ISOAD Become a Member Search
2025
Impact Factor
9.6

Most Downloaded

  • Published in last 1 year
  • In last 2 years
  • In last 3 years
  • All
  • Most Downloaded in Recent Month
  • Most Downloaded in Recent Year
Please wait a minute...
Total 40 results are found
Cerebral Small Vessel Disease: Current and Emerging Therapeutic Strategies
Yuewen Sun, Xiaoqian Song, Chenyang Jin, Yilong Peng, Jing Zhou, Xueping Zheng
2026, 17 (1): 286-303 | DOI: 10.14336/AD.2024.1515
Age-Associated Activation of the cGAS-STING Pathway and Impairment of DNA Damage Repair in Human Primary Alveolar Type II Cells
Chih-Ru Lin, Hassan Hayek, Hannah Simborio, Loukmane Karim, Karim Bahmed, Sudhir Bolla, Nathaniel Marchetti, Gerard J. Criner, Ying Tian, Beata Kosmider
2026, 17 (1): 367-382 | DOI: 10.14336/AD.2024.1175
Green Tea Mitigates the Hallmarks of Aging and Age-Related Multisystem Deterioration
Yusuf Yilmaz
2026, 17 (2): 712-730 | DOI: 10.14336/AD.2025.0398
Towards Precision Aging Biology: Single-Cell Multi-Omics and Advanced AI-Driven Strategies
Sijia Xie, Xinwei Luo, Feitong Hong, Yijie Wei, Yuduo Hao, Xueqin Xie, Xiaolong Li, Guangbo Xie, Fuying Dao, Hao Lyu
2026, 17 (2): 907-926 | DOI: 10.14336/AD.2025.0218
Postbiotic Parabacteroides Distasonis Supplementation Enhances Intestinal and Skeletal Muscle Function in Aged Mice
Pablo Morgado-Cáceres, Hernán Huerta, Cristian Bergman, Reinaldo Figueroa, Paula Farias, Gabriel Quiroz, Ute Woehlbier, Karen Mella, Osmán Díaz-Rivera, Sergio Linsambarth, Paulina Calderón-Romero, Felipe A. Court, Denisse Sepulveda, Daniela Sauma, Patricia Luz-Crawford, Anibal A. Vargas, Catalina Gonzalez-Seguel, J. César Cárdenas, Alenka Lovy
2026, 17 (3): 1534-1556 | DOI: 10.14336/AD.2025.0188
Supplement

1. Supplementary data.pdf (341KB)

Aging-Related Mechanisms Underlying Carcinogenesis: Therapeutic Opportunities.
Ana Guijarro, Giulia Allavena, Livia Pisciotta, Alessio Nencioni, Irene Caffa
| DOI: 10.14336/AD.2025.0861
Enhanced Chondrogenic Potential and Osteoarthritis Treatment Using Cyaonoside A-Induced MSC Delivered via a Hyaluronic Acid-Based Hydrogel System
Xingyan An, Qirong Zhou, Shihao Sheng, Anfu Deng, Han Liu, Xiuhui Wang, Qin Zhang, Yingying Jing, Ke Xu, Chongru He, Robert Chunhua Zhao, Jiacan Su
2026, 17 (1): 466-482 | DOI: 10.14336/AD.2024.10016
Supplement

1. Supplementary data.pdf (810KB)

Inflammatory Bridges: Interconnections Between Alzheimer’s Disease and Bone Health
Hengrui Li, Wendi Wang, Liping Zhang, Tianwei Wang, Jian Liu, Jingguo Wu, Qingbin Ni, Baoliang Sun, Jingyi Sun
2026, 17 (2): 927-981 | DOI: 10.14336/AD.2025.10319
Crossing Pathological Boundaries: Multi-Target Restoration of the Neurovascular Unit in Alzheimer's and Vascular Dementia—From Modern Therapeutics to Traditional Chinese Medicine
Tengyu Zhao, Pengyu Pan, Ying Jia, Yuhan Zhou, Xinyue Zhang, Huibo Guan, Quan Li, Yanyan Zhou
2026, 17 (5): 2353-2381 | DOI: 10.14336/AD.2025.0801
Metabolic Rewiring and Post-Translational Modifications: Unlocking the Mechanisms of Bone Turnover in Osteoporosis
Yuanyuan Li, Qilin Li, Kehan Zhang, Yaxin Wu, Gaoshaer Nuerlan, Xiangyao Wang, Yuxiao Zhang, Ahsawle Ozathaley, Jing Mao, Yan Liu, Shiqiang Gong
2026, 17 (2): 849-876 | DOI: 10.14336/AD.2025.0123
Epigenetic Clocks: Beyond Biological Age, Using the Past to Predict the Present and Future
Runyu Liang, Qiang Tang, Jia Chen, Luwen Zhu
2025, 16 (6): 3520-3545 | DOI: 10.14336/AD.2024.1495
Lactylation: A Novel Epigenetic Regulator of Cellular Senescence
Caiyu Sun, Jiaxuan Li, Lei Dong, Yakui Mou, Bei Zhang, Xicheng Song
2026, 17 (2): 890-906 | DOI: 10.14336/AD.2025.0277
Exploration and Application of Malignant Cell Heterogeneity Analysis with Single-Cell Transcriptome Sequencing Technology
Wen Zhang, Tianliang Liu, Ting Liu, Yu Zhang, Zhenguo Zhao, Xinxin Zhang, Xiaoyang Li, Jiasheng Zhong, Zhicheng Li, Shifu Chen, Libin Xu
2026, 17 (5): 2382-2400 | DOI: 10.14336/AD.2025.0836
Type 2 Diabetes Mellitus: A Metabolic Model of Accelerated Aging - Multi-Organ Mechanisms and Intervention Approaches
Ziran Zhang, Xiaolin He, Yuxin Sun, Jitong Li, Jia Sun
2026, 17 (3): 1399-1422 | DOI: 10.14336/AD.2025.0233
The Impact of Rosemary and Ginger Extracts on Aging and Healthspan in Drosophila
Ricardo Aparicio, Anna M. Salazar, Edward T. Schmid, Armen Khanbabaei, Arun Rajgopal, R. Keith Randolph, David W. Walker
2026, 17 (1): 416-431 | DOI: 10.14336/AD.2024.1558
Supplement

1. Supplementary data.pdf (378KB)

Gut Microbiota-Immune System Interactions in Health and Neurodegenerative Diseases: Insights into Molecular Mechanisms and Therapeutic Applications
Rengasamy Balakrishnan, Shin-Il Kang, Ji-Yeon Lee, Yang-Kook Rho, Byoung-Kook Kim, Dong-Kug Choi
2025, 16 (6): 3421-3452 | DOI: 10.14336/AD.2024.1362
Stroke Exacerbates Respiratory Disorder and Cognition Impairment in Mice with Cerebral Amyloid Angiopathy
YuXing Zhang, Ahmad El Hamamy, Zahid Iqbal, Arya Ranjan, Destiny Sumani, Hung Wen Lin, Louise D. McCullough, Jun Li
2026, 17 (3): 1723-1736 | DOI: 10.14336/AD.2025.0474
NK Cell Senescence in Cancer: From Molecular Mechanisms to Therapeutic Opportunities
Zilin Qiu, Zhengrui Li, Cangang Zhang, Qun Zhao, Zaoqu Liu, Quan Cheng, Jian Zhang, Anqi Lin, Peng Luo
2026, 17 (2): 1002-1033 | DOI: 10.14336/AD.2025.0053
Immunometabolism In Brain Aging and Neurodegeneration: Bridging Metabolic Pathways and Immune Responses
Shokofeh Rahimpour, Briana L. Clary, Sanaz Nasoohi, Yohanna S. Berhanu, Candice M. Brown
2025, 16 (6): 3361-3380 | DOI: 10.14336/AD.2024.1293
Bone Regeneration Enhanced by Quercetin-Capped Selenium Nanoparticles via miR206/Connexin43, WNT, and BMP signaling pathways
Garima Sharma, Yeon Hee Lee, Jin-Chul Kim, Ashish Ranjan Sharma, Sang-Soo Lee
2026, 17 (1): 530-548 | DOI: 10.14336/AD.2025.0025
Supplement

1. Supplementary data.pdf (534KB)

Senescence in Aging and Alzheimer’s Disease
Li Sun, Chu Chen
| DOI: 10.14336/AD.2025.1201
AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent
Qiuqiong Tang, Deyong Xiao, Alexander Veviorskiy, Ying Xin, Sarah W.Y. Lok, Fadi E. Pulous, Peiran Zhang, Yunfeng Zhu, Yongming Ma, Xiao Hu, Shoulai Gu, Chenting Zong, Sabina Mukba, Mikhail Korzinkin, Frank W. Pun, Man Zhang, Alex Aliper, Lijuan Wu, Feng Ren, Li Zhang, Alex Zhavoronkov
2026, 17 (1): 432-451 | DOI: 10.14336/AD.2024.1492
Supplement

1. Supplementary data.pdf (1198KB)

2. TNIK Senomorphic Video.mp4.mp4 (14113KB)

Pros and Cons of Human Brain Organoids to Study Alzheimer’s Disease
Andrea Sainz, Fernando Pérez-Cerdá, Alberto Pérez-Samartín, Mitradas Panicker, Asier Ruiz, Carlos Matute
2025, 16 (6): 3483-3504 | DOI: 10.14336/AD.2024.1409
The Flip Side of the Coin: METTL3 Serves as a Novel Cellular Senescence Accelerator via Negative Regulation of ITGA9
Yuting Li, Linying Huang, Miaochun Fang, Liwen Ye, Haiqing Yang, Weijia Wu, Yuan Yuan, Kun Cao, Hui-ling Zheng, Xuerong Sun, Yun Wu, Xing-Dong Xiong, Xinguang Liu, Shun Xu
2026, 17 (2): 1034-1051 | DOI: 10.14336/AD.2024.1715
Supplement

1. Supplementary data.pdf (650KB)

TBC1D15 Inhibits Autophagy of Microglia through Maintaining the Damaged Swelling Lysosome in Alzheimer’s Disease
You Wu, Yong-ming Zhou, Wei Wu, Wan-rong Jiang, Xin-yuan Zhang, Si-yuan Song, Zhao-hui Yao
2025, 16 (6): 3601-3624 | DOI: 10.14336/AD.2024.1373
Supplement

1. Supplementary data.pdf (676KB)

Ovarian Aging: The Silent Catalyst of Age-Related Disorders in Female Body
Xingyu Liu, Yuanqu Zhao, Yanzhi Feng, Shixuan Wang, Aiyue Luo, Jinjin Zhang
2026, 17 (1): 132-158 | DOI: 10.14336/AD.2024.1468
Aerobic Exercise Improves Cognitive Recovery in Mice with Chronic Cerebral Hypoperfusion by Modulating the Annexin-A1-MAPK Axis and Astrocyte Polarization
Wei Zhang, Jing He, Yuxin Wang, Xiaozhen Wang, He Jin, Xu Zhang, Ling Kong, Yanchuan Wu, Yong Yang, Rong Wang
2025, 16 (6): 3567-3583 | DOI: 10.14336/AD.2024.01213
Advancing Single-Cell Transcriptomic Analysis to Reveal Age-Related Skeletal Muscle Changes: A Systematic Review
Chaoran Liu, Hei Yuet Wong, Ranyang Tao, Baoqi Li, Pui Yan Wong, Chun Ho Tam, Ning Zhang, Ling Qin, Jiankun Xu, Gustavo Duque, Christoph Brochhausen, Wing Hoi Cheung, Ronald Man Yeung Wong
| DOI: 10.14336/AD.2025.0701
Supplement

1. Supplementary data.pdf (631KB)

Decoding Aging through iPSC Reprogramming: Advances and Challenges
Rui-lin Li, Yun-zeng Zou, Sheng Kang
2026, 17 (3): 1179-1189 | DOI: 10.14336/AD.2025.0438
Glucagon Like Peptide-1 Receptor Agonists for Sarcopenia and Muscle Wasting Disorders: A Systematic Review of Efficacy and Mechanisms
Abudureheman Maihemuti, Can Cui, Qianjin Wang, Reziwanguli Amuti, Wai Wang Chau, Senlin Chai, Ning Zhang, Ronald Man Yeung Wong, Ho Ko, Timothy Chi-Yui Kwok, Wing-Hoi Cheung
| DOI: 10.14336/AD.2025.1165
Supplement

1. Supplementary data.pdf (298KB)

Mitochondrial Quality Control: A New Perspective in Skeletal Muscle Dysfunction of Chronic Obstructive Pulmonary Disease
Yanxia Song, Xiaoyu Han, Yingqi Wang, Kangxia Li, Huanping Li, Yizhu Tian, Xiaoqing Ma, Weibing Wu, Jihong Wang
2025, 16 (6): 3291-3310 | DOI: 10.14336/AD.2024.1129
Effective Therapeutic Strategies to Prevent Frailty and Falls in Community-Dwelling Older Adults
Dmitry Tsvetkov, Marleen J. Meyer-Tönnies, Mladen V. Tzvetkov, Werner Weitschies, Stefan Engeli, Anna Lebedeva, Anke Hannemann, Martin C. Jordan, Ulrike Garscha, Luzia Valentini, Daria Antonenko, Lieven N. Kennes, Maik Gollasch
2026, 17 (3): 1286-1305 | DOI: 10.14336/AD.2025.0445
Causality of Aging Hallmarks
Bilu Huang, Xiaowen Hu
2026, 17 (3): 1236-1253 | DOI: 10.14336/AD.2025.0541
Male Monocyte-Like Cells are Prone to a Senescence-Induced Pro-inflammatory State
Luan Hernando Samit, Julia Temp, Irene Algarra Flores, Olesya Vakhrusheva, Yury Ladilov, Maria Luisa Barcena
| DOI: 10.14336/AD.2025.0871
Supplement

1. Supplementary data.pdf (356KB)

Blue Zones, an Analysis of Existing Evidence through a Scoping Review
Cristina Candal-Pedreira, Julia Rey-Brandariz, Lucía Martín-Gisbert, Ana Teijeiro, Guadalupe García, Alberto Ruano-Ravina, Mónica Pérez-Ríos
2026, 17 (3): 1335-1346 | DOI: 10.14336/AD.2025.0461
Supplement

1. Supplementary data.pdf (244KB)

Late Onset Rheumatoid Arthritis
Zhao Peng, Wenjing Liu, BinYu Huang, Qian Wang, Xinping Tian, Sean X. Leng, Lin Kang
| DOI: 10.14336/AD.2025.0898
Diversity of Brain Microvascular Endothelial Cell Functions: Physiology, Ischemia/Hypoxia, and Underlying Protection
Mingxuan Cao, Jia Liu, Xunming Ji
| DOI: 10.14336/AD.2025.0664
Exploring the Mechanisms of Testicular Aging: Advances in Biomarker Research
Wenkang Chen, Hede Zou, Haoran Xu, Rui Cao, Yapeng Zhang, Yongjie Ma, Wei Lin, Hekun Zhang, Jiayou Zhao
2026, 17 (2): 877-889 | DOI: 10.14336/AD.2025.0070
Role of AMPK and Sirtuins in Aging Heart: Basic and Translational Aspects
Maria Luisa Barcena, Muhammad Aslam, Kristina Norman, Christiane Ott, Yury Ladilov
2025, 16 (6): 3335-3360 | DOI: 10.14336/AD.2024.1216
Revisiting the Benefits of Exercise for Alzheimer's Disease through the Lens of Ferroptosis: A New Perspective
Zikang Hao, Xinmeng Guo, Jiawen Wu, Guang Yang
2025, 16 (6): 3268-3283 | DOI: 10.14336/AD.2024.1560