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ISSN 2152-5250
Since 2010
2016 impact factor: 4.648
5 year impact factor: 4.1
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Early edition
The manuscripts published below have been examined by the peer-review process and have been accepted for publication. A "Early edition" manuscript is published online shortly after its acceptance, which is prior to technical editing and formatting and author proofing. Higher Education Press (HEP) provides "Early edition" as an optional and free service which allows authors to make their results available to the research community as soon as possible after acceptance. After a manuscript has been technically edited and formatted, it will be removed from the "Early edition" Web site and published as an Online First article. Please note that technical editing may introduce minor changes to the manuscript text and/or graphics which may affect the content, and all legal disclaimers that apply to the journal pertain. In no event shall HEP be held responsible for errors or consequences arising from the use of any information contained in these "Early edition" manuscripts. To cite this manuscript please use its Digital Object Identifier (DOI(r)), which is identical for all formats of publication.
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Prehospital Notification Procedure Improves Stroke Outcome by Shortening Onset to Needle Time in Chinese Urban Area
Zhang Sheng,Zhang Jungen,Zhang Meixia,Zhong Genlong,Chen Zhicai,Lin Longting,Lou Min
Aging and Disease    DOI: 10.14336/AD.2017.0601
The Value of Contrast-Enhanced Ultrasonography Combined with Real-Time Strain Elastography in the Early Diagnosis of Prostate Cancer
Chang Ying, Yang Jingchun, Hong Hua, Ma Huijuan, Cui Xin, Chen Li
Aging and Disease    DOI: 10.14336/AD.2017.0704
Pro- and Anti-inflammatory Effects of High Cholesterol Diet on Aged Brain
Chen Yali,Yin Mengmei,Cao Xuejin,Hu Gang,Xiao Ming
Aging and Disease    DOI: 10.14336/AD.2017.0706
Mild Therapeutic Hypothermia Protects the Brain from Ischemia/Reperfusion Injury through Upregulation of iASPP
Liu Xiangrong,Wen Shaohong,Zhao Shunying,Yan Feng,Zhao Shangfeng,Wu Di,Ji Xunming
Aging and Disease    DOI: 10.14336/AD.2017.0703
Aging, Metabolism, and Cancer Development: from Peto’s Paradox to the Warburg Effect
Tia R. Tidwell, Kjetil S?reide, Hanne R. Hagland
Aging and Disease    DOI: 10.14336/AD.2017.0713
Glucocerebrosidase mRNA is Diminished in Brain of Lewy Body Diseases and Changes with Disease Progression in Blood
Perez-Roca Laia,Adame-Castillo Cristina,Campdelacreu Jaume,Ispierto Lourdes,Vilas Dolores,Rene Ramon,Alvarez Ramiro,Gascon-Bayarri Jordi,A. Serrano-Munoz Maria,Ariza Aurelio,Beyer Katrin
Aging and Disease    DOI: 10.14336/AD.2017.0505
Effects of Therapeutic Hypothermia Combined with Other Neuroprotective Strategies on Ischemic Stroke: Review of Evidence
Zhang Zheng,Zhang Linlei,Ding Yuchuan,Han Zhao,Ji Xunming
Aging and Disease    DOI: 10.14336/AD.2017.0628
The Short-term Prognostic Value of the Triglyceride-to-high-density Lipoprotein Cholesterol Ratio in Acute Ischemic Stroke
Qi-Wen Deng, Shuo Li, Huan Wang, Lei Zuo, Han-Qing Zhang, Zheng-Tian Gu, Fang-Lan Xing, Fu-Ling Yan
Aging and Disease    DOI: 10.14336/AD.2017.0629
Aged Mice are More Resistant to Influenza Virus Infection due to Reduced Inflammation and Lung Pathology
Lu Jiao,Duan Xuefeng,Zhao Wenming,Wang Jing,Wang Haoyu,Zhou Kai,Fang Min
Aging and Disease    DOI: 10.14336/AD.2017.0701
Mammalian Sterile20-like Kinases: Signalings and Roles in Central Nervous System
Chen Sheng,Fang Yuanjian,Xu Shenbin,Reis Cesar,Zhang Jianmin
Aging and Disease    DOI: 10.14336/AD.2017.0702
Serum Zonulin and Endotoxin Levels in Exceptional Longevity versus Precocious Myocardial Infarction
Pedro Carrera-Bastos, óscar Picazo, Maelán Fontes-Villalba, Helios Pareja-Galeano, Staffan Lindeberg, Manuel Martínez-Selles, Alejandro Lucia, Enzo Emanuele
Aging and Disease    DOI: 10.14336/AD.2017.0630
Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-related Diseases via Anti-oxidation and AMPK Activation
Xu Zhifang,Feng Wei,Shen Qian,Yu Nannan,Yu Kun,Wang Shenjun,Chen Zhigang,Seiji Shioda,Guo Yi
Aging and Disease    DOI: 10.14336/AD.2016.0620
Advances in the Studies of Ginkgo Biloba Leaves Extract on Aging-Related Diseases
Wei Zou, Feng Yan, Bo Zhang, Jiantao LI, Dan Mei
Aging and Disease    DOI: 10.14336/AD.2017.0615
Skin Cancer Epidemics in the Elderly as An Emerging Issue in Geriatric Oncology
Garcovich Simone,Colloca Giuseppe,Sollena Pietro,Bellieni Andrea,Balducci Lodovico,C. Cho William,Bernabei Roberto,Peris Ketty
Aging and Disease    DOI: 10.14336/AD.2017.0503
SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway
Zhang Meng,Deng Yong-Ning,Zhang Jing-Yi,Liu Jie,Li Yan-Bo,Su Hua,Qu Qiu-Min
Aging and Disease    DOI: 10.14336/AD.2017.0517
Exploration of Novel Anti-Oxidant Protein Sestrin in Frailty Syndrome in Elderly
Nitish Rai, G. Venugopalan, Rashmita Pradhan, Akash Ambastha, Upadhyay Ashish Datt, Sadanand Dwivedi, Aparajit B. Dey, Sharmistha Dey
Aging and Disease    DOI: 10.14336/AD.2017.0423
Diagnostic and Immunosuppressive Potential of Elevated Mir-424 Levels in Circulating Immune Cells of Ischemic Stroke Patients
Li Guangwen,Ma Qingfeng,Wang Rongliang,Fan Zhibin,Tao Zhen,Liu Ping,Zhao Haiping,Luo Yumin
Aging and Disease    DOI: 10.14336/AD.2017.0602
Ovarian Cancer Management in the Oldest Old: Improving Outcomes and Tailoring Treatments
Tortorella Lucia,Vizzielli Giuseppe,Fusco Domenico,C. Cho William,Bernabei Roberto,Scambia Giovanni,Colloca Giuseppe
Aging and Disease    DOI: 10.14336/AD.2017.0607
Age-Dependent Decrease in Adropin is Associated with Reduced Levels of Endothelial Nitric Oxide Synthase and Increased Oxidative Stress in the Rat Brain
Changjun Yang, KellyM. DeMars, Eduardo Candelario-Jalil
Aging and Disease    DOI: 10.14336/AD.2017.0523
Promoting Neurovascular Recovery in Aged Mice after Ischemic Stroke - Prophylactic Effect of Omega-3 Polyunsaturated Fatty Acids
Mengfei Cai, Wenting Zhang, Zhongfang Weng, R. Anne Stetler, Xiaoyan Jiang, Yejie Shi, Yanqin Gao, Jun Chen
Aging and Disease    DOI: 10.14336/AD.2017.0520
Age-Related Gray and White Matter Changes in Normal Adult Brains
Farokhian Farnaz,Yang Chunlan,Beheshti Iman,Matsuda Hiroshi,Wu Shuicai
Aging and Disease    DOI: 10.14336/AD.2017.0502
Effect of Traditional Chinese Medicine on Neural Stem Cell Proliferation and Differentiation
Qin Wei,Chen Shiya,Yang Shasha,Xu Qian,Xu Chuanshan,Cai Jing
Aging and Disease    DOI: 10.14336/AD.2017.0428
The Prevalence of Frailty and its Associated Factors in Japanese Hemodialysis Patients
Hidemi Takeuchi, Haruhito A. Uchida, Yuki Kakio, Yuka Okuyama, Michihiro Okuyama, Ryoko Umebayashi, Kentaro Wada, Hitoshi Sugiyama, Ken Sugimoto, Hiromi Rakugi, Jun Wada
Aging and Disease    DOI: 10.14336/AD.2017.0429
Emerging Roles of Ganoderma Lucidum in Anti-aging
Wang Jue,Cao Bin,Zhao Haiping,Feng Juan
Aging and Disease    DOI: 10.14336/AD.2017.04150
Recent Progress in Vascular Aging: Mechanisms and Its Role in Age-related Diseases
Xu Xianglai,Wang Brian,Ren Changhong,Hu Jiangnan,A. Greenberg David,Chen Tianxiang,Xie Liping,Jin Kunlin
Aging and Disease    DOI: 10.14336/AD.2017.05303
Age-related Impairment of Vascular Structure and Functions
Xu Xianglai,Wang Brian,Ren Changhong,Hu Jiangnan,A. Greenberg David,Chen Tianxiang,Xie Liping,Jin Kunlin
Aging and Disease    DOI: 10.14336/AD.2017.0430
Predictors of Memory in Healthy Aging: Polyunsaturated Fatty Acid Balance and Fornix White Matter Integrity
Marta K. Zamroziewicz, Erick J. Paul, Chris E. Zwilling, Aron K. Barbey
Aging and Disease    DOI: 10.14336/AD.2017.0501
Apelin Ameliorates High Glucose-Induced Downregulation of Connexin 43 via AMPK-Dependent Pathway in Neonatal Rat Cardiomyocytes
Li Xiaoting,Yu Lu,Gao Jing,Bi Xukun,Zhang Juhong,Xu Shiming,Wang Meihui,Chen Mengmeng,Qiu Fuyu,Fu Guosheng
Aging and Disease    DOI: 10.14336/AD.2017.0426
Temporal Gene Expression Profiles after Focal Cerebral Ischemia in Mice
Zhang Chengjie,Zhu Yanbing,Wang Song,Zachory Wei Zheng,Qize Jiang Michael,Zhang Yongbo,Pan Yuhualei,Tao Shaoxin,Li Jimei,Wei Ling
Aging and Disease    DOI: 10.14336/AD.2017.0424
Brain Interstitial Fluid Drainage Alterations in Glioma-Bearing Rats
Guan Xiangping,Wang Wei,Wang Aibo,Teng Ze,Han Hongbin
Aging and Disease    DOI: 10.14336/AD.2017.0415
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