01 July 2021. Vol.12 No.4
Figure 3. Effects of NRF2 loss on TH expression in the nigrostriatum of NRF2/α-Syn mice. Representative images of Tyrosine Hydroxylase (TH) immunostaining in the substantia nigra (SN,
A-B) and striatum (ST,
(G) optical density of striatal TH
+ fiber immunoreactivity (presented as percent of control
(H) Unbiased stereological counts estimating total number of TH
+ DA neurons in the lateral tier of the SN.
hα-Syn+/Nrf2+/+ (n=6) and hα-Syn+/Nrf2-/- (n=6); * p<0.01, unpaired t test. Scale bars = 50 mm shown in B for A-B and in F for C-F.