Aging and disease

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01 October 2019. VOL 10, ISSUE 5 Previous Issue Next Issue

Orginal Article

Clinical and Genetic Profiles in Chinese Patients with Huntington’s Disease: A Ten-year Multicenter Study in China
Hong-Lei Li, Xiao-Yan Li, Yi Dong, Yan-Bin Zhang, Hong-Rong Cheng, Shi-Rui Gan, Zhi-Jun Liu, Wang Ni, Jean-Marc Burgunder, X. William Yang, Zhi-Ying Wu

2019, 10 (5): 1003-1011 | DOI: 10.14336/AD.2018.0911

PDF (681KB)
Intravenous Administration of Standard Dose Tirofiban after Mechanical Arterial Recanalization is Safe and Relatively Effective in Acute Ischemic Stroke
Zhe Cheng, Xiaokun Geng, Jie Gao, Mohammed Hussain, Seong-Jin Moon, Huishan Du, Yuchuan Ding

2019, 10 (5): 1049-1057 | DOI: 10.14336/AD.2018.0922

PDF (688KB)
Autoantibodies against AT1 Receptor Contribute to Vascular Aging and Endothelial Cell Senescence
Meili Wang, Xiaochen Yin, Suli Zhang, Chenfeng Mao, Ning Cao, Xiaochun Yang, Jingwei Bian, Weiwei Hao, Qian Fan, Huirong Liu

2019, 10 (5): 1012-1025 | DOI: 10.14336/AD.2018.0919

PDF (1161KB)
Supplement

1. Supplemental data.pdf (576KB)
Calcitriol Analogues Decrease Lung Metastasis but Impair Bone Metabolism in Aged Ovariectomized Mice Bearing 4T1 Mammary Gland Tumours
Artur Anisiewicz, Beata Filip-Psurska, Agata Pawlik, Anna Nasulewicz-Goldeman, Tomasz Piasecki, Konrad Kowalski, Magdalena Maciejewska, Joanna Jarosz, Joanna Banach, Diana Papiernik, Andrzej Mazur, Andrzej Kutner, Jeanette A Maier, Joanna Wietrzyk

2019, 10 (5): 977-991 | DOI: 10.14336/AD.2018.0921

PDF (1691KB)
Supplement

1. .pdf (239KB)
Role of Regulatory T cells in Atorvastatin Induced Absorption of Chronic Subdural Hematoma in Rats
Wei Quan, Zhifei Zhang, Pan Li, Qilong Tian, Jinhao Huang, Yu Qian, Chuang Gao, Wanqiang Su, Zengguang Wang, Jianning Zhang, Alex Zacharek, Poornima Venkat, Jieli Chen, Rongcai Jiang

2019, 10 (5): 992-1002 | DOI: 10.14336/AD.2018.0926

PDF (1084KB)
Characterization of Alzheimer’s Disease Using Ultra-high b-values Apparent Diffusion Coefficient and Diffusion Kurtosis Imaging
Yingnan Xue, Zhenhua Zhang, Caiyun Wen, Huiru Liu, Suyuan Wang, Jiance Li, Qichuan Zhuge, Weijian Chen, Qiong Ye

2019, 10 (5): 1026-1036 | DOI: 10.14336/AD.2018.1129

PDF (862KB)
The Drainage of Interstitial Fluid in the Deep Brain is Controlled by the Integrity of Myelination
Aibo Wang, Rui Wang, Dehua Cui, Xinrui Huang, Lan Yuan, Huipo Liu, Yu Fu, Lei Liang, Wei Wang, Qingyuan He, Chunyan Shi, Xiangping Guan, Ze Teng, Guomei Zhao, Yuanyuan Li, Yajuan Gao, Hongbin Han

2019, 10 (5): 937-948 | DOI: 10.14336/AD.2018.1206

PDF (1529KB)
Supplement

1. .pdf (553KB)

Short Communications

The Peptide-Directed Lysosomal Degradation of CDK5 Exerts Therapeutic Effects against Stroke
Ya-Fan Zhou, Jing Wang, Man-Fei Deng, Bin Chi, Na Wei, Jian-Guo Chen, Dan Liu, Xiaoping Yin, Youming Lu, Ling-Qiang Zhu

2019, 10 (5): 1140-1145 | DOI: 10.14336/AD.2018.1225

PDF (954KB)
Supplement

1. .pdf (458KB)

Review Article

Handgrip Strength and Pulmonary Disease in the Elderly: What is the Link?
Tatiana Rafaela Lemos Lima, Vívian Pinto Almeida, Arthur Sá Ferreira, Fernando Silva Guimarães, Agnaldo José Lopes

2019, 10 (5): 1109-1129 | DOI: 10.14336/AD.2018.1226

PDF (1124KB)

Orginal Article

Hydroxyurea Facilitates Manifestation of Disease Relevant Phenotypes in Patients-Derived IPSCs-Based Modeling of Late-Onset Parkinson’s Disease
Yuan Tan, Minjing Ke, Zhijian Huang, Cheong-Meng Chong, Xiaotong Cen, Jia-Hong Lu, Xiaoli Yao, Dajiang Qin, Huanxing Su

2019, 10 (5): 1037-1048 | DOI: 10.14336/AD.2018.1216

PDF (1828KB)
Metformin Alters Locomotor and Cognitive Function and Brain Metabolism in Normoglycemic Mice
Wenjun Li, Kiran Chaudhari, Ritu Shetty, Ali Winters, Xiaofei Gao, Zeping Hu, Woo-Ping Ge, Nathalie Sumien, Michael Forster, Ran Liu, Shao-Hua Yang

2019, 10 (5): 949-963 | DOI: 10.14336/AD.2019.0120

PDF (1429KB)
Supplement

1. .pdf (138KB)
AMPK Signaling Regulates the Age-Related Decline of Hippocampal Neurogenesis
Brian Z Wang, Jane J Yang, Hongxia Zhang, Charity A Smith, Kunlin Jin

2019, 10 (5): 1058-1074 | DOI: 10.14336/AD.2019.0102

PDF (1870KB)

Review Article

Subtyping of Parkinson’s Disease - Where Are We Up To?
Elizabeth Qian, Yue Huang

2019, 10 (5): 1130-1139 | DOI: 10.14336/AD.2019.0112

PDF (404KB)
Supplement

1. test.png (2KB)

Orginal Article

Dl-3-n-butylphthalide Reduces Neurovascular Inflammation and Ischemic Brain Injury in Mice
Chun-Sheng Yang, Ai Guo, Yulin Li, Kaibin Shi, Fu-Dong Shi, Minshu Li

2019, 10 (5): 964-976 | DOI: 10.14336/AD.2019.0608

PDF (1140KB)
A Model of Chronic Temporal Lobe Epilepsy Presenting Constantly Rhythmic and Robust Spontaneous Seizures, Co-morbidities and Hippocampal Neuropathology
Dinesh Upadhya, Maheedhar Kodali, Daniel Gitai, Olagide W Castro, Gabriele Zanirati, Raghavendra Upadhya, Sahithi Attaluri, Eeshika Mitra, Bing Shuai, Bharathi Hattiangady, Ashok K Shetty

2019, 10 (5): 915-936 | DOI: 10.14336/AD.2019.0720

PDF (1869KB)

Review Article

Preclinical Evidence and Possible Mechanisms of Extracts or Compounds from Cistanches for Alzheimer’s Disease
Xiao-Li Zhou, Meng-Bei Xu, Ting-Yu Jin, Pei-Qing Rong, Guo-Qing Zheng, Yan Lin

2019, 10 (5): 1075-1093 | DOI: 10.14336/AD.2018.0815-1

PDF (2138KB)
Pyroptosis in Liver Disease: New Insights into Disease Mechanisms
Jiali Wu, Su Lin, Bo Wan, Bharat Velani, Yueyong Zhu

2019, 10 (5): 1094-1108 | DOI: 10.14336/AD.2019.0116

PDF (565KB)

Cover Illustration

01 October 2019. Vol.10 No.5
ISF drainage routes in normal rats and demyelinated rats. Due to the obstruction of the compact myelinated fibre tracts (yellow frame and yellow arrow), the traced ISF from the caudate nucleus (Cn)(pink arrow) could not drain to the ECS of the thalamus (Tha) and vice versa, even though these two regions are adjacent to one another. Myelin is identified as the transportation barrier to ISF drainage in the deep brain. At the meantime, it guides the ISF in the caudate nucleus draining to ipsilateral cortex and finally into the subarachnoid space, which maintains the pathway of ISF-CSF exchange. When the integrity of myelin is interrupted (white frame and white arrow), abnormal communication of ISF from the two regions emerges which indicates that the ISF from caudate nucleus (pink arrow) could be drained into the adjacent thalamus (red arrow) and less ISF from caudate nucleus could be drained to the cortex regions. Then the local homeostasis was interrupted. This is a schematic figure for identification purpose and is not be scale.

[Detail]

Cover Illustration

ISF drainage routes in normal rats and demyelinated rats. Due to the obstruction of the compact myelinated fibre tracts (yellow frame and yellow arrow), the traced ISF from the caudate nucleus (Cn)(pink arrow) could not drain to the ECS of the thalamus (Tha) and vice versa, even though these two regions are adjacent to one another. Myelin is identified as the transportation barrier to ISF drainage in the deep brain. At the meantime, it guides the ISF in the caudate nucleus draining to ipsilateral cortex and finally into the subarachnoid space, which maintains the pathway of ISF-CSF exchange. When the integrity of myelin is interrupted (white frame and white arrow), abnormal communication of ISF from the two regions emerges which indicates that the ISF from caudate nucleus (pink arrow) could be drained into the adjacent thalamus (red arrow) and less ISF from caudate nucleus could be drained to the cortex regions. Then the local homeostasis was interrupted. This is a schematic figure for identification purpose and is not be scale.

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