25 March 2022. Vol.13 No.2
Adult mice have a decreased number of both F4/80+ macrophages, and CD90+ mesenchymal cells to the wound are compared to young mice. (A)
Immunohistochemical staining of the healing skin two weeks post-injury shows a large population of CD90+ cells spanning from the junction of intact skin to the active healing zone (active healing zone marked with an arrow). This CD90+ cell population is significantly decreased in the adult mouse both at the junction and active healing area. (B) Immunohistochemical stain of F4/80 shows a decreased number of macrophages in the area of active healing in adult mice compared to young mice.