Aging and disease

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21 November 2014. VOL 5, ISSUE 6 Previous Issue Next Issue

Original Article

Aging is Associated with Impaired Renal Function, INF-gamma Induced Inflammation and with Alterations in Iron Regulatory Proteins Gene Expression
Costa Elísio, Fernandes João, Ribeiro Sandra, Sereno José, Garrido Patrícia, Rocha-Pereira Petronila, Coimbra Susana, Catarino Cristina, Belo Luís, Bronze-da-Rocha Elsa, Vala Helena, Alves Rui, Reis Flávio, Santos-Silva Alice

2014, 5 (6): 356-365 | DOI: 10.14366/AD.2014.0500356
Reduced Apoptosis by Ethanol and Its Association with PKC-δ and Akt Signaling in Ischemic Stroke
Hafeez Adam, Elmadhoun Omar, Peng Changya, Y. Ding Jamie, Geng Xiaokun, Guthikonda Murali, Ding Yuchuan

2014, 5 (6): 366-372 | DOI: 10.14336/AD.2014.0500366

Review Article

Use of Anthropometry for the Prediction of Regional Body Tissue Distribution in Adults: Benefits and Limitations in Clinical Practice
Scafoglieri Aldo, Pieter Clarys Jan, Cattrysse Erik, Bautmans Ivan

2014, 5 (6): 374-393 | DOI: 10.14366/AD.2014.05003743
Regulation and Role of TGFβ Signaling Pathway in Aging and Osteoarthritis Joints
Baugé Catherine, Girard Nicolas, Lhuissier Eva, Bazille Celine, Boumediene Karim

2014, 5 (6): 394-405 | DOI: 10.14336/AD.2014.0500394
The Circadian Timing System: A Recent Addition in the Physiological Mechanisms Underlying Pathological and Aging Processes
Arellanes-Licea Elvira, Caldelas Ivette, De Ita-Pérez Dalia, Díaz-Muñoz* Mauricio

2014, 5 (6): 406-418 | DOI: 10.14336/AD.2014.0500406
Early-life Exposure to Endocrine Disrupting Chemicals and Later-life Health Outcomes: An Epigenetic Bridge?
Vaiserman* Alexander

2014, 5 (6): 419-429 | DOI: 10.14336/AD.2014.0500419
The Role of NMDA Receptors in the Development of Brain Resistance through Pre- and Postconditioning
Celso Constantino Leandra, Inês Tasca Carla, Rodrigues Boeck Carina

2014, 5 (6): 430-441 | DOI: 10.14336/AD.2014.0500430

Cover Illustration

21 November 2014. Vol.5 No.6
Our aim was to contribute to a better understanding of the pathophysiology of anemia in elderly, by studying how aging affects renal function, iron metabolism, erythropoiesis and the inflammatory response, using an experimental animal model. The study was performed in male Wistar, a group of young rats with 2 months age and an old one with 18 months age. Old rats presented a significant higher urea, creatinine, interferon (INF)-gamma, ferritin and soluble transferrin receptor serum levels, as well as increased counts of reticulocytes and RDW. In addition, these rats showed significant lower erythropoietin (EPO) and iron serum levels. Concerning gene expression of iron regulatory proteins, old rats presented significantly higher mRNA levels of hepcidin (Hamp), transferrin (TF), transferrin receptor 2 (TfR2) and hemojuvelin (HJV); divalent metal transporter 1 (DMT1) mRNA levels were significantly higher in duodenal tissue; EPO gene expression was significantly higher in liver and lower in kidney, and the expression of the EPOR was significantly higher in both liver and kidney. Our results showed that aging is associated with impaired renal function, which could be in turn related with the inflammatory process and with a decline in EPO renal production. Moreover, we also propose that aging may be associated with INF-gamma-induced inflammation and with alterations upon iron regulatory proteins gene expression.

[Detail]

Cover Illustration

Our aim was to contribute to a better understanding of the pathophysiology of anemia in elderly, by studying how aging affects renal function, iron metabolism, erythropoiesis and the inflammatory response, using an experimental animal model. The study was performed in male Wistar, a group of young rats with 2 months age and an old one with 18 months age. Old rats presented a significant higher urea, creatinine, interferon (INF)-gamma, ferritin and soluble transferrin receptor serum levels, as well as increased counts of reticulocytes and RDW. In addition, these rats showed significant lower erythropoietin (EPO) and iron serum levels. Concerning gene expression of iron regulatory proteins, old rats presented significantly higher mRNA levels of hepcidin (Hamp), transferrin (TF), transferrin receptor 2 (TfR2) and hemojuvelin (HJV); divalent metal transporter 1 (DMT1) mRNA levels were significantly higher in duodenal tissue; EPO gene expression was significantly higher in liver and lower in kidney, and the expression of the EPOR was significantly higher in both liver and kidney. Our results showed that aging is associated with impaired renal function, which could be in turn related with the inflammatory process and with a decline in EPO renal production. Moreover, we also propose that aging may be associated with INF-gamma-induced inflammation and with alterations upon iron regulatory proteins gene expression.