Aging and disease

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01 September 2021. VOL 12, ISSUE 6 Previous Issue Next Issue

Orginal Article

Proteomic Profiling of Extracellular Vesicles Separated from Plasma of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy
Satoshi Muraoka, Annina M DeLeo, Zijian Yang, Harutsugu Tatebe, Kayo Yukawa-Takamatsu, Seiko Ikezu, Takahiko Tokuda, David Issadore, Robert A Stern, Tsuneya Ikezu

2021, 12 (6): 1363-1375 | DOI: 10.14336/AD.2020.0908

PDF (1176KB)
Supplement

1. Supplementary data.pdf (1144KB)
Enrichment of Phosphorylated Tau (Thr181) and Functionally Interacting Molecules in Chronic Traumatic Encephalopathy Brain-derived Extracellular Vesicles
Satoshi Muraoka, Weiwei Lin, Kayo Takamatsu-Yukawa, Jianqiao Hu, Seiko Ikezu, Michael A DeTure, Dennis W Dickson, Andrew Emili, Tsuneya Ikezu

2021, 12 (6): 1376-1388 | DOI: 10.14336/AD.2020.1007

PDF (1348KB)
Supplement

1. Supplementary data.pdf (1478KB)
Astrocytes & Astrocyte derived Extracellular Vesicles in Morphine Induced Amyloidopathy: Implications for Cognitive Deficits in Opiate Abusers
Susmita Sil, Seema Singh, Divya T Chemparathy, Ernest T Chivero, Lila Gordon, Shilpa Buch

2021, 12 (6): 1389-1408 | DOI: 10.14336/AD.2021.0406

PDF (1412KB)
Supplement

1. Supplementary data.pdf (326KB)

Review

Extracellular Vesicles for the Diagnosis and Treatment of Parkinson’s Disease
Raghavendra Upadhya, Ashok K Shetty

2021, 12 (6): 1438-1450 | DOI: 10.14336/AD.2021.0516

PDF (843KB)
Extracellular Vesicles as Pro- and Anti-inflammatory Mediators, Biomarkers and Potential Therapeutic Agents in Multiple Sclerosis
Mallahalli. S Manu, Hirohiko Hohjoh, Takashi Yamamura

2021, 12 (6): 1451-1461 | DOI: 10.14336/AD.2021.0513

PDF (532KB)
Extracellular Vesicles as Novel Diagnostic and Prognostic Biomarkers for Parkinson’s Disease
Loredana Leggio, Greta Paternò, Silvia Vivarelli, Giovanna G Falzone, Carmela Giachino, Bianca Marchetti, Nunzio Iraci

2021, 12 (6): 1494-1515 | DOI: 10.14336/AD.2021.0527

PDF (1170KB)

Orginal Article

Human Adipose Mesenchymal Stem Cell-derived Exosomes Protect Mice from DSS-Induced Inflammatory Bowel Disease by Promoting Intestinal-stem-cell and Epithelial Regeneration
Hongliang Yu, Xudong Yang, Xian Xiao, Meiqian Xu, Yanlei Yang, Chunling Xue, Xuechun Li, Shihua Wang, Robert Chunhua Zhao

2021, 12 (6): 1423-1437 | DOI: 10.14336/AD.2021.0601

PDF (1572KB)
Supplement

1. Supplementary data.pdf (100KB)

Review

Extracellular Vesicles in Premature Aging and Diseases in Adulthood Due to Developmental Exposures
Marisa R Pinson, Dae D Chung, Amy M Adams, Chiara Scopice, Elizabeth A Payne, Monisha Sivakumar, Rajesh C Miranda

2021, 12 (6): 1516-1535 | DOI: 10.14336/AD.2021.0322

PDF (715KB)
Astrocyte-Derived Extracellular Vesicles (ADEVs): Deciphering their Influences in Aging
Megan E Rouillard, Pearl A Sutter, Olivia R Durham, Cory M Willis, Stephen J Crocker

2021, 12 (6): 1462-1475 | DOI: 10.14336/AD.2021.0608

PDF (1060KB)

Orginal Article

Identification of Molecules Responsible for Therapeutic Effects of Extracellular Vesicles Produced from iPSC-Derived MSCs on Sjo¨gren’s Syndrome
Hyemee Kim, Qingguo Zhao, Heather Barreda, Gagandeep Kaur, Bo Hai, Jong Min Choi, Sung Youn Jung, Fei Liu, Ryang Hwa Lee

2021, 12 (6): 1409-1422 | DOI: 10.14336/AD.2021.0621

PDF (1846KB)
Supplement

1. Supplementary data.pdf (1503KB)

Review

Therapeutic Potential of Nucleic Acids when Combined with Extracellular Vesicles
Brian Jurgielewicz, Steven Stice, Yao Yao

2021, 12 (6): 1476-1493 | DOI: 10.14336/AD.2021.0708

PDF (704KB)

Editorial

Extracellular Vesicles in Health and Disease
Ashok K Shetty, Raghavendra Upadhya

2021, 12 (6): 1358-1362 | DOI: 10.14336/AD.2021.0827

PDF (259KB)

Cover Illustration

01 September 2021. Vol.12 No.6
Figure 1. Potential EV-associated biomarkers for PD. Exosomes (in orange), MDVs (in yellow) and shedding vesicles (in light blue) are secreted in the microenvironment through different biogenetic pathways: fusion of MVB with the plasma membrane and shedding mechanism. EVs are heterogeneous lipid bilayer structures enriched in sphingomyelin (SM), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS), ceramide and cholesterol. EVs can carry different cargoes (DNA, miRNAs, Alfa-Synuclein, PrP^C, LRRK2, DJ-1 and other proteins) from the brain, through the BBB, toward the systemic circulation, where they can be detected as biomarkers. Vesicles reach the target cells through different mechanisms such as uptake or surface binding.

[Detail]

Cover Illustration

Figure 1. Potential EV-associated biomarkers for PD. Exosomes (in orange), MDVs (in yellow) and shedding vesicles (in light blue) are secreted in the microenvironment through different biogenetic pathways: fusion of MVB with the plasma membrane and shedding mechanism. EVs are heterogeneous lipid bilayer structures enriched in sphingomyelin (SM), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS), ceramide and cholesterol. EVs can carry different cargoes (DNA, miRNAs, Alfa-Synuclein, PrP^C, LRRK2, DJ-1 and other proteins) from the brain, through the BBB, toward the systemic circulation, where they can be detected as biomarkers. Vesicles reach the target cells through different mechanisms such as uptake or surface binding.