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2024
Impact Factor
6.9

Early Edition

The papers published below have been examined by the peer-review process and accepted for publication in Aging and Disease. A “Just Accepted” paper is published online shortly after its acceptance, which allows authors to make their results available to the research community as soon as possible after acceptance. When the final version appears, the version of early edition is replaced with the final version, and the paper is moved to the appropriate issue on the Aging and Disease website. The paper will no longer appear in the “Just Accepted”. However, all links (the URL) will not change. “Just Accepted” papers are citable from that date they are posted. To cite this manuscript please include its Digital Object Identifier (DOI), which is identical for all formats of publication.
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Total 203 results are found
The Role of Mitochondria-Associated Endoplasmic Reticulum Membranes in Fibrotic Diseases
Fei Wang, Han Wang, Yun chao Zhang, Cao Dan, Yi Ming Qin, Mei Juan Xie, Xiao Yan Lyu
| DOI: 10.14336/AD.2025.1087
Metabolic-Inflammatory Syndrome: Decoding the Metabolic-Immune Axis for Precision Intervention
Simin Li, Yawei Shi, Chongge You
| DOI: 10.14336/AD.2025.1125
Advancing Single-Cell Transcriptomic Analysis to Reveal Age-Related Skeletal Muscle Changes: A Systematic Review
Chaoran Liu, Hei Yuet Wong, Ranyang Tao, Baoqi Li, Pui Yan Wong, Chun Ho Tam, Ning Zhang, Ling Qin, Jiankun Xu, Gustavo Duque, Christoph Brochhausen, Wing Hoi Cheung, Ronald Man Yeung Wong
| DOI: 10.14336/AD.2025.0701
Supplement

1. Supplementary data.pdf (631KB)

Sphingosine Kinase 2 Inhibition Ameliorates Neuroinflammation in Diet-Induced Obese Mice
Lotte Vanherle, Cecilia Skoug, Lisa Teresa Porschen, Fátima Gimeno-Ferrer, Frank Matthes, João M. N. Duarte, Anja Meissner
| DOI: 10.14336/AD.2025.0636
Supplement

1. Supplementary data.pdf (841KB)

Correlations between Aging, Telomeres, and Natural Compounds
Katarzyna Rakoczy, Laura Wojdyło, Sara Suwała, Karolina Klasen, Jacek Kuźnicki, Marek Ziętek, Julita Kulbacka
| DOI: 10.14336/AD.2025.0853
Annexin A5 in Ischemic Stroke: Molecular Mechanisms and Translational Therapy Strategies
Zhanwei Zhu, Jiachen He, Qi Liu, Jiaqi Guo, Jingbei Liu, Shuaili Xu, Xi Chen, Di Wu
| DOI: 10.14336/AD.2025.1021
Optimal Evaluation and Treatment of Cardiac Rehabilitation for Patients Following TAVR: A Personalized Program Based on The Five Prescriptions
Xue-Song Han, Gang Wang, Yong Miao, Zhi-Yuan Tian, Yong-Chao Zhang, Zong-Yan Li, Xiao-Jia Sun, Qiang Hu
| DOI: 10.14336/AD.2025.0716
Impairment of astrocyte homeostasis and lysosomal function in Alzheimer’s disease pathogenesis
Jenelle M. Collier, Mary McFarland, Sanjana Krishna, Pallavi Kurella, Christian Calderon Pinon, Dandan Sun
| DOI: 10.14336/AD.2025.0694
Aβ Deposition in Extracellular Space Disrupts Glial-Neuron Communication and Triggers Alzheimer's Disease
Ying Chen, Ling Ding, Ziqi Gu, Zixi Tain, Tingting Gao, Feiyan Zhou, Shouzi Zhang, Zhiqian Tong
| DOI: 10.14336/AD.2025.0873
Aging-Related Mechanisms Underlying Carcinogenesis: Therapeutic Opportunities.
Ana Guijarro, Giulia Allavena, Livia Pisciotta, Alessio Nencioni, Irene Caffa
| DOI: 10.14336/AD.2025.0861
Enhancing Mitochondrial Matrix Antioxidant SOD2 in Astrocytes Mitigates Cellular Senescence and Cognitive Impairment in Aging
Matthew P Baier, Sophia I Sharum, Jenna L Wilson, Sanjit Narasimhan, Chinnu Salim, Sreemathi Logan
| DOI: 10.14336/AD.2025.0760
Supplement

1. Supplementary data.pdf (584KB)

Global Burden of Chronic Obstructive Pulmonary Disease and Heart Failure Comorbidity in Older Adults: An Analysis of the Global Burden of Disease Study
Jian Kang, Huiqing Xu, Xiaojing Deng, Yeping Bian, Tianrui Deng, Yunting Xu, Guofeng Ao, Jian Xu, Fei Xu
| DOI: 10.14336/AD.2025.1044
Supplement

1. Supplementary data.pdf (720KB)

Stroke-Induced Retinal Dysfunction: Mechanisms, Diagnostics, and Future Directions
Ting Wang, Zirun Feng, Jin Yang, Cuiying Liu, Heng Zhao, Sheng Huang
| DOI: 10.14336/AD.2025.0451
Early-Life Red Light Exposure Extends Lifespan in C. elegans through ROS-AMPK-Driven Mitochondrial Reprogramming
Yao Zhu, Xin Lin, Huiting Wang, Mingming Song, Tao Yang, Yi Jiao, Chang Liu
| DOI: 10.14336/AD.2025.0791
Supplement

1. Supplementary data.pdf (1495KB)

Diversity of Brain Microvascular Endothelial Cell Functions: Physiology, Ischemia/Hypoxia, and Underlying Protection
Mingxuan Cao, Jia Liu, Xunming Ji
| DOI: 10.14336/AD.2025.0664
Neuronal Necroptosis Drives Neuroinflammation and Cognitive Decline Independent of Neuronal Cell Death
Nidheesh Thadathil, Nicholas A Wolf, Roman Wolf, Carlos Manlio Díaz-García, Sreemathi Logan, Daniel B Owen, Kevin Pham, Willard M Freeman, Arlan Richardson
| DOI: 10.14336/AD.2025.0805
Supplement

1. Supplementary data.pdf (911KB)

Monocytes/Macrophages in Giant Cell Arteritis-Polymyalgia Rheumatica Spectrum Disease
Junyan Guo, Yanlin He, Fan Yang, Weiqian Chen
| DOI: 10.14336/AD.2025.0830
Progress in Disease-Modifying Therapies for Parkinson's Disease
Shuyuan Zhang, Gang Shao, Bin Wu, Liang Xia, Lei Wang, Liwen Li, Kai Jin, Yangfan Zou, Caixing Sun
| DOI: 10.14336/AD.2025.0627
Therapeutic Promise of Exosomal CD73 for Diabetic Bone Disorders: Addressing Mechanistic and Translational Challenges
Jing Lu, DuJiang Yang, Canhao Lai, Xiaoyu Chen, Ruichen Li, GuoYou Wang
| DOI: 10.14336/AD.2025.1154
The Clinical Relevance of FTO as a Demethylase Beyond Cancer: Molecular Mechanisms and Therapeutic Opportunities
Cun-yang Guo, Yi-fei Du, Hui-cong Yan, Xin-ming Fan, Fang-qi Tian, Ping Xu
| DOI: 10.14336/AD.2025.0916
Linking Individual Variability of Multi-modal Connectivity, Lifestyle, Psycho-Social Factors and Cognition in Older Adults
Mingxian Zhang, Susanne Moebus, Nico Dragano, Nora Bittner, Svenja Caspers
| DOI: 10.14336/AD.2025.0428
Supplement

1. Supplementary data.pdf (3397KB)

Targeting the Milieu in Neurodegenerative Disease: Time for “Imprecision Medicine”?
Joseph F. Quinn
| DOI: 10.14336/AD.2025.0966
Association between Visual, Hearing and Dual Sensory Impairment and the Frailty Syndrome
Humberto Yévenes-Briones, Francisco Félix Caballero, Aitana Vázquez-Fernández, Pablo Martinez-Amezcua, Teresa T Fung, Esther Lopez-Garcia
| DOI: 10.14336/AD.2025.0342
Supplement

1. Supplementary data.pdf (313KB)

From Dual Decline to Clinical Consequences: Mechanistic Pathways and Health Outcomes of Motoric Cognitive Risk Syndrome
Yiwei Zhao, Tao Wei, Bo Zhao, Yuanyuan Chen, Zhibin Wang, Yi Tang
| DOI: 10.14336/AD.2025.0730
Lactylation Modification and Aging: A Molecular Link in the Life Process
Min Shi, Honyu Li, Haiyan Lin, Qiang Tang
| DOI: 10.14336/AD.2025.0509
Gut Virome and Aging: Phage-Driven Microbial Stability and Immune Modulation
Kaleem Ullah, Rabia Kanwar, Saqib Ali, Saif Uddin, Izza Izza, Irfan Ahmad, Khalid J. Alzahrani, Abdul Qadeer, Chun-Ting Chu, Chien-Chin Chen
| DOI: 10.14336/AD.2025.0854
Fever Induces Long-Term Synaptic Enhancement and Protects Learning in an Accelerated Aging Model
Fusheng Du, Qi Wan, Oleg O. Glebov
| DOI: 10.14336/AD.2025.0591
Supplement

1. Supplementary data.pdf (936KB)

PGC-1α Regulates Exercise Intensity-Dependent Atrial Remodeling and Fibrillation in Rats
Jingwen Xiao, Jiancheng Zhang, Yan Zhang, Yu Jiang, Chenqi Yang, Xiaona Lin, Zhengnan Lin
| DOI: 10.14336/AD.2025.10621
Circulating Cell-free DNA Fragmentomics Detection and Beyond
Tianliang Liu, Zhicheng Li, Shifu Chen, Jiasheng Zhong
| DOI: 10.14336/AD.2025.1029
Crossing Pathological Boundaries: Multi-Target Restoration of the Neurovascular Unit in Alzheimer's and Vascular Dementia—From Modern Therapeutics to Traditional Chinese Medicine
Tengyu Zhao, Pengyu Pan, Ying Jia, Yuhan Zhou, Xinyue Zhang, Huibo Guan, Quan Li, Yanyan Zhou
| DOI: 10.14336/AD.2025.0801
Age-related Vascular Alterations in the Choroid Plexus: Novel Insights from Pathophysiology and Imaging Studies
Zhe Sun, Chenyang Li, Dominique Leitner, Michelle Wu, Jiangyang Zhang, Thomas Wisniewski, Yulin Ge
| DOI: 10.14336/AD.2025.0735
Early Risk Prediction Model for Stroke-Heart Syndrome Following Endovascular Therapy
Lanjing Wang, Shuangfeng Huang, Yongle Wang, Omar Elmadhoun, Changhong Ren, Wenbo Zhao, Yao Yu, Guiyou Liu, Xunming Ji, Sijie Li
| DOI: 10.14336/AD.2025.10710
Interaction between Brain Natriuretic Peptide and QTc Prolongation on Mortality in Patients with Stroke-Heart Syndrome
Yongle Wang, Mingyi He, Lanjing Wang, Omar Elmadhoun, Fangyan Liu, Wenbo Zhao, Changhong Ren, Yuchuan Ding, Xunming Ji, Sijie Li
| DOI: 10.14336/AD.2025.10711
Epigenetic Clocks Identify Harmful Epigenetic Aging Linked to Depression Severity and Cognitive Deficits in Major Depressive Disorder
Chao Liufu, Tao Pang, Haohao Zheng, Lei Yang, Li Yang, Xuebing Huang, Ying Qian, Suhua Chang
| DOI: 10.14336/AD.2025.0781
Supplement

1. Supplementary data.pdf (788KB)

Nuclear Protein Aggregates Disrupt RNA Processing and Alter Biomechanics in a Muscle Cell Model of OPMD
Milad Shademan, Sarah Flannery, Erik Bos, Tom M.J. Evers, Vahid Sheikhhassani, Alireza Mashaghi, Benno Kusters, Baziel van Engelen, Thom T. Sharp, Roman Fischer, Benedikt M. Kessler, Vered Raz
| DOI: 10.14336/AD.2025.0699
Supplement

1. Supplementary data.pdf (1590KB)

Cross-Trait Meta-Analysis Reveals a Genetic Link between Inflammation and Aging in Giant Cell Arteritis
Laura Martínez-Gutiérrez, Inmaculada Rodriguez-Martin, Gonzalo Borrego-Yaniz, Martin Kerick, International GCA Consortium, UK GCA Consortium, Carlo Salvarani, José Hernández-Rodríguez, María Cinta Cid, Miguel Ángel González-Gay, Ann W. Morgan, Javier Martín, Lourdes Ortiz-Fernández, Ana Márquez
| DOI: 10.14336/AD.2025.0609
Supplement

1. Supplementary data.pdf (2121KB)

Decentralizing Pulmonary Screening for China’s Aging Population: From Hospitals to Communities
Leiwen Fu, Wei Shu, Yuxian Sun, Liang Li, Jian Du
| DOI: 10.14336/AD.2025.1027
Recent Advances in Autophagy and Immunotherapy for the Clearance of Aggregated α-Synuclein in Parkinson’s Disease
Khoshnur Jannat, Sang-Bong Lee, Hong-Ryeol Jung, Rengasamy Balakrishnan, Yon-Suk Kim, Mujeeb Ur Rahman, Dong-Kug Choi
| DOI: 10.14336/AD.2025.0642
Apelin: A Promising Therapeutic Target for Degenerative Diseases of the Musculoskeletal System
Jinkun Xu, Hengzhen Li, Jianfeng Sun, Gaoming Liu, Yuming Yao, Dongliang Yuan, Wenfeng Xiao, Yusheng Li
| DOI: 10.14336/AD.2025.0555
Mechanisms and Pathogenesis of Diabetic Cognitive Impairment: A Comprehensive Review
Chang Qi, Ming Qin, Yu Wang, Cong Li, Huiying Yan, Lina Feng, Mingquan Li
| DOI: 10.14336/AD.2025.0769