Commentary
							
																									
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			              Impact of CircRNAs on Ischemic Stroke
			              
			                Miaomiao Liu, Xiaolin Liu, Maorong Zhou, Shao Guo, Kai Sun
			              
			              
			              
			              
						   
							 
							
			                         						
								    																								
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			              Mechanical Ventilation in COVID-19 Patients: Insights into the Role of Age and Frailty from a Multicentre Observational Study
			              
			                Fiona Ecarnot, Paola Rebora, Emanuele Focà, Alberto Zucchelli, Giuseppe Citerio, Maria Grazia Valsecchi, Alessandra Marengoni, Giuseppe Bellelli, for the FRACoViD Team
			              
			              
			              
			              
						   
							 
							
			                         						
								    																										
							
							Opinion
							
																									
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			              Synergistic Effects of Multiple Factors Involved in COVID-19-dependent Muscle Loss
			              
			                Nicholas Cantu, Sagar Vyavahare, Sandeep Kumar, Jie Chen, Ravindra Kolhe, Carlos M Isales, Mark Hamrick, Sadanand Fulzele
			              
			              
			              
			              
						   
							 							
							
							
			                         						
								    																								
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			              Intrinsic Capacity in Older Adults: Recent Advances
			              
			                Yaru Zhou, Lina Ma
			              
			              
			              
			              
						   
							 
							
			                         						
								    																								
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			              ACE2 and COVID-19 Susceptibility and Severity
			              
			                Ming Zheng
			              
			              
			              
			              
						   
							 
							
			                         						
								    																								
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			              A Potential Target for Clinical Atherosclerosis: A Novel Insight Derived from TPM2
			              
			                Ling-bing Meng, Hong-xuan Xu, Meng-jie Shan, Gai-feng Hu, Long-teng Liu, Yu-hui Chen, Yun-qing Liu, Li Wang, Zuoguan Chen, Yong-jun Li, Tao Gong, De-ping Liu
			              
			              
			              
			              
						   
							 							
							
							
			                         						
								    																								
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			              Sarcopenic Obesity: An Emerging Public Health Problem
			              
			                Tong Ji, Yun Li, Lina Ma
			              
			              
			              
			              
						   
							 
							
			                         						
								    																										
							
							Review
							
																									
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			              The Therapeutic Potential of tRNA-derived Small RNAs in Neurodegenerative Disorders
			              
			                Haihua Tian, Zhenyu Hu, Chuang Wang
			              
			              
			              
			              
						   
							 
							
			                         						
								    																								
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			              Clinical Characteristics, Transmissibility, Pathogenicity, Susceptible Populations, and Re-infectivity of Prominent COVID-19 Variants
			              
			                Zhen Yang, Shuo Zhang, Yu-Ping Tang, Sai Zhang, Ding-Qiao Xu, Shi-Jun Yue, Qi-Ling Liu
			              
			              
			              
			              
						   
							 
							
			                         						
								    																								
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			              Dehydroepiandrosterone, Cancer, and Aging
			              
			                Arthur G Schwartz
			              
			              
			              
			              
						   
							 
							
			                         						
								    																								
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			              DNA Methylation Modulates Aging Process in Adipocytes
			              
			                Hao Xie, Xin Liu, Qing Zhou, Teng Huang, Lu Zhang, Jia Gao, Yuhan Wang, Yanjun Liu, Tong Yan, Shu Zhang, Cong-Yi Wang
			              
			              
			              
			              
						   
							 
							
			                         						
								    																								
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			              Autophagy and Diabetic Encephalopathy: Mechanistic Insights and Potential Therapeutic Implications
			              
			                Li-zhen Cheng, Wei Li, Yi-xin Chen, Yi-jia Lin, Ya Miao
			              
			              
			              
			              
						   
							 
							
			                         						
								    																								
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			              Investigating the Clinical Utility of the Anti-Mullerian Hormone Testing for the Prediction of Age at Menopause and Assessment of Functional Ovarian Reserve: A Practical Approach and Recent Updates
			              
			                Fahimeh Ramezani Tehrani, Faezeh Firouzi, Samira Behboudi-Gandevani
			              
			              
			              
			              
						   
							 
							
			                         						
								    																								
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			              Novel Insights into the Roles and Mechanisms of GLP-1 Receptor Agonists against Aging-Related Diseases
			              
			                Wei Peng, Rui Zhou, Ze-Fang Sun, Jia-Wei Long, Yong-Qiang Gong
			              
			              
			              
			              
						   
							 
							
			                         						
								    																								
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			              The Functional Role of Lipoproteins in Atherosclerosis: Novel Directions for Diagnosis and Targeting Therapy
			              
			                Yongzheng Lu, Xiaolin Cui, Li Zhang, Xu Wang, Yanyan Xu, Zhen Qin, Gangqiong Liu, Qiguang Wang, Kang Tian, Khoon S Lim, Chris J Charles, Jinying Zhang, Junnan Tang
			              
			              
			              
			              
						   
							 
							
			                         						
								    																								
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			              Role of Forkhead Box Protein O1 (FoxO1) in Stroke: A Literature Review
			              
			                Sichao Guo, Ruchi Mangal, Chaitu Dandu, Xiaokun Geng, Yuchuan Ding
			              
			              
			              
			              
						   
							 
							
			                         						
								    																										
							
							Short Communication
							
																									
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			              Global Association of Cause-specific Mortality between the Major Gastrointestinal Cancers and Parkinson’s Disease for the First Two Decades of the New Millennium
			              
			                Lili Lu, Meng Dai, Christina Susanne Mullins, Clemens Schafmayer, Michael Linnebacher
			              
			              
			              
			              
						   
							 
							
			                         						
								    																										
							
							Original Article
							
																									
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			              Aging Impairs the Cellular Interplay between Myeloid Cells and Mesenchymal Cells during Skin Healing in Mice
			              
			                Saeid Amini-Nik, Abdikarim Abdullahi, Roohi Vinaik, Ren Jie Robert Yao, Nancy Yu, Andrea Datu, Cassandra Belo, Marc G Jeschke
			              
			              
			              
			              
						   
							 							
							
							
			                         						
								    																								
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			              CB2R Attenuates Intervertebral Disc Degeneration by Delaying Nucleus Pulposus Cell Senescence through AMPK/GSK3β Pathway
			              
			                Jiacheng Du, Menglei Xu, Fanchen Kong, Pengfei Zhu, Yubo Mao, Yijie Liu, Hong Zhou, Zhongchen Dong, Zilin Yu, Tong Du, Ye Gu, Xiexing Wu, Dechun Geng, Haiqing Mao
			              
			              
			              
			              
						   
							 							
							
							
			                         						
								    																								
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			              Juvenile Plasma Factors Improve Organ Function and Survival following Injury by Promoting Antioxidant Response
			              
			                Xiaogang Chu, Kumar Subramani, Bobby Thomas, Alvin V Terry, Sadanand Fulzele, Raghavan Pillai Raju
			              
			              
			              
			              
						   
							 
							
			                         						
								    																								
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			              Oral Nano-Curcumin in a Model of Chronic Gulf War Illness Alleviates Brain Dysfunction with Modulation of Oxidative Stress, Mitochondrial Function, Neuroinflammation, Neurogenesis, and Gene Expression
			              
			                Sahithi Attaluri, Meenakshi Arora, Leelavathi N Madhu, Maheedhar Kodali, Bing Shuai, Laila Melissari, Raghavendra Upadhya, Xiaolan Rao, Adrian Bates, Eeshika Mitra, Keyhan R Ghahfarouki, M. N. V Ravikumar, Ashok K Shetty
			              
			              
			              
			              
						   
							 
							
			                         						
								    																								
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			              Senior-COVID-Rea Cohort Study: A Geriatric Prediction Model of 30-day Mortality in Patients Aged over 60 Years in ICU for Severe COVID-19
			              
			                Claire Falandry, Laurent Bitker, Paul Abraham, Fabien Subtil, Vincent Collange, Baptiste Balança, Max Haïne, Céline Guichon, Christophe Leroy, Marie Simon, Amélie Malapert, Jean-Baptiste Pialat, Laurent Jallades, Alain Lepape, Arnaud Friggeri, Fabrice Thiolliere