Aging and disease

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01 December 2015. VOL 6, ISSUE 6 Previous Issue Next Issue

Original Article

Limb Ischemic Perconditioning Attenuates Blood-Brain Barrier Disruption by Inhibiting Activity of MMP-9 and Occludin Degradation after Focal Cerebral Ischemia
Changhong Ren, Ning Li, Brian Wang, Yong Yang, Jinhuan Gao, Sijie Li, Yuchuan Ding, Kunlin Jin, Xunming Ji

2015, 6 (6): 406-417 | DOI: 10.14336/AD.2015.0812

PDF (1434KB)
Cortisol Supplement Combined with Psychotherapy and Citalopram Improves Depression Outcomes in Patients with Hypocortisolism after Traumatic Brain Injury
Lanlan Luo, Yan Chai, Rongcai Jiang, Xin Chen, Tao Yan

2015, 6 (6): 418-425 | DOI: 10.14336/AD.2015.0507

PDF (1025KB)
Low Cerebral Glucose Metabolism: A Potential Predictor for the Severity of Vascular Parkinsonism and Parkinson’s Disease
Yunqi Xu, Xiaobo Wei, Xu Liu, Jinchi Liao, Jiaping Lin, Cansheng Zhu, Xiaochun Meng, Dongsi Xie, Dongman Chao, Albert J Fenoy, Muhua Cheng, Beisha Tang, Zhuohua Zhang, Ying Xia, Qing Wang

2015, 6 (6): 426-436 | DOI: 10.14336/AD.2015.0204

PDF (1030KB)
Topography of Cortical Microbleeds in Alzheimer’s Disease with and without Cerebral Amyloid Angiopathy: A Post-Mortem 7.0-Tesla MRI Study
J. De Reuck, F. Auger, N. Durieux, V. Deramecourt, C. Cordonnier, F. Pasquier, C.A. Maurage, D. Leys, R. Bordet

2015, 6 (6): 437-443 | DOI: 10.14336/AD.2015.0429

PDF (1014KB)
Inflammatory Cytokines Induce Expression of Chemokines by Human Retinal Cells: Role in Chemokine Receptor Mediated Age-related Macular Degeneration
Chandrasekharam N. Nagineni, Vijay K. Kommineni, Nader Ganjbaksh, Krishnasai K. Nagineni, John J. Hooks, Barbara Detrick

2015, 6 (6): 444-455 | DOI: 10.14336/AD.2015.0323

PDF (1423KB)
Genistein, the Isoflavone in Soybean, Causes Amyloid Beta Peptide Accumulation in Human Neuroblastoma Cell Line: Implications in Alzheimer's Disease
Gargi Chatterjee, Debashree Roy, Vineet Kumar Khemka, Mrittika Chattopadhyay, Sasanka Chakrabarti

2015, 6 (6): 456-465 | DOI: 10.14336/AD.2015.0327

PDF (1529KB)
Influence of Pulmonary Rehabilitation on Lung Function Changes After the Lung Resection for Primary Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease
Natasa Mujovic, Nebojsa Mujovic, Dragan Subotic, Maja Ercegovac, Andjela Milovanovic, Ljubica Nikcevic, Vladimir Zugic, Dejan Nikolic

2015, 6 (6): 466-477 | DOI: 10.14336/AD.2015.0503

PDF (977KB)
Overexpression of miR-1260b in Non-small Cell Lung Cancer is Associated with Lymph Node Metastasis
Limin Xu, Liqin Li, Jing Li, Hongwei Li, Qibin Shen, Jinliang Ping, Zhihong Ma, Jing Zhong, Licheng Dai

2015, 6 (6): 478-485 | DOI: 10.14336/AD.2015.0620

PDF (1031KB)
Relationship between CYP17A1 Genetic Polymorphism and Essential Hypertension in a Chinese Population
Chuan-Fang Dai, Xiang Xie*, Yi-Tong Ma*, Yi-Ning Yang, Xiao-Mei Li, Zhen-Yan Fu, Fen Liu, Bang-Dang Chen, Min-Tao Gai

2015, 6 (6): 486-498 | DOI: 10.14336/AD.2015.0505

PDF (1188KB)

Review Article

Cell Therapy for Parkinson’s Disease: New Hope from Reprogramming Technologies
Zhiguo Chen

2015, 6 (6): 499-503 | DOI: 10.14336/AD.2014.1201

PDF (718KB)

Cover Illustration

01 December 2015. Vol.6 No.6
Remote ischemic PerC reduced TJ gap formation. Representative images of claudin-5 positive vessels (green) in the penumbra of the rat brain. Vessels in the penumbra of sham-operated brain showed a continuous, linear labeling of claudin-5. In the MCAO group, a discontinuous, less regular distribution of claudin-5 in the vessels was noted (arrows), which was barely detectable in the PerC-treated group.

[Detail]

Cover Illustration

Remote ischemic PerC reduced TJ gap formation. Representative images of claudin-5 positive vessels (green) in the penumbra of the rat brain. Vessels in the penumbra of sham-operated brain showed a continuous, linear labeling of claudin-5. In the MCAO group, a discontinuous, less regular distribution of claudin-5 in the vessels was noted (arrows), which was barely detectable in the PerC-treated group.