiro, Lulu Wang, Pooja Upadhyaya, Charles E. Ribak

2011, 2 (4): 286-293

PDF (751KB)
Astrocyte Alterations in the Hippocampus Following Pilocarpine-induced Seizures in Aged Rats
Gabriel M Arisi, Megan Ruch, Maira L Foresti, Sanjib Mukherjee, Charles E Ribak, Lee A Shapiro

2011, 2 (4): 294-300

PDF (610KB)
m1 Acetylcholine Receptor Expression is Decreased in Hippocampal CA1 region of Aged Epileptic Animals
Clarissa Fantin Cavarsan, Renata Della Torre Avanzi, Claudio Marcos Queiroz, Gilberto Fernando Xavier, Luiz Eugênio Mello, Luciene Covolan

2011, 2 (4): 301-307 | DOI: dx.doi.org/10.14336/AD.2011.0816

PDF (689KB)
Aging-induced Seizure-related Changes to the Hippocampal Mossy Fiber Pathway in Forebrain Specific BDNF Overexpressing Mice
Kate L. Weidner, Jeffrey H. Goodman, Kathryn K. Chadman, Daniel P. McCloskey

2011, 2 (4): 308-317

PDF (820KB)
Electrical and Pharmacological Stimuli Reveal a Greater Susceptibility for CA3 Network Excitability in Hippocampal Slices from Aged vs. Adult Fischer 344 Rats
Daniel J. Kanak, Ryan T. Jones, Ashish Tokhi, Amy L. Willingham, Hitten P. Zaveri, Gregory M. Rose, Peter R. Patrylo

2011, 2 (4): 318-331

PDF (1108KB)
Chronic Cellular Hyperexcitability in Elderly Epileptic Rats with Spontaneous Seizures Induced by Kainic Acid Status Epilepticus while Young Adults
Kun Zhang, Gleb P. Tolstykh, Russell M. Sanchez, Jose E. Cavazos

2011, 2 (4): 332-338

PDF (599KB)

Cover Illustration

01 April 2011. Vol.2 No.4
It is known that the incidence of epilepsy increases with age, but only a few studies have investigated the consequences and mechanisms of seizure and epilepsy in aged animals. Astrocytic changes are known to directly influence neuronal excitability and seizure susceptibility. However, information regarding alterations to astrocytes after seizures in aged animals is lacking in the literature. In the present study, the density and morphology of astrocytes expressing GFAP were investigated in the hippocampus of aged rats that experienced status epilepticus induced by pilocarpine. One month after seizures, astrocytes in aged rats have increased volume and present activated morphology. Despite these morphological changes, the density of astrocytes was not altered in the hippocampus of aged rats after seizures.

[Detail]

Cover Illustration

It is known that the incidence of epilepsy increases with age, but only a few studies have investigated the consequences and mechanisms of seizure and epilepsy in aged animals. Astrocytic changes are known to directly influence neuronal excitability and seizure susceptibility. However, information regarding alterations to astrocytes after seizures in aged animals is lacking in the literature. In the present study, the density and morphology of astrocytes expressing GFAP were investigated in the hippocampus of aged rats that experienced status epilepticus induced by pilocarpine. One month after seizures, astrocytes in aged rats have increased volume and present activated morphology. Despite these morphological changes, the density of astrocytes was not altered in the hippocampus of aged rats after seizures.