Aging and disease

Table of Content

09 May 2020. VOL 11, ISSUE 3 Previous Issue Next Issue

Editorial

Adipose Stem Cells (ASCs) and Stromal Vascular Fraction (SVF) as a Potential Therapy in Combating (COVID-19)-Disease
Pietro Gentile, Aris Sterodimas

2020, 11 (3): 465-469 | DOI: 10.14336/AD.2020.0422

PDF (235KB)

Short Communication

Molecular Aging Markers in Patients with Klinefelter Syndrome
Eva Pohl, Sina Muschal, Sabine Kliesch, Michael Zitzmann, Julia Rohayem, Jörg Gromoll, Sandra Laurentino

2020, 11 (3): 470-476 | DOI: 10.14336/AD.2019.0801

PDF (458KB)

Commentary

Mesenchymal Stem Cells for Coronavirus (COVID-19)-Induced Pneumonia: Revisiting the Paracrine Hypothesis with New Hopes?
Selçuk Öztürk, Ayşe Eser Elçin, Yaşar Murat Elçin

2020, 11 (3): 477-479 | DOI: 10.14336/AD.2020.0403

PDF (299KB)

Perspective

COVID-19 in India: Are Biological and Environmental Factors Helping to Stem the Incidence and Severity?
Sankha Shubhra Chakrabarti, Upinder Kaur, Anindita Banerjee, Upasana Ganguly, Tuhina Banerjee, Sarama Saha, Gaurav Parashar, Suvarna Prasad, Suddhachitta Chakrabarti, Amit Mittal, Bimal Kumar Agrawal, Ravindra Kumar Rawal, Robert Chunhua Zhao, Indrajeet Singh Gambhir, Rahul Khanna, Ashok K Shetty, Kunlin Jin, Sasanka Chakrabarti

2020, 11 (3): 480-488 | DOI: 10.14336/AD.2020.0402

PDF (726KB)

Opinion

Whole-lung Low Dose Irradiation for SARS-Cov2 Induced Pneumonia in the Geriatric Population: An Old Effective Treatment for a New Disease? Recommendation of the International Geriatric Radiotherapy Group
Pedro C Lara, Nam P Nguyen, David Macias-Verde, Javier Burgos-Burgos, Meritxell Arenas, Alice Zamagni, Vincent Vinh-Hung, Brigitta G Baumert, Micaela Motta, Arthur Sun Myint, Marta Bonet, Tiberiu Popescu, Te Vuong, Gokula Kumar Appalanaido, Lurdes Trigo, Ulf Karlsson, Juliette Thariat

2020, 11 (3): 489-493 | DOI: 10.14336/AD.2020.0506

PDF (300KB)

Orginal Article

Longitudinal Association of Telomere Attrition with the Effects of Antihypertensive Treatment and Blood Pressure Lowering
Shuyuan Zhang, Rongxia Li, Yunyun Yang, Yu Chen, Shujun Yang, Jian Li, Cunjin Wu, Tao Kong, Tianlong Liu, Jun Cai, Li Fu, Yanan Zhao, Rutai Hui, Weili Zhang

2020, 11 (3): 494-508 | DOI: 10.14336/AD.2019.0721

PDF (814KB)
Supplement

1. Supplementary data.pdf (801KB)
COVID-19 Virulence in Aged Patients Might Be Impacted by the Host Cellular MicroRNAs Abundance/Profile
Sadanand Fulzele, Bikash Sahay, Ibrahim Yusufu, Tae Jin Lee, Ashok Sharma, Ravindra Kolhe, Carlos M Isales

2020, 11 (3): 509-522 | DOI: 10.14336/AD.2020.0428

PDF (793KB)
Supplement

1. Supplementary data.pdf (970KB)
Mib2 Deficiency Inhibits Microglial Activation and Alleviates Ischemia-Induced Brain Injury
Xiaoheng Li, Yajin Liao, Yuan Dong, Shuoshuo Li, Fengchao Wang, Rong Wu, Zengqiang Yuan, Jinbo Cheng

2020, 11 (3): 523-535 | DOI: 10.14336/AD.2019.0807

PDF (1613KB)
Supplement

1. Supplementary data.pdf (395KB)
Cellular and Molecular Biomarkers Indicate Premature Aging in Pseudoxanthoma Elasticum Patients
Janina Tiemann, Thomas Wagner, Olivier M Vanakker, Matthias van Gils, José-Luis Bueno Cabrera, Bettina Ibold, Isabel Faust, Cornelius Knabbe, Doris Hendig

2020, 11 (3): 536-546 | DOI: 10.14336/AD.2019.0610

PDF (651KB)
Neuroprotective Effects of Endogenous Secretory Receptor for Advanced Glycation End-products in Brain Ischemia
Yu Shimizu, Ai Harashima, Seiichi Munesue, Masahiro Oishi, Tsuyoshi Hattori, Osamu Hori, Yasuko Kitao, Hiroshi Yamamoto, Nontaphat Leerach, Mitsutoshi Nakada, Yasuhiko Yamamoto, Yasuhiko Hayashi

2020, 11 (3): 547-558 | DOI: 10.14336/AD.2019.0715

PDF (847KB)
Oxyphylla A Promotes Degradation of α-Synuclein for Neuroprotection via Activation of Immunoproteasome
Hefeng Zhou, Shengnan Li, Chuwen Li, Xuanjun Yang, Haitao Li, Hanbing Zhong, Jia-Hong Lu, Simon Ming-Yuen Lee

2020, 11 (3): 559-574 | DOI: 10.14336/AD.2019.0612

PDF (2036KB)
Supplement

1. Supplementary data.pdf (121KB)
Aging-Induced Brain-Derived Neurotrophic Factor in Adipocyte Progenitors Contributes to Adipose Tissue Dysfunction
Hyun-Doo Song, Sang Nam Kim, Abhirup Saha, Sang-Yeop Ahn, Seun Akindehin, Yeonho Son, Yoon Keun Cho, MinSu Kim, Ji-Hyun Park, Young-Suk Jung, Yun-Hee Lee

2020, 11 (3): 575-587 | DOI: 10.14336/AD.2019.0810

PDF (1819KB)
Supplement

1. Supplementary data.pdf (1159KB)
Renoprotective Effect of a Dipeptidyl Peptidase-4 Inhibitor on Aging Mice
Tae H Ban, Eun N Kim, Min Y Kim, Ji H Lim, Jong H Lee, Hyung D Kim, Hye E Yoon, Cheol W Park, Bum S Choi

2020, 11 (3): 588-602 | DOI: 10.14336/AD.2019.0620

PDF (2057KB)
SRμCT Reveals 3D Microstructural Alterations of the Vascular and Neuronal Network in a Rat Model of Chronic Compressive Thoracic Spinal Cord Injury
Liyuan Jiang, Yong Cao, Zhen Liu, Shuangfei Ni, Jun Liu, Yoon Ha, Zixiang Luo, Chengjun Li, Shaohua Liu, Jingsong Li, Xianzhen Yin, Tianding Wu, Hongbin Lu, Jianzhong Hu

2020, 11 (3): 603-617 | DOI: 10.14336/AD.2019.0529

PDF (1252KB)
T1-weighted MRI-driven Brain Age Estimation in Alzheimer’s Disease and Parkinson’s Disease
Iman Beheshti, Shiwangi Mishra, Daichi Sone, Pritee Khanna, Hiroshi Matsuda

2020, 11 (3): 618-628 | DOI: 10.14336/AD.2019.0617

PDF (961KB)
Lactulose Suppresses Osteoclastogenesis and Ameliorates Estrogen Deficiency-Induced Bone Loss in Mice
Xiao Chen, Zheng Zhang, Yan Hu, Jin Cui, Xin Zhi, Xiaoqun Li, Hao Jiang, Yao Wang, Zhengrong Gu, Zili Qiu, Xin Dong, Yuhong Li, Jiacan Su

2020, 11 (3): 629-641 | DOI: 10.14336/AD.2019.0613

PDF (1244KB)
Supplement

1. Supplementary data.pdf (808KB)
Immune Characteristics of Patients with Coronavirus Disease 2019 (COVID-19)
Xiaotian Dong, Mengyan Wang, Shuangchun Liu, Jiaqi Zhu, Yanping Xu, Hongcui Cao, Lanjuan Li

2020, 11 (3): 642-648 | DOI: 10.14336/AD.2020.0317

PDF (624KB)

Review

Management of The Elderly Cancer Patients Complexity: The Radiation Oncology Potential
Giuseppe Colloca, Luca Tagliaferri, Beatrice Di Capua, Maria Antonietta Gambacorta, Vito Lanzotti, Andrea Bellieni, Silvio Monfardini, Lodovico Balducci, Roberto Bernabei, William C Cho, Vincenzo Valentini

2020, 11 (3): 649-657 | DOI: 10.14336/AD.2019.0616

PDF (386KB)
Dementia Risk in Type 2 Diabetes Patients: Acarbose Use and Its Joint Effects with Metformin and Pioglitazone
Chin-Hsiao Tseng

2020, 11 (3): 658-667 | DOI: 10.14336/AD.2019.0621

PDF (901KB)
Comorbid Chronic Diseases are Strongly Correlated with Disease Severity among COVID-19 Patients: A Systematic Review and Meta-Analysis
Hong Liu, Shiyan Chen, Min Liu, Hao Nie, Hongyun Lu

2020, 11 (3): 668-678 | DOI: 10.14336/AD.2020.0502

PDF (983KB)
Parkinson Disease and Orthostatic Hypotension in the Elderly: Recognition and Management of Risk Factors for Falls
Peter A LeWitt, Steve Kymes, Robert A Hauser

2020, 11 (3): 679-691 | DOI: 10.14336/AD.2019.0805

PDF (512KB)
Implications of Long Non-Coding RNAs in Age-Altered Proteostasis
Cristina-Sorina Catana, Catalina-Angela Crișan, Dana Opre, Ioana Berindan-Neagoe

2020, 11 (3): 692-704 | DOI: 10.14336/AD.2019.0814

PDF (770KB)
The Critical Role of Nurr1 as a Mediator and Therapeutic Target in Alzheimer’s Disease-related Pathogenesis
Seong Gak Jeon, Anji Yoo, Dong Wook Chun, Sang Bum Hong, Hyunju Chung, Jin-il Kim, Minho Moon

2020, 11 (3): 705-724 | DOI: 10.14336/AD.2019.0718

PDF (790KB)

Cover Illustration

09 May 2020. Vol.11 No.3
Figure 3. Characteristic 3D morphological alterations of the thoracic spinal cord microvasculature at different time points after surgery to induce chronic compression. (A-C) Representative 3D cross-sectional images of the spinal cord microvasculature after 1 and 6 months of chronic compression. (D-F) Pseudocolored image of the spinal cord microvasculature correlated with vessel thickness at the corresponding time point after compression surgery.

[Detail]

Cover Illustration

Figure 3. Characteristic 3D morphological alterations of the thoracic spinal cord microvasculature at different time points after surgery to induce chronic compression. (A-C) Representative 3D cross-sectional images of the spinal cord microvasculature after 1 and 6 months of chronic compression. (D-F) Pseudocolored image of the spinal cord microvasculature correlated with vessel thickness at the corresponding time point after compression surgery.

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