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2024
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Total 40 results are found
Cerebral Small Vessel Disease: Current and Emerging Therapeutic Strategies
Yuewen Sun, Xiaoqian Song, Chenyang Jin, Yilong Peng, Jing Zhou, Xueping Zheng
2026, 17 (1): 286-303 | DOI: 10.14336/AD.2024.1515
The Expanding Burden of Neurodegenerative Diseases: An Unmet Medical and Social Need
Shu Wang, Yin Jiang, Anchao Yang, Fangang Meng, Jianguo Zhang
2025, 16 (5): 2937-2952 | DOI: 10.14336/AD.2024.1071
Green Tea Mitigates the Hallmarks of Aging and Age-Related Multisystem Deterioration
Yusuf Yilmaz
2026, 17 (2): 712-730 | DOI: 10.14336/AD.2025.0398
Age-Associated Activation of the cGAS-STING Pathway and Impairment of DNA Damage Repair in Human Primary Alveolar Type II Cells
Chih-Ru Lin, Hassan Hayek, Hannah Simborio, Loukmane Karim, Karim Bahmed, Sudhir Bolla, Nathaniel Marchetti, Gerard J. Criner, Ying Tian, Beata Kosmider
2026, 17 (1): 367-382 | DOI: 10.14336/AD.2024.1175
Mitochondrial Dysfunction: A Roadmap for Understanding and Tackling Cardiovascular Aging
Han Zhang, Mairedan Muhetarijiang, Ryan J. Chen, Xiaosheng Hu, Jie Han, Liangrong Zheng, Ting Chen
2025, 16 (5): 2575-2614 | DOI: 10.14336/AD.2024.0058
Towards Precision Aging Biology: Single-Cell Multi-Omics and Advanced AI-Driven Strategies
Sijia Xie, Xinwei Luo, Feitong Hong, Yijie Wei, Yuduo Hao, Xueqin Xie, Xiaolong Li, Guangbo Xie, Fuying Dao, Hao Lyu
2026, 17 (2): 907-926 | DOI: 10.14336/AD.2025.0218
Enhanced Chondrogenic Potential and Osteoarthritis Treatment Using Cyaonoside A-Induced MSC Delivered via a Hyaluronic Acid-Based Hydrogel System
Xingyan An, Qirong Zhou, Shihao Sheng, Anfu Deng, Han Liu, Xiuhui Wang, Qin Zhang, Yingying Jing, Ke Xu, Chongru He, Robert Chunhua Zhao, Jiacan Su
2026, 17 (1): 466-482 | DOI: 10.14336/AD.2024.10016
Supplement

1. Supplementary data.pdf (810KB)

Brain Iron Dyshomeostasis and Ferroptosis in Alzheimer’s Disease Pathophysiology: Two Faces of the Same Coin
Mariarosa Mezzanotte, Serena Stanga
2025, 16 (5): 2615-2640 | DOI: 10.14336/AD.2024.0094
The Organ-Joint Axes in Osteoarthritis: Significant Pathogenesis and Therapeutic Targets
Dinglong Yang, Yujing Chen, Junfei Guo, Xin Xu, Mingyi Yang, Jiale Xie, Ke Xu, Peng Xu
2025, 16 (5): 2999-3021 | DOI: 10.14336/AD.2024.1223
Excitotoxicity, Oxytosis/Ferroptosis, and Neurodegeneration: Emerging Insights into Mitochondrial Mechanisms
Sameera Khan, Nargis Bano, Shakir Ahamad, Urmilla John, Nawab John Dar, Shahnawaz Ali Bhat
2025, 16 (5): 2504-2543 | DOI: 10.14336/AD.2024.0125-1
Supplement

1. Supplementary data.pdf (290KB)

Postbiotic Parabacteroides Distasonis Supplementation Enhances Intestinal and Skeletal Muscle Function in Aged Mice
Pablo Morgado-Cáceres, Hernán Huerta, Cristian Bergman, Reinaldo Figueroa, Paula Farias, Gabriel Quiroz, Ute Woehlbier, Karen Mella, Osmán Díaz-Rivera, Sergio Linsambarth, Paulina Calderón-Romero, Felipe A. Court, Denisse Sepulveda, Daniela Sauma, Patricia Luz-Crawford, Anibal A. Vargas, Catalina Gonzalez-Seguel, J. César Cárdenas, Alenka Lovy
2026, 17 (3): 1534-1556 | DOI: 10.14336/AD.2025.0188
Supplement

1. Supplementary data.pdf (341KB)

Inflammatory Bridges: Interconnections Between Alzheimer’s Disease and Bone Health
Hengrui Li, Wendi Wang, Liping Zhang, Tianwei Wang, Jian Liu, Jingguo Wu, Qingbin Ni, Baoliang Sun, Jingyi Sun
2026, 17 (2): 927-981 | DOI: 10.14336/AD.2025.10319
Metabolic Rewiring and Post-Translational Modifications: Unlocking the Mechanisms of Bone Turnover in Osteoporosis
Yuanyuan Li, Qilin Li, Kehan Zhang, Yaxin Wu, Gaoshaer Nuerlan, Xiangyao Wang, Yuxiao Zhang, Ahsawle Ozathaley, Jing Mao, Yan Liu, Shiqiang Gong
2026, 17 (2): 849-876 | DOI: 10.14336/AD.2025.0123
Crossing Pathological Boundaries: Multi-Target Restoration of the Neurovascular Unit in Alzheimer's and Vascular Dementia—From Modern Therapeutics to Traditional Chinese Medicine
Tengyu Zhao, Pengyu Pan, Ying Jia, Yuhan Zhou, Xinyue Zhang, Huibo Guan, Quan Li, Yanyan Zhou
| DOI: 10.14336/AD.2025.0801
Lactylation: A Novel Epigenetic Regulator of Cellular Senescence
Caiyu Sun, Jiaxuan Li, Lei Dong, Yakui Mou, Bei Zhang, Xicheng Song
2026, 17 (2): 890-906 | DOI: 10.14336/AD.2025.0277
Epigenetic Clocks: Beyond Biological Age, Using the Past to Predict the Present and Future
Runyu Liang, Qiang Tang, Jia Chen, Luwen Zhu
2025, 16 (6): 3520-3545 | DOI: 10.14336/AD.2024.1495
Mitochondria-Associated Membranes in Aging and Senescence
Zhaojia Wang, Xiao Du, Shiran Yu, Xuzhen Yan, Yanguo Xin
2025, 16 (4): 2250-2272 | DOI: 10.14336/AD.2024.0652
The Impact of Rosemary and Ginger Extracts on Aging and Healthspan in Drosophila
Ricardo Aparicio, Anna M. Salazar, Edward T. Schmid, Armen Khanbabaei, Arun Rajgopal, R. Keith Randolph, David W. Walker
2026, 17 (1): 416-431 | DOI: 10.14336/AD.2024.1558
Supplement

1. Supplementary data.pdf (378KB)

Gut Microbiota-Immune System Interactions in Health and Neurodegenerative Diseases: Insights into Molecular Mechanisms and Therapeutic Applications
Rengasamy Balakrishnan, Shin-Il Kang, Ji-Yeon Lee, Yang-Kook Rho, Byoung-Kook Kim, Dong-Kug Choi
2025, 16 (6): 3421-3452 | DOI: 10.14336/AD.2024.1362
Aging-Related Mechanisms Underlying Carcinogenesis: Therapeutic Opportunities.
Ana Guijarro, Giulia Allavena, Livia Pisciotta, Alessio Nencioni, Irene Caffa
| DOI: 10.14336/AD.2025.0861
Type 2 Diabetes Mellitus: A Metabolic Model of Accelerated Aging - Multi-Organ Mechanisms and Intervention Approaches
Ziran Zhang, Xiaolin He, Yuxin Sun, Jitong Li, Jia Sun
2026, 17 (3): 1399-1422 | DOI: 10.14336/AD.2025.0233
Immunometabolism In Brain Aging and Neurodegeneration: Bridging Metabolic Pathways and Immune Responses
Shokofeh Rahimpour, Briana L. Clary, Sanaz Nasoohi, Yohanna S. Berhanu, Candice M. Brown
2025, 16 (6): 3361-3380 | DOI: 10.14336/AD.2024.1293
Aging Deteriorates Blood Brain Barrier Function and Polarizes Adaptive T Cell Expansion Contributing to Neurocognitive Damage in Experimental Cirrhosis
Sebastián Martínez-López, María Salud García-Gutiérrez, Francisco Navarrete, Isabel Gómez-Hurtado, Pedro Zapater, Enrique Ángel, Oriol Juanola, Juan L López-Cánovas, Paula Boix, Manel C Hadid, Amaya Puig-Kröger, Manuel D Gahete, Jorge Manzanares, Esther Caparrós, Rubén Francés
2025, 16 (5): 3112-3127 | DOI: 10.14336/AD.2024.0932
Supplement

1. Supplementary data.pdf (1052KB)

NK Cell Senescence in Cancer: From Molecular Mechanisms to Therapeutic Opportunities
Zilin Qiu, Zhengrui Li, Cangang Zhang, Qun Zhao, Zaoqu Liu, Quan Cheng, Jian Zhang, Anqi Lin, Peng Luo
2026, 17 (2): 1002-1033 | DOI: 10.14336/AD.2025.0053
Pros and Cons of Human Brain Organoids to Study Alzheimer’s Disease
Andrea Sainz, Fernando Pérez-Cerdá, Alberto Pérez-Samartín, Mitradas Panicker, Asier Ruiz, Carlos Matute
2025, 16 (6): 3483-3504 | DOI: 10.14336/AD.2024.1409
A Framework for an Effective Healthy Longevity Clinic
Sergey Mironov, Olga Borysova, Ivan Morgunov, Zhongjun Zhou, Alexey Moskalev
2025, 16 (4): 1971-1986 | DOI: 10.14336/AD.2024.0328-1
Supplement

1. Supplementary data.pdf (481KB)

TBC1D15 Inhibits Autophagy of Microglia through Maintaining the Damaged Swelling Lysosome in Alzheimer’s Disease
You Wu, Yong-ming Zhou, Wei Wu, Wan-rong Jiang, Xin-yuan Zhang, Si-yuan Song, Zhao-hui Yao
2025, 16 (6): 3601-3624 | DOI: 10.14336/AD.2024.1373
Supplement

1. Supplementary data.pdf (676KB)

The Management of Sarcopenic Dysphagia: A Multidisciplinary Approach Leveraging Emerging Technologies
Wei Deng, Xiao-Feng Zeng, Li-Ying Zhang, Ji-Rong Yue, Xiao-Li Huang
2025, 16 (5): 2752-2769 | DOI: 10.14336/AD.2024.0741
Bone Regeneration Enhanced by Quercetin-Capped Selenium Nanoparticles via miR206/Connexin43, WNT, and BMP signaling pathways
Garima Sharma, Yeon Hee Lee, Jin-Chul Kim, Ashish Ranjan Sharma, Sang-Soo Lee
2026, 17 (1): 530-548 | DOI: 10.14336/AD.2025.0025
Supplement

1. Supplementary data.pdf (534KB)

Aerobic Exercise Improves Cognitive Recovery in Mice with Chronic Cerebral Hypoperfusion by Modulating the Annexin-A1-MAPK Axis and Astrocyte Polarization
Wei Zhang, Jing He, Yuxin Wang, Xiaozhen Wang, He Jin, Xu Zhang, Ling Kong, Yanchuan Wu, Yong Yang, Rong Wang
2025, 16 (6): 3567-3583 | DOI: 10.14336/AD.2024.01213
The Impact of Aging on Ocular Diseases: Unveiling Complex Interactions
Luling You, Yumeng Lin, Yizhuo Zheng, Zhongyu Han, Liuzhi Zeng, Haoran Chen
2025, 16 (5): 2803-2830 | DOI: 10.14336/AD.2024.0850
C. elegans Presenilin Mediates Inter-Organelle Contacts and Communication that Is Required for Lysosome Activity
Kerry C. Ryan, Zahra Ashkavand, Jocelyn T. Laboy, Ling Wang, Margarida Barroso, Kenneth R. Norman
2025, 16 (5): 3022-3039 | DOI: 10.14336/AD.2024.0228
Supplement

1. Supplementary data.pdf (434KB)

Stroke Exacerbates Respiratory Disorder and Cognition Impairment in Mice with Cerebral Amyloid Angiopathy
YuXing Zhang, Ahmad El Hamamy, Zahid Iqbal, Arya Ranjan, Destiny Sumani, Hung Wen Lin, Louise D. McCullough, Jun Li
2026, 17 (3): 1723-1736 | DOI: 10.14336/AD.2025.0474
Lactylation: An Innovative Approach to Disease Control
Xiaoxin Jiang, Yanyan Yang, Xiaolu Li, Tianxiang Li, Tao Yu, Xiuxiu Fu
2025, 16 (4): 2130-2150 | DOI: 10.14336/AD.2024.0918
Ovarian Aging: The Silent Catalyst of Age-Related Disorders in Female Body
Xingyu Liu, Yuanqu Zhao, Yanzhi Feng, Shixuan Wang, Aiyue Luo, Jinjin Zhang
2026, 17 (1): 132-158 | DOI: 10.14336/AD.2024.1468
AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent
Qiuqiong Tang, Deyong Xiao, Alexander Veviorskiy, Ying Xin, Sarah W.Y. Lok, Fadi E. Pulous, Peiran Zhang, Yunfeng Zhu, Yongming Ma, Xiao Hu, Shoulai Gu, Chenting Zong, Sabina Mukba, Mikhail Korzinkin, Frank W. Pun, Man Zhang, Alex Aliper, Lijuan Wu, Feng Ren, Li Zhang, Alex Zhavoronkov
2026, 17 (1): 432-451 | DOI: 10.14336/AD.2024.1492
Supplement

1. Supplementary data.pdf (1198KB)

2. TNIK Senomorphic Video.mp4.mp4 (14113KB)

Glucose Metabolism, Lactate, Lactylation and Alzheimer’s Disease
Shuangshuang Hai, Yadan Hou, Meiyan Zhang, Xiaoyan Gao, Tuo Yang, Xiuli Shang, Xiaohong Sun
| DOI: 10.14336/AD.2025.0338
Exploration and Application of Malignant Cell Heterogeneity Analysis with Single-Cell Transcriptome Sequencing Technology
Wen Zhang, Tianliang Liu, Ting Liu, Yu Zhang, Zhenguo Zhao, Xinxin Zhang, Xiaoyang Li, Jiasheng Zhong, Zhicheng Li, Shifu Chen, Libin Xu
| DOI: 10.14336/AD.2025.0836
Senescence in Aging and Alzheimer’s Disease
Li Sun, Chu Chen
| DOI: 10.14336/AD.2025.1201
Spinal Cord Injury and Ageing: The Role of Chronic Neuroinflammation
Tianwei Wang, Zhaoyang Zhang, Jian Liu, Liping Zhang, Qingbin Ni, Baoliang Sun, Jingyi Sun
| DOI: 10.14336/AD.2025.10630