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The manuscripts published below have been examined by the peer-review process and have been accepted for publication. A "Early edition" manuscript is published online shortly after its acceptance, which is prior to technical editing and formatting and author proofing. Higher Education Press (HEP) provides "Early edition" as an optional and free service which allows authors to make their results available to the research community as soon as possible after acceptance. After a manuscript has been technically edited and formatted, it will be removed from the "Early edition" Web site and published as an Online First article. Please note that technical editing may introduce minor changes to the manuscript text and/or graphics which may affect the content, and all legal disclaimers that apply to the journal pertain. In no event shall HEP be held responsible for errors or consequences arising from the use of any information contained in these "Early edition" manuscripts. To cite this manuscript please use its Digital Object Identifier (DOI(r)), which is identical for all formats of publication.

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Intensive Lipid-Lowering Therapy Ameliorates Asymptomatic Intracranial Atherosclerosis

Miao Huijuan,Yang Yujiao,Wang Han,Huo Linyu,Wang Mengnan,Zhou Yinghua,Hua Yang,Ren Ming,Ren Changhong,Ji Xunming,Yang Qi,Guo Xiuhai

Aging and Disease DOI: 10.14336/AD.2018.0526

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Rosenroot (Rhodiola): Potential Applications in Aging-related Diseases

Zhuang Wei,Yue Lifeng,Dang Xiaofang,Chen Fei,Gong Yuewen,Lin Xiaolan,Luo Yumin

Aging and Disease DOI: 10.14336/AD.2018.0511

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Involvement of the MiR-181b-5p/HMGB1 Pathway in Ang II-induced Phenotypic Transformation of Smooth Muscle Cells in Hypertension

Feng-Juan Li, Cheng-Long Zhang, Xiu-Ju Luo, Jun Peng, Tian-Lun Yang

Aging and Disease DOI: 10.14336/AD.2018.0510

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The Whole Exome Sequencing Clarifies the Genotype- Phenotype Correlations in Patients with Early-Onset Dementia

Yangqi Xu, Xiaoli Liu, Junyi Shen, Wotu Tian, Rong Fang, Binyin Li, Jianfang Ma, Li Cao, Shengdi Chen, Guanjun LI, Huidong Tang

Aging and Disease DOI: 10.14336/AD.2018.0208

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Increased Serum C-reactive Protein and Corpus Callosum Alterations in Older Adults

Fabienne Cyprien, Philippe Courtet, Jerome Maller, Chantal Meslin, Karen Ritchie, Marie-Laure Ancelin, Sylvaine Artero

Aging and Disease DOI: 10.14336/AD.2018.0329

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Snapshot: Implications for mTOR in Aging-related Ischemia/Reperfusion Injury

Dong Liu, Liqun Xu, Xiaoyan Zhang, Changhong Shi, Shubin Qiao, Zhiqiang Ma, Jiansong Yuan

Aging and Disease DOI: 10.14336/AD.2018.0501

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Overweight in the Elderly Induces a Switch in Energy Metabolism that Undermines Muscle Integrity

Yaiza Potes, Zulema Perez-Martinez, Juan C. Bermejo-Millo Juan, Adrian Rubio-Gonzalez, Maria Fernandez-Fernandez, Manuel Bermudez, et al.

Aging and Disease DOI: 10.14336/AD.2018.0430

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Elevated Inflammatory Status and Increased Risk of Chronic Disease in Chronological Aging: Inflamm-aging or Inflamm-inactivity?

Michael G. Flynn, Melissa M. Markofski, Andres E. Carrillo

Aging and Disease DOI: 10.14336/AD.2018.0326

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Traditional Oriental Medicines and Alzheimer’s Disease

Seong Gak Jeon, Eun Ji Song, Dongje Lee, Junyong Park, Yunkwon Nam, Jin-il Kim, Minho Moon

Aging and Disease DOI: 10.14336/AD.2018.0328

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Quantitative Evaluation of Gait Disturbance on an Instrumented Timed Up-and-go Test

Shigeki Yamada, Yukihiko Aoyagi, Kazuo Yamamoto, Masatsune Ishikawa

Aging and Disease DOI: 10.14336/AD.2018.0426

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Processing of Mutant β-Amyloid Precursor Protein and the Clinicopathological Features of Familial Alzheimer’s Disease

Christopher Bi, Stephanie Bi, Bin Li

Aging and Disease DOI: 10.14336/AD.2018.0425

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Prospective Study of Glycated Hemoglobin and Trajectories of Depressive Symptoms: The China Health and Retirement Longitudinal Study

Haibin Li, Anxin Wang, Wei Feng, Deqiang Zheng, Qi Gao, Lixin Tao, Jin Guo, Xiaonan Wang, Xia Li, Wei Wang, Xiuhua Guo

Aging and Disease DOI: 10.14336/AD.2018.0410

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MicroRNAs and the Genetic Nexus of Brain Aging, Neuroinflammation, Neurodegeneration, and Brain Trauma

Saumyendra N. Sarkar, Ashley E. Russell, Elizabeth B. Engler-Chiurazzi, Keyana N. Porter, James W. Simpkins

Aging and Disease DOI: 10.14336/AD.2018.0409

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Influence of Environment and Lifestyle on Incidence and Progress of Amyotrophic Lateral Sclerosis in A German ALS Population

Korner Sonja, Kammeyer Johanna, Zapf Antonia, Kuzma-Kozakiewicz Magdalena, Piotrkiewicz Maria, Kuraszkiewicz Bo, enna, Goszczynska Hanna, Gromicho Marta, Grosskreutz Julian, M. Andersen Peter, de Carvalho Mamede, Petri Susanne

Aging and Disease DOI: 10.14336/AD.2018.0327

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Age-Related Changes in Femoral Head Trabecular Microarchitecture

Charlene Greenwood, John Clement, Anthony Dicken, Paul Evans, Iain Lyburn, Richard M. Martin, Nick Stone, Peter Zioupos, Keith Rogers

Aging and Disease DOI: 10.14336/AD.2018.0124

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Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept

Young Chung Hae, Hyun Kim Dae, Kyeong Lee Eun, Wung Chung Ki, Chung Sangwoon, Lee Bonggi, Y. Seo Arnold, Heun Chung Jae, Suk Jung Young, Im Eunok, Lee Jaewon, Deuk Kim Nam, Ja Choi Yeon, Soon Im Dong, Pal Yu Byung

Aging and Disease DOI: 10.14336/AD.2018.0324

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Aging and End Stage Renal Disease Cause A Decrease in Absolute Circulating Lymphocyte Counts with A Shift to A Memory Profile and Diverge in Treg Population

Geraldo Rubens Ramos Freitas, Maria da Luz Fernandes, Fabiana Agena, Omar Jaluul, Sergio Colenci Silva, Francine Brambate Carvalhinho Lemos, Veronica Coelho, Elias David-Neto, Nelson Zocoler Galante

Aging and Disease DOI: 10.14336/AD.2018.0318

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Prospective Views for Whey Protein and/or Resistance Training Against Age-related Sarcopenia

Yuxiao Liao, Zhao Peng, Liangkai Chen, Yan Zhang, Qian Cheng, Andreas K. Nussler, Wei Bao, Liegang Liu, Wei Yang

Aging and Disease DOI: 10.14336/AD.2018.0325

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miRNA-10b Reciprocally Stimulates Osteogenesis and Inhibits Adipogenesis Partly Through the TGF-β/SMAD2 Signaling Pathway

Hongling Li, Junfen Fan, Linyuan Fan, Tangping Li, Yanlei Yang, Haoying Xu, Luchan Deng, Jing Li, Tao Li, Xisheng Weng, Shihua Wang, Chunhua Robert Zhao

Aging and Disease DOI: 10.14336/AD.2018.0214

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Relationship between Hypothyroidism and Endometrial Cancer

Wang Yiqin,Zhou Rong,Wang Jianliu

Aging and Disease DOI: 10.14336/AD.2018.0224

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Vitamin D Receptor in Muscle Atrophy of Elderly Patients: A Key Element of Osteoporosis-Sarcopenia Connection

Manuel Scimeca, Federica Centofanti, Monica Celi, Elena Gasbarra, Giuseppe Novelli, Annalisa Botta, Umberto Tarantino

Aging and Disease DOI: 10.14336/AD.2018.0215

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Increased Inflammatory Response in Old Mice is Associated with More Severe Neuronal Injury at the Acute Stage of Ischemic Stroke

Shen Fanxia,Jiang Lidan,Han Frank,Degos Vincent,Chen Shengdi,Su Hua

Aging and Disease DOI: 10.14336/AD.2018.0205

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DRAM is Involved in Hypoxia/Ischemia-Induced Autophagic Apoptosis in Hepatocytes

Xu Jianji,Zang Yunjin,Liu Dongjie,Yang Tongwang,Wang Jieling,Wang Yanjun,Liu Xiaoni,Chen Dexi

Aging and Disease DOI: 10.14336/AD.2018.0210

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A Transcriptome Study of Progeroid Neurocutaneous Syndrome Reveals POSTN As a New Element in Proline Metabolic Disorder

Yu-Wen Huang, Ming-Fu Chiang, Che-Sheng Ho, Pi-Lien Hung, Mei-Hsin Hsu, Tsung-Han Lee, Julie Lichieh Chu, Hsuan Liu, Petrus Tang, Victor Wailap Ng, Dar-Shong Lin

Aging and Disease DOI: 10.14336/AD.2018.0222

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Intracranial Atherosclerosis Burden and Stroke Recurrence for Symptomatic Intracranial Artery Stenosis (sICAS)

Sun Ping, Liu Liping, Pan Yuesong, Wang Xianwei, Mi Donghua, Pu Yuehua, Liu Xin, Duan Wanying, Yan Hongyi, Wang Chunxue, Zhao Xingquan, Wang Yilong, Wang Yongjun, on behalf of CICAS investigators

Aging and Disease DOI: 10.14336/AD.2018.0301

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Omi/HtrA2 Participates in Age-Related Autophagic Deficiency in Rat Liver

Xu Jiahui,Jiao Kun,Liu Xin,Sun Qi,Wang Ke,Xu Haibo,Zhang Shangyue,Wu Ye,Wu Linguo,Liu Dan,Wang Wen,Liu Huirong

Aging and Disease DOI: 10.14336/AD.2018.0221

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Kidney Disease in Elderly: Importance of Collaboration between Geriatrics and Nephrology

Faheemuddin Azher Ahmed

Aging and Disease DOI: 10.14336/AD.2018.0223

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Chronic Kidney Disease Is Linked to Carotid Nodular Calcification, An Unstable Plaque Not Correlated to Inflammation

Cardellini Marina, Rovella Valentina, Scimeca Manuel, Anemona Lucia, Bischetti Simone, Casella Sara, Saggini Andrea, Bonanno Elena, Ballanti Marta, Davato Francesca, Menghini Rossella, Ippoliti Arnaldo, Santeusanio Giuseppe, Di Daniele Nicola, Federici Massimo, Mauriello Alessandro

Aging and Disease DOI: 10.14336/AD.2018.0117

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Glycation Damage: A Possible Hub for Major Pathophysiological Disorders and Aging

Maxime Fournet, Frederic Bontee, Alexis Desmouliere

Aging and Disease DOI: 10.14336/AD.2017.1121

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REST rs3796529 Genotype and Rate of Functional Deterioration in Alzheimer's Disease

Poyin Huang, Cheng-Sheng Chen, Yuan-Han Yang, Mei-Chuan Chou, Ya-Hsuan Chang, Chiou-Lian Lai, Hsuan-Yu Chen, Ching-Kuan Liu

Aging and Disease DOI: 10.14336/AD.2018.0116

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