Aging and disease

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01 April 2016. VOL 7, ISSUE 2 Previous Issue Next Issue

Guest Editor Introduction

2016, 7 (2): 215-215

PDF (230KB)

Review Article

The Role of Autophagy, Mitophagy and Lysosomal Functions in Modulating Bioenergetics and Survival in the Context of Redox and Proteotoxic Damage: Implications for Neurodegenerative Diseases
Matthew Redmann, Victor Darley-Usmar, Jianhua Zhang

2016, 7 (2): 150-162 | DOI: 10.14336/AD.2015.0820

PDF (964KB)
Oxidation of K⁺ Channels in Aging and Neurodegeneration
Federico Sesti

2016, 7 (2): 130-135 | DOI: 10.14336/AD.2015.0901

PDF (582KB)
Brain Lipotoxicity of Phytanic Acid and Very Long-chain Fatty Acids. Harmful Cellular/Mitochondrial Activities in Refsum Disease and X-Linked Adrenoleukodystrophy
Peter Schönfeld, Georg Reiser

2016, 7 (2): 136-149 | DOI: 10.14336/AD.2015.0823

PDF (921KB)
The Neuroprotective Properties of the Amyloid Precursor Protein Following Traumatic Brain Injury
Stephanie Plummer, Corinna Van den Heuvel, Emma Thornton, Frances Corrigan, Roberto Cappai

2016, 7 (2): 163-179 | DOI: 10.14336/AD.2015.0907

PDF (875KB)

Original Article

Aortic Complex Plaque Predicts the Risk of Cryptogenic Ischemic Cerebrovascular Disease Recurrence
Jing Dong, Xin Ma, Jingyuan Qie, Xunming Ji

2016, 7 (2): 114-120 | DOI: 10.14336/AD.2015.0923

PDF (770KB)

Review Article

Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases
Salminen Antero, Kaarniranta Kai, Kauppinen Anu

2016, 7 (2): 180-200 | DOI: 10.14336/AD.2015.0929

PDF (879KB)
Age-associated Cognitive Decline: Insights into Molecular Switches and Recovery Avenues
Arpita Konar, Padmanabh Singh, Mahendra K. Thakur

2016, 7 (2): 121-129 | DOI: 10.14336/AD.2015.1004

PDF (713KB)
Mitochondrial Dysfunction in Alzheimer’s Disease and the Rationale for Bioenergetics Based Therapies
Isaac G. Onyango, Jameel Dennis, Shaharyah M. Khan

2016, 7 (2): 201-214 | DOI: 10.14336/AD.2015.1007

PDF (901KB)

Editorial Commentary

Aging and Neurodegeneration: A Tangle of Models and Mechanisms
Sasanka Chakrabarti, Kochupurackal P. Mohanakumar

2016, 7 (2): 111-113 | DOI: 10.14336/AD.2016.0312

PDF (372KB)

Cover Illustration

01 April 2016. Vol.7 No.2
Axial CTA images of aortic plaques in four grades. A) No plaque at the aortic arch. B) a calcified plaque at the lateral wall of aortic arch with thickness less than 4 mm. C) Multiple mixed plaques at the aortic arch and descending aorta which are thicker than 4 mm. D) ulcer plaque at the lateral wall of aortic arch (black arrows indicate plaques).

[Detail]

Cover Illustration

Axial CTA images of aortic plaques in four grades. A) No plaque at the aortic arch. B) a calcified plaque at the lateral wall of aortic arch with thickness less than 4 mm. C) Multiple mixed plaques at the aortic arch and descending aorta which are thicker than 4 mm. D) ulcer plaque at the lateral wall of aortic arch (black arrows indicate plaques).