Aging and disease

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10 March 2014. VOL 5, ISSUE 2 Previous Issue Next Issue

Aging and Injury: Alterations in Cellular Energetics and Organ Function
Ninu Poulose, Raghavan Raju

2014, 5 (2): 101-108 | DOI: 10.14336/AD.2014.0500101
Hemodynamic Aging as the Consequence of Structural Changes Associated with Early Vascular Aging (EVA)
Peter M Nilsson

2014, 5 (2): 109-113 | DOI: 10.14336/AD.2014.0500109
Vascular Hyperpermeability and Aging
Ryan Oakley, Binu Tharakan

2014, 5 (2): 114-125 | DOI: 10.14336/AD.2014.0500114
Sepsis in Old Age: Review of Human and Animal Studies
Marlene E Starr, Hiroshi Saito

2014, 5 (2): 126-136 | DOI: 10.14336/AD.2014.0500126
Sepsis-induced Cardiac Mitochondrial Damage and Potential Therapeutic Interventions in the Elderly
Qun S. Zang, Steven E. Wolf, Joseph P. Minei

2014, 5 (2): 137-149 | DOI: 10.14336/AD.2014.0500137
NAD⁺ Metabolism in Age-Related Hearing Loss
Hyung-Jin Kim, Gi-Su Oh, Seong-Kyu Choe, Tae Hwan Kwak, Raekil Park, Hong-Seob So

2014, 5 (2): 150-159 | DOI: 10.14336/AD.2014.0500150
Gender Differences, Aging and Hormonal Status in Mucosal Injury and Repair
Irina Grishina, Anne Fenton, Sumathi Sankaran-Walters

2014, 5 (2): 160-169 | DOI: 10.14336/AD.2014.0500160
Susceptibility to Focal and Global Brain Ischemia of Alzheimer Mice Displaying Aβ Deposits: Effect of Immunoglobulin
Riikka Heikkinen, Tarja Malm, Janne Heikkilä, Anu Muona, Heikki Tanila, Milla Koistinaho, Jari Koistinaho

2014, 5 (2): 76-87 | DOI: 10.14336/AD.2014.050076
Resveratrol Suppresses Expression of VEGF by Human Retinal Pigment Epithelial Cells: Potential Nutraceutical for Age-related Macular Degeneration
Chandrasekharam N. Nagineni, Raghavan Raju, Krishnasai K. Nagineni, Vijay K. Kommineni, Aswini Cherukuri, R. Krishnan Kutty, John J. Hooks, Barbara Detrick

2014, 5 (2): 88-100 | DOI: 10.14366/AD.2014.050088

Cover Illustration

10 March 2014. Vol.5 No.2
As the “baby boomers” age, the percentage of the population over sixty-five years of age is increasing rapidly. Chronic disease management is an important component in the care of the elderly. The effects of aging on different organ systems are also pertinent; such as the weakening homeostatic response to injury in the older individuals. Mucosal surfaces have the largest combined surface area in the body and are the site of important host microbe interactions, especially in the gut which is prone to injury, both from local and systemic insult. This susceptibility has been known to increase with age. Therefore it is important to understand the interplay between aging, injury and recovery at the mucosal surface. Sex hormones play an important role in the maintenance of the mucosal barrier function as well as the mucosa associated immune function in both genders. Menopause in women is a defined time period in which major hormonal changes occur such as a decline in systemic estradiol levels. The differential levels of sex hormones contribute to the sexual dimorphism seen in response to injury at the mucosal surface, prior to and following menopause. Thus the effect of sex hormone and aging on mucosal mechanisms in response to injury is an important area of investigation.

[Detail]

Cover Illustration

As the “baby boomers” age, the percentage of the population over sixty-five years of age is increasing rapidly. Chronic disease management is an important component in the care of the elderly. The effects of aging on different organ systems are also pertinent; such as the weakening homeostatic response to injury in the older individuals. Mucosal surfaces have the largest combined surface area in the body and are the site of important host microbe interactions, especially in the gut which is prone to injury, both from local and systemic insult. This susceptibility has been known to increase with age. Therefore it is important to understand the interplay between aging, injury and recovery at the mucosal surface. Sex hormones play an important role in the maintenance of the mucosal barrier function as well as the mucosa associated immune function in both genders. Menopause in women is a defined time period in which major hormonal changes occur such as a decline in systemic estradiol levels. The differential levels of sex hormones contribute to the sexual dimorphism seen in response to injury at the mucosal surface, prior to and following menopause. Thus the effect of sex hormone and aging on mucosal mechanisms in response to injury is an important area of investigation.