Figure 1. Deposition of tau oligomers in cerebrovasculature of human Alzheimer’s Disease (AD) brains. Representative images of oligomeric tau (T22, red), and total tau (tau 5, green) cerebrovascular immunoreactivity in cortical sections of AD (G-L) and age-matched control (M-O) brains. For all studies, n=3 brains/group; 10-15 sections from each sample were analyzed for tau oligomers. All AD samples were tested and were positive for tau oligomers. Merged images are shown with DAPI (blue). In all panels, arrows indicate tau inclusions. Mean percent colocalization ± SEM of T22 with Tau 5 is reported in the figure. Scale bar 50 µm.