Aging and disease

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01 February 2012. VOL 3, ISSUE 2 Previous Issue Next Issue

Amyloid Deposition and Advanced Age Fails to Induce Alzheimer’s Type Progression in a Double Knock-In Mouse Model
Gauri H. Malthankar-Phatak, Yin-Guo Lin, Nicholas Giovannone, Robert Siman

2012, 3 (2): 141-155

PDF (1606KB)
Differential Age-related Changes in Bone Geometry between the Humerus and the Femur in Healthy Men
Matti D. Allen, S. Jared McMillan, Cliff S. Klein, Charles L. Rice, Greg D. Marsh

2012, 3 (2): 156-163

PDF (481KB)
The Subtelomere of Short Telomeres is Hypermethylated in Alzheimer’s Disease
Jing-Zhi Guan, Wei-Ping Guan, Toyoki Maeda, Naoki Makino

2012, 3 (2): 164-170

PDF (579KB)
Aging and the Pathogenic Response to Burn
Meenakshi Rani, Martin G. Schwacha

2012, 3 (2): 171-180

PDF (482KB)
Reorganization of Brain Networks in Aging and Age-related Diseases
Junfeng Sun, Shanbao Tong, Guo-Yuan Yang

2012, 3 (2): 181-193

PDF (1435KB)
Melatonin in Aging and Disease —Multiple Consequences of Reduced Secretion, Options and Limits of Treatment
Rüdiger Hardeland

2012, 3 (2): 194-225

PDF (819KB)

Cover Illustration

01 February 2012. Vol.3 No.2
Aging is an important and critical factor that contributes to the clinical outcome of burn patients. The very young and the elderly are more likely to succumb after major burn as compared to their adult counterparts. With the aging population, improved understanding of the mechanisms underlying age-associated complications after burns becomes even more demanding. It is widely accepted that elderly burn patients have significantly increased morbidity and mortality. Irrespective of the type of burn injury, the aged population shows slower recoveries and suffers more complications. Age-associated immune dysfunction, immunosenescence, may predispose the elderly burn patients to more infections, slower healing and/or to other complications. Furthermore, pre-existing, age-related medical conditions such as, pulmonary/cardiovascular dysfunctions and diabetes in the elderly are other important factors that contribute to their poorer outcomes after major burn. The present review describes the impact of aging on burn patients outcomes.

[Detail]

Cover Illustration

Aging is an important and critical factor that contributes to the clinical outcome of burn patients. The very young and the elderly are more likely to succumb after major burn as compared to their adult counterparts. With the aging population, improved understanding of the mechanisms underlying age-associated complications after burns becomes even more demanding. It is widely accepted that elderly burn patients have significantly increased morbidity and mortality. Irrespective of the type of burn injury, the aged population shows slower recoveries and suffers more complications. Age-associated immune dysfunction, immunosenescence, may predispose the elderly burn patients to more infections, slower healing and/or to other complications. Furthermore, pre-existing, age-related medical conditions such as, pulmonary/cardiovascular dysfunctions and diabetes in the elderly are other important factors that contribute to their poorer outcomes after major burn. The present review describes the impact of aging on burn patients outcomes.