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Just Accepted
The manuscripts published below have been examined by the peer-review process and have been accepted for publication. A “Just Accepted” manuscript is published online shortly after its acceptance, which is prior to technical editing and formatting and author proofing. Higher Education Press (HEP) provides “Just Accepted” as an optional and free service which allows authors to make their results available to the research community as soon as possible after acceptance. After a manuscript has been technically edited and formatted, it will be removed from the “Just Accepted” Web site and published as an Online First article. Please note that technical editing may introduce minor changes to the manuscript text and/or graphics which may affect the content, and all legal disclaimers that apply to the journal pertain. In no event shall HEP be held responsible for errors or consequences arising from the use of any information contained in these “Just Accepted” manuscripts. To cite this manuscript please use its Digital Object Identifier (DOI(r)), which is identical for all formats of publication.
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Pathological Mechanisms and Potential Therapeutic Targets of Pulmonary Arterial Hypertension: A Review
Ying Xiao, Pei-Pei Chen, Rui-Lin Zhou, Yang Zhang, Zhuang Tian, Shu-Yang Zhang
Aging and disease    DOI: 10.14336/AD.2020.0111
Accepted: 16 January 2020

A Glimmer of Hope: Maintain Mitochondrial Homeostasis to Mitigate Alzheimer’s Disease
Wenbo Li, Ling Kui, Tsirukis Demetrios, Xun Gong, Min Tang
Aging and disease    DOI: 10.14336/AD.2020.0105
Accepted: 10 January 2020

Prebiotics Regulation of Intestinal Microbiota Attenuates Cognitive Dysfunction Induced by Surgery Stimulation in APP/PS1 Mice
Dengyang Han, Zhengqian Li, Taotao Liu, Ning Yang, Yue Li, Jindan He, Min Qian, Zhongshen Kuang, Wen Zhang, Cheng Ni, Xiangyang Guo
Aging and disease    DOI: 10.14336/AD.2020.0106
Accepted: 08 January 2020

Age-related CCL12 Aggravates Intracerebral Hemorrhage-induced Brain Injury via Recruitment of Macrophages and T Lymphocytes
Jiacheng Huang, Guoqiang Yang, Xiaoyi Xiong, Maolin Wang, Junjie Yuan, Qing Zhang, Changxiong Gong, Zhongming Qiu, Zhaoyou Meng, Rui Xu, Qiong Chen, Ru Chen, Lexing Xie, Qi Xie, Wenjie Zi, Guohui Jiang, Yu Zhou, Qingwu Yang
Aging and disease    DOI: 10.14336/AD.2019.1229
Accepted: 07 January 2020

Age-Related Decline in Expression of Molecular Chaperones Induces Endoplasmic Reticulum Stress and Chondrocyte Apoptosis in Articular Cartilage
Li Tan, Thomas C. Register, Raghunatha R. Yammani
Aging and disease    DOI: 10.14336/AD.2019.1130
Accepted: 07 January 2020

Chondroprotective Effects of Combination Therapy of Acupotomy and Human Adipose Mesenchymal Stem Cells in Knee Osteoarthritis Rabbits via the GSK3β-Cyclin D1-CDK4/CDK6 Signaling Pathway
Xingyan An, Tong Wang, Wei Zhang, Hongliang Yu, Robert Chunhua Zhao, Yan Guo, Chunjiu Wang, Luxue Qin, Changqing Guo
Aging and disease    DOI: 10.14336/AD.2019.1104
Accepted: 04 January 2020
Online available: 04 January 2020

Infrapatellar Fat Pad and Knee Osteoarthritis
Ni Zeng, Zhi-Peng Yan, Xin-Yuan Chen, Guo-Xin Ni
Aging and disease    DOI: 10.14336/AD.2019.1116
Accepted: 06 December 2019

An updated review of the epigenetic mechanism underlying the pathogenesis of age-related macular degeneration
Xiaohua Li, Shikun He, Mingwei Zhao
Aging and disease    DOI: 10.14336/AD.2019.1126
Accepted: 05 December 2019

Pyroptosis Plays a Role in Osteoarthritis
Senbo An, Huiyu Hu, Yusheng Li, Yihe Hu
Aging and disease    DOI: 10.14336/AD.2019.1127
Accepted: 30 November 2019

Influence of Frailty on Outcome in Older Patients Undergoing Non-Cardiac Surgery - A Systematic Review and Meta-Analysis
Elke K.M. Tjeertes, Joris M.K. van Fessem, Francesco U.S. Mattace-Raso, Anton G.M. Hoofwijk, Robert Jan Stolker, Sanne E. Hoeks
Aging and disease    DOI: 10.14336/AD.2019.1024
Accepted: 26 November 2019

Trends in LDL-C and Non-HDL-C Levels with Age
Peng Zhang, Qian Su, Xiaomiao Ye, Ping Guan, Chengjun Chen, Yanwen Hang, Jian Dong, Zhongjie Xu, Wei Hu
Aging and disease    DOI: 10.14336/AD.2019.1025
Accepted: 19 November 2019

Management of The Elderly Cancer Patients Complexity: The Radiation Oncology Potential
Giuseppe Colloca, Luca Tagliaferri, Beatrice Di Capua, Maria Antonietta Gambacorta, Vito Lanzotti, Andrea Bellieni, Silvio Monfardini, Lodovico Balducci, Roberto Bernabei, William C. Cho, Vincenzo Valentini
Aging and disease    DOI: 10.14336/AD.2019.0616
Accepted: 19 November 2019

Six Visual Rating Scales as A Biomarker for Monitoring Atrophied Brain Volume in Parkinson's Disease
Yu Lin, Ying Fu, Yi-Fang Zeng, Jian-Ping Hu, Xiao-Zhen Lin, Nai-Qing Cai, Qiang Weng, Yi-Jing Zhao, Yi Lin, Dai-Rong Cao, Ning Wang
Aging and disease    DOI: 10.14336/AD.2019.1103
Accepted: 12 November 2019

The Significance of 8-oxoGsn in Age-Related Diseases
Xinmu Zhang, Lin Li
Aging and disease    DOI: 10.14336/AD.2019.1021
Accepted: 07 November 2019

A Novel Individual-based Determination of Postoperative Cognitive Dysfunction in Mice
Jing Zhong, Jun Li, Changhong Miao, Zhiyi Zuo
Aging and disease    DOI: 10.14336/AD.2019.1029
Accepted: 31 October 2019

Practical Approaches to Treat ED in PDE5i Nonresponders
Zhonglin Cai, Xiaoqing Song, Jianzhong Zhang, Bin Yang, Hongjun Li
Aging and disease    DOI: 10.14336/AD.2019.1028
Accepted: 29 October 2019

lncRNA Xist Regulates Osteoblast Differentiation by Sponging miR-19a-3p in Aging-induced Osteoporosis
Shijie Chen, Yuezhan Li, Shuang Zhi, Zhiyu Ding, Yan Huang, Weiguo Wang, Ruping Zheng, Haiyang Yu, Jianlong Wang, Minghua Hu, Jinglei Miao, Jinsong Li
Aging and disease    DOI: 10.14336/AD.2019.0724
Accepted: 27 October 2019

Exercise Programs for Muscle Mass, Muscle Strength and Physical Performance in Older Adults with Sarcopenia: A Systematic Review and Meta-Analysis
Wangxiao Bao, Yun Sun, Tianfang Zhang, Liliang Zou, Xiaohong Wu, Daming Wang, Zuobing Chen
Aging and disease    DOI: 10.14336/AD.2019.1012
Accepted: 23 October 2019

Cell Cycle Deficits in Neurodegenerative Disorders: Uncovering Molecular Mechanisms to Drive Innovative Therapeutic Development
Chitra Joseph, Abubakar Siddiq Mangani, Veer Gupta, Nitin Chitranshi, Ting Shen, Yogita Dheer, Devaraj KB, Mehdi Mirzaei, Yuyi You, Stuart L. Graham, Vivek Gupta
Aging and disease    DOI: 10.14336/AD.2019.0923
Accepted: 22 October 2019

Biogenesis, features, functions, and disease relationships of a specific Circular RNA: CDR1as
Ziyuan Guo, Qidong Cao, Zhuo Zhao, Chunli Song
Aging and disease    DOI: 10.14336/AD.2019.0920
Accepted: 20 October 2019

Artemisinin Improved Neuronal Functions in Alzheimer's Disease Animal Model 3xtg Mice and Neuronal Cells via Stimulating the ERK/CREB Signaling Pathway
Xia Zhao, Shuai Li, Uma Gaur, Wenhua Zheng
Aging and disease    DOI: 10.14336/AD.2019.0813
Accepted: 12 October 2019

The Impact of CRISPR-Cas9 on Age-related Disorders: From Pathology to Therapy
Allen Caobi, Rajib Kumar Dutta, Luis D. Garbinski, Maria Esteban-Lopez, Yasemin Ceyhan, Mickensone Andre, Marko Manevski, Chet Raj Ojha, Jessica Lapierre, Sneham Tiwari, Tiyash Parira, Nazira El-Hage
Aging and disease    DOI: 10.14336/AD.2019.0927
Accepted: 11 October 2019

DICER1 in the Pathogenesis of Age-related Macular Degeneration (AMD) - Alu RNA Accumulation versus miRNA Dysregulation
Kai Kaarniranta, Elzbieta Pawlowska, Joanna Szczepanska, Janusz Blasiak
Aging and disease    DOI: 10.14336/AD.2019.0809
Accepted: 08 October 2019

β-Hydroxybutyrate Suppresses Lipid Accumulation in Aged Liver through GPR109A-mediated Signaling
A Kyoung Lee, Dae Hyun Kim, EunJin Bang, Yeon Ja Choi, Hae Young Chung
Aging and disease    DOI: 10.14336/AD.2019.0926
Accepted: 04 October 2019

Parkinson Disease and Orthostatic Hypotension in the Elderly: Recognition and Management of Risk Factors for Falls
Peter A. LeWitt, Steve Kymes, Robert A. Hauser
Aging and disease    DOI: 10.14336/AD.2019.0805
Accepted: 03 October 2019

Dementia Risk in Type 2 Diabetes Patients: Acarbose Use and Its Joint Effects with Metformin and Pioglitazone
Chin-Hsiao Tseng
Aging and disease    DOI: 10.14336/AD.2019.021
Accepted: 02 October 2019

Implications of Long Non-Coding RNAs in Age-Altered Proteostasis
Cristina-Sorina Catana, Catalina-Angela Crișan, Dana Opre, Ioana Berindan-Neagoe
Aging and disease    DOI: 10.14336/AD.2019.0814
Accepted: 02 October 2019

Gait Characteristics and Brain Activity in Parkinson’s Disease with Concomitant Postural Abnormalities
Meng-sha Yao, Li-che Zhou, Yu-yan Tan, Hong Jiang, Zhi-chun Chen, Lin Zhu, Ning-di Luo, Quan-zhou Wu, Wen-yan Kang, Jun Liu
Aging and disease    DOI: 10.14336/AD.2019.0929
Accepted: 02 October 2019

Mib2 Deficiency Inhibits Microglial Activation and Alleviates Ischemia-Induced Brain Injury
Xiaoheng Li, Yajin Liao, Yuan Dong, Shuoshuo Li, Fengchao Wang, Rong Wu, Zengqiang Yuan, Jinbo Cheng
Aging and disease    DOI: 10.14336/AD.2019.0807
Accepted: 24 September 2019

Potential Biochemical Mechanisms of Brain Injury in Diabetes Mellitus
Wei-Xing Ma, Jing Tang, Zhi-Wen Lei, Chun-Yan Li, Li-Qing Zhao, Chao Lin, Tao Sun, Zheng-Yi Li, Ying-Hui Jiang, Jun-Tao Jia, Cheng-Zhu Liang, Jun-Hong Liu, Liang-Jun Yan
Aging and disease    DOI: 10.14336/AD.2019.0910
Accepted: 23 September 2019

Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Diseases: An Update
Feng Zhang, Long Niu, Xinyao Liu, Yufei Liu, Song Li, Huan Yu, Weidong Le
Aging and disease    DOI: 10.14336/AD.2019.0324
Accepted: 29 August 2019

Sirtuins and their Biological Relevance in Aging and Age-Related Diseases
Lijun Zhao, Jianzhong Cao, Kexin Hu, Xiaodong He, Dou Yun, Tanjun Tong, Limin Han
Aging and disease    DOI: 10.14336/AD.2019.0820
Accepted: 22 August 2019

Longitudinal Association of Telomere Attrition with the Effects of Antihypertensive Treatment and Blood Pressure Lowering
Shuyuan Zhang, Rongxia Li, Yunyun Yang, Yu Chen, Shujun Yang, Jian Li, Cunjin Wu, Tao Kong, Tianlong Liu, Jun Cai, Li Fu, Yanan Zhao, Rutai Hui, Weili Zhang
Aging and disease    DOI: 10.14336/AD.2019.0721
Accepted: 21 August 2019

Oxyphylla A Promotes Degradation of α-Synuclein for Neuroprotection via Activation of Immunoproteasome
Hefeng Zhou, Shengnan Li, Chuwen Li, Xuanjun Yang, Haitao Li, Hanbing Zhong, Jia-Hong Lu, Simon Ming-Yuen Lee
Aging and disease    DOI: 10.14336/AD.2019.0612
Accepted: 21 August 2019

Aging-Induced Brain-Derived Neurotrophic Factor in Adipocyte Progenitors Contributes to Adipose Tissue Dysfunction
Hyun-Doo Song, Sang Nam Kim, Abhirup Saha, Sang-Yeop Ahn, Seun Akindehin, Yeonho Son, Yoon Keun Cho, MinSu Kim, Ji-Hyun Park, Young-Suk Jung, Yun-Hee Lee
Aging and disease    DOI: 10.14336/AD.2019.0810
Accepted: 14 August 2019

Renoprotective Effect of a Dipeptidyl Peptidase-4 Inhibitor on Aging Mice
Tae H. Ban, Eun N. Kim, Min Y. Kim, Ji H. Lim, Jong H. Lee, Hyung D. Kim, Hye E. Yoon, Cheol W. Park, Bum S. Choi
Aging and disease    DOI: 10.14336/AD.2019.0620
Accepted: 09 August 2019

Lactulose Suppresses Osteoclastogenesis and Ameliorates Estrogen Deficiency-Induced Bone Loss in Mice
Xiao Chen, Zheng Zhang, Yan Hu, Jin Cui, Xin Zhi, Xiaoqun Li, Hao Jiang, Yao Wang, Zhengrong Gu, Zili Qiu, Xin Dong, Yuhong Li, Jiacan Su
Aging and disease    DOI: 10.14336/AD.2019.0613
Accepted: 05 August 2019

The Critical Role of Nurr1 as a Mediator and Therapeutic Target in Alzheimer’s Disease-related Pathogenesis
Jeon Seong Gak, Yoo Anji, Chun Dong Wook, Hong Sang Bum, Chung Hyunju, Kim Jin-il, Moon Minho
Aging and disease    DOI: 10.14336/AD.2019.0718
Accepted: 01 August 2019
Online available: 02 August 2019

Cellular and Molecular Biomarkers Indicate Premature Aging in Pseudoxanthoma Elasticum Patients
Janina Tiemann, Thomas Wagner, Olivier M. Vanakker, Matthias van Gils, José-Luis Bueno Cabrera, Bettina Ibold, Isabel Faust, Cornelius Knabbe, Doris Hendig
Aging and disease    DOI: 10.14336/AD.2019.0610
Accepted: 31 July 2019

Neuroprotective Effects of Endogenous Secretory Receptor for Advanced Glycation End-products in Brain Ischemia
Yu Shimizu, Ai Harashima, Seiichi Munesue, Masahiro Oishi, Tsuyoshi Hattori, Osamu Hori, Yasuko Kitao, Hiroshi Yamamoto, Nontaphat Leerach, Mitsutoshi Nakada, Yasuhiko Yamamoto, Yasuhiko Hayashi
Aging and disease    DOI: 10.14336/AD.2019.0715
Accepted: 26 July 2019

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