Aging and disease

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10 May 2014. VOL 5, ISSUE 3 Previous Issue Next Issue

Raised Serum Proinflammatory Cytokines in Alzheimer’s Disease with Depression
Vineet Kumar Khemka, Anirban Ganguly, Debajit Bagchi, Arindam Ghosh, Aritri Bir, Atanu Biswas, Sita Chattopadhyay, Sasanka Chakrabarti

2014, 5 (3): 170-176 | DOI: 10.14336/AD.2014.0500170
Hip Fractures in a Geriatric Population - Rehabilitation Based on Patients Needs
Natasa Radosavljevic, Dejan Nikolic, Milica Lazovic, Aleksandar Jeremic

2014, 5 (3): 177-182 | DOI: 10.14336/AD.2014.0500177
Strength and Endurance Training Prescription in Healthy and Frail Elderly
Eduardo Lusa Cadore, Ronei Silveira Pinto, Martim Bottaro, Mikel Izquierdo

2014, 5 (3): 183-195 | DOI: 10.14336/AD.2014.0500183
Aging Is Not a Disease: Implications for Intervention
Suresh I. S. Rattan

2014, 5 (3): 196-202 | DOI: 10.14336/AD.2014.0500196
Link between PI3K/AKT/PTEN Pathway and NOX Proteinin Diseases
Atsuko Nakanishi, Yoko Wada, Yasuko Kitagishi, Satoru Matsuda

2014, 5 (3): 203-211 | DOI: 10.14336/AD.2014.0500203
Lifestyle and Advanced Glycation End Products (AGEs) Burden: Its Relevance to Healthy Aging
Chandan Prasad, Victorine Imrhan, Francesco Marotta, Shanil Juma, Parakat Vijayagopal

2014, 5 (3): 212-217 | DOI: 10.14336/AD.2014.0500212

Cover Illustration

10 May 2014. Vol.5 No.3
Accumulating evidence has revealed that thePI3K/AKT/PTENpathway acts as a pivotal determinant of cell fate regarding senescence and apoptosis, which is mediated by intracellular reactive oxygen species (ROS) generation. NADPH oxidase (NOX) family of enzymes generates the ROS. The regulation of NOX enzymes is complex, with many members of this family exhibiting complexity in terms of subunit composition, cellular location, and tissue-specific expression. Cells are continuously exposed to the ROS, which represent mutagens and are thought to be a major contributor to several diseases including cancer and aging process. Therefore, cellular ROS sensing and metabolism are firmly regulated by a variety of proteins involved in the redox mechanism. In this review, the roles of oxidative stress in PI3K/AKT/PTEN signaling are summarized with a focus on the links between the pathways and NOX protein in several diseases including cancer and aging.

[Detail]

Cover Illustration

Accumulating evidence has revealed that thePI3K/AKT/PTENpathway acts as a pivotal determinant of cell fate regarding senescence and apoptosis, which is mediated by intracellular reactive oxygen species (ROS) generation. NADPH oxidase (NOX) family of enzymes generates the ROS. The regulation of NOX enzymes is complex, with many members of this family exhibiting complexity in terms of subunit composition, cellular location, and tissue-specific expression. Cells are continuously exposed to the ROS, which represent mutagens and are thought to be a major contributor to several diseases including cancer and aging process. Therefore, cellular ROS sensing and metabolism are firmly regulated by a variety of proteins involved in the redox mechanism. In this review, the roles of oxidative stress in PI3K/AKT/PTEN signaling are summarized with a focus on the links between the pathways and NOX protein in several diseases including cancer and aging.