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Differences in intracortical myelin content between the two cohorts. Vertex-wise significant differences in intracortical myelin content derived from the T1w/T2w ratio between the two cohorts after adjusting by age, gender, education years, BMI, and APOE genotype. Statistical results are summarized in Table 2.

Pubdate： 2024-08-12 Viewed： 3702

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12 August 2025. VOL 16, ISSUE 5
**Impact of HOMA-IR and APOE genotype on intracortical myelin. (A)** Differences in intracortical myelin, as derived from the T1w/T2w ratio, between APOE ?4 carriers (?4⁺) and non-carriers (?4^-). Regions in red indicate decreased intracortical myelin in APOE ?4 carriers compared to noncarriers. (B) Association between intracortical myelin content and HOMA-IR. Regions in red indicate a positive association with HOMA-IR. Statistical results are summarized in Table 10.

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Cover Illustration

**Impact of HOMA-IR and APOE genotype on intracortical myelin. (A)** Differences in intracortical myelin, as derived from the T1w/T2w ratio, between APOE ?4 carriers (?4⁺) and non-carriers (?4^-). Regions in red indicate decreased intracortical myelin in APOE ?4 carriers compared to noncarriers. (B) Association between intracortical myelin content and HOMA-IR. Regions in red indicate a positive association with HOMA-IR. Statistical results are summarized in Table 10.