Aging and disease

Early Edition

Inflammaging: From Mechanisms to Clinical Implications and Targeted Interventions
Rola S. Zeidan, Aditya S. Shirali, Simon Reinhard, Anna Picca, Patricia Vial, Lisiane Pruinelli, Joe G.N. Garcia, Christian Leeuwenburgh, Stephen Anton

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1. Supplementary data.pdf (175KB)

Accepted: 2026-04-24 DOI: 10.14336/AD.2025.1557
Perceived Hypoacusis and Loneliness: A Longitudinal Between- and Within-Individual Association in Mexican Older Adults
Liliana Giraldo-Rodríguez, Diana Ramos-Félix, Paloma Roa-Rojas, Karen Eloina Pérez-D’Aquino, Teresa Álvarez-Cisneros

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Accepted: 2026-04-23 DOI: 10.14336/AD.2025.1199
The Relationship between Ergothioneine, Allantoin and Neocortical Amyloid Load
Shaun Eslick, Irwin Cheah Kee-Mun, Pratishtha Chatterjee, Sarah Jerome, Barry Halliwell, Ralph Martins

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Accepted: 2026-04-20 DOI: 10.14336/AD.2026.0091
Targeting PPAR Signaling for Neurovascular Protection: Advances in Natural Product-Based Therapeutics
Xinyi Ouyang, Yijing Xiang, Longbiao Tan, Jiali Zou, Yufan Long, Kangwen Ning, Shuang Zhang, Fenglin Wang, Ting Liu, Dan Huang, Huiping Liu, Guomin Zhang

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1. Supplementary data.pdf (357KB)

Accepted: 2026-04-20 DOI: 10.14336/AD.2026.0094
Chronic Swimming Routine Promotes Gut Microbiota Remodeling and Improvements in Physical Resilience, Episodic-Like Memory, and Inflammatory Status in Late Middle-Aged Mice
Paola Llanos, Ronakarina Pires-Valero, Johana Rojas-Paillal, Jamileth More, Francisco Silva-Olivares, Luan Americo da Silva, Camila Astudillo-Guerrero, Pamela J. Urrutia, Fernanda Figueroa-Ajraz, Claudia Ibacache-Quiroga, Yulia A. Nevzorova, Francisco J. Cubero, Gonzalo Jorquera

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1. Supplementary data.pdf (884KB)

Accepted: 2026-04-17 DOI: 10.14336/AD.2026.0192

Current issue

01 June 2026. VOL 17, ISSUE 3 Previous Issue

Perspective

A Standardized Protocol for Mouse Longevity Studies in Preclinical Drug Development
Alex Zhavoronkov, Qian Wang, Yujie Liu, Wenbin Hou, Yuelei Shen, Dominika Wilczok, Kristen Fortney, Alex Aliper, Man Zhang, Feng Ren, Richard A. Miller

2026, 17 (3): 1169-1179 | DOI: 10.14336/AD.2025.0508

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Pespective

Decoding Aging through iPSC Reprogramming: Advances and Challenges
Rui-lin Li, Yun-zeng Zou, Sheng Kang

2026, 17 (3): 1179-1189 | DOI: 10.14336/AD.2025.0438

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Review

The Inflammasome–miR Axis in Alzheimer’s Disease and Chronic Pain: Molecular Mechanisms and Therapeutic Opportunities
Botond Gaál, Roland Takács, Csaba Matta, Krisztián Juhász, Béla Fülesdi, Zoltán Szekanecz, Szilvia Benkő, László Ducza

2026, 17 (3): 1190-1223 | DOI: 10.14336/AD.2025.0353

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Supplement

1. Supplementary data.pdf (220KB)
The Complex Bidirectional Relationship Between Aging and Atherosclerosis: Mechanistic Insights and Translational Opportunities
Binquan You, Dong Yi, Bingyin Wang, Hua Yan

2026, 17 (3): 1223-1236 | DOI: 10.14336/AD.2025.10620

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Causality of Aging Hallmarks
Bilu Huang, Xiaowen Hu

2026, 17 (3): 1236-1253 | DOI: 10.14336/AD.2025.0541

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What do You Need to Know after Diabetes and before Diabetic Retinopathy?
Shiyu Zhang, Jia Liu, Heng Zhao, Yuan Gao, Changhong Ren, Xuxiang Zhang

2026, 17 (3): 1254-1285 | DOI: 10.14336/AD.2025.0289

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Effective Therapeutic Strategies to Prevent Frailty and Falls in Community-Dwelling Older Adults
Dmitry Tsvetkov, Marleen J. Meyer-Tönnies, Mladen V. Tzvetkov, Werner Weitschies, Stefan Engeli, Anna Lebedeva, Anke Hannemann, Martin C. Jordan, Ulrike Garscha, Luzia Valentini, Daria Antonenko, Lieven N. Kennes, Maik Gollasch

2026, 17 (3): 1286-1305 | DOI: 10.14336/AD.2025.0445

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The Multimodal Nanomaterials of Phototherapy for Tumor Treatment
Yanan Bao, Wenxin Chou, Yusen Hou, Shanlin Yang, Yi Li, Yuxia Zhao, Hongyou Zhao

2026, 17 (3): 1306-1334 | DOI: 10.14336/AD.2025.0448

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Blue Zones, an Analysis of Existing Evidence through a Scoping Review
Cristina Candal-Pedreira, Julia Rey-Brandariz, Lucía Martín-Gisbert, Ana Teijeiro, Guadalupe García, Alberto Ruano-Ravina, Mónica Pérez-Ríos

2026, 17 (3): 1335-1346 | DOI: 10.14336/AD.2025.0461

PDF (429KB)
Supplement

1. Supplementary data.pdf (244KB)
Tumor Immunosenescence Driven by Chronic Inflammation: Mechanisms, Microenvironment Remodeling and Therapeutic Strategies
Yiran Liu, Yang Yu, Yuanyuan Chen, Jing Zhuang, Changgang Sun

2026, 17 (3): 1347-1370 | DOI: 10.14336/AD.2025.0471

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RSV Infection and Neurodegenerative Diseases: A Hypothesis of Energy Metabolism Disruption via the Lung-Brain Axis
Zeping Liu, Yan Zhou, Mingming Qi, Fangyuan Ren, Yurong Tan

2026, 17 (3): 1370-1381 | DOI: 10.14336/AD.2025.0534

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Spatial Insights in Cardiovascular Aging
Zhongling Dai, Huiqin Ding, Quan Zhang, Liyao Fu, Shi Tai

2026, 17 (3): 1382-1398 | DOI: 10.14336/AD.2025.0272

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Type 2 Diabetes Mellitus: A Metabolic Model of Accelerated Aging - Multi-Organ Mechanisms and Intervention Approaches
Ziran Zhang, Xiaolin He, Yuxin Sun, Jitong Li, Jia Sun

2026, 17 (3): 1399-1422 | DOI: 10.14336/AD.2025.0233

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A Comprehensive Review of the Correlations of Measurement Parameters among Modern Technologies for Sarcopenia Assessment
Dawei Zhang, Sai Kit Lam, Yongping Zheng

2026, 17 (3): 1423-1445 | DOI: 10.14336/AD.2025.0145

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Supplement

1. Supplementary data.pdf (595KB)
Pericytes in the Development and Progression of Brain Diseases
Qingbin Wu, Xinyi Cui, Xiaochen Yuan, Jianqun Han, Hongwei Li, Ruijuan Xiu

2026, 17 (3): 1446-1460 | DOI: 10.14336/AD.2025.0028

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Optic Atrophy 1: The Conductor of Cellular Harmony and Age-Related Pathologies
Ye Xu, Jingwen Zhu, Qixiang Shao, Hui Wang

2026, 17 (3): 1460-1483 | DOI: 10.14336/AD.2025.0017

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Gut Fungi in Alzheimer's Disease: Mechanisms, Biomarkers and Therapeutic Potential
Ziyu Liu, Zhuo Chen, Xiaoyan Zhang, Yi Ge, Duo Yuan, Huihong Zhai

2026, 17 (3): 1484-1499 | DOI: 10.14336/AD.2024.1310

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Original Article

The Cognitive Functions Dementia Battery: A Novel Computerized Tool for Neurocognitive Disorders
Raquel Lemos, Sofia Areias-Marques, Alexandros Lazaridis, Johanna Zils, Cristina Martins, Sílvia Almeida, Luísa Alves, David Brieber, Albino J. Oliveira-Maia

2026, 17 (3): 1499-1515 | DOI: 10.14336/AD.2025.0412

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Supplement

1. Supplementary data.pdf (440KB)
Microcirculation Dysfunction in Subacute Stroke: The Role of Delayed Capillary Pericyte Loss
Yiya Xu, Chao Chen, Jilin Weng, Ting Chen, Yingchao He, Zhiwei Song, Yinzhou Wang

2026, 17 (3): 1516-1533 | DOI: 10.14336/AD.2025.0197

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Supplement

1. Supplementary data.pdf (1613KB)
Postbiotic Parabacteroides Distasonis Supplementation Enhances Intestinal and Skeletal Muscle Function in Aged Mice
Pablo Morgado-Cáceres, Hernán Huerta, Cristian Bergman, Reinaldo Figueroa, Paula Farias, Gabriel Quiroz, Ute Woehlbier, Karen Mella, Osmán Díaz-Rivera, Sergio Linsambarth, Paulina Calderón-Romero, Felipe A. Court, Denisse Sepulveda, Daniela Sauma, Patricia Luz-Crawford, Anibal A. Vargas, Catalina Gonzalez-Seguel, J. César Cárdenas, Alenka Lovy

2026, 17 (3): 1534-1556 | DOI: 10.14336/AD.2025.0188

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Supplement

1. Supplementary data.pdf (341KB)
Neurofilament-Light Chain and Glial Fibrillary Acidic Protein as Blood-Based Delirium Risk Markers: A Multicohort Study
Maria Cristina Ferrara, Lucía Lozano-Vicario, Beatrice Arosio, Cristina D’Orlando, Lara De Luca, Alice Margherita Ornago, Elena Pinardi, Paolo Mazzola, Chukwuma Okoye, Riccardo Gamberale, Francesca Remelli, Massimiliano Castellazzi, Giovanni Zatti, Giuseppe Foti, Ángel Javier Muñoz-Vázquez, Nicolás Martínez-Velilla, Stefano Volpato, Giuseppe Bellelli, on behalf of the ORTODEL group (Appendix 1)

2026, 17 (3): 1556-1568 | DOI: 10.14336/AD.2025.0107

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Supplement

1. Supplementary data.pdf (717KB)
Layer-Specific Colocalization of Microglia with Amyloid Plaques in the Middle Temporal Gyrus Predicts Cognitive Decline in Alzheimer's Disease
Wellydo Kesllowd Marinho Escarião, Guilherme Henrique Viana da Silva, Hellen Suzane Clemente de Castro, Sayonara Pereira da Silva, Nelyane Nayara Martins de Santana, Ramon Hypolito Lima, Felipe Porto Fiuza

2026, 17 (3): 1568-1589 | DOI: 10.14336/AD.2025.0409

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Supplement

1. Supplementary data.pdf (459KB)
Anillin Recedes in p53-Dependent Senescence of Tumor Cells and Reappears in Cells Escaping from Senescence
Tomasz Buko, Karolina Staniak, Magdalena Dudkowska, Dorota Janiszewska, Dominika Dębowska, Agnieszka Gadecka, Anna Bielak-Zmijewska

2026, 17 (3): 1590-1603 | DOI: 10.14336/AD.2025.0402

PDF (966KB)
Supplement

1. Supplementary data.pdf (899KB)
Lanatoside C, a Novel Senolytic, Ameliorates Atherosclerosis in Mice
Eok-Cheon Kim, Youlim Son, Seon-Hui Kim, Soo-Ji Kim, So-Young Park, Jae-Ryong Kim

2026, 17 (3): 1603-1616 | DOI: 10.14336/AD.2025.1219

PDF (1401KB)
Supplement

1. Supplementary data.pdf (448KB)
Neutrophil Extracellular Traps Promote AIM2-Dependent Microglial Pyroptosis Following Stroke
Hanze Chen, Linhui Ni, Jinhua Zhang, Xu Zheng, Yigang Chen, Xing Jin, Beibei Hu, Xinxin Xu, Qiwen Tang, Shuang Li, Yonggang Hao, Shilong Sun, Chengbin He, Shuxia Cao, Xingyue Hu

2026, 17 (3): 1616-1633 | DOI: 10.14336/AD.2024.1733

PDF (1448KB)
Supplement

1. Supplementary data.pdf (1499KB)
Microglial Histaminergic Signaling Promotes Interleukin-10 Production and Ameliorates Motor Dysfunction in Parkinson's Disease
Yining Wang, Minglai Zhao, Lingjuan Li, Xiaoying Liu, Liqin Lang, Xin Zhang, Zengxin Qi

2026, 17 (3): 1633-1654 | DOI: 10.14336/AD.2025.0088

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Associations of Elevated Red Cell Distribution Width (RDW) with Decreased Physical and Cognitive Function in Older Adults, and The Potential Mediation by Mitochondrial Energetics: The Study of Muscle, Mobility and Aging (SOMMA)
Kyoung Min Kim, Li-Yung Lui, Theresa Mau, Paul M. Coen, Steven R Cummings

2026, 17 (3): 1654-1663 | DOI: 10.14336/AD.2024.1724

PDF (744KB)
Supplement

1. Supplementary data.pdf (278KB)
Advanced Age Worsens Phenotypes of Ocular Hypertension in Mice
Priyamvada M. Pitale, Solomon E. Gibson, Caroline C. Keehn, Arman T. Yazdian, Guofu Shen, Benjamin J. Frankfort

2026, 17 (3): 1664-1676 | DOI: 10.14336/AD.2025.0349

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Supplement

1. Supplementary data.pdf (316KB)
Risk Factors for Oropharyngeal Dysphagia in Older Adults - Evidence from Consorci Sanitari Del Maresme and Mataró University Hospital, Catalonia, Spain
Lucilla Guidotti, Jorge Iván Castañeda-Maldonado, Marta Santiago, Pere Clavé, Omar Ortega

2026, 17 (3): 1677-1699 | DOI: 10.14336/AD.2025.0345

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Association between Visual, Hearing and Dual Sensory Impairment and the Frailty Syndrome
Humberto Yévenes-Briones, Francisco Félix Caballero, Aitana Vázquez-Fernández, Pablo Martinez-Amezcua, Teresa T Fung, Esther Lopez-Garcia

2026, 17 (3): 1700-1709 | DOI: 10.14336/AD.2025.0342

PDF (433KB)
Supplement

1. Supplementary data.pdf (313KB)
Exploring the Complex Relationship between Biological Aging and Cancer in a Prospective Italian Population Cohort
Martina Morelli, Antonietta Pepe, Simona Costanzo, Teresa Panzera, Sara Magnacca, Amalia De Curtis, Maria Loreto Muñoz Venegas, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello, Alessandro Gialluisi, on-behalf-of the Moli-sani Study Investigators

2026, 17 (3): 1710-1722 | DOI: 10.14336/AD.2025.0204

PDF (765KB)
Supplement

1. Supplementary data.pdf (831KB)
Stroke Exacerbates Respiratory Disorder and Cognition Impairment in Mice with Cerebral Amyloid Angiopathy
YuXing Zhang, Ahmad El Hamamy, Zahid Iqbal, Arya Ranjan, Destiny Sumani, Hung Wen Lin, Louise D. McCullough, Jun Li

2026, 17 (3): 1723-1736 | DOI: 10.14336/AD.2025.0474

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Short-Chain Fatty Acids Improve Hippocampal Atrophy, Ventricular Dilatation and Cognitive Function Decline in Aged Mice
Pei-Ju Lee, Yu-Chun Lo, You-Yin Chen, Chaur-Jong Hu, Yen-Kuang Lin, Quoc Thao Trang Pham, Nicholas Keyi Sim, Chee Kin Then, Shing-Chuan Shen

2026, 17 (3): 1737-1755 | DOI: 10.14336/AD.2025.0426

PDF (1951KB)
Supplement

1. Supplementary data.pdf (660KB)

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