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Just Accepted
The manuscripts published below have been examined by the peer-review process and have been accepted for publication. A “Just Accepted” manuscript is published online shortly after its acceptance, which is prior to technical editing and formatting and author proofing. Higher Education Press (HEP) provides “Just Accepted” as an optional and free service which allows authors to make their results available to the research community as soon as possible after acceptance. After a manuscript has been technically edited and formatted, it will be removed from the “Just Accepted” Web site and published as an Online First article. Please note that technical editing may introduce minor changes to the manuscript text and/or graphics which may affect the content, and all legal disclaimers that apply to the journal pertain. In no event shall HEP be held responsible for errors or consequences arising from the use of any information contained in these “Just Accepted” manuscripts. To cite this manuscript please use its Digital Object Identifier (DOI(r)), which is identical for all formats of publication.
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Gut Microbiome and Osteoporosis
Kai Ding, Fei Hua, Wenge Ding
Aging and disease    DOI: 10.14336/AD.2019.0523
Accepted: 14 June 2019

Dl-3-n-butylphthalide Reduces Neurovascular Inflammation and Ischemic Brain Injury in Mice
Chun-Sheng Yang, Ai Guo, Yulin Li, Kaibin Shi, Fu-Dong Shi, Minshu Li
Aging and disease    DOI: 10.14336/AD.2019.0608
Accepted: 13 June 2019

Remote Ischemic Conditioning Improves Attention Network Function and Blood Oxygen Levels in Unacclimatized Adults Exposed to High Altitude
Sijie Li, Cong Han, Karam Asmaro, Shanyi Quan, Ming Li, Changhong Ren, Jun Zhang, Wenbo Zhao, Jiali Xu, Zhiwen Liu, Peng Zhang, Lingling Zhu, Yuchuan Ding, Kai Wang, Xunming Ji, Lian Duan
Aging and disease    DOI: 10.14336/AD.2019.0605
Accepted: 12 June 2019

Aging, Alzheimer’s Disease and Dysfunctional Glycolysis; Similar Effects of Too Much and Too Little
Alan R. Hipkiss
Aging and disease    DOI: 10.14336/AD.2019.0611
Accepted: 12 June 2019

Aging Attenuates Cardiac Contractility and Affects Therapeutic Consequences for Myocardial Infarction
Ming Dong, Ziyi Yang, Hongcheng Fang, Jiaqing Xiang, Cong Xu, Yanqing Zhou, Qianying Wu, Jie Liu
Aging and disease    DOI: 10.14336/AD.2019.0522
Accepted: 10 June 2019

Caveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review
Jinfan Tian, Mohammad Sharif Popal, RongChong Huang, Min Zhang, Xin Zhao, Mingduo Zhang, Xiantao Song
Aging and disease    DOI: 10.14336/AD.2019.09603
Accepted: 09 June 2019

Alteration in the Function and Expression of SLC and ABC Transporters in the Neurovascular Unit in Alzheimer’s Disease and the Clinical Significance
Yongming Jia, Na Wang, Yingbo Zhang, Di Xue, Haoming Lou, Xuewei Liu
Aging and disease    DOI: 10.14336/AD.2019.0519
Accepted: 05 June 2019

Hypoxia-Induced Degenerative Protein Modifications Associated with Aging and Age-Associated Disorders
Sunil S. Adav, Siu Kwan Sze
Aging and disease    DOI: 10.14336/AD.2019.0604
Accepted: 05 June 2019

Pretreatment Geriatric Assessments of Elderly Patients with Glioma: Development and Implications
Yaning Wang, Binghao Zhao, Wanqi Chen, Lei Liu, Wenlin Chen, Lizhou Zhou, Ziren Kong, Congxin Dai, Yu Wang, Wenbin Ma
Aging and disease    DOI: 10.14336/AD.2019.0527
Accepted: 02 June 2019

Ketogenic Diet Ameliorates Cardiac Dysfunction via Balancing Mitochondrial Dynamics and Inhibiting Apoptosis in Type 2 Diabetic Mice
Yongzheng Guo, Cheng Zhang, Minghao Luo, Yuehua You, Qiming Zhai, Feifei Shang, Yong Xia, Suxin Luo
Aging and disease    DOI: 10.14336/AD.2019.0510
Accepted: 01 June 2019
Online available: 01 June 2019

Understanding the Physiological Links Between Physical Frailty and Cognitive Decline
Lina Ma, Piu Chan
Aging and disease    DOI: 10.14336/AD.2019.0521
Accepted: 30 May 2019

Astragalus Polysaccharide Extends Lifespan via Mitigating Endoplasmic Reticulum Stress in the Silkworm, Bombyx mori
Jiangbo Song, Min Chen, Zhiquan Li, Jianfei Zhang, Hai Hu, Xiaoling Tong, Fangyin Dai
Aging and disease    DOI: 10.14336/AD.2019.0515
Accepted: 22 May 2019

Statins Induce a DAF-16/Foxo-dependent Longevity Phenotype via JNK-1 through Mevalonate Depletion in C. elegans
Andreas Jahn, Bo Scherer, Gerhard Fritz, Sebastian Honnen
Aging and disease    DOI: 10.14336/AD.2019.0416
Accepted: 19 May 2019

Angelica Sinensis Polysaccharide Suppresses Epithelial-Mesenchymal Transition and Pulmonary Fibrosis via a DANCR/AUF-1/FOXO3 Regulatory Axis
Weibin Qian, Xinrui Cai, Qiuhai Qian, Dongli Wang, Lei Zhang
Aging and disease    DOI: 10.14336/AD.2019.0512
Accepted: 13 May 2019

Neuropsychological Deficits Chronically Developed after Focal Ischemic Stroke and Beneficial Effects of Pharmacological Hypothermia in the Mouse
Weiwei Zhong, Yan Yuan, Xiaohuan Gu, Samuel In-young Kim, Ryan Chin, Modupe Loye, Thomas A Dix, Ling Wei, Shan Ping Yu
Aging and disease    DOI: 10.14336/AD.2019.0507
Accepted: 13 May 2019

Combined Antioxidant, Anti-inflammaging and Mesenchymal Stem Cell Treatment: A Possible Therapeutic Direction in Elderly Patients with Chronic Obstructive Pulmonary Disease
Shijin Xia, Changxi Zhou, Bill Kalionis, Xiaoping Shuang, Haiyan Ge, Wen Gao
Aging and disease    DOI: 10.14336/AD.2019.0508
Accepted: 11 May 2019

The Clinical Efficacy and Safety of Stem Cell Therapy for Diabetes Mellitus: A Systematic Review and Meta-Analysis
Yazhen Zhang, Wenyi Chen, Bing Feng, Hongcui Cao
Aging and disease    DOI: 10.14336/AD.2019.0421
Accepted: 10 May 2019

Type 2 Myocardial Infarction: A Geriatric Population-based Model of Pathogenesis
Alain Putot, Melanie Jeanmichel², Frederic Chague, Patrick Manckoundia, Yves Cottin, Marianne Zeller
Aging and disease    DOI: 10.14336/AD.2019.0405
Accepted: 08 May 2019

Metastasis Patterns and Prognosis of Octogenarians with NSCLC: A Population-based Study
Yu Gu, Junhua Zhang, Zhirui Zhou, Di Liu, Hongcheng Zhu, Junmiao Wen, Xinyan Xu, Tianxiang Chen, Min Fan
Aging and disease    DOI: 10.14336/AD.2019.0414
Accepted: 07 May 2019

Predictive Value of Pin1 in Cervical Low-Grade Squamous Intraepithelial Lesions and Inhibition of Pin1 Exerts Potent Anticancer Activity against Human Cervical Cancer
Yan-Tong Guo, Yan Lu, Yi-Yang Jia, Hui-Nan Qu, Da Qi, Xin-Qi Wang, Pei-Ye Song, Xiang-Shu Jin, Wen-Hong Xu, Yuan Dong, Ying-Ying Liang, Cheng-Shi Quan*
Aging and disease    DOI: 10.14336/AD.2019.0415
Accepted: 07 May 2019

AmpliSeq Transcriptome of Laser Captured Neurons from Alzheimer Brain: Comparison of Single Cell Versus Neuron Pools
Wenjun Deng, Changhong Xing, Rob David, Diego Mastroeni, MingMing Ning, Eng H. Lo, Paul D. Coleman
Aging and disease    DOI: 10.14336/AD.2019.0225
Accepted: 12 April 2019

Long-term HIV-1 Tat Expression in the Brain Led to Neurobehavioral, Pathological, and Epigenetic Changes Reminiscent of Accelerated Aging
Xiaojie Zhao, Yan Fan, Philip H. Vann, Jessica M. Wong, Nathalie Sumien, Johnny J. He
Aging and disease    DOI: 10.14336/AD.2019.0323
Accepted: 11 April 2019

Roles and Functions of Exosomal Non-coding RNAs in Vascular Aging
Yu-Qing Ni#, Xiao Lin#, Jun-Kun Zhan, You-Shuo Liu
Aging and disease    DOI: 10.14336/AD.2019.0402
Accepted: 08 April 2019

Antidiabetic Drug Metformin Ameliorates Depressive-Like Behavior in Mice with Chronic Restraint Stress via Activation of AMP-Activated Protein Kinase
Heng Ai, Weiqing Fang, Hanyi Hu, Xupang Hu, Wen Lu
Aging and disease    DOI: 10.14336/AD.2019.0403
Accepted: 07 April 2019

The Emerging Role of Sestrin2 in Cell Metabolism, and Cardiovascular and Age-Related Diseases
Wanqing Sun, Yishi Wang, Yang Zheng, Nanhu Quan
Aging and disease    DOI: 10.14336/AD.2019.0320
Accepted: 30 March 2019

Neurological Manifestation of Incretin-Based Therapies in Patients with Type 2 Diabetes: A Systematic Review and Network Meta-Analysis
Le Gao, Shuqing Yu, Andrea Cipriani, Shanshan Wu, Yi Huang, Zilu Zhang, Jun Yang, Yixin Sun, Zhirong Yang, Sanbao Chai, Yuan Zhang, Linong Ji, Siyan Zhan, Feng Sun
Aging and disease    DOI: 10.14336/AD.2019.0303
Accepted: 23 March 2019

The Long-lasting Radioprotective Effect of Caffeic Acid in Mice Exposed to Total Body Irradiation by Modulating Reactive Oxygen Species Generation and Hematopoietic Stem Cell Senescence-Accompanied Long-term Residual Bone Marrow Injury
Hyun-Jaung Sim, Govinda Bhattarai, Joshua Lee, Jeong-Chae Lee, Sung-Ho Kook
Aging and disease    DOI: 10.14336/AD.2019.0208
Accepted: 18 March 2019

Physical Activity and Alzheimer’s Disease: A Narrative Review
Piotr Gronek, Stefan Balko, Joanna Gronek, Adam Zajac, Adam Maszczyk, Roman Celka, Agnieszka Doberska, Wojciech Czarny, Robert Podstawski, Cain C. T. Clark, Fang Yu
Aging and disease    DOI: 10.14336/AD.2019.0226
Accepted: 12 March 2019

Plasma Lipoprotein-associated Phospholipase A2 and Superoxide Dismutase are Independent Predicators of Cognitive Impairment in Cerebral Small Vessel Disease Patients: Diagnosis and Assessment
Shuzhen Zhu, Xiaobo Wei, Xiaohua Yang, Zifeng Huang, Zihan Chang, Fen Xie, Qin Yang, Wei Xiang, Hongjun Yang, Changhai Ding, Ying Xia, Zhong-Ping Feng, Hong-Shuo Sun, Midori A. Yenari, Lin Shi, Vincent CT Mok, Qing Wang
Aging and disease    DOI: 10.14336/AD.2019.0304
Accepted: 06 March 2019

Verapamil Ameliorates Motor Neuron Degeneration and Improves Lifespan in the SOD1G93A Mouse Model of ALS by Enhancing Autophagic Flux
Xiaojie Zhang, Sheng Chen, Kaili Lu, Feng Wang, Jiangshan Deng, Zhouwei Xu, Xiuzhe Wang, Qinming Zhou, Weidong Le, Yuwu Zhao
Aging and disease    DOI: 10.14336/AD.2019.0228
Accepted: 03 March 2019

Five-Minute Cognitive Test as A New Quick Screening of Cognitive Impairment in The Elderly
Jie Zhang, Lijun Wang, Xia Deng, Guoqiang Fei, Lirong Jin, Xiaoli Pan, Liuhan Cai, Anthony D. Albano, Chunjiu Zhong
Aging and disease    DOI: 10.14336/AD.2019.0115
Accepted: 02 March 2019

Genetic Spectrum and Variability in Chinese Patients with Amyotrophic Lateral Sclerosis
Zhi-Jun Liu, Hui-Xia Lin, Qiao Wei, Qi-Jie Zhang, Cong-Xin Chen, Qing-Qing Tao, Gong-Lu Liu, Wang Ni, Aaron D. Gitler, Hong-Fu Li, Zhi-Ying Wu
Aging and disease    DOI: 10.14336/AD.2019.0215
Accepted: 02 March 2019

Novel Role of Lck in Leptin-Induced Inflammation and Implications for Renal Aging
Dae Hyun Kim, June Whoun Park, Hyoung Oh Jeong, Bonggi Lee, Ki Wung Chung, Yujeong Lee, Hee Jin Jung, Min Kyung Hyun, A Kyoung Lee, Byeong Moo Kim, Jaewon Lee, Byung Pal Yu, Hae Young Chung
Aging and disease    DOI: 10.14336/AD.2019.0218
Accepted: 21 February 2019

Frailty Predicts an Increased Risk of End-Stage Renal Disease with Risk Competition by Mortality among 165,461 Diabetic Kidney Disease Patients
Chia-Ter Chao, Jui Wang, Jenq-Wen Huang, Ding-Cheng Chan, Kuo-Liong Chien, on behalf of the COhort of GEriatric Nephrology in NTUHstudy group
Aging and disease    DOI: 10.14336/AD.2019.0216
Accepted: 19 February 2019

Disability Transitions and Health Expectancies among Elderly People Aged 65 Years and Over in China: A Nationwide Longitudinal Study
Chengbei Hou, Yuan Ma, Xinghua Yang, Lixin Tao, Deqiang Zheng, Xiangtong Liu, Xiaonan Wang, Xia Li, Wei Wang, Xianghua Fang, Xiuhua Guo
Aging and disease    DOI: 10.14336/AD.2019.0121
Accepted: 19 February 2019

Subtyping of Parkinson’s Disease - Where Are We Up To?
Elizabeth Qian, Yue Huang
Aging and disease    DOI: 10.14336/AD.2019.0112
Accepted: 18 February 2019

Aging Influences Hepatic Microvascular Biology and Liver Fibrosis in Advanced Chronic Liver Disease
Raquel Maeso-Díaz, Martí Ortega-Ribera, Erica Lafoz, Juan José Lozano, Anna Baiges, Rubén Francés, Agustín Albillos, Carmen Peralta, Juan Carlos García-Pagán, Jaime Bosch, Victoria C Cogger, Jordi Gracia-Sancho
Aging and disease    DOI: 10.14336/AD.2019.0127
Accepted: 18 February 2019

Pyroptosis in Liver Disease: New Insights into Disease Mechanisms
Jiali Wu, Su Lin, Bo Wan, Bharat Velani, Yueyong Zhu
Aging and disease    DOI: 10.14336/AD.2019.1216
Accepted: 01 February 2019

AMPK Signaling Regulates the Age-Related Decline of Hippocampal Neurogenesis
Z. Wang Brian, J. Yang Jane, Zhang Hongxia, A. Smith Charity, Jin Kunlin
Aging and disease    DOI: 10.14336/AD.2019.0102
Accepted: 26 January 2019

Metformin Alters Locomotor and Cognitive Function and Brain Metabolism in Normoglycemic Mice
Wenjun Li, Kiran Chaudhari, Ritu Shetty, Ali Winters, Xiaofei Gao, Zeping Hu, Woo-Ping Ge, Nathalie Sumien, Michael Forster, Ran Liu, Shao-Hua Yang
Aging and disease    DOI: 10.14336/AD.2019.0120
Accepted: 25 January 2019

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