Aging and disease

Rapidly Progressive Dementia with Asymmetric Rigidity Following ChAdOx1 nCoV-19 Vaccination Sankha Shubhra Chakrabarti, Ashutosh Tiwari, Sumit Jaiswal, Upinder Kaur, Ishan Kumar, Amit Mittal, Anup Singh, Kunlin Jin, Sasanka Chakrabarti: 2022, 13 (3): 633-636 | DOI: 10.14336/AD.2021.1102; PDF (363KB)

DeepMAge: A Methylation Aging Clock Developed with Deep Learning Fedor Galkin, Polina Mamoshina, Kirill Kochetov, Denis Sidorenko, Alex Zhavoronkov: 2021, 12 (5): 1252-1262 | DOI: 10.14336/AD.2020.1202; PDF (742KB)
Supplement; 1. Supplementary data.pdf (2088KB)

Metabolic Strategies in Healthcare: A New Era Matthew CL Phillips: 2022, 13 (3): 655-672 | DOI: 10.14336/AD.2021.1018; PDF (855KB)

New Insights into the Roles and Mechanisms of Spermidine in Aging and Age-Related Diseases Yu-Qing Ni, You-Shuo Liu: 2021, 12 (8): 1948-1963 | DOI: 10.14336/AD.2021.0603; PDF (645KB)

Comparative Analysis of Aducanumab, Zagotenemab and Pioglitazone as Targeted Treatment Strategies for Alzheimer’s Disease Morteza Abyadeh, Vivek Gupta, Veer Gupta, Nitin Chitranshi, Yunqi Wu, Ardeshir Amirkhani, Anna Meyfour, Samran Sheriff, Ting Shen, Kunal Dhiman, Ghasem H. Salekdeh, Paul A. Haynes, Stuart L. Graham, Mehdi Mirzaei: 2021, 12 (8): 1964-1976 | DOI: 10.14336/AD.2021.0719; PDF (536KB)

Premature Senescence of T-cells Favors Bone Loss During Osteolytic Diseases. A New Concern in the Osteoimmunology Arena Luis González-Osuna, Alfredo Sierra-Cristancho, Carolina Rojas, Emilio A Cafferata, Samanta Melgar-Rodríguez, Angélica M Cárdenas, Rolando Vernal: 2021, 12 (5): 1150-1161 | DOI: 10.14336/AD.2021.0110; PDF (1165KB)

Exercise in Aging: Be Balanced Joanna Gronek, Michał Boraczyński, Piotr Gronek, Dariusz Wieliński, Jacek Tarnas, Sławomir Marszałek, Yi-Yuan Tang: 2021, 12 (5): 1140-1149 | DOI: 10.14336/AD.2021.0107; PDF (639KB)

Cognitive Impairment and Metabolite Profile Alterations in the Hippocampus and Cortex of Male and Female Mice Exposed to a Fat and Sugar-Rich Diet are Normalized by Diet Reversal Alba M Garcia-Serrano, Adélaïde A Mohr, Juliette Philippe, Cecilia Skoug, Peter Spégel, João M.N Duarte: 2022, 13 (1): 267-283 | DOI: 10.14336/AD.2021.0720; PDF (1307KB)
Supplement; 1. Supplementary data.pdf (119KB)

Pharmacology and Potential Implications of Nicotinamide Adenine Dinucleotide Precursors Jing She, Rui Sheng, Zheng-Hong Qin: 2021, 12 (8): 1879-1897 | DOI: 10.14336/AD.2021.0523; PDF (621KB)

Depression and Dementia in Older Adults: A Neuropsychological Review Syuichi Tetsuka: 2021, 12 (8): 1920-1934 | DOI: 10.14336/AD.2021.0526; PDF (543KB)

Pharmacological Blockade of NLRP3 Inflammasome/IL-1β-Positive Loop Mitigates Endothelial Cell Senescence and Dysfunction Alejandra Romero, Pilar Dongil, Inés Valencia, Susana Vallejo, Álvaro San Hipólito-Luengo, Guillermo Díaz-Araya, José L Bartha, María M González-Arlanzón, Fernando Rivilla, Fernando de la Cuesta, Carlos F Sánchez-Ferrer, Concepción Peiró: 2022, 13 (1): 284-297 | DOI: 10.14336/AD.2021.0617; PDF (1545KB)
Supplement; 1. Supplementary data.pdf (503KB)

Polyphenols Could Prevent SARS-CoV-2 Infection by Modulating the Expression of miRNAs in the Host Cells Dragan Milenkovic, Tatjana Ruskovska, Ana Rodriguez-Mateos, Christian Heiss: 2021, 12 (5): 1169-1182 | DOI: 10.14336/AD.2021.0223; PDF (765KB)

The Effect of COVID-19-related Lockdowns on Diet and Physical Activity in Older Adults: A Systematic Review Elisabeth Anne Larson, Karlen Stade Bader-Larsen, Faidon Magkos: 2021, 12 (8): 1935-1947 | DOI: 10.14336/AD.2021.0606; PDF (772KB)

The Proper Diet and Regular Physical Activity Slow Down the Development of Parkinson Disease Patryk Andrzej Chromiec, Zofia Kinga Urbaś, Martyna Jacko, Jan Jacek Kaczor: 2021, 12 (7): 1605-1623 | DOI: 10.14336/AD.2021.0123; PDF (652KB)

The Role of SGLT2 Inhibitors in Vascular Aging Le Liu, Yu-Qing Ni, Jun-Kun Zhan, You-Shuo Liu: 2021, 12 (5): 1323-1336 | DOI: 10.14336/AD.2020.1229; PDF (737KB)

cGAS- Stimulator of Interferon Genes Signaling in Central Nervous System Disorders Fengjuan Li, Ningqun Wang, Yangmin Zheng, Yumin Luo, Yongbo Zhang: 2021, 12 (7): 1658-1674 | DOI: 10.14336/AD.2021.0304; PDF (1087KB)

A Unique Type of Highly-Activated Microglia Evoking Brain Inflammation via Mif/Cd74 Signaling Axis in Aged Mice Chenghao Jin, Yijie Shao, Xiaotao Zhang, Jiani Xiang, Ruize Zhang, Zeyu Sun, Shuhao Mei, Jingyi Zhou, Jianmin Zhang, Ligen Shi: 2021, 12 (8): 2125-2139 | DOI: 10.14336/AD.2021.0520; PDF (2051KB)
Supplement; 1. Supplementary data.pdf (1992KB)

Targeting NLRP3 Inflammasome in the Treatment Of Diabetes and Diabetic Complications: Role of Natural Compounds from Herbal Medicine Ying Bai, Qianqian Mu, Xueli Bao, Jiacheng Zuo, Xin Fang, Jing Hua, Dongwei Zhang, Guangjian Jiang, Ping Li, Sihua Gao, Dandan Zhao: 2021, 12 (7): 1587-1604 | DOI: 10.14336/AD.2021.0318; PDF (975KB)

The Cause of Alzheimer’s Disease: The Theory of Multipathology Convergence to Chronic Neuronal Stress Boris Decourt, Gary X D’Souza, Jiong Shi, Aaron Ritter, Jasmin Suazo, Marwan N Sabbagh: 2022, 13 (1): 37-60 | DOI: 10.14336/AD.2021.0529; PDF (1536KB)

Irreversibility of Pulmonary Fibrosis Qing Yang Yu, Xiao Xiao Tang: 2022, 13 (1): 73-86 | DOI: 10.14336/AD.2021.0730; PDF (691KB)

tRNA-derived fragments as New Hallmarks of Aging and Age-related Diseases Ya Yuan, Jiamei Li, Zhi He, Xiaolan Fan, Xueping Mao, Mingyao Yang, Deying Yang: 2021, 12 (5): 1304-1322 | DOI: 10.14336/AD.2021.0115; PDF (937KB)

Proteomic Profiling of Extracellular Vesicles Separated from Plasma of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy Satoshi Muraoka, Annina M DeLeo, Zijian Yang, Harutsugu Tatebe, Kayo Yukawa-Takamatsu, Seiko Ikezu, Takahiko Tokuda, David Issadore, Robert A Stern, Tsuneya Ikezu: 2021, 12 (6): 1363-1375 | DOI: 10.14336/AD.2020.0908; PDF (1176KB)
Supplement; 1. Supplementary data.pdf (1144KB)

Extracellular Vesicles as Novel Diagnostic and Prognostic Biomarkers for Parkinson’s Disease Loredana Leggio, Greta Paternò, Silvia Vivarelli, Giovanna G Falzone, Carmela Giachino, Bianca Marchetti, Nunzio Iraci: 2021, 12 (6): 1494-1515 | DOI: 10.14336/AD.2021.0527; PDF (1170KB)

Aspirin Positively Contributes to Drosophila Intestinal Homeostasis and Delays Aging through Targeting Imd Yangyang Zhu, Qingshuang Cai, Xianrui Zheng, Lei Liu, Yongzhi Hua, Beibei Du, Guomin Zhao, Jiangliu Yu, Zhao Zhuo, Zhongwen Xie, Shanming Ji: 2021, 12 (7): 1821-1834 | DOI: 10.14336/AD.2020.1008; PDF (1830KB)
Supplement; 1. Supplementary data.pdf (842KB)

The Aged Intestine: Performance and Rejuvenation Qiwen Wang, Yadong Qi, Weiyi Shen, Jilei Xu, Lan Wang, Shujie Chen, Tongyao Hou, Jianmin Si: 2021, 12 (7): 1693-1912 | DOI: 10.14336/AD.2021.0202; PDF (1051KB)

Neuroplastic Effect of Exercise Through Astrocytes Activation and Cellular Crosstalk Fengwu Li, Xiaokun Geng, Ho Jun Yun, Yazeed Haddad, Yuhua Chen, Yuchuan Ding: 2021, 12 (7): 1644-1657 | DOI: 10.14336/AD.2021.0325; PDF (1867KB)

Human Adipose Mesenchymal Stem Cell-derived Exosomes Protect Mice from DSS-Induced Inflammatory Bowel Disease by Promoting Intestinal-stem-cell and Epithelial Regeneration Hongliang Yu, Xudong Yang, Xian Xiao, Meiqian Xu, Yanlei Yang, Chunling Xue, Xuechun Li, Shihua Wang, Robert Chunhua Zhao: 2021, 12 (6): 1423-1437 | DOI: 10.14336/AD.2021.0601; PDF (1572KB)
Supplement; 1. Supplementary data.pdf (100KB)

Extracellular Vesicles for the Diagnosis and Treatment of Parkinson’s Disease Raghavendra Upadhya, Ashok K Shetty: 2021, 12 (6): 1438-1450 | DOI: 10.14336/AD.2021.0516; PDF (843KB)

Therapeutic Potential of Nucleic Acids when Combined with Extracellular Vesicles Brian Jurgielewicz, Steven Stice, Yao Yao: 2021, 12 (6): 1476-1493 | DOI: 10.14336/AD.2021.0708; PDF (704KB)

Blocking C3d ⁺/GFAP ⁺ A1 Astrocyte Conversion with Semaglutide Attenuates Blood-Brain Barrier Disruption in Mice after Ischemic Stroke Qi Zhang, Chang Liu, Rubing Shi, Shiyi Zhou, Huimin Shan, Lidong Deng, Tingting Chen, Yiyan Guo, Zhijun Zhang, Guo-Yuan Yang, Yongting Wang, Yaohui Tang: 2022, 13 (3): 943-959 | DOI: 10.14336/AD.2021.1029; PDF (1915KB)
Supplement; 1. Supplementary data.pdf (888KB)

MSC-Derived Exosomes can Enhance the Angiogenesis of Human Brain MECs and Show Therapeutic Potential in a Mouse Model of Parkinson's Disease Chunling Xue, Xuechun Li, Li Ba, Mingjia Zhang, Ying Yang, Yang Gao, Zhao Sun, Qin Han, Robert Chunhua Zhao: 2021, 12 (5): 1211-1222 | DOI: 10.14336/AD.2020.1221; PDF (1718KB)

Promising Intervention Approaches to Potentially Resolve Neuroinflammation And Steroid Hormones Alterations in Alzheimer’s Disease and Its Neuropsychiatric Symptoms Catia Scassellati, Antonio Carlo Galoforo, Ciro Esposito, Miriam Ciani, Giovanni Ricevuti, Cristian Bonvicini: 2021, 12 (5): 1337-1357 | DOI: 10.14336/AD.2021.0122; PDF (1633KB)
Supplement; 1. Supplementary data.pdf (290KB)

Intrinsic Capacity in Older Adults: Recent Advances Yaru Zhou, Lina Ma: 2022, 13 (2): 353-359 | DOI: 10.14336/AD.2021.0818; PDF (361KB)

ACE2 and COVID-19 Susceptibility and Severity Ming Zheng: 2022, 13 (2): 360-372 | DOI: 10.14336/AD.2021.0805; PDF (1806KB)

Alzheimer Disease: Recent Updates on Apolipoprotein E and Gut Microbiome Mediation of Oxidative Stress, and Prospective Interventional Agents Benson OA Botchway, Favour C Okoye, Yili Chen, William E Arthur, Marong Fang: 2022, 13 (1): 87-102 | DOI: 10.14336/AD.2021.0616; PDF (535KB)
Supplement; 1. Supplementary data.pdf (157KB)

Extracellular GAPDH Promotes Alzheimer Disease Progression by Enhancing Amyloid-β Aggregation and Cytotoxicity Vladimir F Lazarev, Magda Tsolaki, Elena R Mikhaylova, Konstantin A Benken, Maxim A Shevtsov, Alina D Nikotina, Mirna Lechpammer, Vladimir A Mitkevich, Alexander A Makarov, Alexey A Moskalev, Sergey A Kozin, Boris A Margulis, Irina V Guzhova, Evgeny Nudler: 2021, 12 (5): 1223-1237 | DOI: 10.14336/AD.2020.1230; PDF (1913KB)
Supplement; 1. Supplementary data.pdf (493KB)

Enrichment of Phosphorylated Tau (Thr181) and Functionally Interacting Molecules in Chronic Traumatic Encephalopathy Brain-derived Extracellular Vesicles Satoshi Muraoka, Weiwei Lin, Kayo Takamatsu-Yukawa, Jianqiao Hu, Seiko Ikezu, Michael A DeTure, Dennis W Dickson, Andrew Emili, Tsuneya Ikezu: 2021, 12 (6): 1376-1388 | DOI: 10.14336/AD.2020.1007; PDF (1348KB)
Supplement; 1. Supplementary data.pdf (1478KB)

Serum from Older Adults Increases Apoptosis and Molecular Aging Markers in Human Hippocampal Progenitor Cells Chiara de Lucia, Tytus Murphy, Aleksandra Maruszak, Paul Wright, Timothy R Powell, Naomi Hartopp, Simone de Jong, Michael J O'Sullivan, Gerome Breen, Jack Price, Simon Lovestone, Sandrine Thuret: 2021, 12 (8): 2151-2172 | DOI: 10.14336/AD.2021.0409; PDF (1600KB)
Supplement; 1. Supplementary data.pdf (1416KB)

Regulatory T cells in COVID-19 Huan Wang, Zhao Wang, Wen Cao, Qianqian Wu, Yujia Yuan, Xiangjian Zhang: 2021, 12 (7): 1545-1553 | DOI: 10.14336/AD.2021.0709; PDF (481KB)

Cellular Senescence in Cardiovascular Diseases: A Systematic Review Can Hu, Xin Zhang, Teng Teng, Zhen-Guo Ma, Qi-Zhu Tang: 2022, 13 (1): 103-128 | DOI: 10.14336/AD.2021.0927; PDF (883KB)

E-mail Alert

RSS

Most Read