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Total 40 results are found
Age-Related Dysfunction in Balance: A Comprehensive Review of Causes, Consequences, and Interventions
Jixian Wang, Yongfang Li, Guo-Yuan Yang, Kunlin Jin
2025, 16 (2): 714-737 | DOI: 10.14336/AD.2024.0124-1
Consequences of Aging on Bone
Lingli Zhang, Qiao Guan, Zhikun Wang, Jie Feng, Jun Zou, Bo Gao
2024, 15 (6): 2417-2452 | DOI: 10.14336/AD.2023.1115
Aging Gut Microbiome in Healthy and Unhealthy Aging
Yangyanqiu Wang, Zhanbo Qu, Jian Chu, Shuwen Han
2025, 16 (2): 980-1002 | DOI: 10.14336/AD.2024.0331
Exercise-Induced Central Fatigue: Biomarkers and Non-Medicinal Interventions
Ying Yang, Zhi Feng, Yu-hang Luo, Jue-miao Chen, Yu Zhang, Yi-jun Liao, Hui Jiang, Yinxi Long, Bo Wei
2025, 16 (3): 1302-1315 | DOI: 10.14336/AD.2024.0567
The Expanding Burden of Neurodegenerative Diseases: An Unmet Medical and Social Need
Shu Wang, Yin Jiang, Anchao Yang, Fangang Meng, Jianguo Zhang
2025, 16 (5): 2937-2952 | DOI: 10.14336/AD.2024.1071
Cerebral Small Vessel Disease: Current and Emerging Therapeutic Strategies
Yuewen Sun, Xiaoqian Song, Chenyang Jin, Yilong Peng, Jing Zhou, Xueping Zheng
2026, 17 (1): 286-303 | DOI: 10.14336/AD.2024.1515
Targeting Cellular Senescence in Aging and Age-Related Diseases: Challenges, Considerations, and the Emerging Role of Senolytic and Senomorphic Therapies
Liyao Zheng, Shipei He, Hong Wang, Jinling Li, Yuanyuan Liu, Sijia Liu
2024, 15 (6): 2554-2594 | DOI: 10.14336/AD.2024.0206
ROS-Induced Endothelial Dysfunction in the Pathogenesis of Atherosclerosis
Ruiyi Yan, Xiao Zhang, Wenlong Xu, Jiayao Li, Yixin Sun, Shengyan Cui, Ran Xu, Wenjing Li, Liqun Jiao, Tao Wang
2025, 16 (1): 250-268 | DOI: 10.14336/AD.2024.0309
Long-Term Improvement in Hippocampal-Dependent Learning Ability in Healthy, Aged Individuals Following High Intensity Interval Training
Daniel G. Blackmore, Mia A. Schaumberg, Maryam Ziaei, Samuel Belford, Xuan Vinh To, Imogen O’Keeffe, Anne Bernard, Jules Mitchell, Emily Hume, Grace L. Rose, Thomas Shaw, Ashley York, Markus Barth, Elizabeth J. Cooper, Tina L. Skinner, Fatima Nasrallah, Stephan Riek, Perry F. Bartlett
2025, 16 (3): 1732-1754 | DOI: 10.14336/AD.2024.0642
Supplement

1. Supplementary data.pdf (6754KB)

Tryptophan Metabolism in Alzheimer’s Disease with the Involvement of Microglia and Astrocyte Crosstalk and Gut-Brain Axis
Lushuang Xie, Qiaofeng Wu, Kelin Li, Mohammed A. S. Khan, Andrew Zhang, Bharati Sinha, Sihui Li, Sulie L. Chang, David L. Brody, Mark W. Grinstaff, Shuanhu Zhou, Gil Alterovitz, Pinghua Liu, Xin Wang
2024, 15 (5): 2168-2190 | DOI: 10.14336/AD.2024.0134
Molecular Mechanisms of Phase Separation and Amyloidosis of ALS/FTD-linked FUS and TDP-43
Jianxing Song
2024, 15 (5): 2084-2112 | DOI: 10.14336/AD.2023.1118
Disulfidptosis, A Novel Cell Death Pathway: Molecular Landscape and Therapeutic Implications
Qiuyang Gu, Yumei An, Mingyuan Xu, Xinqi Huang, Xueshi Chen, Xianzhe Li, Haiyan Shan, Mingyang Zhang
2025, 16 (2): 917-945 | DOI: 10.14336/AD.2024.0083
The Role of p53 in Regulating Chronic Inflammation and PANoptosis in Diabetic Wounds
Wenjie He, Ming Tang, Rifang Gu, Xingqian Wu, Xinrui Mu, Xuqiang Nie
2025, 16 (1): 373-393 | DOI: 10.14336/AD.2024.0212
Aging and “Age-Related” Diseases - What Is the Relation?
Wolfgang Kopp
2025, 16 (3): 1316-1346 | DOI: 10.14336/AD.2024.0570
Therapeutic Potential of Quercetin as an Antioxidant for Bone-Muscle-Tendon Regeneration and Aging
Jae Gyu Kim, Ashish Ranjan Sharma, Yeon-Hee Lee, Srijan Chatterjee, Yean Jung Choi, Roshani Rajvansh, Chiranjib Chakraborty, Sang-Soo Lee
2025, 16 (3): 1414-1437 | DOI: 10.14336/AD.2024.0282
Inflammatory Pathogenesis of Post-stroke Depression
Xinyu Feng, Xiaojuan Ma, Juan Li, Qing Zhou, Yao Liu, Jingyi Song, Jiaqi Liu, Qingqing Situ, Lingyue Wang, Jingzhi Zhang, Facai Lin
2025, 16 (1): 209-238 | DOI: 10.14336/AD.2024.0203
Deformability of Heterogeneous Red Blood Cells in Aging and Related Pathologies
Dmitry S. Prudinnik, Aigul Kussanova, Ivan A. Vorobjev, Alexander Tikhonov, Fazly I. Ataullakhanov, Natasha S. Barteneva
2025, 16 (3): 1242-1264 | DOI: 10.14336/AD.2024.0526
Revisiting Skeletal Muscle Dysfunction and Exercise in Chronic Obstructive Pulmonary Disease: Emerging Significance of Myokines
Lihua Han, Peijun Li, Qinglan He, Chen Yang, Meiling Jiang, Yingqi Wang, Yuanyuan Cao, Xiaoyu Han, Xiaodan Liu, Weibing Wu
2024, 15 (6): 2453-2469 | DOI: 10.14336/AD.2023.1125
Telomeres: Dysfunction, Maintenance, Aging and Cancer
Pan Liao, Bo Yan, Conglin Wang, Ping Lei
2024, 15 (6): 2595-2631 | DOI: 10.14336/AD.2023.1128
The identification of a Distinct Astrocyte Subtype that Diminishes in Alzheimer’s Disease
Haichao Wei, Joseph Withrow, Jyotirmoy Rakshit, Faiz Ul Amin, Joshua Nahm, Francesca E. Mowry, Zhengmei Mao, Meenakshi B. Bhattacharjee, Jay-Jiguang Zhu, Yongjie Yang, Jia Qian Wu
2024, 15 (6): 2752-2769 | DOI: 10.14336/AD.2024.0205-1
Supplement

1. Supplementary data.pdf (1029KB)

Exploring the Intricate Nexus of Sarcopenia and Cognitive Impairment
Yiwen Xing, Xiaxia Li, Lina Ma
2024, 15 (6): 2334-2344 | DOI: 10.14336/AD.2023.1013
Aging-Related Sarcopenia: Metabolic Characteristics and Therapeutic Strategies
Yonglian Chen, Jinhui Wu
2025, 16 (2): 1003-1022 | DOI: 10.14336/AD.2024.0407
Role of Crosstalk between Glial Cells and Immune Cells in Blood-Brain Barrier Damage and Protection after Acute Ischemic Stroke
Yihui Wang, Wencao Liu, Panpan Geng, Weihong Du, Chun Guo, Qian Wang, Guo-qing Zheng, Xinchun Jin
2024, 15 (6): 2507-2525 | DOI: 10.14336/AD.2023.1010
Vascular Aging and Atherosclerosis: A Perspective on Aging
Shudong Ma, Xuena Xie, Rong Yuan, Qiqi Xin, Yu Miao, Sean Xiao Leng, Keji Chen, Weihong Cong
2025, 16 (1): 33-48 | DOI: 10.14336/AD.2024.0201-1
Glial Cell Activation and Immune Responses in Glaucoma: A Systematic Review of Human Postmortem Studies of the Retina and Optic Nerve
Akanksha Salkar, Roshana Vander Wall, Devaraj Basavarajappa, Nitin Chitranshi, Gabriella E. Parilla, Mehdi Mirzaei, Peng Yan, Stuart Graham, Yuyi You
2024, 15 (5): 2069-2083 | DOI: 10.14336/AD.2024.0103
Supplement

1. Supplementary data.pdf (245KB)

Age-Associated Activation of the cGAS-STING Pathway and Impairment of DNA Damage Repair in Human Primary Alveolar Type II Cells
Chih-Ru Lin, Hassan Hayek, Hannah Simborio, Loukmane Karim, Karim Bahmed, Sudhir Bolla, Nathaniel Marchetti, Gerard J. Criner, Ying Tian, Beata Kosmider
2026, 17 (1): 367-382 | DOI: 10.14336/AD.2024.1175
The Role of Liquid-Liquid Phase Separation in the Accumulation of Pathological Proteins: New Perspectives on the Mechanism of Neurodegenerative Diseases
Xingyu Lu, Jiongtong Lu, Shengnan Li, Sifan Feng, Yan Wang, Lili Cui
2025, 16 (2): 769-786 | DOI: 10.14336/AD.2024.0209
Neuroinflammation and Post-Stroke Depression: Focus on the Microglia and Astrocytes
Weizhuo Lu, Jiyue Wen
2025, 16 (1): 394-407 | DOI: 10.14336/AD.2024.0214-1
Green Tea Mitigates the Hallmarks of Aging and Age-Related Multisystem Deterioration
Yusuf Yilmaz
2026, 17 (2): 712-730 | DOI: 10.14336/AD.2025.0398
Endogenous Retroviruses Unveiled: A Comprehensive Review of Inflammatory Signaling/Senescence-Related Pathways and Therapeutic Strategies
Xin-ran Zhao, Jia-bin Zong, Yu-xiao Liu, Tuersun Aili, Min Qiu, Jie-hong Wu, Bo Hu
2025, 16 (2): 738-756 | DOI: 10.14336/AD.2024.0123-1
Revolutionizing Diabetic Foot Ulcer Care: The Senotherapeutic Approach
Guiqin Zhang, Priyadarshani Nadeeshika Samarawickrama, Li Gui, Yuan Ma, Mei Cao, Hong Zhu, Wei Li, Honglin Yang, Kecheng Li, Yang Yang, Enfang Zhu, Wen Li, Yonghan He
2025, 16 (2): 946-970 | DOI: 10.14336/AD.2024.0065
Role of Serotonylation and SERT Posttranslational Modifications in Alzheimer's Disease Pathogenesis
Arubala P. Reddy, Priyanka Rawat, Nicholas Rohr, Razelle Alvir, Jasbir Bisht, Mst Anika Bushra, Jennifer Luong, Aananya P. Reddy
2025, 16 (2): 841-858 | DOI: 10.14336/AD.2024.0328
Immunological Landscape of Retinal Ischemia-Reperfusion Injury: Insights into Resident and Peripheral Immune Cell Responses
Shan He, Cuiying Liu, Changhong Ren, Heng Zhao, Xuxiang Zhang
2025, 16 (1): 115-136 | DOI: 10.14336/AD.2024.0129
Irisin: A Potentially Fresh Insight into the Molecular Mechanisms Underlying Vascular Aging
Yinghui Wang, Manying Wang, Yuehui Wang
2024, 15 (6): 2491-2506 | DOI: 10.14336/AD.2023.1112
Isthmin-1 Improves Aging-Related Cardiac Dysfunction in Mice through Enhancing Glycolysis and SIRT1 Deacetylase Activity
Min Hu, Xin Zhang, Yi-Peng Gao, Yu-Xin Hu, Teng Teng, Sha-Sha Wang, Qi-Zhu Tang
2024, 15 (6): 2682-2696 | DOI: 10.14336/AD.2024.0113
Supplement

1. Supplementary data.pdf (2330KB)

Exercise as a Metabolic Regulator: Targeting AMPK/mTOR-Autophagy Crosstalk to Counteract Sarcopenic Obesity
Daoqi Zhang, Congfei Lu, Kai Sang
2026, 17 (4): 1904-1915 | DOI: 10.14336/AD.2025.0419
Association of Plasma Markers of Alzheimer’s Disease, Neurodegeneration, and Neuroinflammation with the Choroid Plexus Integrity in Aging
Mustapha Bouhrara, Keenan A. Walker, Joseph S. R. Alisch, Zhaoyuan Gong, Caio H. Mazucanti, Alexandria Lewis, Abhay R. Moghekar, Lisa Turek, Victoria Collingham, Nader Shehadeh, Giovanna Fantoni, Mary Kaileh, Christopher M. Bergeron, Jan Bergeron, Susan M. Resnick, Josephine M. Egan
2024, 15 (5): 2230-2240 | DOI: 10.14336/AD.2023.1226
Multi-Trajectories of Intrinsic Capacity Decline and Their Impact on Age-Related Outcomes: A 20-Year National Longitudinal Cohort Study
Lin-Chieh Meng, Hui-Min Chuang, Wan-Hsuan Lu, Wei-Ju Lee, Chih-Kuang Liang, Ching-Hui Loh, Fei-Yuan Hsiao, Liang-Kung Chen
2024, 15 (6): 2697-2709 | DOI: 10.14336/AD.2023.1115-1
Mitochondrial Dysfunction: A Roadmap for Understanding and Tackling Cardiovascular Aging
Han Zhang, Mairedan Muhetarijiang, Ryan J. Chen, Xiaosheng Hu, Jie Han, Liangrong Zheng, Ting Chen
2025, 16 (5): 2575-2614 | DOI: 10.14336/AD.2024.0058
Fecal Microbiota Transplantation Attenuates Frailty via Gut-Muscle Axis in Old Mice
Mengpei Zhu, Yumei Huang, Ziwen Wang, Ze Jin, Jiali Cao, Qiangqiang Zhong, Zhifan Xiong
2025, 16 (2): 1180-1198 | DOI: 10.14336/AD.2024.0321
Supplement

1. Supplementary data.pdf (500KB)