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Just Accepted
The manuscripts published below have been examined by the peer-review process and have been accepted for publication. A “Just Accepted” manuscript is published online shortly after its acceptance, which is prior to technical editing and formatting and author proofing. Higher Education Press (HEP) provides “Just Accepted” as an optional and free service which allows authors to make their results available to the research community as soon as possible after acceptance. After a manuscript has been technically edited and formatted, it will be removed from the “Just Accepted” Web site and published as an Online First article. Please note that technical editing may introduce minor changes to the manuscript text and/or graphics which may affect the content, and all legal disclaimers that apply to the journal pertain. In no event shall HEP be held responsible for errors or consequences arising from the use of any information contained in these “Just Accepted” manuscripts. To cite this manuscript please use its Digital Object Identifier (DOI(r)), which is identical for all formats of publication.
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The Long-lasting Radioprotective Effect of Caffeic Acid in Mice Exposed to Total Body Irradiation by Modulating Reactive Oxygen Species Generation and Hematopoietic Stem Cell Senescence-Accompanied Long-term Residual Bone Marrow Injury
Hyun-Jaung Sim, Govinda Bhattarai, Joshua Lee, Jeong-Chae Lee, Sung-Ho Kook
Aging and disease    DOI: 10.14336/AD.2019.0208
Accepted: 18 March 2019

Physical Activity and Alzheimer’s Disease: A Narrative Review
Piotr Gronek, Stefan Balko, Joanna Gronek, Adam Zajac, Adam Maszczyk, Roman Celka, Agnieszka Doberska, Wojciech Czarny, Robert Podstawski, Cain C. T. Clark, Fang Yu
Aging and disease    DOI: 10.14336/AD.2019.0226
Accepted: 12 March 2019

Plasma Lipoprotein-associated Phospholipase A2 and Superoxide Dismutase are Independent Predicators of Cognitive Impairment in Cerebral Small Vessel Disease Patients: Diagnosis and Assessment
Shuzhen Zhu, Xiaobo Wei, Xiaohua Yang, Zifeng Huang, Zihan Chang, Fen Xie, Qin Yang, Wei Xiang, Hongjun Yang, Changhai Ding, Ying Xia, Zhong-Ping Feng, Hong-Shuo Sun, Midori A. Yenari, Lin Shi, Vincent CT Mok, Qing Wang
Aging and disease    DOI: 10.14336/AD.2019.0304
Accepted: 06 March 2019

Verapamil Ameliorates Motor Neuron Degeneration and Improves Lifespan in the SOD1G93A Mouse Model of ALS by Enhancing Autophagic Flux
Xiaojie Zhang, Sheng Chen, Kaili Lu, Feng Wang, Jiangshan Deng, Zhouwei Xu, Xiuzhe Wang, Qinming Zhou, Weidong Le, Yuwu Zhao
Aging and disease    DOI: 10.14336/AD.2019.0228
Accepted: 03 March 2019

Five-Minute Cognitive Test as A New Quick Screening of Cognitive Impairment in The Elderly
Jie Zhang, Lijun Wang, Xia Deng, Guoqiang Fei, Lirong Jin, Xiaoli Pan, Liuhan Cai, Anthony D. Albano, Chunjiu Zhong
Aging and disease    DOI: 10.14336/AD.2019.0115
Accepted: 02 March 2019

Genetic Spectrum and Variability in Chinese Patients with Amyotrophic Lateral Sclerosis
Zhi-Jun Liu, Hui-Xia Lin, Qiao Wei, Qi-Jie Zhang, Cong-Xin Chen, Qing-Qing Tao, Gong-Lu Liu, Wang Ni, Aaron D. Gitler, Hong-Fu Li, Zhi-Ying Wu
Aging and disease    DOI: 10.14336/AD.2019.0215
Accepted: 02 March 2019

Novel Role of Lck in Leptin-Induced Inflammation and Implications for Renal Aging
Dae Hyun Kim, June Whoun Park, Hyoung Oh Jeong, Bonggi Lee, Ki Wung Chung, Yujeong Lee, Hee Jin Jung, Min Kyung Hyun, A Kyoung Lee, Byeong Moo Kim, Jaewon Lee, Byung Pal Yu, Hae Young Chung
Aging and disease    DOI: 10.14336/AD.2019.0218
Accepted: 21 February 2019

Disability Transitions and Health Expectancies among Elderly People Aged 65 Years and Over in China: A Nationwide Longitudinal Study
Chengbei Hou, Yuan Ma, Xinghua Yang, Lixin Tao, Deqiang Zheng, Xiangtong Liu, Xiaonan Wang, Xia Li, Wei Wang, Xianghua Fang, Xiuhua Guo
Aging and disease    DOI: 10.14336/AD.2019.0121
Accepted: 19 February 2019

Frailty Predicts an Increased Risk of End-Stage Renal Disease with Risk Competition by Mortality among 165,461 Diabetic Kidney Disease Patients
Chia-Ter Chao, Jui Wang, Jenq-Wen Huang, Ding-Cheng Chan, Kuo-Liong Chien, on behalf of the COhort of GEriatric Nephrology in NTUHstudy group
Aging and disease    DOI: 10.14336/AD.2019.0216
Accepted: 19 February 2019

Aging Influences Hepatic Microvascular Biology and Liver Fibrosis in Advanced Chronic Liver Disease
Raquel Maeso-Díaz, Martí Ortega-Ribera, Erica Lafoz, Juan José Lozano, Anna Baiges, Rubén Francés, Agustín Albillos, Carmen Peralta, Juan Carlos García-Pagán, Jaime Bosch, Victoria C Cogger, Jordi Gracia-Sancho
Aging and disease    DOI: 10.14336/AD.2019.0127
Accepted: 18 February 2019

Subtyping of Parkinson’s Disease - Where Are We Up To?
Elizabeth Qian, Yue Huang
Aging and disease    DOI: 10.14336/AD.2019.0112
Accepted: 18 February 2019

Pyroptosis in Liver Disease: New Insights into Disease Mechanisms
Jiali Wu, Su Lin, Bo Wan, Bharat Velani, Yueyong Zhu
Aging and disease    DOI: 10.14336/AD.2019.1216
Accepted: 01 February 2019

Emerging Roles of Complement Protein C1q in Neurodegeneration
Cho* Kyoungjoo
Aging and disease    DOI: 10.14336/AD.2019.0118
Accepted: 27 January 2019

AMPK Signaling Regulates the Age-Related Decline of Hippocampal Neurogenesis
Z. Wang Brian, J. Yang Jane, Zhang Hongxia, A. Smith Charity, Jin Kunlin
Aging and disease    DOI: 10.14336/AD.2019.0102
Accepted: 26 January 2019

Significance of Complement System in Ischemic Stroke: A Comprehensive Review
Yuanyuan Ma, Yanqun Liu, Zhijun Zhang, Guo-Yuan Yang
Aging and disease    DOI: 10.14336/AD.2019.0119
Accepted: 25 January 2019
Online available: 12 February 2019

Metformin Alters Locomotor and Cognitive Function and Brain Metabolism in Normoglycemic Mice
Wenjun Li, Kiran Chaudhari, Ritu Shetty, Ali Winters, Xiaofei Gao, Zeping Hu, Woo-Ping Ge, Nathalie Sumien, Michael Forster, Ran Liu, Shao-Hua Yang
Aging and disease    DOI: 10.14336/AD.2019.0120
Accepted: 25 January 2019

Hydroxyurea Facilitates Manifestation of Disease Relevant Phenotypes in Patients-Derived IPSCs-Based Modeling of Late-Onset Parkinson’s Disease
Tan Yuan, Ke Minjing, Huang Zhijian, Chong Cheong-Meng, Cen Xiaotong, Lu Jia-Hong, Yao Xiaoli, Qin Dajiang, Su Huanxing
Aging and disease    DOI: 10.14336/AD.2018.1216
Accepted: 08 January 2019

The Neuronal Activation of Deep Cerebellar Nuclei Is Essential for Environmental Enrichment-Induced Post-Stroke Motor Recovery
Zhang Qun, Wu Jun-fa, Shi Qi-li, Li Ming-yue, Wang Chuan-jie, Wang Xin, Wang Wen-yuan, Wu Yi
Aging and disease    DOI: 10.14336/AD.2018.1220
Accepted: 07 January 2019

The Peptide-Directed Lysosomal Degradation of CDK5 Exerts Therapeutic Effects against Stroke
Zhou Ya-Fan, Wang Jing, Deng Man-Fei, Chi Bin, Wei Na, Chen Jian-Guo, Liu Dan, Yin Xiaoping, Lu Youming, Zhu Ling-Qiang
Aging and disease    DOI: 10.14336/AD.2018.1225
Accepted: 31 December 2018

Handgrip Strength and Pulmonary Disease in the Elderly: What is the Link?
Rafaela Lemos Lima Tatiana, Pinto Almeida Vívian, Sá Ferreira Arthur, Silva Guimarães Fernando, José Lopes Agnaldo
Aging and disease    DOI: 10.14336/AD.2018.1226
Accepted: 31 December 2018

Salsalate Prevents β-Cell Dedifferentiation in OLETF Rats with Type 2 Diabetes through Notch1 Pathway
Han Fei, Li Xiaochen, Yang Juhong, Liu Haiyi, Zhang Yi, Yang Xiaoyun, Yang Shaohua, Chang Bai, Chen Liming, Chang Baocheng
Aging and disease    DOI: 10.14336/AD.2018.1221
Accepted: 30 December 2018

Collagen XIX Alpha 1 Improves Prognosis in Amyotrophic Lateral Sclerosis
C. Calvo Ana, Atencia Cibreiro Gabriela, Torre Merino Paz, F. Roy Juan, Galiana Adrián, Juárez Rufián Alexandra, M. Cano Juan, A. Martín Miguel, Moreno Laura, Larrodé Pilar, Cordero Vázquez Pilar, Galán Lucía, Mora Jesús, L. Muñoz-Blanco José, J. Muñoz María, Zaragoza Pilar, Pegoraro Elena, Sorarù Gianni, Mora Marina, Lunetta Christian, Penco Silvana, Tarlarini Claudia, Esteban Jesús, Osta Rosario, García Redondo Alberto
Aging and disease    DOI: 10.14336/AD.2018.0917
Accepted: 11 December 2018

The Drainage of Interstitial Fluid in the Deep Brain is Controlled by the Integrity of Myelination
Wang Aibo, Wang Rui, Cui Dehua, Huang Xinrui, Yuan Lan, Liu Huipo, Fu Yu, Liang Lei, Wang Wei, He Qingyuan, Shi Chunyan, Guan Xiangping, Teng Ze, Zhao Guomei, Li Yuanyuan, Gao Yajuan, Han Hongbin
Aging and disease    DOI: 10.14336/AD.2018.1206
Accepted: 08 December 2018
Online available: 08 December 2018

The role of CD2AP in the Pathogenesis of Alzheimer's Disease
Tao Qing-Qing, Chen Yu-Chao, Wu Zhi-Ying
Aging and disease    DOI: 10.14336/AD.2018.1025
Accepted: 08 December 2018

IgE Aggravates the Senescence of Smooth Muscle Cells in Abdominal Aortic Aneurysm by Upregulating LincRNA-p21
Guo Wenjun, Gao Ran, Zhang Wei, Ge Weipeng, Ren Meng, Li Bolun, Zhao Hongmei, Wang Jing
Aging and disease    DOI: 10.14336/AD.2018.1128
Accepted: 06 December 2018

Characterization of Alzheimer’s Disease Using Ultra-high b-values Apparent Diffusion Coefficient and Diffusion Kurtosis Imaging
Xue Yingnan, Zhang Zhenhua, Wen Caiyun, Liu Huiru, Wang Suyuan, Li Jiance, Zhuge Qichuan, Chen Weijian, Ye Qiong
Aging and disease    DOI: 10.14336/AD.2018.1129
Accepted: 03 December 2018

Galectin-3 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension
Li Tangzhiming, Zha Lihuang, Luo Hui, Li Suqi, Zhao Lin, He Jingni, Li Xiaohui, Qi Qiangqiang, Liu Yuwei, Yu Zaixin
Aging and disease    DOI: 10.14336/AD.2018.1001
Accepted: 27 November 2018

Metabolomics Coupled with Transcriptomics Approach Deciphering Age Relevance in Sepsis
Xu Dingqiao, Liao Shanting, Li Pei, Zhang Qian, Lv Yan, Fu Xiaowei, Yang Minghua, Wang Junsong, Kong Lingyi
Aging and disease    DOI: 10.14336/AD.2018.1027
Accepted: 26 November 2018

Increased Serum Matrix Metalloproteinase-9 Levels are Associated with Anti-Jo1 but not Anti-MDA5 in Myositis Patients
Liu Yanjuan, Luo Hui, Wang Li, Li Caiyan, Liu Liyun, Huang Li, Liu Ke, Liu Meidong, Gao Siming, Xiao Yizhi, Zhu Honglin, Zuo Xiaoxia, Li Quan-Zhen, Zhang Huali
Aging and disease    DOI: 10.14336/AD.2018.1120
Accepted: 26 November 2018
Online available: 27 November 2018

Rejuvenating Strategies of Tissue-specific Stem Cells for Healthy Aging
Wang Minjun, Chen Jiajia, Chen Fei, Liu Qinggui, Sun Yu, Yan Chen, Yang Tao, Bao Yiwen, Hu Yi-Ping
Aging and disease    DOI: 10.14336/AD.2018.1119
Accepted: 26 November 2018

Two Novel Mutations and a de novo Mutation in PSEN1 in Early-onset Alzheimer’s Disease
Li Yu-Sheng, Yang Zhi-Hua, Zhang Yao, Yang Jing, Shang Dan-Dan, Zhang Shu-Yu, Wu Jun, Ji Yan, Zhao Lu, Shi Chang-He, Xu Yu-Ming
Aging and disease    DOI: 10.14336/AD.2018.1109
Accepted: 23 November 2018

Interplay between Exosomes and Autophagy in Cardiovascular Diseases: Novel Promising Target for Diagnostic and Therapeutic Application
Tian Jinfan, Sharif Popal Mohammad, Zhao Yingke, Liu Yanfei, Chen Keji, Liu Yue
Aging and disease    DOI: 10.14336/AD.2018.1020
Accepted: 20 November 2018

Health and Aging: Unifying Concepts, Scores, Biomarkers and Pathways
Fuellen Georg, Jansen Ludger, A. Cohen Alan, Luyten Walter, Gogol Manfred, Simm Andreas, Saul Nadine, Cirulli Francesca, Berry Alessandra, Antal Peter, Köhling Rüdiger, Wouters Brecht, Möller Steffen
Aging and disease    DOI: 10.14336/AD.2018.1030
Accepted: 19 November 2018

Entorhinal Cortex Atrophy in Early, Drug-naive Parkinson’s Disease with Mild Cognitive Impairment
Jia Xiuqin, Wang Zhijiang, Yang Tao, Li Ying, Gao Shuai, Wu Guorong, Jiang Tao, Liang Peipeng
Aging and disease    DOI: 10.14336/AD.2018.1116
Accepted: 18 November 2018
Online available: 18 November 2018

Role of Regulatory T cells in Atorvastatin Induced Absorption of Chronic Subdural Hematoma in Rats
Quan Wei, Zhang Zhifei, Li Pan, Tian Qilong, Huang Jinhao, Qian Yu, Gao Chuang, Su Wanqiang, Wang Zengguang, Zhang Jianning, Zacharek Alex, Venkat Poornima, Chen Jieli, Jiang Rongcai
Aging and disease    DOI: 10.14336/AD.2018.0926
Accepted: 16 November 2018

TNF𝛼-induced Up-regulation of Ascl2 Affects the Differentiation and Proliferation of Neural Stem Cells
Liu Zhongfeng, Wang Xuan, Jiang Kewen, Ji Xunming, Alex Zhang Y., Chen Zhiguo
Aging and disease    DOI: 10.14336/AD.2018.1028
Accepted: 16 November 2018

The Potential Markers of Circulating microRNAs and long non-coding RNAs in Alzheimer's Disease
Zhao Yanfang, Zhang Yuan, Zhang Lei, Dong Yanhan, Hongfang Ji, Liang Shen
Aging and disease    DOI: 10.14336/AD.2018.1105
Accepted: 13 November 2018

Processing of Mutant β-Amyloid Precursor Protein and the Clinicopathological Features of Familial Alzheimer’s Disease
Bi Christopher, Bi Stephanie, Li Bin
Aging and disease    DOI: 10.14336/AD.2018.0425
Accepted: 12 November 2018

Autophagy Activation is Associated with Neuroprotection in Diabetes-associated Cognitive Decline
Wu Yanqing, Ye Libing, Yuan Yuan, Jiang Ting, Guo Xin, Wang Zhouguang, Xu Ke, Xu Zeping, Liu Yanlong, Zhong Xingfeng, Ye Junmin, Zhang Hongyu, Li Xiaokun, Xiao Jian
Aging and disease    DOI: 10.14336/AD.2018.1024
Accepted: 12 November 2018

Anatomical Links between White Matter Hyperintensity and Medial Temporal Atrophy Reveal Impairment of Executive Functions
Yamanaka Takehiko, Uchida Yuto, Sakurai Keita, Kato Daisuke, Mizuno Masayuki, Sato Toyohiro, Madokoro Yuta, Kondo Yuko, Suzuki Ayuko, Ueki Yoshino, Ishii Fumiyasu, V Borlongan Cesar, Matsukawa Noriyuki
Aging and disease    DOI: 10.14336/AD.2018.0929
Accepted: 09 November 2018

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