Aging and disease

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Total 40 results are found

Exercise-Induced Central Fatigue: Biomarkers and Non-Medicinal Interventions Ying Yang, Zhi Feng, Yu-hang Luo, Jue-miao Chen, Yu Zhang, Yi-jun Liao, Hui Jiang, Yinxi Long, Bo Wei: 2025, 16 (3): 1302-1315 | DOI: 10.14336/AD.2024.0567; PDF (469KB)

Long-Term Improvement in Hippocampal-Dependent Learning Ability in Healthy, Aged Individuals Following High Intensity Interval Training Daniel G. Blackmore, Mia A. Schaumberg, Maryam Ziaei, Samuel Belford, Xuan Vinh To, Imogen O’Keeffe, Anne Bernard, Jules Mitchell, Emily Hume, Grace L. Rose, Thomas Shaw, Ashley York, Markus Barth, Elizabeth J. Cooper, Tina L. Skinner, Fatima Nasrallah, Stephan Riek, Perry F. Bartlett: 2025, 16 (3): 1732-1754 | DOI: 10.14336/AD.2024.0642; PDF (1507KB)
Supplement; 1. Supplementary data.pdf (6754KB)

Cerebral Small Vessel Disease: Current and Emerging Therapeutic Strategies Yuewen Sun, Xiaoqian Song, Chenyang Jin, Yilong Peng, Jing Zhou, Xueping Zheng: 2026, 17 (1): 286-303 | DOI: 10.14336/AD.2024.1515; PDF (567KB)

The Expanding Burden of Neurodegenerative Diseases: An Unmet Medical and Social Need Shu Wang, Yin Jiang, Anchao Yang, Fangang Meng, Jianguo Zhang: 2025, 16 (5): 2937-2952 | DOI: 10.14336/AD.2024.1071; PDF (1253KB)

Therapeutic Potential of Quercetin as an Antioxidant for Bone-Muscle-Tendon Regeneration and Aging Jae Gyu Kim, Ashish Ranjan Sharma, Yeon-Hee Lee, Srijan Chatterjee, Yean Jung Choi, Roshani Rajvansh, Chiranjib Chakraborty, Sang-Soo Lee: 2025, 16 (3): 1414-1437 | DOI: 10.14336/AD.2024.0282; PDF (696KB)

Aging and “Age-Related” Diseases - What Is the Relation? Wolfgang Kopp: 2025, 16 (3): 1316-1346 | DOI: 10.14336/AD.2024.0570; PDF (802KB)

Deformability of Heterogeneous Red Blood Cells in Aging and Related Pathologies Dmitry S. Prudinnik, Aigul Kussanova, Ivan A. Vorobjev, Alexander Tikhonov, Fazly I. Ataullakhanov, Natasha S. Barteneva: 2025, 16 (3): 1242-1264 | DOI: 10.14336/AD.2024.0526; PDF (1188KB)

Green Tea Mitigates the Hallmarks of Aging and Age-Related Multisystem Deterioration Yusuf Yilmaz: 2026, 17 (2): 712-730 | DOI: 10.14336/AD.2025.0398; PDF (711KB)

Mitochondrial Dysfunction: A Roadmap for Understanding and Tackling Cardiovascular Aging Han Zhang, Mairedan Muhetarijiang, Ryan J. Chen, Xiaosheng Hu, Jie Han, Liangrong Zheng, Ting Chen: 2025, 16 (5): 2575-2614 | DOI: 10.14336/AD.2024.0058; PDF (1586KB)

The Role of the Complement System in Synaptic Pruning after Stroke Hongying Liu, Min Jiang, Zhiying Chen, Chuan Li, Xiaoping Yin, Xiaorong Zhang, Moxin Wu: 2025, 16 (3): 1452-1470 | DOI: 10.14336/AD.2024.0373; PDF (897KB)

Gut Microbiota and Its Metabolites: The Emerging Bridge Between Coronary Artery Disease and Anxiety and Depression? Haiyang Chen, Lijun Zhang, Yanwei Li, Xiangxi Meng, Yunpeng Chi, Meiyan Liu: 2025, 16 (3): 1265-1284 | DOI: 10.14336/AD.2024.0538; PDF (625KB)

Age-Associated Activation of the cGAS-STING Pathway and Impairment of DNA Damage Repair in Human Primary Alveolar Type II Cells Chih-Ru Lin, Hassan Hayek, Hannah Simborio, Loukmane Karim, Karim Bahmed, Sudhir Bolla, Nathaniel Marchetti, Gerard J. Criner, Ying Tian, Beata Kosmider: 2026, 17 (1): 367-382 | DOI: 10.14336/AD.2024.1175; PDF (1357KB)

Targeting the Ophthalmic Diseases Using Extracellular Vesicles ‘Exosomes’: Current Insights on Their Clinical Approval and Present Trials Hanxiang Yu, Jinsong Wu, Gaoxiang Pan: 2025, 16 (3): 1225-1241 | DOI: 10.14336/AD.2024.0535; PDF (860KB)

Exercise as a Metabolic Regulator: Targeting AMPK/mTOR-Autophagy Crosstalk to Counteract Sarcopenic Obesity Daoqi Zhang, Congfei Lu, Kai Sang: | DOI: 10.14336/AD.2025.0419; PDF (509KB)

Recent Advances in Our Understanding of Age-Related Macular Degeneration: Mitochondrial Dysfunction, Redox Signaling, and the Complement System Francesco Buonfiglio, Christina A. Korb, Bernhard Stoffelns, Norbert Pfeiffer, Adrian Gericke: 2025, 16 (3): 1535-1575 | DOI: 10.14336/AD.2024.0124; PDF (1735KB)

Enhanced Chondrogenic Potential and Osteoarthritis Treatment Using Cyaonoside A-Induced MSC Delivered via a Hyaluronic Acid-Based Hydrogel System Xingyan An, Qirong Zhou, Shihao Sheng, Anfu Deng, Han Liu, Xiuhui Wang, Qin Zhang, Yingying Jing, Ke Xu, Chongru He, Robert Chunhua Zhao, Jiacan Su: 2026, 17 (1): 466-482 | DOI: 10.14336/AD.2024.10016; PDF (1816KB)
Supplement; 1. Supplementary data.pdf (810KB)

Brain Iron Dyshomeostasis and Ferroptosis in Alzheimer’s Disease Pathophysiology: Two Faces of the Same Coin Mariarosa Mezzanotte, Serena Stanga: 2025, 16 (5): 2615-2640 | DOI: 10.14336/AD.2024.0094; PDF (967KB)

Towards Precision Aging Biology: Single-Cell Multi-Omics and Advanced AI-Driven Strategies Sijia Xie, Xinwei Luo, Feitong Hong, Yijie Wei, Yuduo Hao, Xueqin Xie, Xiaolong Li, Guangbo Xie, Fuying Dao, Hao Lyu: 2026, 17 (2): 907-926 | DOI: 10.14336/AD.2025.0218; PDF (819KB)

Excitotoxicity, Oxytosis/Ferroptosis, and Neurodegeneration: Emerging Insights into Mitochondrial Mechanisms Sameera Khan, Nargis Bano, Shakir Ahamad, Urmilla John, Nawab John Dar, Shahnawaz Ali Bhat: 2025, 16 (5): 2504-2543 | DOI: 10.14336/AD.2024.0125-1; PDF (1706KB)
Supplement; 1. Supplementary data.pdf (290KB)

Epigenetic Dysregulation and Osteocyte Senescence: Convergent Drivers of Osteosarcopenia in Aging Bone and Muscle Shahneela Nusrat, Rahman Ud Din, Muhammad Akram Tariq, Haisheng Yang: | DOI: 10.14336/AD.2025.0370; PDF (668KB)

The Organ-Joint Axes in Osteoarthritis: Significant Pathogenesis and Therapeutic Targets Dinglong Yang, Yujing Chen, Junfei Guo, Xin Xu, Mingyi Yang, Jiale Xie, Ke Xu, Peng Xu: 2025, 16 (5): 2999-3021 | DOI: 10.14336/AD.2024.1223; PDF (876KB)

Inflammatory Bridges: Interconnections Between Alzheimer’s Disease and Bone Health Hengrui Li, Wendi Wang, Liping Zhang, Tianwei Wang, Jian Liu, Jingguo Wu, Qingbin Ni, Baoliang Sun, Jingyi Sun: 2026, 17 (2): 927-981 | DOI: 10.14336/AD.2025.10319; PDF (1112KB)

SARS-CoV-2 S Protein Reduces Cytoprotective Defenses and Promotes Human Endothelial Cell Senescence Alicia Villacampa, Licia Shamoon, Inés Valencia, Cristina Morales, Sofía Figueiras, Fernando de la Cuesta, Dolores Sánchez-Niño, Guillermo Díaz-Araya, Isabel Sánchez-Pérez, Óscar Lorenzo, Carlos Félix Sánchez-Ferrer, Concepción Peiró: 2025, 16 (3): 1626-1638 | DOI: 10.14336/AD.2024.0405; PDF (1235KB)
Supplement; 1. Supplementary data.pdf (737KB)

Expert Consensus on the Application of Stem Cells in Psoriasis Research and Clinical Trials Ye-Hong Kuang, Wu Zhu, Ge Lin, La-Mei Cheng, Qun Qin, Zhi-Jun Huang, Yu-Ling Shi, Chun-Lei Zhang, Jin-Hua Xu, Ke-Xiang Yan, Cheng-Zhi Lv, Wei Li, Qin Han, Ilia Stambler, Lee Wei Lim, Sasanka Chakrabarti, Brun Ulfhake, Kyung-Jin Min, Georgina Ellison-Hughes, William C Cho, Kunlin Jin, Danni Yao, Chuanjian Lu, Robert Chunhua Zhao, Xiang Chen: 2025, 16 (3): 1363-1377 | DOI: 10.14336/AD.2024.0012; PDF (615KB)

Delaying Renal Aging: Metformin Holds Promise as a Potential Treatment Qiao Zheng, Jin Zhao, Jinguo Yuan, Yunlong Qin, Zhanxin Zhu, Jie Liu, Shiren Sun: 2025, 16 (3): 1397-1413 | DOI: 10.14336/AD.2024.0168; PDF (755KB)

Metabolic Rewiring and Post-Translational Modifications: Unlocking the Mechanisms of Bone Turnover in Osteoporosis Yuanyuan Li, Qilin Li, Kehan Zhang, Yaxin Wu, Gaoshaer Nuerlan, Xiangyao Wang, Yuxiao Zhang, Ahsawle Ozathaley, Jing Mao, Yan Liu, Shiqiang Gong: 2026, 17 (2): 849-876 | DOI: 10.14336/AD.2025.0123; PDF (863KB)

Lactylation: A Novel Epigenetic Regulator of Cellular Senescence Caiyu Sun, Jiaxuan Li, Lei Dong, Yakui Mou, Bei Zhang, Xicheng Song: 2026, 17 (2): 890-906 | DOI: 10.14336/AD.2025.0277; PDF (2242KB)

Postbiotic Parabacteroides Distasonis Supplementation Enhances Intestinal and Skeletal Muscle Function in Aged Mice Pablo Morgado-Cáceres, Hernán Huerta, Cristian Bergman, Reinaldo Figueroa, Paula Farias, Gabriel Quiroz, Ute Woehlbier, Karen Mella, Osmán Díaz-Rivera, Sergio Linsambarth, Paulina Calderón-Romero, Felipe A. Court, Denisse Sepulveda, Daniela Sauma, Patricia Luz-Crawford, Anibal A. Vargas, Catalina Gonzalez-Seguel, J. César Cárdenas, Alenka Lovy: | DOI: 10.14336/AD.2025.0188; PDF (1755KB)
Supplement; 1. Supplementary data.pdf (341KB)

Cellular Components of the Blood-Brain Barrier and Their Involvement in Aging-Associated Cognitive Impairment Kaiyuan Shen, Yi Shi, Xin Wang, Susan WS Leung: 2025, 16 (3): 1513-1534 | DOI: 10.14336/AD.202.0424; PDF (656KB)

Gut Microbiota-Immune System Interactions in Health and Neurodegenerative Diseases: Insights into Molecular Mechanisms and Therapeutic Applications Rengasamy Balakrishnan, Shin-Il Kang, Ji-Yeon Lee, Yang-Kook Rho, Byoung-Kook Kim, Dong-Kug Choi: 2025, 16 (6): 3421-3452 | DOI: 10.14336/AD.2024.1362; PDF (1587KB)

Mitochondria-Associated Membranes in Aging and Senescence Zhaojia Wang, Xiao Du, Shiran Yu, Xuzhen Yan, Yanguo Xin: 2025, 16 (4): 2250-2272 | DOI: 10.14336/AD.2024.0652; PDF (918KB)

Aging Deteriorates Blood Brain Barrier Function and Polarizes Adaptive T Cell Expansion Contributing to Neurocognitive Damage in Experimental Cirrhosis Sebastián Martínez-López, María Salud García-Gutiérrez, Francisco Navarrete, Isabel Gómez-Hurtado, Pedro Zapater, Enrique Ángel, Oriol Juanola, Juan L López-Cánovas, Paula Boix, Manel C Hadid, Amaya Puig-Kröger, Manuel D Gahete, Jorge Manzanares, Esther Caparrós, Rubén Francés: 2025, 16 (5): 3112-3127 | DOI: 10.14336/AD.2024.0932; PDF (1758KB)
Supplement; 1. Supplementary data.pdf (1052KB)

Immunometabolism In Brain Aging and Neurodegeneration: Bridging Metabolic Pathways and Immune Responses Shokofeh Rahimpour, Briana L. Clary, Sanaz Nasoohi, Yohanna S. Berhanu, Candice M. Brown: 2025, 16 (6): 3361-3380 | DOI: 10.14336/AD.2024.1293; PDF (958KB)

The Impact of Rosemary and Ginger Extracts on Aging and Healthspan in Drosophila Ricardo Aparicio, Anna M. Salazar, Edward T. Schmid, Armen Khanbabaei, Arun Rajgopal, R. Keith Randolph, David W. Walker: 2026, 17 (1): 416-431 | DOI: 10.14336/AD.2024.1558; PDF (1460KB)
Supplement; 1. Supplementary data.pdf (378KB)

Cellular Aging and Senescence in Cancer: A Holistic Review of Cellular Fate Determinants Muhammad Tufail, Yu-Qi Huang, Jia-Ju Hu, Jie Liang, Cai-Yun He, Wen-Dong Wan, Can-Hua Jiang, Hong Wu, Ning Li: 2025, 16 (3): 1483-1512 | DOI: 10.14336/AD.2024.0421; PDF (1028KB)

Epigenetic Clocks: Beyond Biological Age, Using the Past to Predict the Present and Future Runyu Liang, Qiang Tang, Jia Chen, Luwen Zhu: 2025, 16 (6): 3520-3545 | DOI: 10.14336/AD.2024.1495; PDF (986KB)

TBC1D15 Inhibits Autophagy of Microglia through Maintaining the Damaged Swelling Lysosome in Alzheimer’s Disease You Wu, Yong-ming Zhou, Wei Wu, Wan-rong Jiang, Xin-yuan Zhang, Si-yuan Song, Zhao-hui Yao: 2025, 16 (6): 3601-3624 | DOI: 10.14336/AD.2024.1373; PDF (2693KB)
Supplement; 1. Supplementary data.pdf (676KB)

Pros and Cons of Human Brain Organoids to Study Alzheimer’s Disease Andrea Sainz, Fernando Pérez-Cerdá, Alberto Pérez-Samartín, Mitradas Panicker, Asier Ruiz, Carlos Matute: 2025, 16 (6): 3483-3504 | DOI: 10.14336/AD.2024.1409; PDF (1051KB)

Crossing Pathological Boundaries: Multi-Target Restoration of the Neurovascular Unit in Alzheimer's and Vascular Dementia—From Modern Therapeutics to Traditional Chinese Medicine Tengyu Zhao, Pengyu Pan, Ying Jia, Yuhan Zhou, Xinyue Zhang, Huibo Guan, Quan Li, Yanyan Zhou: | DOI: 10.14336/AD.2025.0801; PDF (1076KB)

C. elegans Presenilin Mediates Inter-Organelle Contacts and Communication that Is Required for Lysosome Activity Kerry C. Ryan, Zahra Ashkavand, Jocelyn T. Laboy, Ling Wang, Margarida Barroso, Kenneth R. Norman: 2025, 16 (5): 3022-3039 | DOI: 10.14336/AD.2024.0228; PDF (1624KB)
Supplement; 1. Supplementary data.pdf (434KB)

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