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2024
Impact Factor
6.9

Early Edition

The papers published below have been examined by the peer-review process and accepted for publication in Aging and Disease. A “Just Accepted” paper is published online shortly after its acceptance, which allows authors to make their results available to the research community as soon as possible after acceptance. When the final version appears, the version of early edition is replaced with the final version, and the paper is moved to the appropriate issue on the Aging and Disease website. The paper will no longer appear in the “Just Accepted”. However, all links (the URL) will not change. “Just Accepted” papers are citable from that date they are posted. To cite this manuscript please include its Digital Object Identifier (DOI), which is identical for all formats of publication.
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Total 224 results are found
Extracellular Space Barrier Dysfunction Disrupts Interstitial Fluid Drainage and Is Associated with Memory Heterogeneity in Cognitive Aging
Xin Mao, Rui Wang, Wanyi Fu, Hanbo Tan, Tianzi Gao, Dan Du, Yang Shi, Shufan Yang, Changming Wang, Yu Fu, Shaoyi Su, Meng Xu, Hongbin Han
| DOI: 10.14336/AD.2026.0422
Supplement

1. Supplementary data.pdf (1149KB)

Peripheral Immune Challenge Drives Enteric α-Synuclein and Tau Pathology in LRRK2 G2019S Mice
Carmela Giachino, Federico Bertoli, Cataldo Tirolo, Claudio Giuliano, Marika Mearelli, Meike Jakobi, Nicole Schneiderhan-Marra, Francesca L’Episcopo, Michela Deleidi
| DOI: 10.14336/AD.2026.0342
Supplement

1. Supplementary data.pdf (480KB)

Integrating AI and Causal Genetics to Prioritize Therapeutic Targets for Aging and Age-Related Diseases
Geoffrey H. D. Leung, Jianjiu Chen, I. Aylin Ergun, Evgeny Izumchenko, Alex Aliper, Feng Ren, Frank W. Pun, Alex Zhavoronkov
| DOI: 10.14336/AD.2026.0356
Supplement

1. Supplementary data.pdf (1593KB)

A Biological Alignment Framework for Interpreting Anti-Inflammatory Cardiovascular Trials in Atherosclerosis
Hua Yan, Dong Yi, Bingyin Wang
| DOI: 10.14336/AD.2026.10405
Community-Based Ocular Screening Integrated into Primary Healthcare for Older Adults: Design and 2-Year Follow-Up Results
Gu Zheng, Shiqi Hu, Yiming Zhao, Yanyan Lin, Hairui Jiao, Wanwan He, Tianhao Huang, Shilei Wang, Cong Ye, Meixiao Shen, Ming Li, Jie Chen, Xinting Liu, Fan Lu
| DOI: 10.14336/AD.2026.10331
Supplement

1. Supplementary data.pdf (159KB)

Vascular Aging Across the Cardiovascular-Alzheimer’s Continuum: Hemodynamics and Artificial Intelligence
Ziqiang Zhou, Ruihua Zhang, Jinwen Wang, Yajie Yu, Shepeng Wei, Weiqing Wan
| DOI: 10.14336/AD.2026.0539
Spatiotemporal White Matter Pathology in Chronic Cerebral Hypoperfusion: Insights from the BCAS Mouse Model of Vascular Cognitive Impairment and Dementia
Milton H. Hamblin, Austin C. Boese, Joseph Y. Zhou, Tanvi Bobba, Jean-Pyo Lee
| DOI: 10.14336/AD.2026.0256
Immersive Technologies of Virtual and Augmented Reality (VR/AR) in Patient-Centered Neurorehabilitation
Fahad Somaa, Azka Khan, Mubin Mustafa Kiyani
| DOI: 10.14336/AD.2026.0360
Circadian Rhythms, Metabolic Disorders, and Cardiovascular Aging: Molecular Crosstalk and Clinical Translation
Jing Wang, Qianwen Xu, Dongchen Zhou, Biqi Zhang, Xiaosheng Hu, Ting Chen
| DOI: 10.14336/AD.2026.0314
Supplement

1. Supplementary data.pdf (290KB)

Cognitive Frailty in Older Adults with Ischemic Stroke: Epidemiology, Mechanisms, and Multidimensional Management Strategies
Yang Li, Xiaoxing Lai, Wanchen Song, Kexin Zhang, Donglei Shi, Zhiyuan Zhang
| DOI: 10.14336/AD.2026.0305
Epigenetic Clocks in the Cosmic Silence of a Deep Underground Laboratory: Implications for Aging and Space Exploration
Javier A. Menendez, Carlos Peña-Garay, Tomás Alarcón, Elisabet Cuyàs
| DOI: 10.14336/AD.2026.0468
Mitochondrial Dynamics in Cellular Senescence: Mechanisms, Context Dependence, and Therapeutic Potential
Dan Wu, Shihao Jiang, Chenyang Li, Xianqi Wang, Yuexiang Ma, Peiwen Wang, Yanan Xu, Heliang Fu, Qianmei Wang, Kuo Shen, Rui Zheng, Junjie Li
| DOI: 10.14336/AD.2026.0323
Optimizing Antibody-Based Therapies for Alzheimer’s Disease: From Clinical Limitations to Molecular Engineering Innovations
Qian Liu, Rong-Rong Lin
| DOI: 10.14336/AD.2026.0292
Delphi-derived Framework for Healthspan-Oriented Care: The Cardiometabolic Health Perspective
Marek Postula, & Svjatoslavs Kistkins, Anna Nowak-Szwed, Salvatore DeRosa, Karol Kaminski, Anna Erat, Uģis Klētnieks, Othmar Moser, Dmitrijs Bliznuks, Ilia Stambler, Emīls Sjundjukovs, Jaron Rabinovici, Morten Scheibye-Knudsen, Alex Zhavoronkov, Vadim N. Gladyshev, Steve Horvath, Bruno Vellas, George A. Kuchel, Harald Sourij, Evelyne Bischof, Andreas F.H. Pfeiffer
| DOI: 10.14336/AD.2026.0279
Supplement

1. Supplementary data.pdf (541KB)

Brain Dysfunction in Genetically Determined Accelerated Aging Syndromes
Jelena Vasilevska, Nelli A. Arakelyan, Anastasiya L. Kungurtseva, Alisa V. Vitebskaya, Evgeny I. Rogaev
| DOI: 10.14336/AD.2026.0370
Aging Biomarkers in Osteoporosis: A Systematic Review of Molecular Mechanisms, Biological Aging, and Population Evidence
Miaosen Liu, Su Yon Jung
| DOI: 10.14336/AD.2025.1653
Supplement

1. Supplementary data.pdf (1290KB)

PCSK9 in Brain Health and Disease: Liver-Vascular-Brain Interactions in Aging and Disease
Mengqi Zhang, Neel S. Singhal
| DOI: 10.14336/AD.2026.0209
Astrocytic Ferroptosis: An Integrative Hub Linking Metabolic Dyshomeostasis, Glial Crosstalk, and Neurodegeneration in Alzheimer’s Disease
Zhimin Lu, Chang Meng, Xiaoyan Ren, Shuo Zhang, Xinqing Xu, Shaofei Hao, Qinglu Wang, Daoqing Zhou
| DOI: 10.14336/AD.2026.0328
Melatonin in Circadian Rhythm and Brain Health: Neuroprotective Effects and Therapeutic Potential
Yuxiao Feng, Yanpo Si, Xin Pang, Shuying Feng, Yuewen Zhang, Shujuan Xue, Tao Guo
| DOI: 10.14336/AD.2026.0119
Harnessing Neuronal Autophagy: Bridging Mechanistic Breakthroughs to Therapeutic Interventions
Nuzhat Ahsan, Farheen Badrealam Khan, Jhinuk Basu, Mohd Shariq, Nida Zaidi, Rizwan Hasan Khan, Reshmi Raj, Mohammed Akli Ayoub, Avadhesha Surolia, Ghulam Md Ashraf
| DOI: 10.14336/AD.2025.0804
Cellular Senescence in the Absence of Galactic Cosmic-Ray Muons
Àngela Llop-Hernández, Júlia López, Sara Verdura, Rebecca Hernández-Antolín, Laura Cid-Barrio, Carlos Peña-Garay, Tomás Alarcón, Elisabet Cuyàs, Javier A. Menendez
| DOI: 10.14336/AD.2026.0025
Supplement

1. Supplementary data.pdf (1185KB)

The Dickkopf Protein Family in Non-Neoplastic Disorders: Emerging Roles and Therapeutic Targeting
Juju Zhou, Xiaoqian Zhu, Weihan Chen, Junjuan Tan, Liwei Hong, Lingya Yang, Yonglin Liu, Tiantian Zhai, Kai Chen
| DOI: 10.14336/AD.2025.1506
Difference between Biological Age and Chronological Age Predicts Mortality and Hospitalization in a Longitudinal Adult Cohort
Abigail Goshen, Evelyne Bischof, Edward H. Livingston, Daphna Katz, Chaim Haber, Nitsan Halabi, Michal Cohen Shelly, Shlomo Segev, Yael Mintz, Tzipora Strauss
| DOI: 10.14336/AD.2026.0260
Supplement

1. Supplementary data.pdf (371KB)

LRRC8A in Aging and Aging-Related Diseases: Emerging Evidence and Therapeutic Potential
Yuman Wang, Teding Chang, Anding Liu, Cuntai Zhang
| DOI: 10.14336/AD.2026.0301
Deep Venous Perivascular Space Dysfunction Reflects Glymphatic Aging and Predicts Cognitive Vulnerability: In Vivo Human Evidence
Kemeng Zhang, Ying Zhou, Yifei Li, Xin Huang, Mengmeng Fang, Kai Wei, Min Lou
| DOI: 10.14336/AD.2025.1587
Supplement

1. Supplementary data.pdf (249KB)

The Impact of Aging on Hemorrhagic Transformation after Recanalization for Acute Ischemic Stroke: From Mechanisms to Targeted Treatments
Bo Wu, Yuhong Li, Zirui Chen, Qinhong Li, Rongsu Huang, Dongyun Zhang, Jichao Yuan, Yujie Chen, Nan Wu
| DOI: 10.14336/AD.2026.0143
Serum Calcification Propensity and CPP2 Size - Deranged Mineral Buffering and The Risk of Mortality in Older Adults
Mirjam Schuchardt, Nina Mielke, Muhammad Helmi Barghouth, Jaqueline Herrmann, Ioana Alesutan, Andreas Pasch, Markus van der Giet, Kai-Uwe Eckardt, Elke Schaeffner, Natalie Ebert, Markus Tölle, Jakob Voelkl
| DOI: 10.14336/AD.2025.1335
Supplement

1. Supplementary data.pdf (542KB)

circHIPK3 Sustains Ribosome Biogenesis and Protects Against Cardiac Aging by Stabilizing Ncl mRNA and Supporting its LLPS
Huiling Zhang, Tonggan Lu, Xinlan Lv, Yu Zhang, Ao Li, Zirui Zhao, Han Zhou, Bin Liu, Yan Xu, Yangxin Li
| DOI: 10.14336/AD.2026.0142
Supplement

1. Supplementary data.pdf (665KB)

Coronary Artery Disease Is Linked with Demyelination and Iron Deposition in White Matter Watershed Areas
Ali Rezaei, Zacharie Potvin-Jutras, Stefanie A. Tremblay, Safa Sanami, Dalia Sabra, Julia Huck, Christine Gagnon, Lindsay Wright, Ilana R. Leppert, Christine L. Tardif, Josep Iglesies-Grau, Anil Nigam, Louis Bherer, Claudine J. Gauthier
| DOI: 10.14336/AD.2026.0252
Supplement

1. Supplementary data.pdf (171KB)

Stagnation and Progression: How Glymphatic Failure Promotes Meningioma Malignancy in Aging
Wenfei Zhou, Naili Wei, Feng Xu, Chenrui Li, Ruiting Deng, Yuanfeng Yu, Yue Qiu, Yefei Lv, Hao Meng, Jiading Lu, Haojun Li, Yixuan Hao, Ronghua Huang, Xiaoyu Ji, Hailiang Tang, Jian Chen
| DOI: 10.14336/AD.2026.0116
The Copper-Gut-Brain Axis: A Triple Inflammatory Pathway Driving Neuroinflammation in Alzheimer's Disease
Ashwin Ambi
| DOI: 10.14336/AD.2026.0375
Overcoming Extracellular Matrix Barriers: Biomaterial-Assisted microRNA Delivery for Fibrous Musculoskeletal Regeneration
Ashish Ranjan Sharma, Yeon-Hee Lee, Garima Sharma, Jae Gyu Kim, Jin-Chul Kim, Holger Jahr, Sang-Soo Lee
| DOI: 10.14336/AD.2026.0343
Metabolic Transition Windows in Tissue Repair: Timing, Boundary Conditions and Resolution
Fangyuan Zhu, Feixin Liang, Sijia Song
| DOI: 10.14336/AD.2026.0204
HFpEF, Aging, Inflammaging, and the Future of Anti-Inflammatory: Therapy in Heart Failure with Preserved Ejection Fraction
Arkadiusz Grzeczka, Szymon Graczyk, Jan Gröschel, Sebastian Spethmann, Pawel Kordowitzki
| DOI: 10.14336/AD.2026.0265
Circadian Rhythm, Clock Genes and Osteoarthritis: The Dream of a Good Night’s Sleep
Hong Xu, Xinzhan Mao, Qichen Long, Antonia Rujia Sun, Indira Prasadam, Ross Crawford, Yang Chen, Yanping Wang, Xiwei Fan
| DOI: 10.14336/AD.2026.0105
Cellular Senescence Drives Diabetic Atherosclerosis: Aging Mechanisms and Integrative Therapeutic Implications
Yu Deng, Guangtao Pan, Shanyan Chen, Xiang Jia, Xu Zhang, Tianle Wang, Aochuan Sun, Zhengtang Liu, Mishan Wu, Chaojun Chen
| DOI: 10.14336/AD.2026.0182
Aging-Associated CCL8⁺ Senescent Macrophages Recruit CCR1⁺ Neutrophils to Promote NETs Formation and Impair Meningeal Lymphatic Drainage
Ye Yuan, Ruoli Wang, Qiuguang He, Zhongyi Zhang, Jing Yi, Junyi Chen, Yuxin Xie, You You, Linhui Zhang, Ziyi Yang, Shengwan He, Yihao Tao, Zongyi Xie
| DOI: 10.14336/AD.2026.0132
Supplement

1. Supplementary data.pdf (404KB)

Therapeutic Potential of Micheliolide and ACT001 in Age-Related Diseases: Molecular Mechanisms and Clinical Prospects
Hui Xu, Xin Cong, Lian-Jun Lin
| DOI: 10.14336/AD.2025.1556
Peanut Procyanidin A Delays Hematopoietic Stem Cells Aging through Cox5a
Ying Wang, Bingzheng Zhang, Junfei Lu, Lin Liu, Xiaoyu Tang, Changzheng Li, Xi Zeng, Chuqing Fan, Yuncong Qiao, Cheng Chen, Yu Zhang, Jiajia Chen, Zhiyi Li, Yucheng Luo, Guizhi Yang, Juan Shen, Bing Liu
| DOI: 10.14336/AD.2025.1354
Inflammaging: From Mechanisms to Clinical Implications and Targeted Interventions
Rola S. Zeidan, Aditya S. Shirali, Simon Reinhard, Anna Picca, Patricia Vial, Lisiane Pruinelli, Joe G.N. Garcia, Christian Leeuwenburgh, Stephen Anton
| DOI: 10.14336/AD.2025.1557
Supplement

1. Supplementary data.pdf (175KB)