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2024
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Total 40 results are found
Long-Term Improvement in Hippocampal-Dependent Learning Ability in Healthy, Aged Individuals Following High Intensity Interval Training
Daniel G. Blackmore, Mia A. Schaumberg, Maryam Ziaei, Samuel Belford, Xuan Vinh To, Imogen O’Keeffe, Anne Bernard, Jules Mitchell, Emily Hume, Grace L. Rose, Thomas Shaw, Ashley York, Markus Barth, Elizabeth J. Cooper, Tina L. Skinner, Fatima Nasrallah, Stephan Riek, Perry F. Bartlett
2025, 16 (3): 1732-1754 | DOI: 10.14336/AD.2024.0642
Supplement

1. Supplementary data.pdf (6754KB)

The Expanding Burden of Neurodegenerative Diseases: An Unmet Medical and Social Need
Shu Wang, Yin Jiang, Anchao Yang, Fangang Meng, Jianguo Zhang
2025, 16 (5): 2937-2952 | DOI: 10.14336/AD.2024.1071
AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent
Qiuqiong Tang, Deyong Xiao, Alexander Veviorskiy, Ying Xin, Sarah W.Y. Lok, Fadi E. Pulous, Peiran Zhang, Yunfeng Zhu, Yongming Ma, Xiao Hu, Shoulai Gu, Chenting Zong, Sabina Mukba, Mikhail Korzinkin, Frank W. Pun, Man Zhang, Alex Aliper, Lijuan Wu, Feng Ren, Li Zhang, Alex Zhavoronkov
2026, 17 (1): 432-451 | DOI: 10.14336/AD.2024.1492
Supplement

1. Supplementary data.pdf (1198KB)

2. TNIK Senomorphic Video.mp4.mp4 (14113KB)

Cerebral Small Vessel Disease: Current and Emerging Therapeutic Strategies
Yuewen Sun, Xiaoqian Song, Chenyang Jin, Yilong Peng, Jing Zhou, Xueping Zheng
2026, 17 (1): 286-303 | DOI: 10.14336/AD.2024.1515
Perimenopausal Hormone Replacement Treatments as a Geroprotective Approach - Adapting Clinical Guidance
Jaron Rabinovici, Henk-Peter Oonk, Zhongwei Huang, Tashiya Mirando, Moran Zhou, Tzipora Strauss, Lia-Raluca Olari, Dominika Wilczok, Andrea B. Maier, Evelyne Bischof
| DOI: 10.14336/AD.2025.1391
Reduced Blood Choline in Obesity Is Associated with Metabolic and Alzheimer’s Biomarkers
Wendy Winslow, Jessica M. Judd, Savannah Tallino, Geidy E. Serrano, Thomas G. Beach, Lori R. Roust, Eleanna De Filippis, Brooke Brown, Christos Katsanos, Ramon Velazquez
| DOI: 10.14336/AD.2025.1207
Peakspan: Defining, Quantifying and Extending the Boundaries of Peak Productive Lifespan
Authors: Alex Zhavoronkov, Kejun Ying, Dominika Wilczok
| DOI: 10.14336/AD.2026.0080
Causality of Aging Hallmarks
Bilu Huang, Xiaowen Hu
| DOI: 10.14336/AD.2025.0541
Epigenetic Clocks: Beyond Biological Age, Using the Past to Predict the Present and Future
Runyu Liang, Qiang Tang, Jia Chen, Luwen Zhu
2025, 16 (6): 3520-3545 | DOI: 10.14336/AD.2024.1495
Blue Zones, an Analysis of Existing Evidence through a Scoping Review
Cristina Candal-Pedreira, Lucía Martín-Gisbert, Ana Teijeiro, Guadalupe García, Alberto Ruano-Ravina, Mónica Pérez-Ríos
| DOI: 10.14336/AD.2025.0461
Supplement

1. Supplementary data.pdf (244KB)

LLMs and AI Life Models for Traditional Chinese Medicine-derived Geroprotector Formulation
Fedor Galkin, Feng Ren, Alex Zhavoronkov
2026, 17 (2): 1155-1168 | DOI: 10.14336/AD.2024.1697
Green Tea Mitigates the Hallmarks of Aging and Age-Related Multisystem Deterioration
Yusuf Yilmaz
2026, 17 (2): 712-730 | DOI: 10.14336/AD.2025.0398
Ovarian Aging: The Silent Catalyst of Age-Related Disorders in Female Body
Xingyu Liu, Yuanqu Zhao, Yanzhi Feng, Shixuan Wang, Aiyue Luo, Jinjin Zhang
2026, 17 (1): 132-158 | DOI: 10.14336/AD.2024.1468
Deformability of Heterogeneous Red Blood Cells in Aging and Related Pathologies
Dmitry S. Prudinnik, Aigul Kussanova, Ivan A. Vorobjev, Alexander Tikhonov, Fazly I. Ataullakhanov, Natasha S. Barteneva
2025, 16 (3): 1242-1264 | DOI: 10.14336/AD.2024.0526
Exercise-Induced Central Fatigue: Biomarkers and Non-Medicinal Interventions
Ying Yang, Zhi Feng, Yu-hang Luo, Jue-miao Chen, Yu Zhang, Yi-jun Liao, Hui Jiang, Yinxi Long, Bo Wei
2025, 16 (3): 1302-1315 | DOI: 10.14336/AD.2024.0567
Aging and “Age-Related” Diseases - What Is the Relation?
Wolfgang Kopp
2025, 16 (3): 1316-1346 | DOI: 10.14336/AD.2024.0570
Expert Consensus on the Application of Stem Cells in Psoriasis Research and Clinical Trials
Ye-Hong Kuang, Wu Zhu, Ge Lin, La-Mei Cheng, Qun Qin, Zhi-Jun Huang, Yu-Ling Shi, Chun-Lei Zhang, Jin-Hua Xu, Ke-Xiang Yan, Cheng-Zhi Lv, Wei Li, Qin Han, Ilia Stambler, Lee Wei Lim, Sasanka Chakrabarti, Brun Ulfhake, Kyung-Jin Min, Georgina Ellison-Hughes, William C Cho, Kunlin Jin, Danni Yao, Chuanjian Lu, Robert Chunhua Zhao, Xiang Chen
2025, 16 (3): 1363-1377 | DOI: 10.14336/AD.2024.0012
Cellular Aging and Senescence in Cancer: A Holistic Review of Cellular Fate Determinants
Muhammad Tufail, Yu-Qi Huang, Jia-Ju Hu, Jie Liang, Cai-Yun He, Wen-Dong Wan, Can-Hua Jiang, Hong Wu, Ning Li
2025, 16 (3): 1483-1512 | DOI: 10.14336/AD.2024.0421
Recent Advances in Our Understanding of Age-Related Macular Degeneration: Mitochondrial Dysfunction, Redox Signaling, and the Complement System
Francesco Buonfiglio, Christina A. Korb, Bernhard Stoffelns, Norbert Pfeiffer, Adrian Gericke
2025, 16 (3): 1535-1575 | DOI: 10.14336/AD.2024.0124
Therapeutic Potential of Quercetin as an Antioxidant for Bone-Muscle-Tendon Regeneration and Aging
Jae Gyu Kim, Ashish Ranjan Sharma, Yeon-Hee Lee, Srijan Chatterjee, Yean Jung Choi, Roshani Rajvansh, Chiranjib Chakraborty, Sang-Soo Lee
2025, 16 (3): 1414-1437 | DOI: 10.14336/AD.2024.0282
The Impact of Aging on Ocular Diseases: Unveiling Complex Interactions
Luling You, Yumeng Lin, Yizhuo Zheng, Zhongyu Han, Liuzhi Zeng, Haoran Chen
2025, 16 (5): 2803-2830 | DOI: 10.14336/AD.2024.0850
SLC7A11 in Fibrosis: Molecular Mechanisms and Future Prospects
Juntong Chen, Yanjie He, Ru Chen, Zhiyong Yang, Xiaomeng Luo, Fan Yang
2026, 17 (2): 731-759 | DOI: 10.14336/AD.2025.0106
Excitotoxicity, Oxytosis/Ferroptosis, and Neurodegeneration: Emerging Insights into Mitochondrial Mechanisms
Sameera Khan, Nargis Bano, Shakir Ahamad, Urmilla John, Nawab John Dar, Shahnawaz Ali Bhat
2025, 16 (5): 2504-2543 | DOI: 10.14336/AD.2024.0125-1
Supplement

1. Supplementary data.pdf (290KB)

Circulating Ketone Bodies, Pyruvate, and Citrate and Risk of Cognitive Decline, Structural Brain Abnormalities, and Dementia
Laia Gutierrez-Tordera, Kristine F. Moseholm, Marta Trius-Soler, Mònica Bulló, Annette Fitzpatrick, Margery A. Connelly, Oscar L. Lopez, Majken K. Jensen, Marta Guasch-Ferré, Kenneth J. Mukamal
2025, 16 (5): 3055-3068 | DOI: 10.14336/AD.2024.0754
Supplement

1. Supplementary data.pdf (534KB)

The Impact of Rosemary and Ginger Extracts on Aging and Healthspan in Drosophila
Ricardo Aparicio, Anna M. Salazar, Edward T. Schmid, Armen Khanbabaei, Arun Rajgopal, R. Keith Randolph, David W. Walker
2026, 17 (1): 416-431 | DOI: 10.14336/AD.2024.1558
Supplement

1. Supplementary data.pdf (378KB)

Human Aging and Age-Related Diseases: From Underlying Mechanisms to Pro-Longevity Interventions
Piotr Paweł Chmielewski, Krzysztof Data, Bartłomiej Strzelec, Maryam Farzaneh, Amir Anbiyaiee, Uzma Zaheer, Shahab Uddin, Mohadeseh Sheykhi-Sabzehpoush, Paul Mozdziak, Maciej Zabel, Piotr Dzięgiel, Bartosz Kempisty
2025, 16 (4): 1853-1877 | DOI: 10.14336/AD.2024.0280
Towards Precision Aging Biology: Single-Cell Multi-Omics and Advanced AI-Driven Strategies
Sijia Xie, Xinwei Luo, Feitong Hong, Yijie Wei, Yuduo Hao, Xueqin Xie, Xiaolong Li, Guangbo Xie, Fuying Dao, Hao Lyu
2026, 17 (2): 907-926 | DOI: 10.14336/AD.2025.0218
Senescent Astrocytes Derived from Human Pluripotent Stem Cells Reveal Age-Related Changes and Implications for Neurodegeneration
Dongyun Kim, Seo Hyun Yoo, Gyu-Bum Yeon, Seung Soo Oh, Won-Ho Shin, Hoon-Chul Kang, Cheol-Koo Lee, Hyung Wook Kim, Dae-Sung Kim
2025, 16 (3): 1709-1731 | DOI: 10.14336/AD.2024.0089
Supplement

1. Supplementary data.pdf (1310KB)

The Management of Sarcopenic Dysphagia: A Multidisciplinary Approach Leveraging Emerging Technologies
Wei Deng, Xiao-Feng Zeng, Li-Ying Zhang, Ji-Rong Yue, Xiao-Li Huang
2025, 16 (5): 2752-2769 | DOI: 10.14336/AD.2024.0741
Engineered Mitochondrial Transplantation as An Anti-Aging Therapy
Rui Zhao, Chen Dong, Qian Liang, Jianlin Gao, Chi Sun, Zhifeng Gu, Yujuan Zhu
2025, 16 (4): 1918-1945 | DOI: 10.14336/AD.2024.0231
Type 2 Diabetes Mellitus: A Metabolic Model of Accelerated Aging - Multi-Organ Mechanisms and Intervention Approaches
Ziran Zhang, Xiaolin He, Yuxin Sun, Jitong Li, Jia Sun
| DOI: 10.14336/AD.2025.0233
A Combination of Low-Dose Δ9-THC and Celecoxib as a Therapeutic Strategy for Alzheimer’s Disease
Jian Zhang, Dexiao Zhu, Mei Hu, Mingzhe Pan, Chu Chen
| DOI: 10.14336/AD.2025.1206
Supplement

1. Supplementary data.pdf (4873KB)

Pros and Cons of Human Brain Organoids to Study Alzheimer’s Disease
Andrea Sainz, Fernando Pérez-Cerdá, Alberto Pérez-Samartín, Mitradas Panicker, Asier Ruiz, Carlos Matute
2025, 16 (6): 3483-3504 | DOI: 10.14336/AD.2024.1409
The Role of the Complement System in Synaptic Pruning after Stroke
Hongying Liu, Min Jiang, Zhiying Chen, Chuan Li, Xiaoping Yin, Xiaorong Zhang, Moxin Wu
2025, 16 (3): 1452-1470 | DOI: 10.14336/AD.2024.0373
The Role of Hypoxia in Longevity
Ayesha Nisar, Sawar Khan, Yongzhang Pan, Li Hu, Pengyun Yang, Naheemat Modupeola Gold, Zhen Zhou, Shengjie Yuan, Meiting Zi, Sardar Azhar Mehmood, Yonghan He
2026, 17 (1): 62-90 | DOI: 10.14336/AD.2024.1630
Mitochondrial Dysfunction: A Roadmap for Understanding and Tackling Cardiovascular Aging
Han Zhang, Mairedan Muhetarijiang, Ryan J. Chen, Xiaosheng Hu, Jie Han, Liangrong Zheng, Ting Chen
2025, 16 (5): 2575-2614 | DOI: 10.14336/AD.2024.0058
Brain Iron Dyshomeostasis and Ferroptosis in Alzheimer’s Disease Pathophysiology: Two Faces of the Same Coin
Mariarosa Mezzanotte, Serena Stanga
2025, 16 (5): 2615-2640 | DOI: 10.14336/AD.2024.0094
A Standardized Protocol for Mouse Longevity Studies in Preclinical Drug Development
Alex Zhavoronkov, Qian Wang, Yujie Liu, Wenbin Hou, Yuelei Shen, Dominika Wilczok, Kristen Fortney, Alex Aliper, Man Zhang, Feng Ren, Richard A. Miller
| DOI: 10.14336/AD.2025.0508
The Organ-Joint Axes in Osteoarthritis: Significant Pathogenesis and Therapeutic Targets
Dinglong Yang, Yujing Chen, Junfei Guo, Xin Xu, Mingyi Yang, Jiale Xie, Ke Xu, Peng Xu
2025, 16 (5): 2999-3021 | DOI: 10.14336/AD.2024.1223
Targeting the Ophthalmic Diseases Using Extracellular Vesicles ‘Exosomes’: Current Insights on Their Clinical Approval and Present Trials
Hanxiang Yu, Jinsong Wu, Gaoxiang Pan
2025, 16 (3): 1225-1241 | DOI: 10.14336/AD.2024.0535