Aging and disease

Table of Content

01 August 2018. VOL 9, ISSUE 4 Previous Issue Next Issue

Short Communication

Voxel-based Specific Regional Analysis System for Alzheimer’s Disease (VSRAD) on 3-tesla Normal Database: Diagnostic Accuracy in Two Independent Cohorts with Early Alzheimer’s Disease
Daichi Sone, Etsuko Imabayashi, Norihide Maikusa, Masayo Ogawa, Noriko Sato, Hiroshi Matsuda, Japanese-Alzheimer’s Disease Neuroimaging Initiative

2018, 9 (4): 755-760 | DOI: 10.14336/AD.2017.0818

PDF (537KB)

Orginal Article

Involvement of Kif4a in Spindle Formation and Chromosome Segregation in Mouse Oocytes
Feng Tang, Meng-Hao Pan, Yujie Lu, Xiang Wan, Yu Zhang, Shao-Chen Sun

2018, 9 (4): 623-633 | DOI: 10.14336/AD.2017.0901

PDF (843KB)
Fucoidan Protects Dopaminergic Neurons by Enhancing the Mitochondrial Function in a Rotenone-induced Rat Model of Parkinson’s Disease
Li Zhang, Junwei Hao, Yan Zheng, Ruijun Su, Yajin Liao, Xiaoli Gong, Limin Liu, Xiaomin Wang

2018, 9 (4): 590-604 | DOI: 10.14336/AD.2017.0831

PDF (2887KB)
Neuroprotective Effect of Caffeic Acid Phenethyl Ester in A Mouse Model of Alzheimer’s Disease Involves Nrf2/HO-1 Pathway
Fabiana Morroni, Giulia Sita, Agnese Graziosi, Eleonora Turrini, Carmela Fimognari, Andrea Tarozzi, Patrizia Hrelia

2018, 9 (4): 605-622 | DOI: 10.14336/AD.2017.0903

PDF (1035KB)
The Role of Pulmonary and Systemic Immunosenescence in Acute Lung Injury
Christina Brandenberger, Katharina Maria Kling, Marius Vital, Mühlfeld Christian

2018, 9 (4): 553-565 | DOI: 10.14336/AD.2017.0902

PDF (1390KB)
Gait Analyses in Mice: Effects of Age and Glutathione Deficiency
J. Thomas Mock, Sherilynn G Knight, Philip H Vann, Jessica M Wong, Delaney L Davis, Michael J Forster, Nathalie Sumien

2018, 9 (4): 634-646 | DOI: 10.14336/AD.2017.0925

PDF (1091KB)
Effect of Aging and Glucagon-like Peptide 2 on Intestinal Microbiota in SD Rats
Jiayu Wu, Weiying Ren, Li Li, Man Luo, Kan Xu, Jiping Shen, Jia Wang, Guilin Chang, Yi Lu, Yiming Qi, Binger Xu, Yuting He, Yu Hu

2018, 9 (4): 566-577 | DOI: 10.14336/AD.2017.1001

PDF (1171KB)
Glibenclamide Enhances the Therapeutic Benefits of Early Hypothermia after Severe Stroke in Rats
Shuzhen Zhu, Xiaoya Gao, Kaibin Huang, Yong Gu, Yafang Hu, Yongming Wu, Zhong Ji, Qing Wang, Suyue Pan

2018, 9 (4): 685-695 | DOI: 10.14336/AD.2017.0927

PDF (1252KB)

Review Article

The Prevalence of Mild Cognitive Impairment in China: A Systematic Review
Jiang Xue, Jiarui Li, Jiaming Liang, Shulin Chen

2018, 9 (4): 706-715 | DOI: 10.14336/AD.2017.0928

PDF (645KB)

Short Communication

Removal of Chylomicron Remnants from the Bloodstream is Delayed in Aged Subjects
Carmen G Vinagre, Fatima R Freitas, Carlos H de Mesquita, Juliana C Vinagre, Ana Carolina Mariani, Roberto Kalil-Filho, Raul C Maranhão

2018, 9 (4): 748-754 | DOI: 10.14336/AD.2017.1003

PDF (542KB)

Review Article

Superoxide Radical Dismutation as New Therapeutic Strategy in Parkinson’s Disease
Federica De Lazzari, Luigi Bubacco, Alexander J Whitworth, Marco Bisaglia

2018, 9 (4): 716-728 | DOI: 10.14336/AD.2017.1018

PDF (659KB)

Orginal Article

Pkcδ Activation is Involved in ROS-Mediated Mitochondrial Dysfunction and Apoptosis in Cardiomyocytes Exposed to Advanced Glycation End Products (Ages)
Yao-Chih Yang, Cheng-Yen Tsai, Chien-Lin Chen, Chia-Hua Kuo, Chien-Wen Hou, Shi-Yann Cheng, Ritu Aneja, Chih-Yang Huang, Wei-Wen Kuo

2018, 9 (4): 647-663 | DOI: 10.14336/AD.2017.0924

PDF (2167KB)

Review Article

Mitochondrial Pharmacology of Dimebon (Latrepirdine) Calls for a New Look at its Possible Therapeutic Potential in Alzheimer’s Disease
Schamim H Eckert, Janett Gaca, Nathalie Kolesova, Kristina Friedland, Gunter P Eckert, Walter E Muller

2018, 9 (4): 729-744 | DOI: 10.14336/AD.2017.1014

PDF (1032KB)

Orginal Article

N-acetylcysteine Treatment Reduces Age-related Hearing Loss and Memory Impairment in the Senescence-Accelerated Prone 8 (SAMP8) Mouse Model
Aurore Marie, Johann Meunier, Emilie Brun, Susanna Malmstrom, Veronique Baudoux, Elodie Flaszka, Gaëlle Naert, François Roman, Sylvie Cosnier-Pucheu, Sergio Gonzalez-Gonzalez

2018, 9 (4): 664-673 | DOI: 10.14336/AD.2017.0930

PDF (832KB)
Hyperglycemia Alters Astrocyte Metabolism and Inhibits Astrocyte Proliferation
Wenjun Li, Gourav Roy Choudhury, Ali Winters, Jude Prah, Wenping Lin, Ran Liu, Shao-Hua Yang

2018, 9 (4): 674-684 | DOI: 10.14336/AD.2017.1208

PDF (1040KB)

Opinion

Kidney Disease in Elderly: Importance of Collaboration between Geriatrics and Nephrology
Faheemuddin Azher Ahmed

2018, 9 (4): 745-747 | DOI: 10.14336/AD.2018.0223

PDF (259KB)

Orginal Article

The Whole Exome Sequencing Clarifies the Genotype- Phenotype Correlations in Patients with Early-Onset Dementia
Yangqi Xu, Xiaoli Liu, Junyi Shen, Wotu Tian, Rong Fang, Binyin Li, Jianfang Ma, Li Cao, Shengdi Chen, Guanjun Li, Huidong Tang

2018, 9 (4): 696-705 | DOI: 10.14336/AD.2018.0208

PDF (678KB)
Synergistically Induced Hypothermia and Enhanced Neuroprotection by Pharmacological and Physical Approaches in Stroke
Jun Zhang, Kaiyin Liu, Omar Elmadhoun, Xunming Ji, Yunxia Duan, Jingfei Shi, Xiaoduo He, Xiangrong Liu, Di Wu, Ruiwen Che, Xiaokun Geng, Yuchuan Ding

2018, 9 (4): 578-589 | DOI: 10.14336/AD.2017.0817

PDF (859KB)

Short Communication

Hypoxia, hibernation and Neuroprotection: An Experimental Study in Mice
Changhong Ren, Sijie Li, Gary Rajah, Guo Shao, Guowei Lu, Rongrong Han, Qingjian Huang, Haiyan Li, Yuchuan Ding, Kunlin Jin, Xunming Ji

2018, 9 (4): 761-768 | DOI: 10.14336/AD.2018.0702

PDF (850KB)

Cover Illustration

01 August 2018. Vol.9 No.4
Figure 4. Scanning electron microscopy cochleae representative images of mice treated with NAC (right panels) and vehicle (left panels). A) Global view of middle part of cochlea showing the presence of IHC and OHC of treated mice. Arrows and asterisks mark the loss of OHC and IHC respectively. Scale bar = 15 µm. B) Magnification of OHC stereocilia of NAC and vehicle treated mice. Scale bar = 3 µm. C) Magnification of IHC stereocilia of NAC and vehicle treated mice. Scale bar = 5 µm. n = 3 mice by group. These images are representative images of 3 independent animals.

[Detail]

Cover Illustration

Figure 4. Scanning electron microscopy cochleae representative images of mice treated with NAC (right panels) and vehicle (left panels). A) Global view of middle part of cochlea showing the presence of IHC and OHC of treated mice. Arrows and asterisks mark the loss of OHC and IHC respectively. Scale bar = 15 µm. B) Magnification of OHC stereocilia of NAC and vehicle treated mice. Scale bar = 3 µm. C) Magnification of IHC stereocilia of NAC and vehicle treated mice. Scale bar = 5 µm. n = 3 mice by group. These images are representative images of 3 independent animals.

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