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2024
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Total 40 results are found
The Expanding Burden of Neurodegenerative Diseases: An Unmet Medical and Social Need
Shu Wang, Yin Jiang, Anchao Yang, Fangang Meng, Jianguo Zhang
2025, 16 (5): 2937-2952 | DOI: 10.14336/AD.2024.1071
AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent
Qiuqiong Tang, Deyong Xiao, Alexander Veviorskiy, Ying Xin, Sarah W.Y. Lok, Fadi E. Pulous, Peiran Zhang, Yunfeng Zhu, Yongming Ma, Xiao Hu, Shoulai Gu, Chenting Zong, Sabina Mukba, Mikhail Korzinkin, Frank W. Pun, Man Zhang, Alex Aliper, Lijuan Wu, Feng Ren, Li Zhang, Alex Zhavoronkov
2026, 17 (1): 432-451 | DOI: 10.14336/AD.2024.1492
Supplement

1. Supplementary data.pdf (1198KB)

2. TNIK Senomorphic Video.mp4.mp4 (14113KB)

Cerebral Small Vessel Disease: Current and Emerging Therapeutic Strategies
Yuewen Sun, Xiaoqian Song, Chenyang Jin, Yilong Peng, Jing Zhou, Xueping Zheng
2026, 17 (1): 286-303 | DOI: 10.14336/AD.2024.1515
Peakspan: Defining, Quantifying and Extending the Boundaries of Peak Productive Lifespan
Authors: Alex Zhavoronkov, Kejun Ying, Dominika Wilczok
| DOI: 10.14336/AD.2026.0080
Perimenopausal Hormone Replacement Treatments as a Geroprotective Approach - Adapting Clinical Guidance
Jaron Rabinovici, Henk-Peter Oonk, Zhongwei Huang, Tashiya Mirando, Moran Zhou, Tzipora Strauss, Lia-Raluca Olari, Dominika Wilczok, Andrea B. Maier, Evelyne Bischof
| DOI: 10.14336/AD.2025.1391
Causality of Aging Hallmarks
Bilu Huang, Xiaowen Hu
2026, 17 (3): 1236-1253 | DOI: 10.14336/AD.2025.0541
Blue Zones, an Analysis of Existing Evidence through a Scoping Review
Cristina Candal-Pedreira, Julia Rey-Brandariz, Lucía Martín-Gisbert, Ana Teijeiro, Guadalupe García, Alberto Ruano-Ravina, Mónica Pérez-Ríos
2026, 17 (3): 1335-1346 | DOI: 10.14336/AD.2025.0461
Supplement

1. Supplementary data.pdf (244KB)

Reduced Blood Choline in Obesity Is Associated with Metabolic and Alzheimer’s Biomarkers
Wendy Winslow, Jessica M. Judd, Savannah Tallino, Geidy E. Serrano, Thomas G. Beach, Lori R. Roust, Eleanna De Filippis, Brooke Brown, Christos Katsanos, Ramon Velazquez
| DOI: 10.14336/AD.2025.1207
Epigenetic Clocks: Beyond Biological Age, Using the Past to Predict the Present and Future
Runyu Liang, Qiang Tang, Jia Chen, Luwen Zhu
2025, 16 (6): 3520-3545 | DOI: 10.14336/AD.2024.1495
Green Tea Mitigates the Hallmarks of Aging and Age-Related Multisystem Deterioration
Yusuf Yilmaz
2026, 17 (2): 712-730 | DOI: 10.14336/AD.2025.0398
LLMs and AI Life Models for Traditional Chinese Medicine-derived Geroprotector Formulation
Fedor Galkin, Feng Ren, Alex Zhavoronkov
2026, 17 (2): 1155-1168 | DOI: 10.14336/AD.2024.1697
Ovarian Aging: The Silent Catalyst of Age-Related Disorders in Female Body
Xingyu Liu, Yuanqu Zhao, Yanzhi Feng, Shixuan Wang, Aiyue Luo, Jinjin Zhang
2026, 17 (1): 132-158 | DOI: 10.14336/AD.2024.1468
SLC7A11 in Fibrosis: Molecular Mechanisms and Future Prospects
Juntong Chen, Yanjie He, Ru Chen, Zhiyong Yang, Xiaomeng Luo, Fan Yang
2026, 17 (2): 731-759 | DOI: 10.14336/AD.2025.0106
The Impact of Aging on Ocular Diseases: Unveiling Complex Interactions
Luling You, Yumeng Lin, Yizhuo Zheng, Zhongyu Han, Liuzhi Zeng, Haoran Chen
2025, 16 (5): 2803-2830 | DOI: 10.14336/AD.2024.0850
Dietary Interventions for Healthy Aging: An Epigenetic Perspective
Xinyu Zhang, Ziyue Xie, Huimin Bian, Yu Li, Ruigong Zhu, Jia Sun
| DOI: 10.14336/AD.2026.0333
The Impact of Rosemary and Ginger Extracts on Aging and Healthspan in Drosophila
Ricardo Aparicio, Anna M. Salazar, Edward T. Schmid, Armen Khanbabaei, Arun Rajgopal, R. Keith Randolph, David W. Walker
2026, 17 (1): 416-431 | DOI: 10.14336/AD.2024.1558
Supplement

1. Supplementary data.pdf (378KB)

Type 2 Diabetes Mellitus: A Metabolic Model of Accelerated Aging - Multi-Organ Mechanisms and Intervention Approaches
Ziran Zhang, Xiaolin He, Yuxin Sun, Jitong Li, Jia Sun
2026, 17 (3): 1399-1422 | DOI: 10.14336/AD.2025.0233
Excitotoxicity, Oxytosis/Ferroptosis, and Neurodegeneration: Emerging Insights into Mitochondrial Mechanisms
Sameera Khan, Nargis Bano, Shakir Ahamad, Urmilla John, Nawab John Dar, Shahnawaz Ali Bhat
2025, 16 (5): 2504-2543 | DOI: 10.14336/AD.2024.0125-1
Supplement

1. Supplementary data.pdf (290KB)

Human Aging and Age-Related Diseases: From Underlying Mechanisms to Pro-Longevity Interventions
Piotr Paweł Chmielewski, Krzysztof Data, Bartłomiej Strzelec, Maryam Farzaneh, Amir Anbiyaiee, Uzma Zaheer, Shahab Uddin, Mohadeseh Sheykhi-Sabzehpoush, Paul Mozdziak, Maciej Zabel, Piotr Dzięgiel, Bartosz Kempisty
2025, 16 (4): 1853-1877 | DOI: 10.14336/AD.2024.0280
Circulating Ketone Bodies, Pyruvate, and Citrate and Risk of Cognitive Decline, Structural Brain Abnormalities, and Dementia
Laia Gutierrez-Tordera, Kristine F. Moseholm, Marta Trius-Soler, Mònica Bulló, Annette Fitzpatrick, Margery A. Connelly, Oscar L. Lopez, Majken K. Jensen, Marta Guasch-Ferré, Kenneth J. Mukamal
2025, 16 (5): 3055-3068 | DOI: 10.14336/AD.2024.0754
Supplement

1. Supplementary data.pdf (534KB)

Towards Precision Aging Biology: Single-Cell Multi-Omics and Advanced AI-Driven Strategies
Sijia Xie, Xinwei Luo, Feitong Hong, Yijie Wei, Yuduo Hao, Xueqin Xie, Xiaolong Li, Guangbo Xie, Fuying Dao, Hao Lyu
2026, 17 (2): 907-926 | DOI: 10.14336/AD.2025.0218
Engineered Mitochondrial Transplantation as An Anti-Aging Therapy
Rui Zhao, Chen Dong, Qian Liang, Jianlin Gao, Chi Sun, Zhifeng Gu, Yujuan Zhu
2025, 16 (4): 1918-1945 | DOI: 10.14336/AD.2024.0231
A Combination of Low-Dose Δ9-THC and Celecoxib as a Therapeutic Strategy for Alzheimer’s Disease
Jian Zhang, Dexiao Zhu, Mei Hu, Mingzhe Pan, Chu Chen
| DOI: 10.14336/AD.2025.1206
Supplement

1. Supplementary data.pdf (4873KB)

The Management of Sarcopenic Dysphagia: A Multidisciplinary Approach Leveraging Emerging Technologies
Wei Deng, Xiao-Feng Zeng, Li-Ying Zhang, Ji-Rong Yue, Xiao-Li Huang
2025, 16 (5): 2752-2769 | DOI: 10.14336/AD.2024.0741
Pros and Cons of Human Brain Organoids to Study Alzheimer’s Disease
Andrea Sainz, Fernando Pérez-Cerdá, Alberto Pérez-Samartín, Mitradas Panicker, Asier Ruiz, Carlos Matute
2025, 16 (6): 3483-3504 | DOI: 10.14336/AD.2024.1409
The Role of Hypoxia in Longevity
Ayesha Nisar, Sawar Khan, Yongzhang Pan, Li Hu, Pengyun Yang, Naheemat Modupeola Gold, Zhen Zhou, Shengjie Yuan, Meiting Zi, Sardar Azhar Mehmood, Yonghan He
2026, 17 (1): 62-90 | DOI: 10.14336/AD.2024.1630
A Standardized Protocol for Mouse Longevity Studies in Preclinical Drug Development
Alex Zhavoronkov, Qian Wang, Yujie Liu, Wenbin Hou, Yuelei Shen, Dominika Wilczok, Kristen Fortney, Alex Aliper, Man Zhang, Feng Ren, Richard A. Miller
2026, 17 (3): 1169-1179 | DOI: 10.14336/AD.2025.0508
Engineering the Future of Longevity R&D: The Case for AI-Driven, Integrated Biotechnology Ecosystems
Alex Zhavoronkov, Chuen Yan Leung
| DOI: 10.14336/AD.2025.1313
Mitochondrial Dysfunction: A Roadmap for Understanding and Tackling Cardiovascular Aging
Han Zhang, Mairedan Muhetarijiang, Ryan J. Chen, Xiaosheng Hu, Jie Han, Liangrong Zheng, Ting Chen
2025, 16 (5): 2575-2614 | DOI: 10.14336/AD.2024.0058
Brain Iron Dyshomeostasis and Ferroptosis in Alzheimer’s Disease Pathophysiology: Two Faces of the Same Coin
Mariarosa Mezzanotte, Serena Stanga
2025, 16 (5): 2615-2640 | DOI: 10.14336/AD.2024.0094
The Organ-Joint Axes in Osteoarthritis: Significant Pathogenesis and Therapeutic Targets
Dinglong Yang, Yujing Chen, Junfei Guo, Xin Xu, Mingyi Yang, Jiale Xie, Ke Xu, Peng Xu
2025, 16 (5): 2999-3021 | DOI: 10.14336/AD.2024.1223
Bone Health and Physical Activity - The Complex Mechanism
Alicja Nowak, Małgorzata Ogurkowska
2025, 16 (6): 3400-3420 | DOI: 10.14336/AD.2024.1316
Capsaicin and TRPV1: A Novel Therapeutic Approach to Mitigate Vascular Aging
Xing-Yu Cui, Jun-Kun Zhan
2026, 17 (1): 256-274 | DOI: 10.14336/AD.2024.1292
Role of AMPK and Sirtuins in Aging Heart: Basic and Translational Aspects
Maria Luisa Barcena, Muhammad Aslam, Kristina Norman, Christiane Ott, Yury Ladilov
2025, 16 (6): 3335-3360 | DOI: 10.14336/AD.2024.1216
Targeting T-cell Aging to Remodel the Aging Immune System and Revitalize Geriatric Immunotherapy
Mi Chen, Zhou Su, Jianxin Xue
2026, 17 (2): 607-624 | DOI: 10.14336/AD.2025.0061
Metabolic Dysfunction in Idiopathic Intracranial Hypertension: Current Theories and Updates
Hui Li, Lu Liu, Yifan Zhou, Huimin Jiang, Weiyue Zhang, Chenxia Zhou, Chuanjie Wu, Chen Zhou, Xunming Ji
2025, 16 (6): 3311-3334 | DOI: 10.14336/AD.2024.1147
A Framework for an Effective Healthy Longevity Clinic
Sergey Mironov, Olga Borysova, Ivan Morgunov, Zhongjun Zhou, Alexey Moskalev
2025, 16 (4): 1971-1986 | DOI: 10.14336/AD.2024.0328-1
Supplement

1. Supplementary data.pdf (481KB)

Glucagon Like Peptide-1 Receptor Agonists for Sarcopenia and Muscle Wasting Disorders: A Systematic Review of Efficacy and Mechanisms
Abudureheman Maihemuti, Can Cui, Qianjin Wang, Reziwanguli Amuti, Wai Wang Chau, Senlin Chai, Ning Zhang, Ronald Man Yeung Wong, Ho Ko, Timothy Chi-Yui Kwok, Wing-Hoi Cheung
| DOI: 10.14336/AD.2025.1165
Supplement

1. Supplementary data.pdf (298KB)

C. elegans Presenilin Mediates Inter-Organelle Contacts and Communication that Is Required for Lysosome Activity
Kerry C. Ryan, Zahra Ashkavand, Jocelyn T. Laboy, Ling Wang, Margarida Barroso, Kenneth R. Norman
2025, 16 (5): 3022-3039 | DOI: 10.14336/AD.2024.0228
Supplement

1. Supplementary data.pdf (434KB)

Decoding Aging through iPSC Reprogramming: Advances and Challenges
Rui-lin Li, Yun-zeng Zou, Sheng Kang
2026, 17 (3): 1179-1189 | DOI: 10.14336/AD.2025.0438