Aging and disease

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01 February 2021. VOL 12, ISSUE 1 Previous Issue Next Issue

Letter to the Editor

Promoting Resilience in the Age of COVID-19 Pandemic: A New Era of Strategic Foresight
Hanna Lu, Jing Li, Xi Ni

2021, 12 (1): 1-2 | DOI: 10.14336/AD.2020.1011

PDF (292KB)
Coronavirus Disease (COVID-19): A Perspective from Immunosenescence
Miguel Genebat, Laura Tarancón-Díez, Rebeca de Pablo-Bernal, Alba Calderón, Mª Ángeles Muñoz-Fernández, Manuel Leal

2021, 12 (1): 3-6 | DOI: 10.14336/AD.2020.0831

PDF (308KB)

Commentary

Age in the Time of COVID-19: An Ethical Analysis
Sorin Hostiuc, Ionut Negoi, Oana Maria-Isailă, Ioana Diaconescu, Mihaela Hostiuc, Eduard Drima

2021, 12 (1): 7-13 | DOI: 10.14336/AD.2020.0929

PDF (354KB)
Low level of Vitamin C and dysregulation of Vitamin C transporter might be involved in the severity of COVID-19 Infection
Taylor Patterson, Carlos M Isales, Sadanand Fulzele

2021, 12 (1): 14-26 | DOI: 10.14336/AD.2020.0918

PDF (555KB)
Neurological Manifestations of COVID-19: Causality or Coincidence?
Fangfang Zhao, Ziping Han, Rongliang Wang, Yumin Luo

2021, 12 (1): 27-35 | DOI: 10.14336/AD.2020.0917

PDF (447KB)
Interdisciplinary Research in Alzheimer’s Disease and the Roles International Societies Can Play
Shawn Zheng Kai Tan, Robert Chunhua Zhao, Sasanka Chakrabarti, Ilia Stambler, Kunlin Jin, Lee Wei Lim

2021, 12 (1): 36-41 | DOI: 10.14336/AD.2020.0602

PDF (370KB)

Short Communication

Prediction of SARS-CoV Interaction with Host Proteins during Lung Aging Reveals a Potential Role for TRIB3 in COVID-19
Diogo de Moraes, Brunno Vivone Buquete Paiva, Sarah Santiloni Cury, Raissa Guimarães Ludwig, João Pessoa Araújo Junior, Marcelo Alves da Silva Mori, Robson Francisco Carvalho

2021, 12 (1): 42-49 | DOI: 10.14336/AD.2020.1112

PDF (918KB)
Supplement

1. Supplementary data.pdf (407KB)

Orginal Article

Transcranial Focused Ultrasound Stimulation Improves Neurorehabilitation after Middle Cerebral Artery Occlusion in Mice
Jixian Wang, Guofeng Li, Lidong Deng, Muyassar Mamtilahun, Lu Jiang, Weibao Qiu, Hairong Zheng, Junfeng Sun, Qing Xie, Guo-Yuan Yang

2021, 12 (1): 50-60 | DOI: 10.14336/AD.2020.0623

PDF (577KB)
Metabolic Healthy Obesity, Vitamin D Status, and Risk of COVID-19
Shu Li, Zhi Cao, Hongxi Yang, Yuan Zhang, Fusheng Xu, Yaogang Wang

2021, 12 (1): 61-71 | DOI: 10.14336/AD.2020.1108

PDF (1180KB)
Supplement

1. Supplementary data.pdf (909KB)
Brain-derived CCR5 Contributes to Neuroprotection and Brain Repair after Experimental Stroke
Suning Ping, Xuecheng Qiu, Michele Kyle, Li-Ru Zhao

2021, 12 (1): 72-92 | DOI: 10.14336/AD.2020.0406

PDF (2506KB)
Supplement

1. Supplementary data.pdf (1368KB)
Identifying Biomarkers Associated with Venous Infarction in Acute/Subacute Cerebral Venous Thrombosis
Jiangang Duan, Xinyi Leng, Ziping Han, Yanning Cai, Chunxiu Wang, Gary Rajah, Haiqing Song, Yuchuan Ding, Xunming Ji

2021, 12 (1): 93-101 | DOI: 10.14336/AD.2020.0405

PDF (545KB)
Hydrogen Peroxide-Induced Senescence Reduces the Wound Healing-Promoting Effects of Mesenchymal Stem Cell-Derived Exosomes Partially via miR-146a
Meiqian Xu, Xiaodong Su, Xian Xiao, Hongliang Yu, Xiaoxia Li, Armand Keating, Shihua Wang, Robert Chunhua Zhao

2021, 12 (1): 102-115 | DOI: 10.14336/AD.2020.0624

PDF (1489KB)
Supplement

1. Supplementary data.pdf (181KB)
Ischemic Conditioning Ameliorated Hypertension and Vascular Remodeling of Spontaneously Hypertensive Rat via Inflammatory Regulation
Yu Gao, Changhong Ren, Xiaohua Li, Wantong Yu, Sijie Li, Haiyan Li, Yan Wang, Dong Li, Ming Ren, Xunming Ji

2021, 12 (1): 116-131 | DOI: 10.14336/AD.2020.0320

PDF (1890KB)

Mini review

Roles of the MYST Family in the Pathogenesis of Alzheimer’s Disease via Histone or Non-histone Acetylation
Yuhong Li, Hui Huang, Man Zhu, Hua Bai, Xiaowei Huang

2021, 12 (1): 132-142 | DOI: 10.14336/AD.2020.0329

PDF (1230KB)

Review

Radiomics in Stroke Neuroimaging: Techniques, Applications, and Challenges
Qian Chen, Tianyi Xia, Mingyue Zhang, Nengzhi Xia, Jinjin Liu, Yunjun Yang

2021, 12 (1): 143-154 | DOI: 10.14336/AD.2020.0421

PDF (564KB)
A Comprehensive Summary of the Knowledge on COVID-19 Treatment
Yu Peng, Hongxun Tao, Senthil Kumaran Satyanarayanan, Kunlin Jin, Huanxing Su

2021, 12 (1): 155-191 | DOI: 10.14336/AD.2020.1124

PDF (1307KB)
Supplement

1. Supplementary data.pdf (630KB)

2. Supplementary data.pdf (628KB)
The Mechanism of Physical Activity-induced Amelioration of Parkinson’s Disease: A Narrative Review
Piotr Gronek, Aline Nogueira Haas, Wojciech Czarny, Robert Podstawski, Marcela do Santos Delabary, Cain CT Clark, Michał Boraczyński, Maria Tarnas, Paulina Wycichowska, Mariola Pawlaczyk, Joanna Gronek

2021, 12 (1): 192-202 | DOI: 10.14336/AD.2020.0407

PDF (651KB)
Pathogenesis and Management in Cerebrovenous Outflow Disorders
Chaobo Bai, Zhongao Wang, Christopher Stone, Da Zhou, Jiayue Ding, Yuchuan Ding, Xunming Ji, Ran Meng

2021, 12 (1): 203-222 | DOI: 10.14336/AD.2020.0404

PDF (900KB)
Comprehensive Perspectives on Experimental Models for Parkinson’s Disease
Minjing Ke, Cheong-Meng Chong, Qi Zhu, Ke Zhang, Cui-Zan Cai, Jia-Hong Lu, Dajiang Qin, Huanxing Su

2021, 12 (1): 223-246 | DOI: 10.14336/AD.2020.0331

PDF (844KB)
The Role of Immune Cells in the Pathogenesis of Idiopathic Inflammatory Myopathies
Lijuan Zhao, Qi Wang, Bin Zhou, Lihua Zhang, Honglin Zhu

2021, 12 (1): 247-260 | DOI: 10.14336/AD.2020.0410

PDF (464KB)
Mechanism of Ferroptosis: A Potential Target for Cardiovascular Diseases Treatment
Jie Ju, Ya-nan Song, Kun Wang

2021, 12 (1): 261-276 | DOI: 10.14336/AD.2020.0323

PDF (962KB)
Immune Cell Number, Phenotype, and Function in the Elderly with Sepsis
Wanxue He, Kun Xiao, Min Fang, Lixin Xie

2021, 12 (1): 277-296 | DOI: 10.14336/AD.2020.0627

PDF (483KB)
Melatonin: Effects on Cartilage Homeostasis and Therapeutic Prospects in Cartilage-related Diseases
Wen-qing Xie, Song-feng Chen, Xiao-hua Tao, Li-yang Zhang, Pei-wu Hu, Wei-li Pan, Yi-bin Fan, Yu-sheng Li

2021, 12 (1): 297-307 | DOI: 10.14336/AD.2020.0519

PDF (627KB)
Pharmacological Treatment of Vascular Dementia: A Molecular Mechanism Perspective
Huang Kuang, Zhi-Feng Zhou, Yu-Ge Zhu, Zhi-Kai Wan, Mei-Wen Yang, Fen-Fang Hong, Shu-Long Yang

2021, 12 (1): 308-326 | DOI: 10.14336/AD.2020.0427

PDF (1040KB)

Cover Illustration

01 February 2021. Vol.12 No.1
Figure 1. The development of COVID19. Viral infection: TMPRSS2 cleaves the S protein of SARS-CoV-2; The RBD on the S1 subunit binds to ACE2 on the cell surface. Following entry into the cell, viral RNA is released and combined with RdRp to synthesize a full-length negative-strand RNA as an RNA replication template. After translation, structural proteins are localized to the inner membrane of Golgi for assembly. Cytokine storm syndrome: The immune system is over-activated, followed by the overproduction of multiple inflammatory factors. Multiple immune cells are recruited. As a result, healthy cells are damaged by overactive immune response. Acute respiratory distress syndrome: In the exudative phase, macrophages are activated and release pro-inflammatory mediators, which leads to the aggregation of neutrophils and monocytes. Activated neutrophils induce further damage. The injury leads to loss of barrier function and fluid accumulation in the interstitium and alveoli. In the proliferative period, the tissue homeostasis is recovered.

[Detail]

Cover Illustration

Figure 1. The development of COVID19. Viral infection: TMPRSS2 cleaves the S protein of SARS-CoV-2; The RBD on the S1 subunit binds to ACE2 on the cell surface. Following entry into the cell, viral RNA is released and combined with RdRp to synthesize a full-length negative-strand RNA as an RNA replication template. After translation, structural proteins are localized to the inner membrane of Golgi for assembly. Cytokine storm syndrome: The immune system is over-activated, followed by the overproduction of multiple inflammatory factors. Multiple immune cells are recruited. As a result, healthy cells are damaged by overactive immune response. Acute respiratory distress syndrome: In the exudative phase, macrophages are activated and release pro-inflammatory mediators, which leads to the aggregation of neutrophils and monocytes. Activated neutrophils induce further damage. The injury leads to loss of barrier function and fluid accumulation in the interstitium and alveoli. In the proliferative period, the tissue homeostasis is recovered.