Aging and disease

Table of Content

09 January 2016. VOL 7, ISSUE 3 Previous Issue Next Issue

Letter to the Editor/Erratum

Question Marks Left Over a Quantitative Assessment of Apolipoprotein C3 Gene Polymorphisms
Philipp G. Sand

2016, 7 (3): 216-219 | DOI: 10.14336/AD.2016.0502

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Original Article

Linear and Curvilinear Trajectories of Cortical Loss with Advancing Age and Disease Duration in Parkinson’s Disease
Daniel O. Claassen, David G. Dobolyi, David A. Isaacs, Olivia C. Roman, Joshua Herb, Scott A. Wylie, Joseph S. Neimat, Manus J. Donahue, Peter Hedera, David H. Zald, Bennett A. Landman, Aaron B. Bowman, Benoit M. Dawant, Swati Rane

2016, 7 (3): 220-229 | DOI: 10.14336/AD.2015.1110

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Effect of a Leucine-rich Repeat Kinase 2 Variant on Motor and Non-motor Symptoms in Chinese Parkinson’s Disease Patients
Qian Sun, Tian Wang, Tian-Fang Jiang, Pei Huang, Dun-Hui Li, Ying Wang, Qin Xiao, Jun Liu, Sheng-Di Chen

2016, 7 (3): 230-236 | DOI: 10.14336/AD.2015.1026

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Higher Plasma LDL-Cholesterol is Associated with Preserved Executive and Fine Motor Functions in Parkinson’s Disease
Nicholas W. Sterling, Maya Lichtenstein, Eun-Young Lee, Mechelle M. Lewis, Alicia Evans, Paul J. Eslinger, Guangwei Du, Xiang Gao, Honglei Chen, Lan Kong, Xuemei Huang

2016, 7 (3): 237-245 | DOI: 10.14336/AD.2015.1030

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Predictors of Difficulty in Medication Intake in Europe: a Cross-country Analysis Based on SHARE
Daniela Figueiredo, Laetitia Teixeira, Veronica Poveda, Constança Paúl, Alice Santos-Silva, Elísio Costa

2016, 7 (3): 246-253 | DOI: 10.14336/AD.2015.0925

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Failure of Elevating Calcium Induces Oxidative Stress Tolerance and Imparts Cisplatin Resistance in Ovarian Cancer Cells
Liwei Ma, Hongjun Wang, Chunyan Wang, Jing Su, Qi Xie, Lu Xu, Yang Yu, Shibing Liu, Songyan Li, Ye Xu, Zhixin Li

2016, 7 (3): 254-266 | DOI: 10.14336/AD.2016.0118

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Proteolytic Cleavage of Apolipoprotein E in the Down Syndrome Brain
Ryan J. Day, Katie L. McCarty, Kayla E. Ockerse, Elizabeth Head, Troy T. Rohn

2016, 7 (3): 267-277 | DOI: 10.14336/AD.2015.1020

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Levels and Rates of Physical Activity in Older Adults with Multiple Sclerosis
Rachel E. Klaren, Emerson Sebastiao, Chung-Yi Chiu, Dominique Kinnett-Hopkins, Edward McAuley, Robert W. Motl

2016, 7 (3): 278-284 | DOI: 10.14336/AD.2015.1025

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Successful Aging among Elders Living in the Mani Continental Region vs. Insular Areas of the Mediterranean: the MEDIS Study
Anargiros Mariolis, Alexandra Foscolou, Stefanos Tyrovolas, Suzanne Piscopo, Giuseppe Valacchi, Nikos Tsakountakis, Akis Zeimbekis, Vassiliki Bountziouka, Efthimios Gotsis, George Metallinos, Dimitra Tyrovola, Josep-Antoni Tur, Antonia-Leda Matalas, Christos Lionis, Evangelos Polychronopoulos, Demosthenes Panagiotakos, for the MEDIS study group

2016, 7 (3): 285-294 | DOI: 10.14336/AD.2015.1002

PDF (937KB)

Review Article

Epigenetic Regulation of Oxidative Stress in Ischemic Stroke
Haiping Zhao, Ziping Han, Xunming Ji, Yumin Luo

2016, 7 (3): 295-306 | DOI: 10.14336/AD.2015.1009

PDF (966KB)
The Role of Oxidative Stress in Etiopathogenesis of Chemotherapy Induced Cognitive Impairment (CICI)-“Chemobrain”
Amelia Maria Gaman, Adriana Uzoni, Aurel Popa-Wagner, Anghel Andrei, Eugen-Bogdan Petcu

2016, 7 (3): 307-317 | DOI: 10.14336/AD.2015.1022

PDF (738KB)

Cover Illustration

09 January 2016. Vol.7 No.3
Figure. The effect of age on cortical thickness in healthy Ccontrols and Parkinson’s disease. Green highlighted regions represent those regions that follow a linear rate of atrophy. Red highlighted regions depict rates of early decline (decreasing quickly at first, then stabilizing), while regions in yellow depict regions that atrophy faster over time (stable at first, then decreasing quickly). Regions in orange depict early decline, stabilization, followed by late decline, which is notable in later decades of life (early-stable-late). PD patients show characteristic frontal cortical thinning with age. Regions in yellow depict regions that atrophy faster over time (concave down, decreasing curve or late decline). Regions in blue shown in the right column are regions showing an interaction between age and disease.

[Detail]

Cover Illustration

Figure. The effect of age on cortical thickness in healthy Ccontrols and Parkinson’s disease. Green highlighted regions represent those regions that follow a linear rate of atrophy. Red highlighted regions depict rates of early decline (decreasing quickly at first, then stabilizing), while regions in yellow depict regions that atrophy faster over time (stable at first, then decreasing quickly). Regions in orange depict early decline, stabilization, followed by late decline, which is notable in later decades of life (early-stable-late). PD patients show characteristic frontal cortical thinning with age. Regions in yellow depict regions that atrophy faster over time (concave down, decreasing curve or late decline). Regions in blue shown in the right column are regions showing an interaction between age and disease.

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