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2024
Impact Factor
6.9

Early Edition

The papers published below have been examined by the peer-review process and accepted for publication in Aging and Disease. A “Just Accepted” paper is published online shortly after its acceptance, which allows authors to make their results available to the research community as soon as possible after acceptance. When the final version appears, the version of early edition is replaced with the final version, and the paper is moved to the appropriate issue on the Aging and Disease website. The paper will no longer appear in the “Just Accepted”. However, all links (the URL) will not change. “Just Accepted” papers are citable from that date they are posted. To cite this manuscript please include its Digital Object Identifier (DOI), which is identical for all formats of publication.
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Total 225 results are found
Prolonged Mild Sleep Restriction Changes Epigenome-Wide DNA Methylation in Peripheral Blood Cells: A Randomized Crossover Trial
Rocio Barragán, Christian K. Dye, Brooke Aggarwal, Sanja Jelic, Oscar Coltell, Dolores Corella, Marie-Pierre St-Onge
| DOI: 10.14336/AD.2025.1261
Supplement

1. Supplementary data.pdf (1513KB)

The Microglial Lactate-Lactylation Axis as a Metabolic-Epigenetic Driver of Alzheimer’s Disease
Zhaoxie Yu, Hanzhang Li, Yao Wang, Yanan Li, Feng Shen, Yanchun Wang
| DOI: 10.14336/AD.2025.1487
Fundamental Cell-Intrinsic Mechanism Underlying Age-Dependent Accumulation of Senescent Cells
Pavel I. Deryabin, Aleksandra V. Borodkina
| DOI: 10.14336/AD.2026.0137
Systemic Cytokine Alterations in Periodontitis Independent of Comorbidities: A Systematic Review and Meta-Analysis
Elin Kindstedt, Magnus Wänman, Wendy Yi-Ying Wu, Klara Hofer-Mattsson, Anna Lövgren, Pernilla Lundberg
| DOI: 10.14336/AD.2026.0110
Supplement

1. Supplementary data.pdf (1803KB)

Cellular Senescence in Gastric Cancer: Molecular Mechanisms, Microenvironment Remodeling and Therapeutic Implications
Zhiyuan Shi, Zhao Sun, Yuan Liu, Yuping Ge, Ning Jia, Yuwei Hua, Lin Zhao, Xiang Wang, Yi Ba
| DOI: 10.14336/AD.2025.1571
Epigenetic Noise and Regulatory Entropy in Aging: A Quantitative Systems-Level Framework
Hamilton Ribeiro Correia, Tomás Balseiro, Lucas Caramujo, Sandra Balseiro
| DOI: 10.14336/AD.2026.0215
Critical Considerations for Mesenchymal Stem Cell-based Therapies in Osteoarthritis and Spinal Cord Injury: A Narrative Review
Shaolong Li, Chenxi Zhao, Wei Wang, Wenhan An, Xinyu Liu, Hengxing Zhou, Xiaohong Kong, David D. Dean, Shiqing Feng, Xiao-Dong Chen
| DOI: 10.14336/AD.2026.0003
Ethical Considerations for Clinical Research in Persons with a Terminal Illness
Caroline R. Morehouse, Christine Grady, Benjamin E. Berkman, Robert Steel, David S. Wendler, Saskia Hendriks
| DOI: 10.14336/AD.2026.0099
Targeting the Gut-Retina Axis in Age-Related Retinopathies: Microbiome-Immunometabolic Pathways and Gerotherapeutic Perspectives
Zhihui Feng, Kexin Wang, Xiaosu Wang, Bizhu Zhao, Zixu Huang, Shenao Ding, Jiehao Zhang, Mengli Sun, Meiqi Ma, Yameng Zhao, Yongheng Cui, Zongming Song, Ye Tao
| DOI: 10.14336/AD.2025.1248
The Mitochondrial Blueprint of Skin Aging: From Damage Signals to Dermatologic Interventions
Sarah M. Antonevich, Kate M. Miller, Shasa Hu, Monica Rodriguez-Silva, Carlos T. Moraes, Ivan Jozic
| DOI: 10.14336/AD.2025.1585
Quantum Sensing for Precision Organ Aging Assessment
Jingyi Niu, Ya Peng, Lin Yin, Minghua Wu
| DOI: 10.14336/AD.2025.1500
Peakspan: Defining, Quantifying and Extending the Boundaries of Peak Productive Lifespan
Authors: Alex Zhavoronkov, Kejun Ying, Dominika Wilczok
| DOI: 10.14336/AD.2026.0080
Anti-Tumor Immunotherapy of Scutellaria Baicalensis-Derived Vesicles on Immune Checkpoint Modulation in Colorectal Cancer
Dianxin Cui, Weilin Qiao, Weixuan Chen, Peng Li, Shengpeng Wang, Fengyun Liao, Fei Li, Kewei Wang, Yitao Wang, Huanxing Su, Zhangfeng Zhong
| DOI: 10.14336/AD.2026.0040
Dissecting the Impact of α-MSH-MC1R-cAMP Signaling on UVA-Induced Stress in Fibroblasts - Implications for Regulation of Cutaneous Photoaging
Markus Böhm, Agatha Stegemann, Agnieszka Wolnicka-Głubisz, Bartlomiej Olajossy, Nicole Schäfer, Stephan Niland, Johannes Eble, Verena Raker, Kerstin Steinbrink, Susanne Grässel, Lionel Larue
| DOI: 10.14336/AD.2025.1518
Supplement

1. Supplementary data.pdf (655KB)

Danggui-Shaoyao San Promotes Microglia-Mediated Oligodendrocyte Maturation and White Matter Repair After Stroke
Fang Tong, Yihan Liu, Nan Deng, Yong Yang, Sijie Li, Ziping Han, Jingfei Shi, Xunming Ji, Changhong Ren
| DOI: 10.14336/AD.2026.10202
Supplement

1. Supplementary data.pdf (154KB)

Spatial Transcriptomic Analysis Reveals Dysregulated Pro-Inflammatory Signaling in the Aged Lung
Brianna M. Doratt, Ethan G. Napier, Mahdi Eskandarian Boroujeni, Michael H. Davies, Christine F. Brainson, Eliot R. Spindel, Ilhem Messaoudi
| DOI: 10.14336/AD.2025.1317
Supplement

1. Supplementary data.pdf (1768KB)

Receptor-Specific Adenosine Signalling Governs Astrocyte Glycogen Homeostasis
Kaja Belko Parkel, Živa Tajda Gržina, Robert Zorec, Marko Kreft
| DOI: 10.14336/AD.2025.1389
Supplement

1. Supplementary data.pdf (175KB)

Dual effect of Vascular Calcification in Abdominal Aortic Aneurysm Progression: A Narrative Review from Multi-Scales
Kexin Zhao, Weichang Zhang, Chang Shu
| DOI: 10.14336/AD.2025.1422
Aging of the Blood-Brain Barrier and Altered Permeability to Peripheral Immune Cells: Implications for Central Nervous System Disorders
Yu Gu, Liting Zhang, Zixin Du, Caiyun Wang, Wenyuan Deng, Yong U Liu, Beisha Tang
| DOI: 10.14336/AD.2026.0013
Longevity vs. Healthy Longevity: Different Outcomes Underlain by Different Mechanisms
Daria Kashtanova, Aleksandra Mamchur, Maria Bruttan, Veronika Daniel, Mikhail Ivanov, Elena Zelenova, Irina Dzhumaniiazova, Lorena Matkava, Mikhail Terekhov, Antonina Rumyantzeva, Konstantin Grammatikati, Sergey Mitrofanov, Vladimir Yudin, Valentina Maksyutina, Ekaterina Maralova, Aleksey Ivashechkin, Aleksandra Nekrasova, Irina Strazhesko, Valentin Makarov, Anton Keskinov, Olga Tkacheva, Sergey Yudin, Veronika Skvortsova
| DOI: 10.14336/AD.2025.0828
Supplement

1. Supplementary data.pdf (495KB)

Dysregulated Lipid Metabolism and Neurovascular Unit Dysfunction: Novel Mechanisms Linking Alzheimer’s Disease and Vascular Dementia
MengGe Li, HuiYue Wang, ZhenYan Tang, ShuSheng Yang, Li Lin
| DOI: 10.14336/AD.2025.1464
Health Related Quality of Life in Adults with 13 Chronic Diseases before Age 65 and after Age 65 Using Fuzzy Rough Analysis of SF-36 Domains
Marlena Krawczyk-Suszek, Zofia Matusiewicz, Teresa Mroczek, Andrzej Kleinrok
| DOI: 10.14336/AD.2025.0928
The Effects of Aging and Anti-Aging Dietary Restriction on Brain Glutathione and Thioredoxin Redox Systems
Leah E. Jamerson, Patrick C. Bradshaw
| DOI: 10.14336/AD.2025.1505
Supplement

1. Supplementary data.pdf (513KB)

Neuroinflammation and Cellular Senescence in Brain Aging and Neurodegeneration
Linlin Zhang, longtu Li, Xin Wang, Liang Ma, Li Yan, Qian Xiang, Yimin Cui, Zhiyan Liu
| DOI: 10.14336/AD.2025.1538
Cuproptosis and Aging: Molecular Mechanisms and Therapeutic Implications
Jingyan Hong, Yaxin Liu, Quan Peng, Zhigang Mei, Guozuo Wang
| DOI: 10.14336/AD.2025.1305
Recent Advances in The Molecular Regulation of Cardiac Hypertrophy Related to Heart Failure
Wen Cao, Qin Yang, Guo-Wei He
| DOI: 10.14336/AD.2025.1501
Macrophage Senescence: Friend or Foe?
Xunxi Deng, Zhiyi Yin, Shi Tai, Yongjun Wang, Liyao Fu
| DOI: 10.14336/AD.2025.1394
Meta-Analysis and Bioinformatic Analysis of Human Fluid Proteomic Studies Reveal Key Biological Pathways Related to Aging and Frailty
Sophie Guillotin, Sandrine Andrieu, Nicolas Delcourt
| DOI: 10.14336/AD.2025.0793
Supplement

1. Supplementary data.pdf (601KB)

TRF2 Upregulates Protein Phosphatase 2A Subunit PPP2R2C to Attenuate DNA Damage Response at Telomeres and Pericentromeres Upon Replicative Stress
Xiuyun Zhai, Cuicui Wang, Yilin Ying, Waiian Leong, Lianxiang Chen, Bohua Wei, Xiaojiao Cheng, Sheng Huang, Qiaowen Chen, Yiming Lu, Eric Gilson, Jing Ye
| DOI: 10.14336/AD.2025.1249
Supplement

1. Supplementary data.pdf (1630KB)

Organ-Brain Axis in Alzheimer’s Disease: A Systemic Perspective on Pathogenesis and Progression
Yebeen Kim, Jaewoon Jung, Asifiwe Clarisse Cirunduzi, Seonghyun Yoon, Seokyoung Bang, Seung-Hoon Yang
| DOI: 10.14336/AD.2025.1537
The Impact of Young and/or Exercised Plasma Transfusions in Neurodegenerative Conditions: A Scoping Review
Michael J. Kirton, Emily R. Cox, Ulrik Wisløff, Atefe R. Tari, Lance C. Dalleck, Claire Drummond, Belinda Lange, Ranjay Chakraborty, Kym Williams, Norma Bulamu, Alline Beleigoli, Joyce S. Ramos
| DOI: 10.14336/AD.2025.0849
Supplement

1. Supplementary data.pdf (515KB)

The α-MSH-MC1R Axis Modulates Sex-Specific Senescence and Inflammation Processes in Human Articular Chondrocytes and Mice Knee Joints
Nicole Schäfer, Paul Kalke, Ravikumar Mayakrishnan, Jian Mei, Luisa Kollatz, Marianne Ehrnsperger, Hadrian Platzer, Brian Johnstone, Arndt F. Schilling, Babak Moradi, Markus Böhm, Susanne Grässel
| DOI: 10.14336/AD.2025.1307
Supplement

1. Supplementary data.pdf (1442KB)

Alzheimer's Disease Continuum: Evaluating the Relationship between Fluid Biomarkers and Patients’ Phenotype and Profile
Rosalinda Di Gerlando, Matteo Cotta Ramusino, Francesca Dragoni, Evelyne Minucchi, Bartolo Rizzo, Elisabetta Zardini, Riccardo Rocco Ferrari, Michele Rossi, Giulia Perini, Alfredo Costa, Annalisa Davin, Stella Gagliardi
| DOI: 10.14336/AD.2025.0971
Supplement

1. Supplementary data.pdf (1430KB)

Revisiting Retinal Vein Occlusion: An Etiologic Classification for Enhanced Patient Management
Xiao Xue¹, Huimin Jiang, Weiyue Zhang, Yifan Zhou, Hui Li, Yuan Gao, Chen Zhou, Xuxiang Zhang¹
| DOI: 10.14336/AD.2025.1572
Osteoarthritic knee: Advances in Epidemiology, Emerging Etiopathologies and Adipose-Derived Stem Cells-based Therapies
Chian-Her Lee, Hsien-Tsung Lu, Ko-Ta Chen, Shen-Han Wu, Ying-Fong Su, Hui-Hsuan Ting, Ai-Chen Lee, Tin-Hsien Ko, Navneet Kumar Dubey
| DOI: 10.14336/AD.2025.1401
Supplement

1. Supplementary data.pdf (147KB)

Thrombolysis in Acute Ischemic Stroke: Advances and Prospects
Zixin Wang, Jiamin Li, Yun Chen, Boyi Yuan, Qingfeng Ma
| DOI: 10.14336/AD.2025.1477
Heat Shock Proteins in Neurodegenerative Diseases
En Ying Yap, Duan Lu Hou, Tuchen Guan, Xiao-Xue Dong, Li Zeng, Laurie H Sanders, Yun-Cheng Wu, Eng King Tan, Zhi Dong Zhou
| DOI: 10.14336/AD.2025.1309
Targeting Macrophage Efferocytosis to Treat Chronic Inflammation in Cancer and Inflammaging
Xin Huang, Baicheng Qu, Maike Chen, Weiyue Zhang
| DOI: 10.14336/AD.2025.1408
Chronic Inflammation and Aging in Rheumatic Diseases
Zewen Wu, Jingxuan Li, Rong Li, Li Zhao, Yazhen Su, Yang Liu, Huijing Zhang, Liyun Zhang
| DOI: 10.14336/AD.2025.1182
Aligning Intrinsic Capacity and Geroscience: Linking Function with Biology
Sha Zhu, Lihua Tao, Chengcheng Fan, Yongzhe Wei, Jagadish K. Chhetri, Piu Chan
| DOI: 10.14336/AD.2025.1419