Aging and disease

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01 January 2012. VOL 3, ISSUE 1 Previous Issue Next Issue

Aging Successfully: a Research and Public Health Priority for the 21^st Century
Abbe N. Vallejo

2012, 3 (1): 1-4

PDF (310KB)
Exercise, Inflammation and Aging
Jeffrey A. Woods, Kenneth R. Wilund, Stephen A. Martin, Brandon M. Kistler

2012, 3 (1): 130-140

PDF (620KB)
Maintaining Brain Health by Monitoring Inflammatory Processes: a Mechanism to Promote Successful Aging
Caterina Rosano, Anna L. Marsland, Peter J. Gianaros

2012, 3 (1): 16-33

PDF (815KB)
Integration of Immunity with Physical and Cognitive Function in Definitions of Successful Aging
Patricia Griffin, Joshua J. Michel, Kristy Huysman, Alison J. Logar, Abbe N. Vallejo

2012, 3 (1): 34-50

PDF (724KB)
Successful Aging as a Continuum of Functional Independence: Lessons from Physical Disability Models of Aging
Kristin A. Lowry, Abbe N. Vallejo, Stephanie A. Studenski

2012, 3 (1): 5-15

PDF (416KB)
Immune Responses to pneumococcal vaccines in children and adults: Rationale for age-specific vaccination
M.A. Julie Westerink, Harry W. Schroeder, Moon H. Nahm

2012, 3 (1): 51-67

PDF (508KB)
Immunosenescence and Challenges of Vaccination against Influenza in the Aging Population
Adrian J. Reber, Tatiana Chirkova, Jin Hyang Kim, Weiping Cao, Renata Biber, David K. Shay, Suryaprakash Sambhara

2012, 3 (1): 68-90

PDF (953KB)
The Role of Nutrition in Enhancing Immunity in Aging
Munkyong Pae, Simin Nikbin Meydani, Dayong Wu

2012, 3 (1): 91-129

PDF (970KB)

Cover Illustration

01 January 2012. Vol.3 No.1
Influenza is an important contributor to morbidity and mortality worldwide. Accumulation of genetic mutations termed antigenic drift, allows influenza viruses to inflict yearly epidemics that may result in 250,000 to 500,000 deaths annually. Over 90% of influenza-related deaths occur in the older adult population. This is at least in part a result of increasing dysregulation of the immune system with age, termed immunosenescence. This dysregulation results in reduced capacity to cope with infections and decreased responsiveness to vaccination. The older adult population is in dire need of improved vaccines capable of eliciting protective responses in the face of a waning immune system. This review focuses on the status of immunity, responses to influenza vaccination, and strategies that are currently being explored to elicit enhanced immune responses in this high risk population.

[Detail]

Cover Illustration

Influenza is an important contributor to morbidity and mortality worldwide. Accumulation of genetic mutations termed antigenic drift, allows influenza viruses to inflict yearly epidemics that may result in 250,000 to 500,000 deaths annually. Over 90% of influenza-related deaths occur in the older adult population. This is at least in part a result of increasing dysregulation of the immune system with age, termed immunosenescence. This dysregulation results in reduced capacity to cope with infections and decreased responsiveness to vaccination. The older adult population is in dire need of improved vaccines capable of eliciting protective responses in the face of a waning immune system. This review focuses on the status of immunity, responses to influenza vaccination, and strategies that are currently being explored to elicit enhanced immune responses in this high risk population.