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Just Accepted
The manuscripts published below have been examined by the peer-review process and have been accepted for publication. A “Just Accepted” manuscript is published online shortly after its acceptance, which is prior to technical editing and formatting and author proofing. Higher Education Press (HEP) provides “Just Accepted” as an optional and free service which allows authors to make their results available to the research community as soon as possible after acceptance. After a manuscript has been technically edited and formatted, it will be removed from the “Just Accepted” Web site and published as an Online First article. Please note that technical editing may introduce minor changes to the manuscript text and/or graphics which may affect the content, and all legal disclaimers that apply to the journal pertain. In no event shall HEP be held responsible for errors or consequences arising from the use of any information contained in these “Just Accepted” manuscripts. To cite this manuscript please use its Digital Object Identifier (DOI(r)), which is identical for all formats of publication.
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Hydroxyurea Facilitates Manifestation of Disease Relevant Phenotypes in Patients-Derived IPSCs-Based Modeling of Late-Onset Parkinson’s Disease
Yuan Tan, Minjing Ke, Zhijian Huang, Cheong-Meng Chong, Xiaotong Cen, Jia-Hong Lu, Xiaoli Yao, Dajiang Qin, Huanxing Su
Aging and disease    DOI: 10.14336/AD.2018.1216
Accepted: 08 January 2019

The Neuronal Activation of Deep Cerebellar Nuclei Is Essential for Environmental Enrichment-Induced Post-Stroke Motor Recovery
Qun Zhang, Jun-fa Wu, Qi-li Shi, Ming-yue Li, Chuan-jie Wang, Xin Wang, Wen-yuan Wang, Yi Wu
Aging and disease    DOI: 10.14336/AD.2018.1220
Accepted: 07 January 2019

The Peptide-Directed Lysosomal Degradation of CDK5 Exerts Therapeutic Effects against Stroke
Ya-Fan Zhou, Jing Wang, Man-Fei Deng, Bin Chi, Na Wei, Jian-Guo Chen, Dan Liu, Xiaoping Yin, Youming Lu, Ling-Qiang Zhu
Aging and disease    DOI: 10.14336/AD.2018.1225
Accepted: 31 December 2018

Handgrip Strength and Pulmonary Disease in the Elderly: What is the Link?
Tatiana Rafaela Lemos Lima, Vívian Pinto Almeida, Arthur Sá Ferreira, Fernando Silva Guimarães, Agnaldo José Lopes
Aging and disease    DOI: 10.14336/AD.2018.1226
Accepted: 31 December 2018

Salsalate Prevents β-Cell Dedifferentiation in OLETF Rats with Type 2 Diabetes through Notch1 Pathway
Fei Han, Xiaochen Li, Juhong Yang, Haiyi Liu, Yi Zhang, Xiaoyun Yang, Shaohua Yang, Bai Chang, Liming Chen, Baocheng Chang
Aging and disease    DOI: 10.14336/AD.2018.1221
Accepted: 30 December 2018

Collagen XIX Alpha 1 Improves Prognosis in Amyotrophic Lateral Sclerosis
Ana C. Calvo, Gabriela Atencia Cibreiro, Paz Torre Merino, Juan F. Roy, Adrián Galiana, Alexandra Juárez Rufián, Juan M. Cano, Miguel A. Martín, Laura Moreno, Pilar Larrodé, Pilar Cordero Vázquez, Lucía Galán, Jesús Mora, José L. Muñoz-Blanco, María J. Muñoz, Pilar Zaragoza, Elena Pegoraro, Gianni Sorarù, Marina Mora, Christian Lunetta, Silvana Penco, Claudia Tarlarini, Jesús Esteban, Rosario Osta, Alberto García Redondo
Aging and disease    DOI: 10.14336/AD.2018.0917
Accepted: 11 December 2018

The Drainage of Interstitial Fluid in the Deep Brain is Controlled by the Integrity of Myelination
Aibo Wang, Rui Wang, Dehua Cui, Xinrui Huang, Lan Yuan, Huipo Liu, Yu Fu, Lei Liang, Wei Wang, Qingyuan He, Chunyan Shi, Xiangping Guan, Ze Teng, Guomei Zhao, Yuanyuan Li, Yajuan Gao, Hongbin Han
Aging and disease    DOI: 10.14336/AD.2018.1206
Accepted: 08 December 2018
Online available: 08 December 2018

The role of CD2AP in the Pathogenesis of Alzheimer's Disease
Qing-Qing Tao, Yu-Chao Chen, Zhi-Ying Wu
Aging and disease    DOI: 10.14336/AD.2018.1025
Accepted: 08 December 2018

IgE Aggravates the Senescence of Smooth Muscle Cells in Abdominal Aortic Aneurysm by Upregulating LincRNA-p21
Wenjun Guo, Ran Gao, Wei Zhang, Weipeng Ge, Meng Ren, Bolun Li, Hongmei Zhao, Jing Wang
Aging and disease    DOI: 10.14336/AD.2018.1128
Accepted: 06 December 2018

Characterization of Alzheimer’s Disease Using Ultra-high b-values Apparent Diffusion Coefficient and Diffusion Kurtosis Imaging
Yingnan Xue, Zhenhua Zhang, Caiyun Wen, Huiru Liu, Suyuan Wang, Jiance Li, Qichuan Zhuge, Weijian Chen, Qiong Ye
Aging and disease    DOI: 10.14336/AD.2018.1129
Accepted: 03 December 2018

Galectin-3 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension
Tangzhiming Li, Lihuang Zha, Hui Luo, Suqi Li, Lin Zhao, Jingni He, Xiaohui Li, Qiangqiang Qi, Yuwei Liu, Zaixin Yu
Aging and disease    DOI: 10.14336/AD.2018.1001
Accepted: 27 November 2018

Metabolomics Coupled with Transcriptomics Approach Deciphering Age Relevance in Sepsis
Dingqiao Xu, Shanting Liao, Pei Li, Qian Zhang, Yan Lv, Xiaowei Fu, Minghua Yang, Junsong Wang, Lingyi Kong
Aging and disease    DOI: 10.14336/AD.2018.1027
Accepted: 26 November 2018

Increased Serum Matrix Metalloproteinase-9 Levels are Associated with Anti-Jo1 but not Anti-MDA5 in Myositis Patients
Yanjuan Liu, Hui Luo, Li Wang, Caiyan Li, Liyun Liu, Li Huang, Ke Liu, Meidong Liu, Siming Gao, Yizhi Xiao, Honglin Zhu, Xiaoxia Zuo, Quan-Zhen Li, Huali Zhang
Aging and disease    DOI: 10.14336/AD.2018.1120
Accepted: 26 November 2018
Online available: 27 November 2018

Rejuvenating Strategies of Tissue-specific Stem Cells for Healthy Aging
Minjun Wang, Jiajia Chen, Fei Chen, Qinggui Liu, Yu Sun, Chen Yan, Tao Yang, Yiwen Bao, Yi-Ping Hu
Aging and disease    DOI: 10.14336/AD.2018.1119
Accepted: 26 November 2018

Two Novel Mutations and a de novo Mutation in PSEN1 in Early-onset Alzheimer’s Disease
Yu-Sheng Li, Zhi-Hua Yang, Yao Zhang, Jing Yang, Dan-Dan Shang, Shu-Yu Zhang, Jun Wu, Yan Ji, Lu Zhao, Chang-He Shi, Yu-Ming Xu
Aging and disease    DOI: 10.14336/AD.2018.1109
Accepted: 23 November 2018

Interplay between Exosomes and Autophagy in Cardiovascular Diseases: Novel Promising Target for Diagnostic and Therapeutic Application
Jinfan Tian, Mohammad Sharif Popal, Yingke Zhao, Yanfei Liu, Keji Chen, Yue Liu
Aging and disease    DOI: 10.14336/AD.2018.1020
Accepted: 20 November 2018

Health and Aging: Unifying Concepts, Scores, Biomarkers and Pathways
Georg Fuellen, Ludger Jansen, Alan A. Cohen, Walter Luyten, Manfred Gogol, Andreas Simm, Nadine Saul, Francesca Cirulli, Alessandra Berry, Peter Antal, Rüdiger Köhling, Brecht Wouters, Steffen Möller
Aging and disease    DOI: 10.14336/AD.2018.1030
Accepted: 19 November 2018

Entorhinal Cortex Atrophy in Early, Drug-naive Parkinson’s Disease with Mild Cognitive Impairment
Xiuqin Jia, Zhijiang Wang, Tao Yang, Ying Li, Shuai Gao, Guorong Wu, Tao Jiang, Peipeng Liang
Aging and disease    DOI: 10.14336/AD.2018.1116
Accepted: 18 November 2018
Online available: 18 November 2018

Role of Regulatory T cells in Atorvastatin Induced Absorption of Chronic Subdural Hematoma in Rats
Wei Quan, Zhifei Zhang, Pan Li, Qilong Tian, Jinhao Huang, Yu Qian, Chuang Gao, Wanqiang Su, Zengguang Wang, Jianning Zhang, Alex Zacharek, Poornima Venkat, Jieli Chen, Rongcai Jiang
Aging and disease    DOI: 10.14336/AD.2018.0926
Accepted: 16 November 2018

TNF𝛼-induced Up-regulation of Ascl2 Affects the Differentiation and Proliferation of Neural Stem Cells
Zhongfeng Liu, Xuan Wang, Kewen Jiang, Xunming Ji, Y. Alex Zhang, Zhiguo Chen
Aging and disease    DOI: 10.14336/AD.2018.1028
Accepted: 16 November 2018

The Potential Markers of Circulating microRNAs and long non-coding RNAs in Alzheimer's Disease
Yanfang Zhao, Yuan Zhang, Lei Zhang, Yanhan Dong, Ji Hongfang, Shen Liang
Aging and disease    DOI: 10.14336/AD.2018.1105
Accepted: 13 November 2018

Processing of Mutant β-Amyloid Precursor Protein and the Clinicopathological Features of Familial Alzheimer’s Disease
Christopher Bi, Stephanie Bi, Bin Li
Aging and disease    DOI: 10.14336/AD.2018.0425
Accepted: 12 November 2018

Autophagy Activation is Associated with Neuroprotection in Diabetes-associated Cognitive Decline
Yanqing Wu, Libing Ye, Yuan Yuan, Ting Jiang, Xin Guo, Zhouguang Wang, Ke Xu, Zeping Xu, Yanlong Liu, Xingfeng Zhong, Junmin Ye, Hongyu Zhang, Xiaokun Li, Jian Xiao
Aging and disease    DOI: 10.14336/AD.2018.1024
Accepted: 12 November 2018

Anatomical Links between White Matter Hyperintensity and Medial Temporal Atrophy Reveal Impairment of Executive Functions
Takehiko Yamanaka, Yuto Uchida, Keita Sakurai, Daisuke Kato, Masayuki Mizuno, Toyohiro Sato, Yuta Madokoro, Yuko Kondo, Ayuko Suzuki, Yoshino Ueki, Fumiyasu Ishii, Cesar V Borlongan, Noriyuki Matsukawa
Aging and disease    DOI: 10.14336/AD.2018.0929
Accepted: 09 November 2018

Deficiency of Yes-Associated Protein Induces Cataract in Mice
Qing He, Yuhao Gao, Lujun Zhou, Tongxing Wang, Zengqiang Yuan
Aging and disease    DOI: 10.14336/AD.2018.0910
Accepted: 13 October 2018

The WNK-SPAK/OSR1 Kinases and the Cation-Chloride Cotransporters as Therapeutic Targets for Neurological Diseases
Huachen Huang, Shanshan Song, Suneel Banerjee, Tong Jiang, Jinwei Zhang, Kristopher T. Kahle, Dandan Sun, Zhongling Zhang
Aging and disease    DOI: 10.14336/AD.2018.0928
Accepted: 02 October 2018

Preclinical Evidence and Possible Mechanisms of Extracts or Compounds from Cistanches for Alzheimer’s Disease
Xiao-Li Zhou, Meng-Bei Xu, Ting-Yu Jin, Pei-Qing Rong, Guo-Qing Zheng*, Yan Lin*
Aging and disease    DOI: 10.14336/AD.2018.015
Accepted: 29 September 2018

Calcitriol Analogues Decrease Lung Metastasis but Impair Bone Metabolism in Aged Ovariectomized Mice Bearing 4T1 Mammary Gland Tumours
Artur Anisiewicz, Beata Filip-Psurska, Agata Pawlik, Anna Nasulewicz-Goldeman, Tomasz Piasecki, Konrad Kowalski, Magdalena Maciejewska, Joanna Jarosz, Joanna Banach, Diana Papiernik, Andrzej Mazur, Andrzej Kutner, Jeanette A. Maier, Joanna Wietrzyk
Aging and disease    DOI: 10.14336/AD.2018.0921
Accepted: 28 September 2018

Autoantibodies against AT1 Receptor Contribute to Vascular Aging and Endothelial Cell Senescence
Meili Wang, Xiaochen Yin, Suli Zhang, Chenfeng Mao, Ning Cao, Xiaochun Yang, Jingwei Bian, Weiwei Hao, Qian Fan, Huirong Liu
Aging and disease    DOI: 10.14336/AD.2018.0919
Accepted: 27 September 2018

Intravenous Administration of Standard Dose Tirofiban after Mechanical Arterial Recanalization is Safe and Relatively Effective in Acute Ischemic Stroke
Zhe Cheng, Xiaokun Geng, Jie Gao, Mohammed Hussain, Seong-Jin Moon, Huishan Du, Yuchuan Ding
Aging and disease    DOI: 10.14336/AD.2018.0922
Accepted: 26 September 2018

Duration and Quality of Sleep and Risk of Physical Function Impairment and Disability in Older Adults: Results from the ENRICA and ELSA Cohorts
Marcela Z. Campanini, Arthur E. Mesas, Jose Antonio Carnicero-Carreño, Fernando Rodríguez-Artalejo, Esther Lopez-Garcia
Aging and disease    DOI: 10.14336/AD.2018.0611
Accepted: 23 September 2018

Clinical and Genetic Profiles in Chinese Patients with Huntington’s Disease: A Ten-year Multicenter Study in China
Hong-Lei Li, Xiao-Yan Li, Yi Dong, Yan-Bin Zhang, Hong-Rong Cheng, Shi-Rui Gan, Zhi-Jun Liu, Wang Ni, Jean-Marc Burgunder, X. William Yang, Zhi-Ying Wu
Aging and disease    DOI: 10.14336/AD.2018.0911
Accepted: 22 September 2018

The Metabolic Activity of Caudate and Prefrontal Cortex Negatively Correlates with the Severity of Idiopathic Parkinson’s Disease
Jun-Sheng Chu, Ting-Hong Liu, Kai-Liang Wang, Chun-Lei Han, Yun-Peng Liu, Shimabukuro Michitomo, Jian-Guo Zhang, Tie Fang, Fan-Gang Meng
Aging and disease    DOI: 10.14336/AD.2018.0814
Accepted: 20 September 2018

Glial S100A6 Degrades β-amyloid Aggregation through Targeting Competition with Zinc Ions
Zhi-Ying Tian, Chun-Yan Wang, Tao Wang, Yan-Chun Li, Zhan-You Wang
Aging and disease    DOI: 10.14336/AD.2018.0912
Accepted: 20 September 2018

Enhancement of Mesenchymal Stem Cell-Driven Bone Regeneration by Resveratrol-Mediated SOX2 Regulation
Yoorim Choi, Dong Suk Yoon, Kyoung-Mi Lee, Seong Mi Choi, Myon-Hee Lee, Kwang Hwan Park, Seung Hwan Han, Jin Woo Lee
Aging and disease    DOI: 10.14336/AD.2018.0802
Accepted: 18 September 2018

The Prognostic Value of Serum Cytokines in Patients with Acute Ischemic Stroke
Xianmei Li, Siyang Lin, Xiaoli Chen, Wensi Huang, Qian Li, Hongxia Zhang, Xudong Chen, Shaohua Yang, Kunlin Jin, Bei Shao
Aging and disease    DOI: 10.14336/AD.2018.0820
Accepted: 14 September 2018

Maintained Properties of Aged Dental Pulp Stem Cells for Superior Periodontal Tissue Regeneration
Linsha Ma, Jingchao Hu, Yu Cao, Yilin Xie, Hua Wang, Zhipeng Fan, Chunmei Zhang, Jinsong Wang, Chu-Tse Wu, Songlin Wang
Aging and disease    DOI: 10.14336/AD.2018.0729
Accepted: 12 September 2018

Subclinical Hypothyroidism: is it Really Subclinical with Aging?
Robin Gourmelon, Sandrine Donadio-Andréi, Karim Chikh, Muriel Rabilloud, Elisabetta Kuczewski, Anne-Sophie Gauchez, Anne Charrié, Pierre-Yves Brard, Raphaëlle Andréani, Jean-Cyril Bourre, Christine Waterlot, Domitille Guédel, Anne Mayer, Emmanuel Disse, Charles Thivolet, Hélène Du Boullay, Claire Falandry, Thomas Gilbert, Anne François-Joubert, Antoine Vignoles, Catherine Ronin, Marc Bonnefoy
Aging and disease    DOI: 10.14336/AD.2018.0817
Accepted: 07 September 2018
Online available: 06 September 2018

Necrostatin-1 Prevents Necroptosis in Brains after Ischemic Stroke via Inhibition of RIPK1-Mediated RIPK3/MLKL Signaling
Xu-Xu Deng, Shan-Shan Li, Feng-Yan SUN
Aging and disease    DOI: 10.14336/AD.2018.0728
Accepted: 04 September 2018

Traditional Oriental Medicines and Alzheimer’s Disease
Seong Gak Jeon, Eun Ji Song, Dongje Lee, Junyong Park, Yunkwon Nam, Jin-il Kim, Minho Moon
Aging and disease    DOI: 10.14336/AD.2018.0328
Accepted: 29 August 2018

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