Aging and disease

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10 July 2014. VOL 5, ISSUE 4 Previous Issue Next Issue

Estimation of Heterogeneity in Diagnostic Parameters of Age-related Diseases
David Blokh, Ilia Stambler

2014, 5 (4): 218-225 | DOI: 10.14336/AD.2014.0500218
Managing Sarcopenia and Its Related-Fractures to Improve Quality of Life in Geriatric Populations
Tetsuro Hida, Atsushi Harada, Shiro Imagama, Naoki Ishiguro

2014, 5 (4): 226-237 | DOI: 10.14336/AD.2014.0500226
Metabolic Disturbances in Diseases with Neurological Involvement
João M. N. Duarte, Patrícia F. Schuck, Gary L. Wenk, Gustavo C. Ferreira

2014, 5 (4): 238-255 | DOI: 10.14336/AD.2014.0500238
Accelerated Aging in Schizophrenia Patients: The Potential Role of Oxidative Stress
Olaoluwa O Okusaga

2014, 5 (4): 256-262 | DOI: 10.14336/AD.2014.0500256
mTOR Signaling from Cellular Senescence to Organismal Aging
Shaohua Xu, Ying Cai, Yuehua Wei

2014, 5 (4): 263-273 | DOI: 10.14336/AD.2014.0500263
Effects of Living at Higher Altitudes on Mortality: A Narrative Review
Martin Burtscher

2014, 5 (4): 274-280 | DOI: 10.14336/AD.2014.0500274
Nothobranchius as a model for aging studies. A review
Alejandro Lucas-Sánchez, Pedro Francisco Almaida-Pagán, Pilar Mendiola, Jorge de Costa

2014, 5 (4): 281-291 | DOI: 10.14336/AD.2014.0500281

Cover Illustration

10 July 2014. Vol.5 No.4
The TOR (target of rapamycin) pathway has been convincingly shown to promote aging in various model organisms. In mice, inhibiting mTOR (mammalian TOR) by rapamycin treatment later in life can significantly extend lifespan and mitigate multiple age-related diseases. However, the underlying mechanisms are poorly understood. Cellular senescence is strongly correlated to organismal aging therefore providing an attractive model to examine the mechanisms by which mTOR inhibition contributes to longevity and delaying the onset of related diseases. In this review, we examine the connections between mTOR and cellular senescence and discuss how understanding cellular senescence on the aspect of mTOR signaling may help to fully appreciate its role in the organismal aging. We also highlight the opposing roles of senescence in various human diseases and discuss the caveats in interpreting the emerging experimental data.

[Detail]

Cover Illustration

The TOR (target of rapamycin) pathway has been convincingly shown to promote aging in various model organisms. In mice, inhibiting mTOR (mammalian TOR) by rapamycin treatment later in life can significantly extend lifespan and mitigate multiple age-related diseases. However, the underlying mechanisms are poorly understood. Cellular senescence is strongly correlated to organismal aging therefore providing an attractive model to examine the mechanisms by which mTOR inhibition contributes to longevity and delaying the onset of related diseases. In this review, we examine the connections between mTOR and cellular senescence and discuss how understanding cellular senescence on the aspect of mTOR signaling may help to fully appreciate its role in the organismal aging. We also highlight the opposing roles of senescence in various human diseases and discuss the caveats in interpreting the emerging experimental data.