Aging and disease

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Total 40 results are found

Transplantation of ACE2 ^- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia Zikuan Leng, Rongjia Zhu, Wei Hou, Yingmei Feng, Yanlei Yang, Qin Han, Guangliang Shan, Fanyan Meng, Dongshu Du, Shihua Wang, Junfen Fan, Wenjing Wang, Luchan Deng, Hongbo Shi, Hongjun Li, Zhongjie Hu, Fengchun Zhang, Jinming Gao, Hongjian Liu, Xiaoxia Li, Yangyang Zhao, Kan Yin, Xijing He, Zhengchao Gao, Yibin Wang, Bo Yang, Ronghua Jin, Ilia Stambler, Lee Wei Lim, Huanxing Su, Alexey Moskalev, Antonio Cano, Sasanka Chakrabarti, Kyung-Jin Min, Georgina Ellison-Hughes, Calogero Caruso, Kunlin Jin, Robert Chunhua Zhao: 2020, 11 (2): 216-228 | DOI: 10.14336/AD.2020.0228; PDF (1473KB)
Supplement; 1. Supplementary data.pdf (1202KB)

Mesenchymal Stem Cell Infusion Shows Promise for Combating Coronavirus (COVID-19)- Induced Pneumonia Ashok K Shetty: 2020, 11 (2): 462-464 | DOI: 10.14336/AD.2020.0301; PDF (212KB)

Multi-organ Dysfunction in Patients with COVID-19: A Systematic Review and Meta-analysis Ting Wu, Zhihong Zuo, Shuntong Kang, Liping Jiang, Xuan Luo, Zanxian Xia, Jing Liu, Xiaojuan Xiao, Mao Ye, Meichun Deng: 2020, 11 (4): 874-894 | DOI: 10.14336/AD.2020.0520; PDF (3152KB)
Supplement; 1. Supplementary data.pdf (1432KB)

TGF-β Signaling: A Therapeutic Target to Reinstate Regenerative Plasticity in Vascular Dementia? Mahesh Kandasamy, Muthuswamy Anusuyadevi, Kiera M Aigner, Michael S Unger, Kathrin M Kniewallner, Diana M Bessa de Sousa, Barbara Altendorfer, Heike Mrowetz, Ulrich Bogdahn, Ludwig Aigner: 2020, 11 (4): 828-850 | DOI: 10.14336/AD.2020.0222; PDF (1219KB)

Comorbid Chronic Diseases are Strongly Correlated with Disease Severity among COVID-19 Patients: A Systematic Review and Meta-Analysis Hong Liu, Shiyan Chen, Min Liu, Hao Nie, Hongyun Lu: 2020, 11 (3): 668-678 | DOI: 10.14336/AD.2020.0502; PDF (983KB)

Parkinson Disease and Orthostatic Hypotension in the Elderly: Recognition and Management of Risk Factors for Falls Peter A LeWitt, Steve Kymes, Robert A Hauser: 2020, 11 (3): 679-691 | DOI: 10.14336/AD.2019.0805; PDF (512KB)

The Potential Markers of Circulating microRNAs and long non-coding RNAs in Alzheimer's Disease Yanfang Zhao, Yuan Zhang, Lei Zhang, Yanhan Dong, Hongfang Ji, Liang Shen: 2019, 10 (6): 1293-1301 | DOI: 10.14336/AD.2018.1105; PDF (628KB)

COVID-19 Virulence in Aged Patients Might Be Impacted by the Host Cellular MicroRNAs Abundance/Profile Sadanand Fulzele, Bikash Sahay, Ibrahim Yusufu, Tae Jin Lee, Ashok Sharma, Ravindra Kolhe, Carlos M Isales: 2020, 11 (3): 509-522 | DOI: 10.14336/AD.2020.0428; PDF (793KB)
Supplement; 1. Supplementary data.pdf (970KB)

Gut Microbiome and Osteoporosis Kai Ding, Fei Hua, Wenge Ding: 2020, 11 (2): 438-447 | DOI: 10.14336/AD.2019.0523; PDF (350KB)

Exercise Programs for Muscle Mass, Muscle Strength and Physical Performance in Older Adults with Sarcopenia: A Systematic Review and Meta-Analysis Wangxiao Bao, Yun Sun, Tianfang Zhang, Liliang Zou, Xiaohong Wu, Daming Wang, Zuobing Chen: 2020, 11 (4): 863-873 | DOI: 10.14336/AD.2019.1012; PDF (1300KB)
Supplement; 1. Supplementary data.pdf (295KB)

Research progress on Mesenchymal Stem Cells (MSCs), Adipose-Derived Mesenchymal Stem Cells (AD-MSCs), Drugs, and Vaccines in Inhibiting COVID-19 Disease Pietro Gentile, Aris Sterodimas, Jacopo Pizzicannella, Claudio Calabrese, Simone Garcovich: 2020, 11 (5): 1191-1201 | DOI: 10.14336/AD.2020.0711; PDF (574KB)

COVID 19 - Clinical Picture in the Elderly Population: A Qualitative Systematic Review Agnieszka Neumann-Podczaska, Salwan R Al-Saad, Lukasz M Karbowski, Michal Chojnicki, Slawomir Tobis, Katarzyna Wieczorowska-Tobis: 2020, 11 (4): 988-1008 | DOI: 10.14336/AD.2020.0620; PDF (792KB)

Pyroptosis Plays a Role in Osteoarthritis Senbo An, Huiyu Hu, Yusheng Li, Yihe Hu: 2020, 11 (5): 1146-1157 | DOI: 10.14336/AD.2019.1127; PDF (500KB)

Physical Activity and Alzheimer’s Disease: A Narrative Review Piotr Gronek, Stefan Balko, Joanna Gronek, Adam Zajac, Adam Maszczyk, Roman Celka, Agnieszka Doberska, Wojciech Czarny, Robert Podstawski, Cain C. T Clark, Fang Yu: 2019, 10 (6): 1282-1292 | DOI: 10.14336/AD.2019.0226; PDF (394KB)

Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Diseases: An Update Feng Zhang, Long Niu, Xinyao Liu, Yufei Liu, Song Li, Huan Yu, Weidong Le: 2020, 11 (2): 315-326 | DOI: 10.14336/AD.2019.0324; PDF (608KB)

p300 in Cardiac Development and Accelerated Cardiac Aging Asish K Ghosh: 2020, 11 (4): 916-926 | DOI: 10.14336/AD.2020.0401; PDF (536KB)

A Review of Exercise as Medicine in Cardiovascular Disease: Pathology and Mechanism Piotr Gronek, Dariusz Wielinski, Piotr Cyganski, Andrzej Rynkiewicz, Adam Zając, Adam Maszczyk, Joanna Gronek, Robert Podstawski, Wojciech Czarny, Stefan Balko, Cain CT. Clark, Roman Celka: 2020, 11 (2): 327-340 | DOI: 10.14336/AD.2019.0516; PDF (491KB)

The Clinical Efficacy and Safety of Stem Cell Therapy for Diabetes Mellitus: A Systematic Review and Meta-Analysis Yazhen Zhang, Wenyi Chen, Bing Feng, Hongcui Cao: 2020, 11 (1): 141-153 | DOI: 10.14336/AD.2019.0421; PDF (1602KB)
Supplement; 1. Supplementary data.pdf (244KB)

Interplay between Exosomes and Autophagy in Cardiovascular Diseases: Novel Promising Target for Diagnostic and Therapeutic Application Jinfan Tian, Mohammad Sharif Popal, Yingke Zhao, Yanfei Liu, Keji Chen, Yue Liu: 2019, 10 (6): 1302-1310 | DOI: 10.14336/AD.2018.1020; PDF (361KB)

TNFα-induced Up-regulation of Ascl2 Affects the Differentiation and Proliferation of Neural Stem Cells Zhongfeng Liu, Xuan Wang, Kewen Jiang, Xunming Ji, Y. Alex Zhang, Zhiguo Chen: 2019, 10 (6): 1207-1220 | DOI: 10.14336/AD.2018.1028; PDF (1722KB)
Supplement; 1. .pdf (1611KB)

Mechanism of Ferroptosis: A Potential Target for Cardiovascular Diseases Treatment Jie Ju, Ya-nan Song, Kun Wang: 2021, 12 (1): 261-276 | DOI: 10.14336/AD.2020.0323; PDF (962KB)

The Interstitial System of the Brain in Health and Disease Ashok K. Shetty, Gabriele Zanirati: 2020, 11 (1): 200-211 | DOI: 10.14336/AD.2020.0103; PDF (939KB)

Alteration in the Function and Expression of SLC and ABC Transporters in the Neurovascular Unit in Alzheimer’s Disease and the Clinical Significance Yongming Jia, Na Wang, Yingbo Zhang, Di Xue, Haoming Lou, Xuewei Liu: 2020, 11 (2): 390-404 | DOI: 10.14336/AD.2019.0519; PDF (621KB)

The Critical Role of Nurr1 as a Mediator and Therapeutic Target in Alzheimer’s Disease-related Pathogenesis Seong Gak Jeon, Anji Yoo, Dong Wook Chun, Sang Bum Hong, Hyunju Chung, Jin-il Kim, Minho Moon: 2020, 11 (3): 705-724 | DOI: 10.14336/AD.2019.0718; PDF (790KB)

COVID-19 in India: Are Biological and Environmental Factors Helping to Stem the Incidence and Severity? Sankha Shubhra Chakrabarti, Upinder Kaur, Anindita Banerjee, Upasana Ganguly, Tuhina Banerjee, Sarama Saha, Gaurav Parashar, Suvarna Prasad, Suddhachitta Chakrabarti, Amit Mittal, Bimal Kumar Agrawal, Ravindra Kumar Rawal, Robert Chunhua Zhao, Indrajeet Singh Gambhir, Rahul Khanna, Ashok K Shetty, Kunlin Jin, Sasanka Chakrabarti: 2020, 11 (3): 480-488 | DOI: 10.14336/AD.2020.0402; PDF (726KB)

Adipose Stem Cells (ASCs) and Stromal Vascular Fraction (SVF) as a Potential Therapy in Combating (COVID-19)-Disease Pietro Gentile, Aris Sterodimas: 2020, 11 (3): 465-469 | DOI: 10.14336/AD.2020.0422; PDF (235KB)

Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience Alexey Moskalev, Ilia Stambler, Calogero Caruso: 2020, 11 (6): 1363-1373 | DOI: 10.14336/AD.2020.0603; PDF (641KB)

The Critical Role of SIRT1 in Parkinson’s Disease: Mechanism and Therapeutic Considerations Xuan Li, Ya Feng, Xi-Xi Wang, Daniel Truong, Yun-Cheng Wu: 2020, 11 (6): 1608-1622 | DOI: 10.14336/AD.2020.0216; PDF (698KB)

Understanding the Physiological Links Between Physical Frailty and Cognitive Decline Lina Ma, Piu Chan: 2020, 11 (2): 405-418 | DOI: 10.14336/AD.2019.0521; PDF (596KB)

COVID-19 and Acute Sarcopenia Carly Welch, Carolyn Greig, Tahir Masud, Daisy Wilson, Thomas A Jackson: 2020, 11 (6): 1345-1351 | DOI: 10.14336/AD.2020.1014; PDF (374KB)

The Emerging Role of Sestrin2 in Cell Metabolism, and Cardiovascular and Age-Related Diseases Wanqing Sun, Yishi Wang, Yang Zheng, Nanhu Quan: 2020, 11 (1): 154-163 | DOI: 10.14336/AD.2019.0320; PDF (443KB)

β-Hydroxybutyrate Suppresses Lipid Accumulation in Aged Liver through GPR109A-mediated Signaling A Kyoung Lee, Dae Hyun Kim, EunJin Bang, Yeon Ja Choi, Hae Young Chung: 2020, 11 (4): 777-790 | DOI: 10.14336/AD.2019.0926; PDF (1076KB)

DICER1 in the Pathogenesis of Age-related Macular Degeneration (AMD) - Alu RNA Accumulation versus miRNA Dysregulation Kai Kaarniranta, Elzbieta Pawlowska, Joanna Szczepanska, Janusz Blasiak: 2020, 11 (4): 851-862 | DOI: 10.14336/AD.2019.0809; PDF (723KB)

Combined Antioxidant, Anti-inflammaging and Mesenchymal Stem Cell Treatment: A Possible Therapeutic Direction in Elderly Patients with Chronic Obstructive Pulmonary Disease Shijin Xia, Changxi Zhou, Bill Kalionis, Xiaoping Shuang, Haiyan Ge, Wen Gao: 2020, 11 (1): 129-140 | DOI: 10.14336/AD.2019.0508; PDF (569KB)

Entorhinal Cortex Atrophy in Early, Drug-naive Parkinson’s Disease with Mild Cognitive Impairment Xiuqin Jia, Zhijiang Wang, Tao Yang, Ying Li, Shuai Gao, Guorong Wu, Tao Jiang, Peipeng Liang: 2019, 10 (6): 1221-1232 | DOI: 10.14336/AD.2018.1116; PDF (982KB)

A Glimmer of Hope: Maintain Mitochondrial Homeostasis to Mitigate Alzheimer’s Disease Wenbo Li, Ling Kui, Tsirukis Demetrios, Xun Gong, Min Tang: 2020, 11 (5): 1260-1275 | DOI: 10.14336/AD.2020.0105; PDF (675KB)

Age-induced NLRP3 Inflammasome Over-activation Increases Lethality of SARS-CoV-2 Pneumonia in Elderly Patients Pedro C Lara, David Macías-Verde, Javier Burgos-Burgos: 2020, 11 (4): 756-762 | DOI: 10.14336/AD.2020.0601; PDF (270KB)

Artemisinin Improved Neuronal Functions in Alzheimer's Disease Animal Model 3xtg Mice and Neuronal Cells via Stimulating the ERK/CREB Signaling Pathway Xia Zhao, Shuai Li, Uma Gaur, Wenhua Zheng: 2020, 11 (4): 801-819 | DOI: 10.14336/AD.2019.0813; PDF (1664KB)
Supplement; 1. Supplementary data.pdf (266KB)

Chondroprotective Effects of Combination Therapy of Acupotomy and Human Adipose Mesenchymal Stem Cells in Knee Osteoarthritis Rabbits via the GSK3β-Cyclin D1-CDK4/CDK6 Signaling Pathway Xingyan An, Tong Wang, Wei Zhang, Hongliang Yu, Robert Chunhua Zhao, Yan Guo, Chunjiu Wang, Luxue Qin, Changqing Guo: 2020, 11 (5): 1116-1132 | DOI: 10.14336/AD.2019.1104; PDF (1182KB)

Lactulose Suppresses Osteoclastogenesis and Ameliorates Estrogen Deficiency-Induced Bone Loss in Mice Xiao Chen, Zheng Zhang, Yan Hu, Jin Cui, Xin Zhi, Xiaoqun Li, Hao Jiang, Yao Wang, Zhengrong Gu, Zili Qiu, Xin Dong, Yuhong Li, Jiacan Su: 2020, 11 (3): 629-641 | DOI: 10.14336/AD.2019.0613; PDF (1244KB)
Supplement; 1. Supplementary data.pdf (808KB)

Cover Illustration

01 October 2021. VOL 12, ISSUE 7
Figure 5. ISF drainage routes in juvenile (≤P30 days) and adult rats. In juvenile rats (≤P30 days), the brain has not been fully myelinated, the oligodendrocytes are small, myelin sheaths are thin, and many axons are nonmyelinated. The interstitial fluid (ISF) was traced from the caudate nucleus (Cn) drained to the ipsilateral cortex along myelin fiber tracts and can communicate with the ISF in the thalamus (Tha) in the opposite direction. After P40, ISF drainage in Cn became regionalized; the movement of ISF to the adjacent thalamus was completely impeded by a barrier structure composed of compact myelin (yellow arrow). The oligodendrocytes in adult rats were more developed than the juvenile rats (blue arrow).

[Detail]

Cover Illustration

Figure 5. ISF drainage routes in juvenile (≤P30 days) and adult rats. In juvenile rats (≤P30 days), the brain has not been fully myelinated, the oligodendrocytes are small, myelin sheaths are thin, and many axons are nonmyelinated. The interstitial fluid (ISF) was traced from the caudate nucleus (Cn) drained to the ipsilateral cortex along myelin fiber tracts and can communicate with the ISF in the thalamus (Tha) in the opposite direction. After P40, ISF drainage in Cn became regionalized; the movement of ISF to the adjacent thalamus was completely impeded by a barrier structure composed of compact myelin (yellow arrow). The oligodendrocytes in adult rats were more developed than the juvenile rats (blue arrow).

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