Aging and disease

Table of Content

01 April 2019. VOL 10, ISSUE 2 Previous Issue Next Issue

Original Article

Influence of Environment and Lifestyle on Incidence and Progress of Amyotrophic Lateral Sclerosis in A German ALS Population
Sonja Korner, Johanna Kammeyer, Antonia Zapf, Magdalena Kuzma-Kozakiewicz, Maria Piotrkiewicz, Bożenna Kuraszkiewicz, Hanna Goszczynska, Marta Gromicho, Julian Grosskreutz, Peter M. Andersen, Mamede de Carvalho, Susanne Petri

2019, 10 (2): 205-216 | DOI: 10.14336/AD.2018.0327

PDF (592KB)
Overweight in the Elderly Induces a Switch in Energy Metabolism that Undermines Muscle Integrity
Yaiza Potes, Zulema Pérez-Martinez, Juan C. Bermejo-Millo, Adrian Rubio-Gonzalez, María Fernandez-Fernández, Manuel Bermudez, Jose M. Arche, Juan J. Solano, Jose A. Boga, Mamen Oliván, Beatriz Caballero, Ignacio Vega-Naredo, Ana Coto-Montes

2019, 10 (2): 217-230 | DOI: 10.14336/AD.2018.0430

PDF (1222KB)
Involvement of the MiR-181b-5p/HMGB1 Pathway in Ang II-induced Phenotypic Transformation of Smooth Muscle Cells in Hypertension
Feng-Juan Li, Cheng-Long Zhang, Xiu-Ju Luo, Jun Peng, Tian-Lun Yang

2019, 10 (2): 231-248 | DOI: 10.14336/AD.2018.0510

PDF (1922KB)
Prospective Study of Glycated Hemoglobin and Trajectories of Depressive Symptoms: The China Health and Retirement Longitudinal Study
Haibin Li, Anxin Wang, Wei Feng, Deqiang Zheng, Qi Gao, Lixin Tao, Jin Guo, Xiaonan Wang, Xia Li, Wei Wang, Xiuhua Guo

2019, 10 (2): 249-257 | DOI: 10.14336/AD.2018.0410

PDF (484KB)
Intensive Lipid-Lowering Therapy Ameliorates Asymptomatic Intracranial Atherosclerosis
Huijuan Miao, Yujiao Yang, Han Wang, Linyu Huo, Mengnan Wang, Yinghua Zhou, Yang Hua, Ming Ren, Changhong Ren, Xunming Ji, Qi Yang, Xiuhai Guo

2019, 10 (2): 258-266 | DOI: 10.14336/AD.2018.0526

PDF (711KB)
Habitual Meat Consumption and Changes in Sleep Duration and Quality in Older Adults
Alberto Lana, Ellen A. Struijk, Lucía Arias-Fernandez, Auxiliadora Graciani, Arthur E. Mesas, Fernando Rodriguez-Artalejo, Esther Lopez-Garcia

2019, 10 (2): 267-277 | DOI: 10.14336/AD.2018.0503

PDF (483KB)
Collagen XIX Alpha 1 Improves Prognosis in Amyotrophic Lateral Sclerosis
Ana C. Calvo, Gabriela Atencia Cibreiro, Paz Torre Merino, Juan F. Roy, Adrián Galiana, Alexandra Juárez Rufián, Juan M. Cano, Miguel A. Martín, Laura Moreno, Pilar Larrodé, Pilar Cordero Vázquez, Lucía Galán, Jesús Mora, José L. Muñoz-Blanco, María J. Muñoz, Pilar Zaragoza, Elena Pegoraro, Gianni Sorarù, Marina Mora, Christian Lunetta, Silvana Penco, Claudia Tarlarini, Jesús Esteban, Rosario Osta, Alberto García Redondo

2019, 10 (2): 278-292 | DOI: 10.14336/AD.2018.0917

PDF (893KB)
Deficiency of Yes-Associated Protein Induces Cataract in Mice
Qing He, Yuhao Gao, Tongxing Wang, Lujun Zhou, Wenxia Zhou, Zengqiang Yuan

2019, 10 (2): 293-306 | DOI: 10.14336/AD.2018.0910

PDF (2231KB)
Supplement

1. .pdf (894KB)

Review

Traditional Oriental Medicines and Alzheimer’s Disease
Seong Gak Jeon, Eun Ji Song, Dongje Lee, Junyong Park, Yunkwon Nam, Jin-il Kim, Minho Moon

2019, 10 (2): 307-328 | DOI: 10.14336/AD.2018.0328

PDF (681KB)
MicroRNAs and the Genetic Nexus of Brain Aging, Neuroinflammation, Neurodegeneration, and Brain Trauma
Saumyendra N. Sarkar, Ashley E. Russell, Elizabeth B. Engler-Chiurazzi, Keyana N. Porter, James W. Simpkins

2019, 10 (2): 329-352 | DOI: 10.14336/AD.2018.0409

PDF (771KB)

Review Article

MicroRNAs or Long Noncoding RNAs in Diagnosis and Prognosis of Coronary Artery Disease
Yuan Zhang, Lei Zhang, Yu Wang, Han Ding, Sheng Xue, Hongzhao Qi, Peifeng Li

2019, 10 (2): 353-366 | DOI: 10.14336/AD.2018.0617

PDF (498KB)

Review

Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept
Hae Young Chung, Dae Hyun Kim, Eun Kyeong Lee, Ki Wung Chung, Sangwoon Chung, Bonggi Lee, Arnold Y. Seo, Jae Heun Chung, Young Suk Jung, Eunok Im, Jaewon Lee, Nam Deuk Kim, Yeon Ja Choi, Dong Soon Im, Byung Pal Yu

2019, 10 (2): 367-382 | DOI: 10.14336/AD.2018.0324

PDF (607KB)

Review Article

Processing of Mutant β-Amyloid Precursor Protein and the Clinicopathological Features of Familial Alzheimer’s Disease
Christopher Bi, Stephanie Bi, Bin Li

2019, 10 (2): 383-403 | DOI: 10.14336/AD.2018.0425

PDF (540KB)
Efficacy and Safety of the Pneumococcal Conjugate-13 Valent Vaccine in Adults
Fawziah Marra, Nirma Khatri Vadlamudi

2019, 10 (2): 404-418 | DOI: 10.14336/AD.2018.0512

PDF (510KB)

Original Article

The Role of Pathological Aging in Cardiac and Pulmonary Fibrosis
Lucy A. Murtha, Matthew Morten, Michael J. Schuliga, Nishani S. Mabotuwana, Sean A. Hardy, David W. Waters, Janette K. Burgess, Doan TM. Ngo, Aaron L. Sverdlov, Darryl A. Knight, Andrew J. Boyle

2019, 10 (2): 419-428 | DOI: 10.14336/AD.2018.0601

PDF (541KB)

Review

Significance of Complement System in Ischemic Stroke: A Comprehensive Review
Yuanyuan Ma, Yanqun Liu, Zhijun Zhang, Guo-Yuan Yang

2019, 10 (2): 429-462 | DOI: 10.14336/AD.2019.0119

PDF (1020KB)

Short Communications

Increased Serum C-reactive Protein and Corpus Callosum Alterations in Older Adults
Fabienne Cyprien, Philippe Courtet, Jerome Maller, Chantal Meslin, Karen Ritchie, Marie-Laure Ancelin, Sylvaine Artero

2019, 10 (2): 463-469 | DOI: 10.14336/AD.2018.0329

PDF (404KB)

Commentary

Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer’s Disease
Ashok K. Shetty, Raghavendra Upadhya, Leelavathi N. Madhu, Maheedhar Kodali

2019, 10 (2): 470-482 | DOI: 10.14336/AD.2019.0330

PDF (445KB)

Cover Illustration

01 April 2019. Vol.10 No.2
Yap deficiency suppresses cell proliferation in vivo and in vitro. (A-F) The Ki67 positive ratio of lens epithelial cells decreased in Yap-deficient mice at different stages (arrowheads indicate Ki67 positive cells). (G) The relative number of Ki67 positive lens epithelial cells (number of Ki67 positive lens epithelial cells / lens epithelium area). The data are shown as mean ± S.E.M. (Student’s t-test, P<0.05, P<0.01, n=10). (H-I) Knockdown efficiency of Yap in αTN4 cell using siRNA. (J-K) Cell viability and growth assay revealed that proliferation was downregulated in Yap knockdown αTN4 cells. The data are shown as mean ± S.E.M. (Two-way RM ANOVA, P<0.01, n=5). Scale bars: 50 μm.

[Detail]

Cover Illustration

Yap deficiency suppresses cell proliferation in vivo and in vitro. (A-F) The Ki67 positive ratio of lens epithelial cells decreased in Yap-deficient mice at different stages (arrowheads indicate Ki67 positive cells). (G) The relative number of Ki67 positive lens epithelial cells (number of Ki67 positive lens epithelial cells / lens epithelium area). The data are shown as mean ± S.E.M. (Student’s t-test, P<0.05, P<0.01, n=10). (H-I) Knockdown efficiency of Yap in αTN4 cell using siRNA. (J-K) Cell viability and growth assay revealed that proliferation was downregulated in Yap knockdown αTN4 cells. The data are shown as mean ± S.E.M. (Two-way RM ANOVA, P<0.01, n=5). Scale bars: 50 μm.

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