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Just Accepted
The manuscripts published below have been examined by the peer-review process and have been accepted for publication. A “Just Accepted” manuscript is published online shortly after its acceptance, which is prior to technical editing and formatting and author proofing. Higher Education Press (HEP) provides “Just Accepted” as an optional and free service which allows authors to make their results available to the research community as soon as possible after acceptance. After a manuscript has been technically edited and formatted, it will be removed from the “Just Accepted” Web site and published as an Online First article. Please note that technical editing may introduce minor changes to the manuscript text and/or graphics which may affect the content, and all legal disclaimers that apply to the journal pertain. In no event shall HEP be held responsible for errors or consequences arising from the use of any information contained in these “Just Accepted” manuscripts. To cite this manuscript please use its Digital Object Identifier (DOI(r)), which is identical for all formats of publication.
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tRNA-derived fragments as New Hallmarks of Aging and Age-related Diseases
Ya Yuan, Jiamei Li, Zhi He, Xiaolan Fan, Xueping Mao, Mingyao Yang, Deying Yang
Aging and disease    DOI: 10.14336/AD.2021.0115
Accepted: 21 January 2021

Extracellular GAPDH Promotes Alzheimer Disease Progression by Enhancing Amyloid-β Aggregation and Cytotoxicity
Vladimir F. Lazarev,Magda Tsolaki,Elena R. Mikhaylova,Konstantin A. Benken,Maxim A. Shevtsov,Alina D. Nikotina,Mirna Lechpammer,Vladimir A. Mitkevich,Alexander A. Makarov,Alexey A. Moskalev,Sergey A. Kozin,Boris A. Margulis,Irina V. Guzhova,Evgeny Nudler
Aging and disease    DOI: 10.14336/AD.2020.1230
Accepted: 20 January 2021
Online available: 20 January 2021

Premature Senescence of T-cells Favors Bone Loss During Osteolytic Diseases. A New Concern in the Osteoimmunology Arena
Luis González-Osuna, Alfredo Sierra-Cristancho, Carolina Rojas, Emilio A. Cafferata, Samanta Melgar-Rodríguez, Angélica M. Cárdenas, Rolando Vernal
Aging and disease    DOI: 10.14336/AD.2021.0110
Accepted: 13 January 2021

Aged-related Function Disorder of Liver is Reversed after Exposing to Young Milieu via Conversion of Hepatocyte Ploidy
Qinggui Liu,Fei Chen,Tao Yang,Jing Su,Shaohua Song,Zhi-Ren Fu,Yao Li,Yi-Ping Hu,Min-Jun Wang
Aging and disease    DOI: 10.14336/AD.2020.1227
Accepted: 13 January 2021

Exercise in Aging: Be Balanced
Joanna Gronek, Michał Boraczyński, Piotr Gronek, Dariusz Wieliński, Jacek Tarnas, Sławomir Marszałek, Yi-Yuan Tang
Aging and disease    DOI: 10.14336/AD.2021.0107
Accepted: 12 January 2021

Shift in the Distributions of Pre-existing Medical Condition, Gender and Age across Different COVID-19 Outcomes
Ming Zheng*, Lun Song*
Aging and disease    DOI: 10.14336/AD.2020.1222
Accepted: 12 January 2021

The Role of SGLT2 Inhibitors in Vascular Aging
Le Liu, Yu-Qing Ni, Jun-Kun Zhan, You- Shuo Liu
Aging and disease    DOI: 10.14336/AD.2020.1229
Accepted: 05 January 2021

MSC-derived Exosomes can Enhance the Angiogenesis of Human Brain MECs and show Therapeutic Potential in a Mouse Model of Parkinson's Disease
Chunling Xue,Xuechun Li,Li Ba,Mingjia Zhang,Ying Yang,Yang Gao,Zhao Sun,Qin Han,Robert Chunhua Zhao
Aging and disease    DOI: 10.14336/AD.2020.1221
Accepted: 04 January 2021

Self-eating and Heart: The Emerging Roles of Autophagy in Calcific Aortic Valve Disease
Yunlong Fan, Jiakang Shao, Shixiong Wei, Chao Song, Yanan Li, Shengli Jiang
Aging and disease    DOI: 10.14336/AD.2021.0101
Accepted: 02 January 2021

Limb Remote Ischemic Conditioning Ameliorates Cognitive Impairment in Rats with Chronic Cerebral Hypoperfusion by Regulating Glucose Transport
Changhong Ren#, Yuanyuan Liu#, Christopher Stone, Ning Li, Sijie Li, Haiyan Li, Zichao Cheng, Jiangnan Hu, Weiguang Li, Kunlin Jin, Xunming Ji, Yuchuan Ding
Aging and disease    DOI: 10.14336/AD.2020.1125
Accepted: 29 December 2020

An Update on Medical and Surgical Treatments of Parkinson’s Disease
Dipali Nemade, Thyagarajan Subramanian, Vikram Shivkumar
Aging and disease    DOI: 10.14336/AD.2020.1225
Accepted: 28 December 2020

Mesenchymal Stem Cells for the Compassionate Treatment of Severe Acute Respiratory Distress Syndrome Due to COVID 19
Martin Iglesias,Patricia Butrón,Iván Torre-Villalvazo,Erik A. Torre-Anaya,Juan Sierra-Madero,José J. Rodriguez-Andoney,Armando R. Tovar-Palacio,Alejandro Zentella-Dehesa,Guillermo Domínguez-Cherit,Tatiana S. Rodriguez-Reyna,Julio Granados-Arriola,Verónica Espisosa-Cruz,Fernando P. Téllez-Pallares,Alexia Lozada-Estrada,Carol A. Zepeda Carrillo,Aldo J. Vázquez-Mézquita,Hector F. Nario-Chaidez
Aging and disease    DOI: 10.14336/AD.2020.1218
Accepted: 21 December 2020

An Account of Immune Senescence in the Clinical Pathophysiology of COVID-19 Infection in Aging
Shilpi Jain, Eden Abrham, M. Nadeem Khan, Ramkumar Mathur
Aging and disease    DOI: 10.14336/AD.2020.1019
Accepted: 20 December 2020

CD36 Signaling in Diabetic Cardiomyopathy
Xudong Zhang, Jiahui Fan, Huaping Li, Chen Chen, Yan Wang
Aging and disease    DOI: 10.14336/AD.2020.1217
Accepted: 18 December 2020

Global Sex Disparity of COVID-19: A Descriptive Review of Sex Hormones and Consideration for the Potential Therapeutic Use of Hormone Replacement Therapy in Older Adults
Samuel C. Okpechi, Jordyn T. Fong, Shawn S. Gill, Jarrod C. Harman, Tina H. Nguyen, Queendaleen C. Chukwurah, IfeanyiChukwu O. Onor, Suresh K. Alahari
Aging and disease    DOI: 10.14336/AD.2020.1211
Accepted: 16 December 2020

Prior Antithrombotic Therapy is Associated with Increased Risk of Death in Patients with Intracerebral Hemorrhage: Findings from the Chinese Stroke Center Alliance (CSCA) Study
Dacheng Liu,Hongqiu Gu,Yuehua Pu,Jingyi Liu,Kaixuan Yang,Wanying Duan,Xin Liu,Ximing Nie,Zhe Zhang,Chunjuan Wang,Xingquan Zhao,Yilong Wang,Zixiao Li,Liping Liu
Aging and disease    DOI: 10.14336/AD.2020.1205
Accepted: 07 December 2020

Age-Related Cognitive and Motor Decline in a Mouse Model of CDKL5 Deficiency Disorder is Associated with Increased Neuronal Senescence and Death
Laura Gennaccaro,Claudia Fuchs,Manuela Loi,Riccardo Pizzo,Sara Alvente,Chiara Berteotti,Leonardo Lupori,Giulia Sagona,Giuseppe Galvani,Antonia Gurgone,Alessandra Raspanti,Giorgio Medici,Marianna Tassinari,Stefania Trazzi,Elisa Ren,Roberto Rimondini,Tommaso Pizzorusso,Giovanna Zoccoli,Maurizio Giustetto,Elisabetta Ciani
Aging and disease    DOI: 10.14336/AD.2020.0827
Accepted: 06 December 2020

Body adaptation to Dance: A Gerontological Perspective
Piotr Gronek, Michał Boraczyński, Aline Nogueira Haas, Jan Adamczyk, Mariola Pawlaczyk, Wojciech Czarny, Cain CT Clark, Urszula Czerniak, Anna Demuth, Roman Celka, Paulina Wycichowska, Joanna Gronek, Magdalena Król-Zielińska
Aging and disease    DOI: 10.14336/AD.2020.1107
Accepted: 04 December 2020

DeepMAge: A Methylation Aging Clock Developed with Deep Learning
Fedor Galkin,Polina Mamoshina,Kirill Kochetov,Denis Sidorenko,Alex Zhavoronkov
Aging and disease    DOI: 10.14336/AD.2020.1202
Accepted: 04 December 2020

Systemic Transplantation of Adult Multipotent Stem Cells Functionally Rejuvenates Aged Articular Cartilage
Seth D. Thompson, Rajeswari Pichika, Richard L. Lieber, G.R. Scott Budinger, Mitra Lavasani
Aging and disease    DOI: 10.14336/AD.2020.1118
Accepted: 03 December 2020

Microglial Polarization: Novel Therapeutic Strategy against Ischemic Stroke
Yimeng Xue, Ding Nie, Lin-Jian Wang, Han-Cheng Qiu, Long Ma, Ming-Xin Dong, Wen-Jun Tu, Jizong Zhao
Aging and disease    DOI: 10.14336/AD.2020.0701
Accepted: 02 December 2020

The Molecular Regulation in the Pathophysiology in Ovarian Aging
Chia-Jung Li, Li-Te Lin, Hsiao-Wen Tsai, Chyi-Uei Chern, Zhi-Hong Wen, Peng-Hui Wang, Kuan-Hao Tsui
Aging and disease    DOI: 10.14336/AD.2020.1113
Accepted: 27 November 2020

Effects of Pyruvate Administration on Mitochondrial Enzymes, Neurological Behaviors, and Neurodegeneration after Traumatic Brain Injury
Prasanth S. Ariyannur, Guoqiang Xing, Erin S. Barry, Brandi Benford, Neil E. Grunberg, Pushpa Sharma
Aging and disease    DOI: 10.14336/AD.2020.1015
Accepted: 24 November 2020

Metformin: A Potential Candidate for Targeting Aging Mechanisms
Die Hu, Fangfang Xie, Yongwei Xiao, Chen Lu, Jianing Zhong, Defa Huang, Jie Chen, Jifu Wei, Yu Jiang, Tianyu Zhong
Aging and disease    DOI: 10.14336/AD.2020.0702
Accepted: 23 November 2020

Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice
Danyang Li#, Mihua Liu#, Zhe Li, Guo Zheng, Amei Chen, Lei Zhao, Ping Yang, Li Wei, Yaxi Chen, Xiong Z Ruan
Aging and disease    DOI: 10.14336/AD.2020.1120
Accepted: 21 November 2020

Systematic Study of Immune Cell Diversity in ischemic postconditioning Using High-Dimensional Single-Cell Analysis with Mass Cytometry
Yang Yao,Yaning Li,Weihua Ni,Zhijun Li,Liangshu Feng,Yan Wang,Jihong Meng,Heng Zhao
Aging and disease    DOI: 10.14336/AD.2020.1115
Accepted: 18 November 2020

Information and Communication Technologies for Managing Frailty: A Systematic Literature Review
Antonio Miguel Cruz, Laura Monsalve, Anna-Maria Ladurner, Luisa Fernanda Jaime, Daniel Wang, Daniel Alejandro Quiroga
Aging and disease    DOI: 10.14336/AD.2020.1114
Accepted: 15 November 2020

Fibrinogen is an Independent Risk Factor for White Matter Hyperintensities in CADASIL but not in Sporadic Cerebral Small Vessel Disease Patients
Xingfang Guo#, Bin Deng#, Lizi Zhong#, Fen Xie#, Qing Qiu, Xiaobo Wei, Wenya Wang, Jiangping Xu, Ganqiang Liu, Wong Peter Tsun Hon, Midori A. Yenari, Shuzhen Zhu, Qing Wang
Aging and disease    DOI: 10.14336/AD.2020.1110
Accepted: 13 November 2020

Non-Muscular Invasive Bladder Cancer: Re-envisioning Therapeutic Journey from Traditional to Regenerative Interventions
Kuan-Wei Shih#, Wei-Chieh Chen#, Ching-Hsin Chang, Ting-En Tai, Jeng-Cheng Wu, Andy C. Huang, Ming-Che Liu
Aging and disease    DOI: 10.14336/AD.2020.1109
Accepted: 11 November 2020

Effects of Antihypertensive Drugs on Cognitive Function in Elderly Patients with Hypertension: A Review
Wei Yang, Hongyu Luo, Yixin Ma, Sicong Si, Huan Zhao
Aging and disease    DOI: 10.14336/AD.2020.1111
Accepted: 11 November 2020

Aspirin Positively Contributes to Drosophila Intestinal Homeostasis and Delays Aging through Targeting Imd
Yangyang Zhu,Qingshuang Cai,Xianrui Zheng,Lei Liu,Yongzhi Hua,Beibei Du,Guomin Zhao,Jiangliu Yu,Zhao Zhuo,Zhongwen Xie,Shanming Ji
Aging and disease    DOI: 10.14336/AD.2020.1008
Accepted: 26 October 2020

The Impact of Frailty on Spine Surgery: Systematic Review on 10 years Clinical Studies
Francesca Veronesi, Veronica Borsari, Lucia Martini, Andrea Visani, Alessandro Gasbarrini, Giovanni Barbanti Brodano, Milena Fini
Aging and disease    DOI: 10.14336/AD.2020.0904
Accepted: 19 October 2020

Enrichment of Phosphorylated Tau (Thr181) and Functionally Interacting Molecules in Chronic Traumatic Encephalopathy Brain-derived Extracellular Vesicles
Satoshi Muraoka,Weiwei Lin,Kayo Takamatsu-Yukawa,Jianqiao Hu,Seiko Ikezu,Michael A. DeTure,Dennis W. Dickson,Andrew Emili,Tsuneya Ikezu
Aging and disease    DOI: 10.14336/AD.2020.1007
Accepted: 13 October 2020

Genome-Wide Screen and Validation of Microglia Pro-Inflammatory Mediators in Stroke
Jianhua Wu,Zhuoze Wu,Aodi He,Tongmei Zhang,Ping Zhang,Jing Jin,Sisi Li,Gaigai Li,Xinyan Li,Shiqi Liang,Lei Pei,Rong Liu,Qing Tian,Ximiao He,Youming Lu,Zhouping Tang,Hao Li
Aging and disease    DOI: 10.14336/AD.2020.0926
Accepted: 05 October 2020

Nilotinib Improves Bioenergetic Profiling in Brain Astroglia in the 3xTg Mouse Model of Alzheimer’s Disease
Aida Adlimoghaddam,Gary G. Odero,Gordon Glazner,R. Scott Turner,Benedict C. Albensi
Aging and disease    DOI: 10.14336/AD.2020.0910
Accepted: 24 September 2020

Metabolomics Signatures of Aging: Recent Advances
Sunil S Adav,Yulan Wang
Aging and disease    DOI: 10.14336/AD.2020.0909
Accepted: 22 September 2020

Adiponectin and Thyroid Cancer: Insight into the Association between Adiponectin and Obesity
Yuanyuan Zhou, Ying Yang, Taicheng Zhou, Bai Li, Zhanjian Wang
Aging and disease    DOI: 10.14336/AD.2020.0919
Accepted: 21 September 2020

Management of Very Old Patients in Intensive Care Units
Xin Ding, Hui Lian, Xiaoting Wang, Chinese Critical Ultrasound Study Group
Aging and disease    DOI: 10.14336/AD.2020.0914
Accepted: 20 September 2020

Iron Accumulation and Lipid Peroxidation in the Aging Retina: Implication of Ferroptosis in Age-Related Macular Degeneration
Tantai Zhao, Xiaojian Guo, Yun Sun
Aging and disease    DOI: 10.14336/AD.2020.0912
Accepted: 16 September 2020

Proteomic Profiling of Extracellular Vesicles Separated from Plasma of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy
Satoshi Muraoka,Annina M. DeLeo,Zijian Yang,Harutsugu Tatebe,Kayo Yukawa-Takamatsu,Seiko Ikezu,Takahiko Tokuda,David Issadore,Robert A. Stern,Tsuneya Ikezu
Aging and disease    DOI: 10.14336/AD.2020.0908
Accepted: 16 September 2020

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