Aging and disease

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01 July 2021. VOL 12, ISSUE 4 Previous Issue Next Issue

Orginal Article

Effects of Pyruvate Administration on Mitochondrial Enzymes, Neurological Behaviors, and Neurodegeneration after Traumatic Brain Injury
Prasanth S Ariyannur, Guoqiang Xing, Erin S Barry, Brandi Benford, Neil E Grunberg, Pushpa Sharma

2021, 12 (4): 983-999 | DOI: 10.14336/AD.2020.1015

PDF (1325KB)

Review

An Update on Medical and Surgical Treatments of Parkinson’s Disease
Dipali Nemade, Thyagarajan Subramanian, Vikram Shivkumar

2021, 12 (4): 1021-1035 | DOI: 10.14336/AD.2020.1225

PDF (535KB)
Contrasting Metabolic Insufficiency in Aging and Dementia
Dennis A Turner

2021, 12 (4): 1081-1096 | DOI: 10.14336/AD.2021.0104

PDF (624KB)
Pediatric Stroke: Overview and Recent Updates
Mary Hollist, Katherine Au, Larry Morgan, Padmashri A Shetty, Riddhi Rane, Abraham Hollist, Angela Amaniampong, Batool F Kirmani

2021, 12 (4): 1043-1055 | DOI: 10.14336/AD.2021.0219

PDF (388KB)

Short Communications

Transcranial Near Infrared Light Stimulations Improve Cognition in Patients with Dementia
Damir Nizamutdinov, Xiaoming Qi, Marvin H Berman, Gordon Dougal, Samantha Dayawansa, Erxi Wu, S. Stephen Yi, Alan B Stevens, Jason H Huang

2021, 12 (4): 954-963 | DOI: 10.14336/AD.2021.0229

PDF (459KB)

Review

Neuromodulation in Drug Resistant Epilepsy
Natalia Rincon, Donald Barr, Naymee Velez-Ruiz

2021, 12 (4): 1070-1080 | DOI: 10.14336/AD.2021.0211

PDF (404KB)
Super-Refractory Status Epilepticus: Prognosis and Recent Advances in Management
Batool F Kirmani, Katherine Au, Lena Ayari, Marita John, Padmashri Shetty, Robert J Delorenzo

2021, 12 (4): 1097-1119 | DOI: 10.14336/AD.2021.0302

PDF (598KB)
Reflex Epilepsy
Samrina Hanif, Shane T Musick

2021, 12 (4): 1010-1020 | DOI: 10.14336/AD.2021.0216

PDF (331KB)
Novel Concepts for the Role of Chloride Cotransporters in Refractory Seizures
Pavel A Kipnis, Shilpa D Kadam

2021, 12 (4): 1056-1069 | DOI: 10.14336/AD.2021.0129

PDF (914KB)

Orginal Article

Acute Stroke Management: Overview and Recent Updates
Hollist Mary, Morgan Larry, Cabatbat Rainier, Au Katherine, F. Kirmani Maaida, F. Kirmani Batool

2021, 12 (4): 1000-1009 | DOI: 10.14336/AD.2021.0311

PDF (583KB)

Review

A Review of Insomnia Treatments for Patients with Mild Cognitive Impairment
Meghan K Mattos, Angela Chang, Katherine Pitcher, Carley Whitt, Lee M Ritterband, Mark S Quigg

2021, 12 (4): 1036-1042 | DOI: 10.14336/AD.2021.0423

PDF (308KB)

Orginal Article

NRF2 Loss Accentuates Parkinsonian Pathology and Behavioral Dysfunction in Human α-Synuclein Overexpressing Mice
Annadurai Anandhan, Nhat Nguyen, Arjun Syal, Luke A Dreher, Matthew Dodson, Donna D Zhang, Lalitha Madhavan

2021, 12 (4): 964-982 | DOI: 10.14336/AD.2021.0511

PDF (2450KB)
Supplement

1. Supplementary data.pdf (477KB)

Review

Adeno-Associated Virus Expression of α-Synuclein as a Tool to Model Parkinson’s Disease: Current Understanding and Knowledge Gaps
Taylor E Huntington, Rahul Srinivasan

2021, 12 (4): 1120-1137 | DOI: 10.14336/AD.2021.0517

PDF (685KB)

Editorial

Neurological and Neurodegenerative Disorders: Novel Concepts and Treatment
Batool F Kirmani, Lee A Shapiro, Ashok K Shetty

2021, 12 (4): 950-953 | DOI: 10.14336/AD.2021.0530

PDF (276KB)

Cover Illustration

01 July 2021. Vol.12 No.4
Figure 3. Effects of NRF2 loss on TH expr‍ession in the nigrostriatum of NRF2/α-Syn mice. Representative images of Tyrosine Hydroxylase (TH) immunostaining in the substantia nigra (SN, A-B) and striatum (ST, C-F) of hα-Syn⁺/Nrf2^+/+ and hα-Syn⁺/Nrf2^-/- mice. (G) optical density of striatal TH⁺ fiber immunoreactivity (presented as percent of control hα-Syn⁺/Nrf2^+/+ values). (H) Unbiased stereological counts estimating total number of TH⁺ DA neurons in the lateral tier of the SN. hα-Syn⁺/Nrf2^+/+(n=6) and hα-Syn⁺/Nrf2^-/- (n=6); * p<0.01, unpaired t test. Scale bars = 50 mm shown in B for A-B and in F for C-F.

[Detail]

Cover Illustration

Figure 3. Effects of NRF2 loss on TH expr‍ession in the nigrostriatum of NRF2/α-Syn mice. Representative images of Tyrosine Hydroxylase (TH) immunostaining in the substantia nigra (SN, A-B) and striatum (ST, C-F) of hα-Syn⁺/Nrf2^+/+ and hα-Syn⁺/Nrf2^-/- mice. (G) optical density of striatal TH⁺ fiber immunoreactivity (presented as percent of control hα-Syn⁺/Nrf2^+/+ values). (H) Unbiased stereological counts estimating total number of TH⁺ DA neurons in the lateral tier of the SN. hα-Syn⁺/Nrf2^+/+(n=6) and hα-Syn⁺/Nrf2^-/- (n=6); * p<0.01, unpaired t test. Scale bars = 50 mm shown in B for A-B and in F for C-F.