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2024
Impact Factor
6.9

Early Edition

The papers published below have been examined by the peer-review process and accepted for publication in Aging and Disease. A “Just Accepted” paper is published online shortly after its acceptance, which allows authors to make their results available to the research community as soon as possible after acceptance. When the final version appears, the version of early edition is replaced with the final version, and the paper is moved to the appropriate issue on the Aging and Disease website. The paper will no longer appear in the “Just Accepted”. However, all links (the URL) will not change. “Just Accepted” papers are citable from that date they are posted. To cite this manuscript please include its Digital Object Identifier (DOI), which is identical for all formats of publication.
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Total 211 results are found
Danggui-Shaoyao San Promotes Microglia-Mediated Oligodendrocyte Maturation and White Matter Repair After Stroke
Fang Tong, Yihan Liu, Nan Deng, Yong Yang, Sijie Li, Ziping Han, Jingfei Shi, Xunming Ji, Changhong Ren
| DOI: 10.14336/AD.2026.10202
Supplement

1. Supplementary data.pdf (154KB)

Spatial Transcriptomic Analysis Reveals Dysregulated Pro-Inflammatory Signaling in the Aged Lung
Brianna M. Doratt, Ethan G. Napier, Mahdi Eskandarian Boroujeni, Michael H. Davies, Christine F. Brainson, Eliot R. Spindel, Ilhem Messaoudi
| DOI: 10.14336/AD.2025.1317
Supplement

1. Supplementary data.pdf (1768KB)

Receptor-Specific Adenosine Signalling Governs Astrocyte Glycogen Homeostasis
Kaja Belko Parkel, Živa Tajda Gržina, Robert Zorec, Marko Kreft
| DOI: 10.14336/AD.2025.1389
Supplement

1. Supplementary data.pdf (175KB)

Dual effect of Vascular Calcification in Abdominal Aortic Aneurysm Progression: A Narrative Review from Multi-Scales
Kexin Zhao, Weichang Zhang, Chang Shu
| DOI: 10.14336/AD.2025.1422
Aging of the Blood-Brain Barrier and Altered Permeability to Peripheral Immune Cells: Implications for Central Nervous System Disorders
Yu Gu, Liting Zhang, Zixin Du, Caiyun Wang, Wenyuan Deng, Yong U Liu, Beisha Tang
| DOI: 10.14336/AD.2026.0013
Longevity vs. Healthy Longevity: Different Outcomes Underlain by Different Mechanisms
Daria Kashtanova, Aleksandra Mamchur, Maria Bruttan, Veronika Daniel, Mikhail Ivanov, Elena Zelenova, Irina Dzhumaniiazova, Lorena Matkava, Mikhail Terekhov, Antonina Rumyantzeva, Konstantin Grammatikati, Sergey Mitrofanov, Vladimir Yudin, Valentina Maksyutina, Ekaterina Maralova, Aleksey Ivashechkin, Aleksandra Nekrasova, Irina Strazhesko, Valentin Makarov, Anton Keskinov, Olga Tkacheva, Sergey Yudin, Veronika Skvortsova
| DOI: 10.14336/AD.2025.0828
Supplement

1. Supplementary data.pdf (495KB)

Dysregulated Lipid Metabolism and Neurovascular Unit Dysfunction: Novel Mechanisms Linking Alzheimer’s Disease and Vascular Dementia
MengGe Li, HuiYue Wang, ZhenYan Tang, ShuSheng Yang, Li Lin
| DOI: 10.14336/AD.2025.1464
Health Related Quality of Life in Adults with 13 Chronic Diseases before Age 65 and after Age 65 Using Fuzzy Rough Analysis of SF-36 Domains
Marlena Krawczyk-Suszek, Zofia Matusiewicz, Teresa Mroczek, Andrzej Kleinrok
| DOI: 10.14336/AD.2025.0928
The Effects of Aging and Anti-Aging Dietary Restriction on Brain Glutathione and Thioredoxin Redox Systems
Leah E. Jamerson, Patrick C. Bradshaw
| DOI: 10.14336/AD.2025.1505
Supplement

1. Supplementary data.pdf (513KB)

Neuroinflammation and Cellular Senescence in Brain Aging and Neurodegeneration
Linlin Zhang, longtu Li, Xin Wang, Liang Ma, Li Yan, Qian Xiang, Yimin Cui, Zhiyan Liu
| DOI: 10.14336/AD.2025.1538
Cuproptosis and Aging: Molecular Mechanisms and Therapeutic Implications
Jingyan Hong, Yaxin Liu, Quan Peng, Zhigang Mei, Guozuo Wang
| DOI: 10.14336/AD.2025.1305
Recent Advances in The Molecular Regulation of Cardiac Hypertrophy Related to Heart Failure
Wen Cao, Qin Yang, Guo-Wei He
| DOI: 10.14336/AD.2025.1501
Macrophage Senescence: Friend or Foe?
Xunxi Deng, Zhiyi Yin, Shi Tai, Yongjun Wang, Liyao Fu
| DOI: 10.14336/AD.2025.1394
Meta-Analysis and Bioinformatic Analysis of Human Fluid Proteomic Studies Reveal Key Biological Pathways Related to Aging and Frailty
Sophie Guillotin, Sandrine Andrieu, Nicolas Delcourt
| DOI: 10.14336/AD.2025.0793
Supplement

1. Supplementary data.pdf (601KB)

TRF2 Upregulates Protein Phosphatase 2A Subunit PPP2R2C to Attenuate DNA Damage Response at Telomeres and Pericentromeres Upon Replicative Stress
Xiuyun Zhai, Cuicui Wang, Yilin Ying, Waiian Leong, Lianxiang Chen, Bohua Wei, Xiaojiao Cheng, Sheng Huang, Qiaowen Chen, Yiming Lu, Eric Gilson, Jing Ye
| DOI: 10.14336/AD.2025.1249
Supplement

1. Supplementary data.pdf (1630KB)

Organ-Brain Axis in Alzheimer’s Disease: A Systemic Perspective on Pathogenesis and Progression
Yebeen Kim, Jaewoon Jung, Asifiwe Clarisse Cirunduzi, Seonghyun Yoon, Seokyoung Bang, Seung-Hoon Yang
| DOI: 10.14336/AD.2025.1537
The Impact of Young and/or Exercised Plasma Transfusions in Neurodegenerative Conditions: A Scoping Review
Michael J. Kirton, Emily R. Cox, Ulrik Wisløff, Atefe R. Tari, Lance C. Dalleck, Claire Drummond, Belinda Lange, Ranjay Chakraborty, Kym Williams, Norma Bulamu, Alline Beleigoli, Joyce S. Ramos
| DOI: 10.14336/AD.2025.0849
Supplement

1. Supplementary data.pdf (515KB)

The α-MSH-MC1R Axis Modulates Sex-Specific Senescence and Inflammation Processes in Human Articular Chondrocytes and Mice Knee Joints
Nicole Schäfer, Paul Kalke, Ravikumar Mayakrishnan, Jian Mei, Luisa Kollatz, Marianne Ehrnsperger, Hadrian Platzer, Brian Johnstone, Arndt F. Schilling, Babak Moradi, Markus Böhm, Susanne Grässel
| DOI: 10.14336/AD.2025.1307
Supplement

1. Supplementary data.pdf (1442KB)

Alzheimer's Disease Continuum: Evaluating the Relationship between Fluid Biomarkers and Patients’ Phenotype and Profile
Rosalinda Di Gerlando, Matteo Cotta Ramusino, Francesca Dragoni, Evelyne Minucchi, Bartolo Rizzo, Elisabetta Zardini, Riccardo Rocco Ferrari, Michele Rossi, Giulia Perini, Alfredo Costa, Annalisa Davin, Stella Gagliardi
| DOI: 10.14336/AD.2025.0971
Supplement

1. Supplementary data.pdf (1430KB)

Revisiting Retinal Vein Occlusion: An Etiologic Classification for Enhanced Patient Management
Xiao Xue¹, Huimin Jiang, Weiyue Zhang, Yifan Zhou, Hui Li, Yuan Gao, Chen Zhou, Xuxiang Zhang¹
| DOI: 10.14336/AD.2025.1572
Osteoarthritic knee: Advances in Epidemiology, Emerging Etiopathologies and Adipose-Derived Stem Cells-based Therapies
Chian-Her Lee, Hsien-Tsung Lu, Ko-Ta Chen, Shen-Han Wu, Ying-Fong Su, Hui-Hsuan Ting, Ai-Chen Lee, Tin-Hsien Ko, Navneet Kumar Dubey
| DOI: 10.14336/AD.2025.1401
Supplement

1. Supplementary data.pdf (147KB)

Thrombolysis in Acute Ischemic Stroke: Advances and Prospects
Zixin Wang, Jiamin Li, Yun Chen, Boyi Yuan, Qingfeng Ma
| DOI: 10.14336/AD.2025.1477
Heat Shock Proteins in Neurodegenerative Diseases
En Ying Yap, Duan Lu Hou, Tuchen Guan, Xiao-Xue Dong, Li Zeng, Laurie H Sanders, Yun-Cheng Wu, Eng King Tan, Zhi Dong Zhou
| DOI: 10.14336/AD.2025.1309
Targeting Macrophage Efferocytosis to Treat Chronic Inflammation in Cancer and Inflammaging
Xin Huang, Baicheng Qu, Maike Chen, Weiyue Zhang
| DOI: 10.14336/AD.2025.1408
Chronic Inflammation and Aging in Rheumatic Diseases
Zewen Wu, Jingxuan Li, Rong Li, Li Zhao, Yazhen Su, Yang Liu, Huijing Zhang, Liyun Zhang
| DOI: 10.14336/AD.2025.1182
Aligning Intrinsic Capacity and Geroscience: Linking Function with Biology
Sha Zhu, Lihua Tao, Chengcheng Fan, Yongzhe Wei, Jagadish K. Chhetri, Piu Chan
| DOI: 10.14336/AD.2025.1419
Increased Stability of Tristetraprolin mRNA Supports Bone Health and Decreases Frailty During Aging
Ramkumar Thiyagarajan, Lixia Zhang, Leticia Andrea Rojas Cortez, Kyu Hwan Kwack, Victoria Maglaras, Nanda Kumar Yellapu, Yukitomo Arao, Kenneth L. Seldeen, Perry J. Blackshear, Bruce R. Troen, Keith L. Kirkwood
| DOI: 10.14336/AD.2025.1243
Supplement

1. Supplementary data.pdf (1343KB)

Functional Pathways of the Gut Microbiome Associated with SCFA Profiles in Preclinical Alzheimer’s Disease
D.M. Sithara Dissanayaka, Thilini N. Jayasinghe, Hamid R. Sohrabi, S.R. Rainey-Smith, Kevin Taddei, Colin L. Masters, Ralph N. Martins, W.M.A.D. Binosha Fernando
| DOI: 10.14336/AD.2025.1539
Supplement

1. Supplementary data.pdf (1339KB)

Alternative Polyadenylation in Aging and Aging-Related Diseases
Mengqi Chen, Xiangyu Zhu, Lejia Hang, Zijie Yan, Li Xu, Fang Liu, Qiong Zhang, Jingjing Huang
| DOI: 10.14336/AD.2025.0882
Mortality among Older Adults Across Multimorbidity Categories and Lifestyle Patterns
Rafael Ogaz-González, Qian Zou, Javier Maroto-Rodriguez, Luis Miguel Gutiérrez-Robledo, Ricardo Escamilla-Santiago, Malaquías López-Cervantes, Eva Corpeleijn
| DOI: 10.14336/AD.2025.1012
Supplement

1. Supplementary data.pdf (691KB)

Genomic and Epigenomic Landscapes of Sarcopenia: From Molecular Etiology to Precision Interventions
Ji-Yong Sung, Jung Woo Lee
| DOI: 10.14336/AD.2025.1463
NPM1 in Aging-Related Multi-System Diseases: Molecular Mechanisms and Therapeutic Implications
Jiayao Li, Jiaqi Jin, Xinyu Yang, Wentao Gao, Haozhi Gong, Xvebing Feng, Huijie Fang, Rui Liu, Shihao Jiang, Yanping Shen, Xiaoting Liang, Yiming He, Liqun Jiao, Xiao Zhang, Tao Wang
| DOI: 10.14336/AD.2025.1258
USP3 Promotes Glioma Progression by Stabilizing PLK1 through Deubiquitination
Feng Yan, Yongzhi Shan, Yaming Wang, Xiaotong Fan, Penghu Wei, Guoguang Zhao
| DOI: 10.14336/AD.2025.01011
Supplement

1. Supplementary data.pdf (1081KB)

Expanding on Gut Microbiota Insights in Sarcopenia and Osteoporosis
Lei Chen, Cong Hong, Yu Xie
| DOI: 10.14336/AD.2025.1592
Perimenopausal Hormone Replacement Treatments as a Geroprotective Approach - Adapting Clinical Guidance
Jaron Rabinovici, Henk-Peter Oonk, Zhongwei Huang, Tashiya Mirando, Moran Zhou, Tzipora Strauss, Lia-Raluca Olari, Dominika Wilczok, Andrea B. Maier, Evelyne Bischof
| DOI: 10.14336/AD.2025.1391
Disease-Associated and Shared Gut Microbes of Sarcopenia and Osteoporosis: A Systematic Review and Meta-Analys
Cong Lu, Haochen Wang, Changjun Li, Houchen Lyu, Liusong Shen, Jian Zhang, Wenni Rong, Jie Wei, Chao Zeng, Guanghua Lei, Yilun Wang, Ning Wang
| DOI: 10.14336/AD.2025.1116
Supplement

1. Supplementary data.pdf (1192KB)

Oncology-Derived Strategies for Age-Related Diseases: Intersections of Oncogenesis, Senescence, and Immunity
Hao Li, Jingzeng Wang, Chao Liu, Xiaofen Wu
| DOI: 10.14336/AD.2025.1168
Mitochondrial Dysfunction in Alzheimer's disease: Focus on Dynamics and Electron Transport Chain
Jiehui Li, Gajendra Kumar, Yuqing Yan, Mengmeng Wang, Ling Xu, Haige Wu, Ye Gao, Yi wang, Yingyi Fan, Ying Bai
| DOI: 10.14336/AD.2025.1046
The Emerging Triad in Cancer and Aging: Cellular Senescence, Microbiome, and Tumor Microenvironment
Xi Gong, Shaogang Wang, Qidong Xia
| DOI: 10.14336/AD.2025.1495
A Combination of Low-Dose Δ9-THC and Celecoxib as a Therapeutic Strategy for Alzheimer’s Disease
Jian Zhang, Dexiao Zhu, Mei Hu, Mingzhe Pan, Chu Chen
| DOI: 10.14336/AD.2025.1206
Supplement

1. Supplementary data.pdf (4873KB)