ISOAD Become a Member Search
2024
Impact Factor
6.9

Early Edition

The papers published below have been examined by the peer-review process and accepted for publication in Aging and Disease. A “Just Accepted” paper is published online shortly after its acceptance, which allows authors to make their results available to the research community as soon as possible after acceptance. When the final version appears, the version of early edition is replaced with the final version, and the paper is moved to the appropriate issue on the Aging and Disease website. The paper will no longer appear in the “Just Accepted”. However, all links (the URL) will not change. “Just Accepted” papers are citable from that date they are posted. To cite this manuscript please include its Digital Object Identifier (DOI), which is identical for all formats of publication.
Please wait a minute...
Total 185 results are found
Therapeutic Promise of Exosomal CD73 for Diabetic Bone Disorders: Addressing Mechanistic and Translational Challenges
Jing Lu, DuJiang Yang, Canhao Lai, Xiaoyu Chen, Ruichen Li, GuoYou Wang
| DOI: 10.14336/AD.2025.1154
The Clinical Relevance of FTO as a Demethylase Beyond Cancer: Molecular Mechanisms and Therapeutic Opportunities
Cun-yang Guo, Yi-fei Du, Hui-cong Yan, Xin-ming Fan, Fang-qi Tian, Ping Xu
| DOI: 10.14336/AD.2025.0916
Linking Individual Variability of Multi-modal Connectivity, Lifestyle, Psycho-Social Factors and Cognition in Older Adults
Mingxian Zhang, Susanne Moebus, Nico Dragano, Nora Bittner, Svenja Caspers
| DOI: 10.14336/AD.2025.0428
Supplement

1. Supplementary data.pdf (3397KB)

Targeting the Milieu in Neurodegenerative Disease: Time for “Imprecision Medicine”?
Joseph F. Quinn
| DOI: 10.14336/AD.2025.0966
Association between Visual, Hearing and Dual Sensory Impairment and the Frailty Syndrome
Humberto Yévenes-Briones, Francisco Félix Caballero, Aitana Vázquez-Fernández, Pablo Martinez-Amezcua, Teresa T Fung, Esther Lopez-Garcia
| DOI: 10.14336/AD.2025.0342
Supplement

1. Supplementary data.pdf (313KB)

From Dual Decline to Clinical Consequences: Mechanistic Pathways and Health Outcomes of Motoric Cognitive Risk Syndrome
Yiwei Zhao, Tao Wei, Bo Zhao, Yuanyuan Chen, Zhibin Wang, Yi Tang
| DOI: 10.14336/AD.2025.0730
Lactylation Modification and Aging: A Molecular Link in the Life Process
Min Shi, Honyu Li, Haiyan Lin, Qiang Tang
| DOI: 10.14336/AD.2025.0509
Gut Virome and Aging: Phage-Driven Microbial Stability and Immune Modulation
Kaleem Ullah, Rabia Kanwar, Saqib Ali, Saif Uddin, Izza Izza, Irfan Ahmad, Khalid J. Alzahrani, Abdul Qadeer, Chun-Ting Chu, Chien-Chin Chen
| DOI: 10.14336/AD.2025.0854
Fever Induces Long-Term Synaptic Enhancement and Protects Learning in an Accelerated Aging Model
Fusheng Du, Qi Wan, Oleg O. Glebov
| DOI: 10.14336/AD.2025.0591
Supplement

1. Supplementary data.pdf (936KB)

PGC-1α Regulates Exercise Intensity-Dependent Atrial Remodeling and Fibrillation in Rats
Jingwen Xiao, Jiancheng Zhang, Yan Zhang, Yu Jiang, Chenqi Yang, Xiaona Lin, Zhengnan Lin
| DOI: 10.14336/AD.2025.10621
Circulating Cell-free DNA Fragmentomics Detection and Beyond
Tianliang Liu, Zhicheng Li, Shifu Chen, Jiasheng Zhong
| DOI: 10.14336/AD.2025.1029
Crossing Pathological Boundaries: Multi-Target Restoration of the Neurovascular Unit in Alzheimer's and Vascular Dementia—From Modern Therapeutics to Traditional Chinese Medicine
Tengyu Zhao, Pengyu Pan, Ying Jia, Yuhan Zhou, Xinyue Zhang, Huibo Guan, Quan Li, Yanyan Zhou
| DOI: 10.14336/AD.2025.0801
Age-related Vascular Alterations in the Choroid Plexus: Novel Insights from Pathophysiology and Imaging Studies
Zhe Sun, Chenyang Li, Dominique Leitner, Michelle Wu, Jiangyang Zhang, Thomas Wisniewski, Yulin Ge
| DOI: 10.14336/AD.2025.0735
Early Risk Prediction Model for Stroke-Heart Syndrome Following Endovascular Therapy
Lanjing Wang, Shuangfeng Huang, Yongle Wang, Omar Elmadhoun, Changhong Ren, Wenbo Zhao, Yao Yu, Guiyou Liu, Xunming Ji, Sijie Li
| DOI: 10.14336/AD.2025.10710
Interaction between Brain Natriuretic Peptide and QTc Prolongation on Mortality in Patients with Stroke-Heart Syndrome
Yongle Wang, Mingyi He, Lanjing Wang, Omar Elmadhoun, Fangyan Liu, Wenbo Zhao, Changhong Ren, Yuchuan Ding, Xunming Ji, Sijie Li
| DOI: 10.14336/AD.2025.10711
Epigenetic Clocks Identify Harmful Epigenetic Aging Linked to Depression Severity and Cognitive Deficits in Major Depressive Disorder
Chao Liufu, Tao Pang, Haohao Zheng, Lei Yang, Li Yang, Xuebing Huang, Ying Qian, Suhua Chang
| DOI: 10.14336/AD.2025.0781
Supplement

1. Supplementary data.pdf (788KB)

Nuclear Protein Aggregates Disrupt RNA Processing and Alter Biomechanics in a Muscle Cell Model of OPMD
Milad Shademan, Sarah Flannery, Erik Bos, Tom M.J. Evers, Vahid Sheikhhassani, Alireza Mashaghi, Benno Kusters, Baziel van Engelen, Thom T. Sharp, Roman Fischer, Benedikt M. Kessler, Vered Raz
| DOI: 10.14336/AD.2025.0699
Supplement

1. Supplementary data.pdf (1590KB)

Cross-Trait Meta-Analysis Reveals a Genetic Link between Inflammation and Aging in Giant Cell Arteritis
Laura Martínez-Gutiérrez, Inmaculada Rodriguez-Martin, Gonzalo Borrego-Yaniz, Martin Kerick, International GCA Consortium, UK GCA Consortium, Carlo Salvarani, José Hernández-Rodríguez, María Cinta Cid, Miguel Ángel González-Gay, Ann W. Morgan, Javier Martín, Lourdes Ortiz-Fernández, Ana Márquez
| DOI: 10.14336/AD.2025.0609
Supplement

1. Supplementary data.pdf (2121KB)

Decentralizing Pulmonary Screening for China’s Aging Population: From Hospitals to Communities
Leiwen Fu, Wei Shu, Yuxian Sun, Liang Li, Jian Du
| DOI: 10.14336/AD.2025.1027
Recent Advances in Autophagy and Immunotherapy for the Clearance of Aggregated α-Synuclein in Parkinson’s Disease
Khoshnur Jannat, Sang-Bong Lee, Hong-Ryeol Jung, Rengasamy Balakrishnan, Yon-Suk Kim, Mujeeb Ur Rahman, Dong-Kug Choi
| DOI: 10.14336/AD.2025.0642
Apelin: A Promising Therapeutic Target for Degenerative Diseases of the Musculoskeletal System
Jinkun Xu, Hengzhen Li, Jianfeng Sun, Gaoming Liu, Yuming Yao, Dongliang Yuan, Wenfeng Xiao, Yusheng Li
| DOI: 10.14336/AD.2025.0555
Mechanisms and Pathogenesis of Diabetic Cognitive Impairment: A Comprehensive Review
Change Qi, Ming Qin, Yu Wang, Cong Li, Huiying Yan, Lina Feng, Mingquan Li
| DOI: 10.14336/AD.2025.0769
Homeostatic DNMT3a Activity Is Required to Restore Cognition and Hippocampal DNA Methylation in the 5xFAD Model of Alzheimer’s Disease
Yanzhi Liu, Chi Him Poon, Long Sum Rachel Tse, Jaydeep Roy, Charlotte Theodora So, Benjamin Chun-Kit Tong, Kwok-Ming Yao, George Lim Tipoe, Harry Steinbusch, Luca Aquili, Allan Kalueff, King-Ho Cheung, Man-Lung Fung, Lee Wei Lim
| DOI: 10.14336/AD.2025.0283
Supplement

1. Supplementary data.pdf (757KB)

D-2HG Inhibits Glutamine Synthetase Activity and Induces Senescence in IDH-Mutant Gliomas
Yuanlin Zhao, Jiankuan Shi, Yuan Yuan, Ying Yang, Xing Gao, Risheng Yang, Yuying Wang, Lijun Zhang, Jing Li, Peizhen Hu, Yingmei Wang, Chao Sun, Ruili Han, Yuqiao Xu, Zengshan Li, Zhe Wang, Yu Gu, Jing Ye
| DOI: 10.14336/AD.2025.0554
Supplement

1. Supplementary data.pdf (391KB)

Immunosenescence: Driver of Cardiac Aging
Simeng Zhu, Guofang Xia, Yifan Shi, Congfeng Xu
| DOI: 10.14336/AD.2025.0590
Antigen-Specifically Activated CD8+ and Double-Negative T Cells Accumulate in the Brain of Alzheimer’s Disease Mice
Juliane Gellrich, Johanna Ruhnau, Lea Köslich, Stefan Gross, Agnes Flöel, Juliane Schulze, Antje Vogelgesang
| DOI: 10.14336/AD.2025.0452
Supplement

1. Supplementary data.pdf (559KB)

SCAP Interacts with Trim27 to Promote Vascular Neointimal Hyperplasia by Regulating the Stability and Ubiquitination of IκBα
Yingcheng Yao, Xing Wang, Chengcheng Xuan, Da Li, Wenqin Huang, Li Wei, Xiong Z Ruan, Danyang Li, Yaxi Chen
| DOI: 10.14336/AD.2025.0584
Supplement

1. Supplementary data.pdf (1988KB)

Association of Unhealthy Lifestyles with Cataract Risk, and The Mediating Role of Metabolic Signature: Analysis of the UK Biobank Prospective Cohort
Jiao Qi, Kaimeng Su, Keke Zhang, Wenwen He, Jiaqi Meng, Yu Du MD, Yi Lu, Xiangjia Zhu
| DOI: 10.14336/AD.2025.0522
Supplement

1. Supplementary data.pdf (506KB)

Hip Fragility Fractures: One Or Two Pathologies? A Systematic Review and Meta-Analysis of Demographic, Diagnostic and Therapeutic Aspects
José Luis Dinamarca-Montecinos, Miguel Yáñez, Ana Aguilera, Jean-Gabriel Minonzio
| DOI: 10.14336/AD.2025.0414
Supplement

1. Supplementary data.pdf (1155KB)

Cognitive Frailty and Health Care Utilization and Costs Among Middle-Aged and Older Adults: Findings from Four Longitudinal Cohort Studies
Yemin Yuan, Zhenyu Shi, Xiaolong Guan, Yiqi Xia, Yanshang Wang, Huaxin Si, Ping He
| DOI: 10.14336/AD.2025.0722
TGF-β-Driven Atrial Fibrosis in Atrial Fibrillation: From Mechanistic Insights to Targeted Therapies
Chen Chen, Pengfei Chen, Wenxi Yu, Lingli Zhao, Yu Yang, Hua Qu, Changgeng Fu, Dazhuo Shi, Ming Guo
| DOI: 10.14336/AD.2025.0564
Apolipoprotein CII: Cornerstone of Pathophysiological Interplay in Aortic Stenosis and type 2 Diabetes Mellitus
Nerea Corbacho-Alonso, Tamara Sastre-Oliva, Inés Perales-Sánchez, German Hernández-Fernandez, Emilio Blanco-López, Luis F. López-Almodovar, Jorge Solis, Luis R. Padial, Teresa Tejerina, Ana E. Lopez-Jimenez, Laura Mourino-Alvarez, Maria G. Barderas
| DOI: 10.14336/AD.2025.0518
Amyloid Beta Regulates Astrocytic Glucose Metabolism and Insulin Signaling in Experimental Models of Alzheimer’s Disease
Melisa Bentivegna, Carlos Pomilio, Melina Bellotto, Nicolás González Pérez, Soledad P Rossi, Amal Gregosa, Daiana Vota, Fátima Merech, María Marta Bonaventura, Jessica Presa, Ángeles Vinuesa, Victoria Lux-Lantos, Soledad Porte Alcón, Flavia Saravia, Juan Beauquis
| DOI: 10.14336/AD.2025.0484
Supplement

1. Supplementary data.pdf (1145KB)

Exploration and Application of Malignant Cell Heterogeneity Analysis with Single-Cell Transcriptome Sequencing Technology
Wen Zhang, Tianliang Liu, Ting Liu, Yu Zhang, Zhenguo Zhao, Xinxin Zhang, Xiaoyang Li, Jiasheng Zhong, Zhicheng Li, Shifu Chen, Libin Xu
| DOI: 10.14336/AD.2025.0836
Burn Injuries Accelerate Biological Aging and Increase the Epigenetically Inferred Risk of Mortality and Frailty
Fadi Khalaf, Serena Yang, Dalia Barayan, Diana Julia Tedesco, Michael Chong, Guillaume Paré, Marc G. Jeschke
| DOI: 10.14336/AD.2025.0407
Supplement

1. Supplementary data.pdf (301KB)

Insights into Biomarkers of Alzheimer's Disease: From Core Markers to Emerging Directions
Weiyao Zhu, Yu Wang, Ming Qin, Qinghe Zhao, Lina Feng, Mingquan Li
| DOI: 10.14336/AD.2025.0761
Exploring the Cerebro-Renovascular Link: Implications of Renal Haemodynamics on Intracranial Arterial Calcification
Joseph Amihere Ackah, Xiang-yan Chen, Huixing Zeng, Yiming Liu, Youcheng Rong, Xuelong Li, Ben Yuk-fai Fong, Ximin Pan, Feng Zhang, Jing Cai
| DOI: 10.14336/AD.2025.0489
Tissue Fibrosis Decoded via Cellular Senescence: Mechanisms, Treatments, and Emerging Technologies
Wenjie Cai, Haoyu Zhang, Zhouzhou Li, Mingyun Cai, Shiwen Yu, Peng Chen, Xinyu Song
| DOI: 10.14336/AD.2025.0503
Targeting Ferroptosis to Eliminate Senescent Cells: Mechanisms and Therapeutic Potential
Sanjay Kumar Kureel, Blake B. Rasmussen
| DOI: 10.14336/AD.2025.0141
Advances in the Regulation by Immune Cells of Skeletal Myositis Outcomes
Shuxian Huang, Yongling Zhao, Yuanpeng Xin, Ziqi Yao, Yi Deng, Qihui Cai, Junyi Xie, Ruixue Wang, Zhaohong Liao
| DOI: 10.14336/AD.2025.0549