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The Potential Mechanism of CD8+ T Cells in Alzheimer's Disease (AD)

The pathology of AD is associated with elevated levels of proinflammatory chemokines. CXCL10 binds to the CXCR3 receptor on T cells, promoting their migration into the diseased brain environment. Similarly, CCL2 interacts with CCR2 to recruit microglia. Once infiltrated, CD8? T cells can activate microglia, thereby exacerbating neuroinflammation and contributing to neuronal damage in AD. For more inforamtion, please see: Emerging Roles of Adaptive Immune Response in Alzheimer's Disease - PMC

Pubdate： 2025-04-01 Viewed： 5359

Cover Illustration

12 August 2025. VOL 16, ISSUE 5
**Impact of HOMA-IR and APOE genotype on intracortical myelin. (A)** Differences in intracortical myelin, as derived from the T1w/T2w ratio, between APOE ?4 carriers (?4⁺) and non-carriers (?4^-). Regions in red indicate decreased intracortical myelin in APOE ?4 carriers compared to noncarriers. (B) Association between intracortical myelin content and HOMA-IR. Regions in red indicate a positive association with HOMA-IR. Statistical results are summarized in Table 10.

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Cover Illustration

**Impact of HOMA-IR and APOE genotype on intracortical myelin. (A)** Differences in intracortical myelin, as derived from the T1w/T2w ratio, between APOE ?4 carriers (?4⁺) and non-carriers (?4^-). Regions in red indicate decreased intracortical myelin in APOE ?4 carriers compared to noncarriers. (B) Association between intracortical myelin content and HOMA-IR. Regions in red indicate a positive association with HOMA-IR. Statistical results are summarized in Table 10.