01 July 2021. Vol.12 No.4
Figure 3. Effects of NRF2 loss on TH expression in the nigrostriatum of NRF2/α-Syn mice. Representative images of Tyrosine Hydroxylase
(TH) immunostaining in the substantia nigra (SN, A-B) and striatum (ST, C-F)
of hα-Syn+/Nrf2+/+ and hα-Syn+/Nrf2-/- mice. (G) optical density of striatal TH+ fiber
immunoreactivity (presented as percent of control hα-Syn+/Nrf2+/+ values). (H) Unbiased stereological
counts estimating total number of TH+ DA neurons in the lateral tier
of the SN. hα-Syn+/Nrf2+/+ (n=6) and hα-Syn+/Nrf2-/- (n=6); * p<0.01, unpaired t
test. Scale bars = 50 mm shown in B for A-B and in F for C-F.