Aging and disease

Mesenchymal Stem Cells for the Compassionate Treatment of Severe Acute Respiratory Distress Syndrome Due to COVID 19 Martin Iglesias, Patricia Butrón, Iván Torre-Villalvazo, Erik A Torre-Anaya, Juan Sierra-Madero, José J Rodriguez-Andoney, Armando R Tovar-Palacio, Alejandro Zentella-Dehesa, Guillermo Domínguez-Cherit, Tatiana S Rodriguez-Reyna, Julio Granados-Arriola, Verónica Espisosa-Cruz, Fernando P Téllez-Pallares, Alexia Lozada-Estrada, Carol A Zepeda Carrillo, Aldo J Vázquez-Mézquita, Hector F Nario-Chaidez: 2021, 12 (2): 360-370 | DOI: 10.14336/AD.2020.1218; PDF (1011KB)
Supplement; 1. Supplementary data.pdf (517KB)

Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience Alexey Moskalev, Ilia Stambler, Calogero Caruso: 2020, 11 (6): 1363-1373 | DOI: 10.14336/AD.2020.0603; PDF (641KB)

Premature Senescence of T-cells Favors Bone Loss During Osteolytic Diseases. A New Concern in the Osteoimmunology Arena Luis González-Osuna, Alfredo Sierra-Cristancho, Carolina Rojas, Emilio A Cafferata, Samanta Melgar-Rodríguez, Angélica M Cárdenas, Rolando Vernal: 2021, 12 (5): 1150-1161 | DOI: 10.14336/AD.2021.0110; PDF (1165KB)

A Potential Role for Photobiomodulation Therapy in Disease Treatment and Prevention in the Era of COVID-19 Ann Liebert, Brian Bicknell, Wayne Markman, Hosen Kiat: 2020, 11 (6): 1352-1362 | DOI: 10.14336/AD.2020.0901; PDF (448KB)

Mechanism of Ferroptosis: A Potential Target for Cardiovascular Diseases Treatment Jie Ju, Ya-nan Song, Kun Wang: 2021, 12 (1): 261-276 | DOI: 10.14336/AD.2020.0323; PDF (962KB)

The Application of Artificial Intelligence in the Genetic Study of Alzheimer’s Disease Rohan Mishra, Bin Li: 2020, 11 (6): 1567-1584 | DOI: 10.14336/AD.2020.0312; PDF (463KB)

Shift in the Distributions of Pre-existing Medical Condition, Gender and Age across Different COVID-19 Outcomes Ming Zheng, Lun Song: 2021, 12 (2): 327-329 | DOI: 10.14336/AD.2020.1222; PDF (430KB)

Serine and Metabolism Regulation: A Novel Mechanism in Antitumor Immunity and Senescence Qi Wu, Xinyue Chen, Juanjuan Li, Shengrong Sun: 2020, 11 (6): 1640-1653 | DOI: 10.14336/AD.2020.0314; PDF (633KB)

Metabolic Healthy Obesity, Vitamin D Status, and Risk of COVID-19 Shu Li, Zhi Cao, Hongxi Yang, Yuan Zhang, Fusheng Xu, Yaogang Wang: 2021, 12 (1): 61-71 | DOI: 10.14336/AD.2020.1108; PDF (1180KB)
Supplement; 1. Supplementary data.pdf (909KB)

Iron Accumulation and Lipid Peroxidation in the Aging Retina: Implication of Ferroptosis in Age-Related Macular Degeneration Tantai Zhao, Xiaojian Guo, Yun Sun: 2021, 12 (2): 529-551 | DOI: 10.14336/AD.2020.0912; PDF (1092KB)

Alteration of Metabolic Profile and Potential Biomarkers in the Plasma of Alzheimer’s Disease Yaping Shao, Yang Ouyang, Tianbai Li, Xinyao Liu, Xiaojiao Xu, Song Li, Guowang Xu, Weidong Le: 2020, 11 (6): 1459-1470 | DOI: 10.14336/AD.2020.0217; PDF (1592KB)
Supplement; 1. Supplementary data.pdf (75KB)

Exercise in Aging: Be Balanced Joanna Gronek, Michał Boraczyński, Piotr Gronek, Dariusz Wieliński, Jacek Tarnas, Sławomir Marszałek, Yi-Yuan Tang: 2021, 12 (5): 1140-1149 | DOI: 10.14336/AD.2021.0107; PDF (639KB)

Metformin: A Potential Candidate for Targeting Aging Mechanisms Die Hu, Fangfang Xie, Yongwei Xiao, Chen Lu, Jianing Zhong, Defa Huang, Jie Chen, Jifu Wei, Yu Jiang, Tianyu Zhong: 2021, 12 (2): 480-493 | DOI: 10.14336/AD.2020.0702; PDF (531KB)

Circular RNAs: Promising Biomarkers for Age-related Diseases Yan-hong Pan, Wei-peng Wu, Xing-dong Xiong: 2020, 11 (6): 1585-1593 | DOI: 10.14336/AD.2020.0309; PDF (524KB)

Of Cross-immunity, Herd Immunity and Country-specific Plans: Experiences from COVID-19 in India Sankha Shubhra Chakrabarti, Upinder Kaur, Anup Singh, Suddhachitta Chakrabarti, Manigreeva Krishnatreya, Bimal Kumar Agrawal, Amit Mittal, Amit Singh, Rahul Khanna, Indrajeet Singh Gambhir, Kunlin Jin, Sasanka Chakrabarti: 2020, 11 (6): 1339-1344 | DOI: 10.14336/AD.2020.1104; PDF (436KB)

Transcranial Focused Ultrasound Stimulation Improves Neurorehabilitation after Middle Cerebral Artery Occlusion in Mice Jixian Wang, Guofeng Li, Lidong Deng, Muyassar Mamtilahun, Lu Jiang, Weibao Qiu, Hairong Zheng, Junfeng Sun, Qing Xie, Guo-Yuan Yang: 2021, 12 (1): 50-60 | DOI: 10.14336/AD.2020.0623; PDF (577KB)

A Comprehensive Summary of the Knowledge on COVID-19 Treatment Yu Peng, Hongxun Tao, Senthil Kumaran Satyanarayanan, Kunlin Jin, Huanxing Su: 2021, 12 (1): 155-191 | DOI: 10.14336/AD.2020.1124; PDF (1307KB)
Supplement; 1. Supplementary data.pdf (630KB); 2. Supplementary data.pdf (628KB)

Pharmacological Treatment of Vascular Dementia: A Molecular Mechanism Perspective Huang Kuang, Zhi-Feng Zhou, Yu-Ge Zhu, Zhi-Kai Wan, Mei-Wen Yang, Fen-Fang Hong, Shu-Long Yang: 2021, 12 (1): 308-326 | DOI: 10.14336/AD.2020.0427; PDF (1040KB)

NRF2 Loss Accentuates Parkinsonian Pathology and Behavioral Dysfunction in Human α-Synuclein Overexpressing Mice Annadurai Anandhan, Nhat Nguyen, Arjun Syal, Luke A Dreher, Matthew Dodson, Donna D Zhang, Lalitha Madhavan: 2021, 12 (4): 964-982 | DOI: 10.14336/AD.2021.0511; PDF (2450KB)
Supplement; 1. Supplementary data.pdf (477KB)

Metabolomics Signatures of Aging: Recent Advances Sunil S Adav, Yulan Wang: 2021, 12 (2): 646-661 | DOI: 10.14336/AD.2020.0909; PDF (578KB)

Polyphenols Could Prevent SARS-CoV-2 Infection by Modulating the Expression of miRNAs in the Host Cells Dragan Milenkovic, Tatjana Ruskovska, Ana Rodriguez-Mateos, Christian Heiss: 2021, 12 (5): 1169-1182 | DOI: 10.14336/AD.2021.0223; PDF (765KB)

Body adaptation to Dance: A Gerontological Perspective Piotr Gronek, Michał Boraczyński, Aline Nogueira Haas, Jan Adamczyk, Mariola Pawlaczyk, Wojciech Czarny, Cain CT Clark, Urszula Czerniak, Anna Demuth, Roman Celka, Paulina Wycichowska, Joanna Gronek, Magdalena Król-Zielińska: 2021, 12 (3): 902-913 | DOI: 10.14336/AD.2020.1107; PDF (455KB)

COVID-19 in Elderly Adults: Clinical Features, Molecular Mechanisms, and Proposed Strategies Ya Yang, Yalei Zhao, Fen Zhang, Lingjian Zhang, Lanjuan Li: 2020, 11 (6): 1481-1495 | DOI: 10.14336/AD.2020.0903; PDF (528KB)

Pathological Mechanisms and Potential Therapeutic Targets of Pulmonary Arterial Hypertension: A Review Ying Xiao, Pei-Pei Chen, Rui-Lin Zhou, Yang Zhang, Zhuang Tian, Shu-Yang Zhang: 2020, 11 (6): 1623-1639 | DOI: 10.14336/AD.2020.0111; PDF (680KB)

Oxidative Stress at the Crossroads of Aging, Stroke and Depression Anwen Shao, Danfeng Lin, Lingling Wang, Sheng Tu, Cameron Lenahan, Jianmin Zhang: 2020, 11 (6): 1537-1566 | DOI: 10.14336/AD.2020.0225; PDF (1278KB)

Cellular Tropism of SARS-CoV-2 across Human Tissues and Age-related Expression of ACE2 and TMPRSS2 in Immune-inflammatory Stromal Cells Ming Zheng: 2021, 12 (3): 718-725 | DOI: 10.14336/AD.2021.0429; PDF (1909KB)

Hydrogen Peroxide-Induced Senescence Reduces the Wound Healing-Promoting Effects of Mesenchymal Stem Cell-Derived Exosomes Partially via miR-146a Meiqian Xu, Xiaodong Su, Xian Xiao, Hongliang Yu, Xiaoxia Li, Armand Keating, Shihua Wang, Robert Chunhua Zhao: 2021, 12 (1): 102-115 | DOI: 10.14336/AD.2020.0624; PDF (1489KB)
Supplement; 1. Supplementary data.pdf (181KB)

Intracerebral Transplantation of Neural Stem Cells Restores Manganese-Induced Cognitive Deficits in Mice Huijuan Shu, Zhongxin Guo, Xiangren Chen, Shuya Qi, Xinxin Xiong, Shuang Xia, Qingyun Huang, Ling Lan, Jiangu Gong, Shaoming Huang, Boning Yang, Guohe Tan: 2021, 12 (2): 371-385 | DOI: 10.14336/AD.2020.0717; PDF (1665KB)

Interdisciplinary Research in Alzheimer’s Disease and the Roles International Societies Can Play Shawn Zheng Kai Tan, Robert Chunhua Zhao, Sasanka Chakrabarti, Ilia Stambler, Kunlin Jin, Lee Wei Lim: 2021, 12 (1): 36-41 | DOI: 10.14336/AD.2020.0602; PDF (370KB)

Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction Sandra Fuertes-Alvarez, Ander Izeta: 2021, 12 (2): 494-514 | DOI: 10.14336/AD.2020.0708; PDF (906KB)

Cellular Senescence Affects Cardiac Regeneration and Repair in Ischemic Heart Disease Chi Yan, Zhimeng Xu, Weiqiang Huang: 2021, 12 (2): 552-569 | DOI: 10.14336/AD.2020.0811; PDF (954KB)

The Mechanism of Physical Activity-induced Amelioration of Parkinson’s Disease: A Narrative Review Piotr Gronek, Aline Nogueira Haas, Wojciech Czarny, Robert Podstawski, Marcela do Santos Delabary, Cain CT Clark, Michał Boraczyński, Maria Tarnas, Paulina Wycichowska, Mariola Pawlaczyk, Joanna Gronek: 2021, 12 (1): 192-202 | DOI: 10.14336/AD.2020.0407; PDF (651KB)

Pediatric Stroke: Overview and Recent Updates Mary Hollist, Katherine Au, Larry Morgan, Padmashri A Shetty, Riddhi Rane, Abraham Hollist, Angela Amaniampong, Batool F Kirmani: 2021, 12 (4): 1043-1055 | DOI: 10.14336/AD.2021.0219; PDF (388KB)

Pathogenesis and Management in Cerebrovenous Outflow Disorders Chaobo Bai, Zhongao Wang, Christopher Stone, Da Zhou, Jiayue Ding, Yuchuan Ding, Xunming Ji, Ran Meng: 2021, 12 (1): 203-222 | DOI: 10.14336/AD.2020.0404; PDF (900KB)

Metabolic Abnormalities in Patients with Chronic Disorders of Consciousness Jie Yu, Fanxia Meng, Fangping He, Fei Chen, Wangxiao Bao, Yamei Yu, Jintao Zhou, Jian Gao, Jingqi Li, Yao Yao, Woo-ping Ge, Benyan Luo: 2021, 12 (2): 386-403 | DOI: 10.14336/AD.2020.0812; PDF (2322KB)
Supplement; 1. Supplementary Data.pdf (750KB)

Global Sex Disparity of COVID-19: A Descriptive Review of Sex Hormones and Consideration for the Potential Therapeutic Use of Hormone Replacement Therapy in Older Adults Samuel C Okpechi, Jordyn T Fong, Shawn S Gill, Jarrod C Harman, Tina H Nguyen, Queendaleen C Chukwurah, IfeanyiChukwu O Onor, Suresh K Alahari: 2021, 12 (2): 671-683 | DOI: 10.14336/AD.2020.1211; PDF (676KB)

Cover Illustration

01 October 2021. VOL 12, ISSUE 7
Figure 5. ISF drainage routes in juvenile (≤P30 days) and adult rats. In juvenile rats (≤P30 days), the brain has not been fully myelinated, the oligodendrocytes are small, myelin sheaths are thin, and many axons are nonmyelinated. The interstitial fluid (ISF) was traced from the caudate nucleus (Cn) drained to the ipsilateral cortex along myelin fiber tracts and can communicate with the ISF in the thalamus (Tha) in the opposite direction. After P40, ISF drainage in Cn became regionalized; the movement of ISF to the adjacent thalamus was completely impeded by a barrier structure composed of compact myelin (yellow arrow). The oligodendrocytes in adult rats were more developed than the juvenile rats (blue arrow).

[Detail]

Cover Illustration

Figure 5. ISF drainage routes in juvenile (≤P30 days) and adult rats. In juvenile rats (≤P30 days), the brain has not been fully myelinated, the oligodendrocytes are small, myelin sheaths are thin, and many axons are nonmyelinated. The interstitial fluid (ISF) was traced from the caudate nucleus (Cn) drained to the ipsilateral cortex along myelin fiber tracts and can communicate with the ISF in the thalamus (Tha) in the opposite direction. After P40, ISF drainage in Cn became regionalized; the movement of ISF to the adjacent thalamus was completely impeded by a barrier structure composed of compact myelin (yellow arrow). The oligodendrocytes in adult rats were more developed than the juvenile rats (blue arrow).

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