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Just Accepted
The manuscripts published below have been examined by the peer-review process and have been accepted for publication. A “Just Accepted” manuscript is published online shortly after its acceptance, which is prior to technical editing and formatting and author proofing. Higher Education Press (HEP) provides “Just Accepted” as an optional and free service which allows authors to make their results available to the research community as soon as possible after acceptance. After a manuscript has been technically edited and formatted, it will be removed from the “Just Accepted” Web site and published as an Online First article. Please note that technical editing may introduce minor changes to the manuscript text and/or graphics which may affect the content, and all legal disclaimers that apply to the journal pertain. In no event shall HEP be held responsible for errors or consequences arising from the use of any information contained in these “Just Accepted” manuscripts. To cite this manuscript please use its Digital Object Identifier (DOI(r)), which is identical for all formats of publication.
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Cell Cycle Deficits in Neurodegenerative Disorders: Uncovering Molecular Mechanisms to Drive Innovative Therapeutic Development
Chitra Joseph, Abubakar Siddiq Mangani, Veer Gupta, Nitin Chitranshi, Ting Shen, Yogita Dheer, Devaraj KB, Mehdi Mirzaei, Yuyi You, Stuart L. Graham, Vivek Gupta
Aging and disease    DOI: 10.14336/AD.2019.0923
Accepted: 22 October 2019

Biogenesis, features, functions, and disease relationships of a specific Circular RNA: CDR1as
Ziyuan Guo, Qidong Cao, Zhuo Zhao, Chunli Song
Aging and disease    DOI: 10.14336/AD.2019.0920
Accepted: 20 October 2019

Artemisinin Improved Neuronal Functions in Alzheimer's Disease Animal Model 3xtg Mice and Neuronal Cells via Stimulating the ERK/CREB Signaling Pathway
Xia Zhao, Shuai Li, Uma Gaur, Wenhua Zheng
Aging and disease    DOI: 10.14336/AD.2019.0813
Accepted: 12 October 2019

The Impact of CRISPR-Cas9 on Age-related Disorders: From Pathology to Therapy
Allen Caobi, Rajib Kumar Dutta, Luis D. Garbinski, Maria Esteban-Lopez, Yasemin Ceyhan, Mickensone Andre, Marko Manevski, Chet Raj Ojha, Jessica Lapierre, Sneham Tiwari, Tiyash Parira, Nazira El-Hage
Aging and disease    DOI: 10.14336/AD.2019.0927
Accepted: 11 October 2019

DICER1 in the Pathogenesis of Age-related Macular Degeneration (AMD) - Alu RNA Accumulation versus miRNA Dysregulation
Kai Kaarniranta, Elzbieta Pawlowska, Joanna Szczepanska, Janusz Blasiak
Aging and disease    DOI: 10.14336/AD.2019.0809
Accepted: 08 October 2019

β-Hydroxybutyrate Suppresses Lipid Accumulation in Aged Liver through GPR109A-mediated Signaling
A Kyoung Lee, Dae Hyun Kim, EunJin Bang, Yeon Ja Choi, Hae Young Chung
Aging and disease    DOI: 10.14336/AD.2019.0926
Accepted: 04 October 2019

Parkinson Disease and Orthostatic Hypotension in the Elderly: Recognition and Management of Risk Factors for Falls
Peter A. LeWitt, Steve Kymes, Robert A. Hauser
Aging and disease    DOI: 10.14336/AD.2019.0805
Accepted: 03 October 2019

Dementia Risk in Type 2 Diabetes Patients: Acarbose Use and Its Joint Effects with Metformin and Pioglitazone
Chin-Hsiao Tseng
Aging and disease    DOI: 10.14336/AD.2019.021
Accepted: 02 October 2019

Gait Characteristics and Brain Activity in Parkinson’s Disease with Concomitant Postural Abnormalities
Meng-sha Yao, Li-che Zhou, Yu-yan Tan, Hong Jiang, Zhi-chun Chen, Lin Zhu, Ning-di Luo, Quan-zhou Wu, Wen-yan Kang, Jun Liu
Aging and disease    DOI: 10.14336/AD.2019.0929
Accepted: 02 October 2019

Implications of Long Non-Coding RNAs in Age-Altered Proteostasis
Cristina-Sorina Catana, Catalina-Angela Crișan, Dana Opre, Ioana Berindan-Neagoe
Aging and disease    DOI: 10.14336/AD.2019.0814
Accepted: 02 October 2019

Mib2 Deficiency Inhibits Microglial Activation and Alleviates Ischemia-Induced Brain Injury
Xiaoheng Li, Yajin Liao, Yuan Dong, Shuoshuo Li, Fengchao Wang, Rong Wu, Zengqiang Yuan, Jinbo Cheng
Aging and disease    DOI: 10.14336/AD.2019.0807
Accepted: 24 September 2019

Potential Biochemical Mechanisms of Brain Injury in Diabetes Mellitus
Wei-Xing Ma, Jing Tang, Zhi-Wen Lei, Chun-Yan Li, Li-Qing Zhao, Chao Lin, Tao Sun, Zheng-Yi Li, Ying-Hui Jiang, Jun-Tao Jia, Cheng-Zhu Liang, Jun-Hong Liu, Liang-Jun Yan
Aging and disease    DOI: 10.14336/AD.2019.0910
Accepted: 23 September 2019

Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Diseases: An Update
Feng Zhang, Long Niu, Xinyao Liu, Yufei Liu, Song Li, Huan Yu, Weidong Le
Aging and disease    DOI: 10.14336/AD.2019.0324
Accepted: 29 August 2019

Sirtuins and their Biological Relevance in Aging and Age-Related Diseases
Lijun Zhao, Jianzhong Cao, Kexin Hu, Xiaodong He, Dou Yun, Tanjun Tong, Limin Han
Aging and disease    DOI: 10.14336/AD.2019.0820
Accepted: 22 August 2019

Longitudinal Association of Telomere Attrition with the Effects of Antihypertensive Treatment and Blood Pressure Lowering
Shuyuan Zhang, Rongxia Li, Yunyun Yang, Yu Chen, Shujun Yang, Jian Li, Cunjin Wu, Tao Kong, Tianlong Liu, Jun Cai, Li Fu, Yanan Zhao, Rutai Hui, Weili Zhang
Aging and disease    DOI: 10.14336/AD.2019.0721
Accepted: 21 August 2019

Oxyphylla A Promotes Degradation of α-Synuclein for Neuroprotection via Activation of Immunoproteasome
Hefeng Zhou, Shengnan Li, Chuwen Li, Xuanjun Yang, Haitao Li, Hanbing Zhong, Jia-Hong Lu, Simon Ming-Yuen Lee
Aging and disease    DOI: 10.14336/AD.2019.0612
Accepted: 21 August 2019

Aging-Induced Brain-Derived Neurotrophic Factor in Adipocyte Progenitors Contributes to Adipose Tissue Dysfunction
Hyun-Doo Song, Sang Nam Kim, Abhirup Saha, Sang-Yeop Ahn, Seun Akindehin, Yeonho Son, Yoon Keun Cho, MinSu Kim, Ji-Hyun Park, Young-Suk Jung, Yun-Hee Lee
Aging and disease    DOI: 10.14336/AD.2019.0810
Accepted: 14 August 2019

Renoprotective Effect of a Dipeptidyl Peptidase-4 Inhibitor on Aging Mice
Tae H. Ban, Eun N. Kim, Min Y. Kim, Ji H. Lim, Jong H. Lee, Hyung D. Kim, Hye E. Yoon, Cheol W. Park, Bum S. Choi
Aging and disease    DOI: 10.14336/AD.2019.0620
Accepted: 09 August 2019

Lactulose Suppresses Osteoclastogenesis and Ameliorates Estrogen Deficiency-Induced Bone Loss in Mice
Xiao Chen, Zheng Zhang, Yan Hu, Jin Cui, Xin Zhi, Xiaoqun Li, Hao Jiang, Yao Wang, Zhengrong Gu, Zili Qiu, Xin Dong, Yuhong Li, Jiacan Su
Aging and disease    DOI: 10.14336/AD.2019.0613
Accepted: 05 August 2019

The Critical Role of Nurr1 as a Mediator and Therapeutic Target in Alzheimer’s Disease-related Pathogenesis
Jeon Seong Gak, Yoo Anji, Chun Dong Wook, Hong Sang Bum, Chung Hyunju, Kim Jin-il, Moon Minho
Aging and disease    DOI: 10.14336/AD.2019.0718
Accepted: 01 August 2019
Online available: 02 August 2019

Cellular and Molecular Biomarkers Indicate Premature Aging in Pseudoxanthoma Elasticum Patients
Janina Tiemann, Thomas Wagner, Olivier M. Vanakker, Matthias van Gils, José-Luis Bueno Cabrera, Bettina Ibold, Isabel Faust, Cornelius Knabbe, Doris Hendig
Aging and disease    DOI: 10.14336/AD.2019.0610
Accepted: 31 July 2019

Macrophages in Noise-Exposed Cochlea: Changes, Regulation and the Potential Role
Weiwei He, Jintao Yu, Yu Sun, Weijia Kong
Aging and disease    DOI: 10.14336/AD.2019.0723
Accepted: 29 July 2019

SRμCT Reveals 3D Microstructural Alterations of the Vascular and Neuronal Network in a Rat Model of Chronic Compressive Thoracic Spinal Cord Injury
Liyuan Jiang, Yong Cao, Zhen Liu, Shuangfei Ni, Jun Liu, Yoon Ha, Zixiang Luo, Chengjun Li, Shaohua Liu, Jingsong Li, Xianzhen Yin, Tianding Wu, Hongbin Lu, Jianzhong Hu
Aging and disease    DOI: 10.14336/AD.2019.0529
Accepted: 26 July 2019

Neuroprotective Effects of Endogenous Secretory Receptor for Advanced Glycation End-products in Brain Ischemia
Yu Shimizu, Ai Harashima, Seiichi Munesue, Masahiro Oishi, Tsuyoshi Hattori, Osamu Hori, Yasuko Kitao, Hiroshi Yamamoto, Nontaphat Leerach, Mitsutoshi Nakada, Yasuhiko Yamamoto, Yasuhiko Hayashi
Aging and disease    DOI: 10.14336/AD.2019.0715
Accepted: 26 July 2019

Role of Mitophagy in Cardiovascular Disease
Yibo Yang, Tianyi Li, Zhibo Li, Ning Liu, Youyou Yan, Bin Liu*
Aging and disease    DOI: 10.14336/AD.2019.0518
Accepted: 22 July 2019

The Paradoxical Effect of Deep Brain Stimulation on Memory
Shawn Zheng Kai Tan, Man-Lung Fung, Junhao Koh, Ying-Shing Chan, Lee Wei Lim*
Aging and disease    DOI: 10.14336/AD.2019.0511
Accepted: 21 July 2019

Divergent Effect of Tacalcitol (PRI-2191) on Th17 Cells in 4T1 Tumor Bearing Young and Old Ovariectomized Mice
Agata Pawlik, Artur Anisiewicz, Beata Filip-Psurska, Dagmara Klopotowska, Magdalena Maciejewska, Andrzej Mazur, Joanna Wietrzyk
Aging and disease    DOI: 10.14336/AD.2019.0618
Accepted: 21 July 2019

Exogenous H2S Induces Hrd1 S-sulfhydration and Prevents CD36 Translocation via VAMP3 Ubiquitylation in Diabetic Hearts
Miao Yu, Haining Du, Bingzhu Wang, Jian Chen, Fangping Lu, Shuo Peng, Yu Sun, Ning Liu, Xiaojiao Sun, Shiyun Dong, Yajun Zhao, Yan Wang, Dechao Zhao, Fanghao Lu, Weihua Zhang
Aging and disease    DOI: 10.14336/AD.2019.0530
Accepted: 21 July 2019

Impaired Frontoparietal Connectivity in Traumatic Individuals with Disorders of Consciousness: A Dynamic Brain Network Analysis
Min Wu, Fali Li, Yuehao Wu, Tieying Zhang, Jian Gao, Peng Xu, Benyan Luo
Aging and disease    DOI: 10.14336/AD.2019.0606
Accepted: 21 July 2019

Exogenous H2S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice
Yu Sun, Fanghao Lu, Xiangjing Yu, Bingzhu Wang, Jian Chen, Fangping Lu, Shuo Peng, Xiaojiao Sun, Miao Yu, He Chen, Yan Wang, Linxue Zhang, Ning Liu, Haining Du, Dechao Zhao, Weihua Zhang
Aging and disease    DOI: 10.14336/AD.2019.0524
Accepted: 21 July 2019

T1-weighted MRI-driven Brain Age Estimation in Alzheimer’s Disease and Parkinson’s Disease
Iman Beheshti, Shiwangi Mishra, Daichi Sone, Pritee Khanna, Hiroshi Matsuda, for the Alzheimer's Disease Neuroimaging Initiative, Parkinson’s Progression Markers Initiative
Aging and disease    DOI: 10.14336/AD.2019.0617
Accepted: 21 July 2019

Disease Progression-Dependent Expression of CD200R1 and CX3CR1 in Mouse Models of Parkinson’s Disease
Le Wang, Yang Liu, Shuxin Yan, Tianshu Du, Xia Fu, Xiaoli Gong, Xinyu Zhou, Ting Zhang, Xiaomin Wang
Aging and disease    DOI: 10.14336/AD.2019.0615
Accepted: 05 July 2019

Association between Loss of Sleep-specific Waves and Age, Sleep Efficiency, Body Mass Index, and Apnea-Hypopnea Index in Human N3 Sleep
Weiguang Li, Ying Duan, Jiaqing Yan, He Gao, Xiaoli Li
Aging and disease    DOI: 10.14336/AD.2019.0420
Accepted: 02 July 2019

A Review of Exercise as Medicine in Cardiovascular Disease: Pathology and Mechanism
Piotr Gronek, Dariusz Wielinski, Piotr Cyganski, Andrzej Rynkiewicz, Adam Zając, Adam Maszczyk, Joanna Gronek, Robert Podstawski, Wojciech Czarny, Stefan Balko, Cain CT. Clark, Roman Celka
Aging and disease    DOI: 10.14336/AD.2019.0516
Accepted: 02 July 2019

Tumor-Derived Soluble MICA Obstructs the NKG2D Pathway to Restrain NK Cytotoxicity
Qizhi Luo, Weiguang Luo, Quan Zhu, Hongjun Huang, Huiyun Peng, Rongjiao Liu, Min Xie, Shili Li, Ming Li, Xiaocui Hu, Yizhou Zou
Aging and disease    DOI: 10.14336/AD.2019.1017
Accepted: 28 June 2019

Gut Microbiome and Osteoporosis
Kai Ding, Fei Hua, Wenge Ding
Aging and disease    DOI: 10.14336/AD.2019.0523
Accepted: 14 June 2019

Remote Ischemic Conditioning Improves Attention Network Function and Blood Oxygen Levels in Unacclimatized Adults Exposed to High Altitude
Sijie Li, Cong Han, Karam Asmaro, Shanyi Quan, Ming Li, Changhong Ren, Jun Zhang, Wenbo Zhao, Jiali Xu, Zhiwen Liu, Peng Zhang, Lingling Zhu, Yuchuan Ding, Kai Wang, Xunming Ji, Lian Duan
Aging and disease    DOI: 10.14336/AD.2019.0605
Accepted: 12 June 2019

Aging, Alzheimer’s Disease and Dysfunctional Glycolysis; Similar Effects of Too Much and Too Little
Alan R. Hipkiss
Aging and disease    DOI: 10.14336/AD.2019.0611
Accepted: 12 June 2019

Aging Attenuates Cardiac Contractility and Affects Therapeutic Consequences for Myocardial Infarction
Ming Dong, Ziyi Yang, Hongcheng Fang, Jiaqing Xiang, Cong Xu, Yanqing Zhou, Qianying Wu, Jie Liu
Aging and disease    DOI: 10.14336/AD.2019.0522
Accepted: 10 June 2019

Caveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review
Jinfan Tian, Mohammad Sharif Popal, RongChong Huang, Min Zhang, Xin Zhao, Mingduo Zhang, Xiantao Song
Aging and disease    DOI: 10.14336/AD.2019.09603
Accepted: 09 June 2019

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