Aging and disease

Long-Term Improvement in Hippocampal-Dependent Learning Ability in Healthy, Aged Individuals Following High Intensity Interval Training Daniel G. Blackmore, Mia A. Schaumberg, Maryam Ziaei, Samuel Belford, Xuan Vinh To, Imogen O’Keeffe, Anne Bernard, Jules Mitchell, Emily Hume, Grace L. Rose, Thomas Shaw, Ashley York, Markus Barth, Elizabeth J. Cooper, Tina L. Skinner, Fatima Nasrallah, Stephan Riek, Perry F. Bartlett: 2025, 16 (3): 1732-1754 | DOI: 10.14336/AD.2024.0642; PDF (1507KB)
Supplement; 1. Supplementary data.pdf (6754KB)

Age-Related Dysfunction in Balance: A Comprehensive Review of Causes, Consequences, and Interventions Jixian Wang, Yongfang Li, Guo-Yuan Yang, Kunlin Jin: 2025, 16 (2): 714-737 | DOI: 10.14336/AD.2024.0124-1; PDF (451KB)

The Expanding Burden of Neurodegenerative Diseases: An Unmet Medical and Social Need Shu Wang, Yin Jiang, Anchao Yang, Fangang Meng, Jianguo Zhang: 2025, 16 (5): 2937-2952 | DOI: 10.14336/AD.2024.1071; PDF (1253KB)

AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent Qiuqiong Tang, Deyong Xiao, Alexander Veviorskiy, Ying Xin, Sarah W.Y. Lok, Fadi E. Pulous, Peiran Zhang, Yunfeng Zhu, Yongming Ma, Xiao Hu, Shoulai Gu, Chenting Zong, Sabina Mukba, Mikhail Korzinkin, Frank W. Pun, Man Zhang, Alex Aliper, Lijuan Wu, Feng Ren, Li Zhang, Alex Zhavoronkov: 2026, 17 (1): 432-451 | DOI: 10.14336/AD.2024.1492; PDF (1509KB)
Supplement; 1. Supplementary data.pdf (1198KB); 2. TNIK Senomorphic Video.mp4.mp4 (14113KB)

Amyloid-β and Phosphorylated Tau are the Key Biomarkers and Predictors of Alzheimer’s Disease Jangampalli Adi Pradeepkiran, Javaria Baig, Md Ariful Islam, Sudhir Kshirsagar, P. Hemachandra Reddy: 2025, 16 (2): 658-682 | DOI: 10.14336/AD.2024.0286; PDF (1120KB)

Cerebral Small Vessel Disease: Current and Emerging Therapeutic Strategies Yuewen Sun, Xiaoqian Song, Chenyang Jin, Yilong Peng, Jing Zhou, Xueping Zheng: 2026, 17 (1): 286-303 | DOI: 10.14336/AD.2024.1515; PDF (567KB)

Reduced Blood Choline in Obesity Is Associated with Metabolic and Alzheimer’s Biomarkers Wendy Winslow, Jessica M. Judd, Savannah Tallino, Geidy E. Serrano, Thomas G. Beach, Lori R. Roust, Eleanna De Filippis, Brooke Brown, Christos Katsanos, Ramon Velazquez: | DOI: 10.14336/AD.2025.1207; PDF (1850KB)

Causality of Aging Hallmarks Bilu Huang, Xiaowen Hu: | DOI: 10.14336/AD.2025.0541; PDF (597KB)

Perimenopausal Hormone Replacement Treatments as a Geroprotective Approach - Adapting Clinical Guidance Jaron Rabinovici, Henk-Peter Oonk, Zhongwei Huang, Tashiya Mirando, Moran Zhou, Tzipora Strauss, Lia-Raluca Olari, Dominika Wilczok, Andrea B. Maier, Evelyne Bischof: | DOI: 10.14336/AD.2025.1391; PDF (516KB)

Epigenetic Clocks: Beyond Biological Age, Using the Past to Predict the Present and Future Runyu Liang, Qiang Tang, Jia Chen, Luwen Zhu: 2025, 16 (6): 3520-3545 | DOI: 10.14336/AD.2024.1495; PDF (986KB)

LLMs and AI Life Models for Traditional Chinese Medicine-derived Geroprotector Formulation Fedor Galkin, Feng Ren, Alex Zhavoronkov: | DOI: 10.14336/AD.2024.1697; PDF (899KB)

Deformability of Heterogeneous Red Blood Cells in Aging and Related Pathologies Dmitry S. Prudinnik, Aigul Kussanova, Ivan A. Vorobjev, Alexander Tikhonov, Fazly I. Ataullakhanov, Natasha S. Barteneva: 2025, 16 (3): 1242-1264 | DOI: 10.14336/AD.2024.0526; PDF (1188KB)

Skin-brain axis in Alzheimer's disease - Pathologic, diagnostic, and therapeutic implications: A Hypothetical Review Hyeon soo Kim, Haram Jung, Yong Ho Park, Su-Hak Heo, Sujin Kim, Minho Moon: 2025, 16 (2): 901-916 | DOI: 10.14336/AD.2024.0406; PDF (639KB)

Revolutionizing Diabetic Foot Ulcer Care: The Senotherapeutic Approach Guiqin Zhang, Priyadarshani Nadeeshika Samarawickrama, Li Gui, Yuan Ma, Mei Cao, Hong Zhu, Wei Li, Honglin Yang, Kecheng Li, Yang Yang, Enfang Zhu, Wen Li, Yonghan He: 2025, 16 (2): 946-970 | DOI: 10.14336/AD.2024.0065; PDF (1049KB)

Expert Consensus on the Application of Stem Cells in Psoriasis Research and Clinical Trials Ye-Hong Kuang, Wu Zhu, Ge Lin, La-Mei Cheng, Qun Qin, Zhi-Jun Huang, Yu-Ling Shi, Chun-Lei Zhang, Jin-Hua Xu, Ke-Xiang Yan, Cheng-Zhi Lv, Wei Li, Qin Han, Ilia Stambler, Lee Wei Lim, Sasanka Chakrabarti, Brun Ulfhake, Kyung-Jin Min, Georgina Ellison-Hughes, William C Cho, Kunlin Jin, Danni Yao, Chuanjian Lu, Robert Chunhua Zhao, Xiang Chen: 2025, 16 (3): 1363-1377 | DOI: 10.14336/AD.2024.0012; PDF (615KB)

Aging-Related Sarcopenia: Metabolic Characteristics and Therapeutic Strategies Yonglian Chen, Jinhui Wu: 2025, 16 (2): 1003-1022 | DOI: 10.14336/AD.2024.0407; PDF (635KB)

Aging and “Age-Related” Diseases - What Is the Relation? Wolfgang Kopp: 2025, 16 (3): 1316-1346 | DOI: 10.14336/AD.2024.0570; PDF (802KB)

Aging Gut Microbiome in Healthy and Unhealthy Aging Yangyanqiu Wang, Zhanbo Qu, Jian Chu, Shuwen Han: 2025, 16 (2): 980-1002 | DOI: 10.14336/AD.2024.0331; PDF (1158KB)

Disulfidptosis, A Novel Cell Death Pathway: Molecular Landscape and Therapeutic Implications Qiuyang Gu, Yumei An, Mingyuan Xu, Xinqi Huang, Xueshi Chen, Xianzhe Li, Haiyan Shan, Mingyang Zhang: 2025, 16 (2): 917-945 | DOI: 10.14336/AD.2024.0083; PDF (1129KB)

Cellular Aging and Senescence in Cancer: A Holistic Review of Cellular Fate Determinants Muhammad Tufail, Yu-Qi Huang, Jia-Ju Hu, Jie Liang, Cai-Yun He, Wen-Dong Wan, Can-Hua Jiang, Hong Wu, Ning Li: 2025, 16 (3): 1483-1512 | DOI: 10.14336/AD.2024.0421; PDF (1028KB)

Therapeutic Potential of Quercetin as an Antioxidant for Bone-Muscle-Tendon Regeneration and Aging Jae Gyu Kim, Ashish Ranjan Sharma, Yeon-Hee Lee, Srijan Chatterjee, Yean Jung Choi, Roshani Rajvansh, Chiranjib Chakraborty, Sang-Soo Lee: 2025, 16 (3): 1414-1437 | DOI: 10.14336/AD.2024.0282; PDF (696KB)

Exercise-Induced Central Fatigue: Biomarkers and Non-Medicinal Interventions Ying Yang, Zhi Feng, Yu-hang Luo, Jue-miao Chen, Yu Zhang, Yi-jun Liao, Hui Jiang, Yinxi Long, Bo Wei: 2025, 16 (3): 1302-1315 | DOI: 10.14336/AD.2024.0567; PDF (469KB)

Recent Advances in Our Understanding of Age-Related Macular Degeneration: Mitochondrial Dysfunction, Redox Signaling, and the Complement System Francesco Buonfiglio, Christina A. Korb, Bernhard Stoffelns, Norbert Pfeiffer, Adrian Gericke: 2025, 16 (3): 1535-1575 | DOI: 10.14336/AD.2024.0124; PDF (1735KB)

Ovarian Aging: The Silent Catalyst of Age-Related Disorders in Female Body Xingyu Liu, Yuanqu Zhao, Yanzhi Feng, Shixuan Wang, Aiyue Luo, Jinjin Zhang: 2026, 17 (1): 132-158 | DOI: 10.14336/AD.2024.1468; PDF (1074KB)

Blue Zones, an Analysis of Existing Evidence through a Scoping Review Cristina Candal-Pedreira, Lucía Martín-Gisbert, Ana Teijeiro, Guadalupe García, Alberto Ruano-Ravina, Mónica Pérez-Ríos: | DOI: 10.14336/AD.2025.0461; PDF (474KB)
Supplement; 1. Supplementary data.pdf (244KB)

The Impact of Aging on Ocular Diseases: Unveiling Complex Interactions Luling You, Yumeng Lin, Yizhuo Zheng, Zhongyu Han, Liuzhi Zeng, Haoran Chen: 2025, 16 (5): 2803-2830 | DOI: 10.14336/AD.2024.0850; PDF (1167KB)

Excitotoxicity, Oxytosis/Ferroptosis, and Neurodegeneration: Emerging Insights into Mitochondrial Mechanisms Sameera Khan, Nargis Bano, Shakir Ahamad, Urmilla John, Nawab John Dar, Shahnawaz Ali Bhat: 2025, 16 (5): 2504-2543 | DOI: 10.14336/AD.2024.0125-1; PDF (1706KB)
Supplement; 1. Supplementary data.pdf (290KB)

Circulating Ketone Bodies, Pyruvate, and Citrate and Risk of Cognitive Decline, Structural Brain Abnormalities, and Dementia Laia Gutierrez-Tordera, Kristine F. Moseholm, Marta Trius-Soler, Mònica Bulló, Annette Fitzpatrick, Margery A. Connelly, Oscar L. Lopez, Majken K. Jensen, Marta Guasch-Ferré, Kenneth J. Mukamal: 2025, 16 (5): 3055-3068 | DOI: 10.14336/AD.2024.0754; PDF (713KB)
Supplement; 1. Supplementary data.pdf (534KB)

Green Tea Mitigates the Hallmarks of Aging and Age-Related Multisystem Deterioration Yusuf Yilmaz: | DOI: 10.14336/AD.2025.0398; PDF (683KB)

Adiponectin mRNA Conjugated with Lipid Nanoparticles Specifically Targets the Pathogenesis of Type 2 Diabetes Rady E. El-Araby, Qisheng Tu, Ying Xie, Tarek Aboushousha, Zhongyu Li, Xiaoyang Xu, Zoe X. Zhu, Lily Q. Dong, Jake Chen: 2025, 16 (2): 1059-1079 | DOI: 10.14336/AD.2024.0162; PDF (2552KB)
Supplement; 1. Supplementary data.pdf (275KB)

Senescent Astrocytes Derived from Human Pluripotent Stem Cells Reveal Age-Related Changes and Implications for Neurodegeneration Dongyun Kim, Seo Hyun Yoo, Gyu-Bum Yeon, Seung Soo Oh, Won-Ho Shin, Hoon-Chul Kang, Cheol-Koo Lee, Hyung Wook Kim, Dae-Sung Kim: 2025, 16 (3): 1709-1731 | DOI: 10.14336/AD.2024.0089; PDF (1753KB)
Supplement; 1. Supplementary data.pdf (1310KB)

The Management of Sarcopenic Dysphagia: A Multidisciplinary Approach Leveraging Emerging Technologies Wei Deng, Xiao-Feng Zeng, Li-Ying Zhang, Ji-Rong Yue, Xiao-Li Huang: 2025, 16 (5): 2752-2769 | DOI: 10.14336/AD.2024.0741; PDF (722KB)

Role of Serotonylation and SERT Posttranslational Modifications in Alzheimer's Disease Pathogenesis Arubala P. Reddy, Priyanka Rawat, Nicholas Rohr, Razelle Alvir, Jasbir Bisht, Mst Anika Bushra, Jennifer Luong, Aananya P. Reddy: 2025, 16 (2): 841-858 | DOI: 10.14336/AD.2024.0328; PDF (864KB)

The Role of the Complement System in Synaptic Pruning after Stroke Hongying Liu, Min Jiang, Zhiying Chen, Chuan Li, Xiaoping Yin, Xiaorong Zhang, Moxin Wu: 2025, 16 (3): 1452-1470 | DOI: 10.14336/AD.2024.0373; PDF (897KB)

Mitochondrial Dysfunction: A Roadmap for Understanding and Tackling Cardiovascular Aging Han Zhang, Mairedan Muhetarijiang, Ryan J. Chen, Xiaosheng Hu, Jie Han, Liangrong Zheng, Ting Chen: 2025, 16 (5): 2575-2614 | DOI: 10.14336/AD.2024.0058; PDF (1586KB)

SLC7A11 in Fibrosis: Molecular Mechanisms and Future Prospects Juntong Chen, Yanjie He, Ru Chen, Zhiyong Yang, Xiaomeng Luo, Fan Yang: | DOI: 10.14336/AD.2025.0106; PDF (1516KB)

Drug Screening and Validation Targeting TDP-43 Proteinopathy for Amyotrophic Lateral Sclerosis Jiaqi Xin, Sen Huang, Jing Wen, Yunhao Li, Ang Li, Senthil Kumaran Satyanarayanan, Xiaoli Yao, Huanxing Su: 2025, 16 (2): 693-713 | DOI: 10.14336/AD.2024.0440; PDF (669KB)

Pros and Cons of Human Brain Organoids to Study Alzheimer’s Disease Andrea Sainz, Fernando Pérez-Cerdá, Alberto Pérez-Samartín, Mitradas Panicker, Asier Ruiz, Carlos Matute: 2025, 16 (6): 3483-3504 | DOI: 10.14336/AD.2024.1409; PDF (1051KB)

Exosomal Proteomics: Unveiling Novel Insights into Lung Cancer Guanhua Yi, Haixin Luo, Yalin Zheng, Wenjing Liu, Denian Wang, Yong Zhang: 2025, 16 (2): 876-900 | DOI: 10.14336/AD.2024.0409; PDF (885KB)

Brain Iron Dyshomeostasis and Ferroptosis in Alzheimer’s Disease Pathophysiology: Two Faces of the Same Coin Mariarosa Mezzanotte, Serena Stanga: 2025, 16 (5): 2615-2640 | DOI: 10.14336/AD.2024.0094; PDF (967KB)

Cover Illustration

01 February 2026. VOL 17, ISSUE 1
The pathophysiology of hydrocephalus. The schematic diagram on the left shows the normal circulation of CSF. Any disruption in the processes of CSF circulation, such as production, movement, or absorption, can lead to the occurrence of hydrocephalus, as depicted on the right. Neuroinflammation, blood clots, iron overload, fibrosis, and ependymal dysfunction are recognized as significant mechanisms of hydrocephalus.

[Detail]

Cover Illustration

The pathophysiology of hydrocephalus. The schematic diagram on the left shows the normal circulation of CSF. Any disruption in the processes of CSF circulation, such as production, movement, or absorption, can lead to the occurrence of hydrocephalus, as depicted on the right. Neuroinflammation, blood clots, iron overload, fibrosis, and ependymal dysfunction are recognized as significant mechanisms of hydrocephalus.

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