Aging and disease

Rapidly Progressive Dementia with Asymmetric Rigidity Following ChAdOx1 nCoV-19 Vaccination Sankha Shubhra Chakrabarti, Ashutosh Tiwari, Sumit Jaiswal, Upinder Kaur, Ishan Kumar, Amit Mittal, Anup Singh, Kunlin Jin, Sasanka Chakrabarti: 2022, 13 (3): 633-636 | DOI: 10.14336/AD.2021.1102; PDF (363KB)

Metabolic Strategies in Healthcare: A New Era Matthew CL Phillips: 2022, 13 (3): 655-672 | DOI: 10.14336/AD.2021.1018; PDF (855KB)

New Insights into the Roles and Mechanisms of Spermidine in Aging and Age-Related Diseases Yu-Qing Ni, You-Shuo Liu: 2021, 12 (8): 1948-1963 | DOI: 10.14336/AD.2021.0603; PDF (645KB)

Comparative Analysis of Aducanumab, Zagotenemab and Pioglitazone as Targeted Treatment Strategies for Alzheimer’s Disease Morteza Abyadeh, Vivek Gupta, Veer Gupta, Nitin Chitranshi, Yunqi Wu, Ardeshir Amirkhani, Anna Meyfour, Samran Sheriff, Ting Shen, Kunal Dhiman, Ghasem H. Salekdeh, Paul A. Haynes, Stuart L. Graham, Mehdi Mirzaei: 2021, 12 (8): 1964-1976 | DOI: 10.14336/AD.2021.0719; PDF (536KB)

Cognitive Impairment and Metabolite Profile Alterations in the Hippocampus and Cortex of Male and Female Mice Exposed to a Fat and Sugar-Rich Diet are Normalized by Diet Reversal Alba M Garcia-Serrano, Adélaïde A Mohr, Juliette Philippe, Cecilia Skoug, Peter Spégel, João M.N Duarte: 2022, 13 (1): 267-283 | DOI: 10.14336/AD.2021.0720; PDF (1307KB)
Supplement; 1. Supplementary data.pdf (119KB)

Pharmacology and Potential Implications of Nicotinamide Adenine Dinucleotide Precursors Jing She, Rui Sheng, Zheng-Hong Qin: 2021, 12 (8): 1879-1897 | DOI: 10.14336/AD.2021.0523; PDF (621KB)

Depression and Dementia in Older Adults: A Neuropsychological Review Syuichi Tetsuka: 2021, 12 (8): 1920-1934 | DOI: 10.14336/AD.2021.0526; PDF (543KB)

Pharmacological Blockade of NLRP3 Inflammasome/IL-1β-Positive Loop Mitigates Endothelial Cell Senescence and Dysfunction Alejandra Romero, Pilar Dongil, Inés Valencia, Susana Vallejo, Álvaro San Hipólito-Luengo, Guillermo Díaz-Araya, José L Bartha, María M González-Arlanzón, Fernando Rivilla, Fernando de la Cuesta, Carlos F Sánchez-Ferrer, Concepción Peiró: 2022, 13 (1): 284-297 | DOI: 10.14336/AD.2021.0617; PDF (1545KB)
Supplement; 1. Supplementary data.pdf (503KB)

Effects of Ketogenic Diet on Neuroinflammation in Neurodegenerative Diseases Ziying Jiang, Xi Yin, Miao Wang, Tong Chen, Yuanyuan Wang, Zhongbao Gao, Zhenfu Wang: 2022, 13 (4): 1146-1165 | DOI: 10.14336/AD.2021.1217; PDF (808KB)

The Effect of COVID-19-related Lockdowns on Diet and Physical Activity in Older Adults: A Systematic Review Elisabeth Anne Larson, Karlen Stade Bader-Larsen, Faidon Magkos: 2021, 12 (8): 1935-1947 | DOI: 10.14336/AD.2021.0606; PDF (772KB)

The Cause of Alzheimer’s Disease: The Theory of Multipathology Convergence to Chronic Neuronal Stress Boris Decourt, Gary X D’Souza, Jiong Shi, Aaron Ritter, Jasmin Suazo, Marwan N Sabbagh: 2022, 13 (1): 37-60 | DOI: 10.14336/AD.2021.0529; PDF (1536KB)

Irreversibility of Pulmonary Fibrosis Qing Yang Yu, Xiao Xiao Tang: 2022, 13 (1): 73-86 | DOI: 10.14336/AD.2021.0730; PDF (691KB)

A Unique Type of Highly-Activated Microglia Evoking Brain Inflammation via Mif/Cd74 Signaling Axis in Aged Mice Chenghao Jin, Yijie Shao, Xiaotao Zhang, Jiani Xiang, Ruize Zhang, Zeyu Sun, Shuhao Mei, Jingyi Zhou, Jianmin Zhang, Ligen Shi: 2021, 12 (8): 2125-2139 | DOI: 10.14336/AD.2021.0520; PDF (2051KB)
Supplement; 1. Supplementary data.pdf (1992KB)

Blocking C3d ⁺/GFAP ⁺ A1 Astrocyte Conversion with Semaglutide Attenuates Blood-Brain Barrier Disruption in Mice after Ischemic Stroke Qi Zhang, Chang Liu, Rubing Shi, Shiyi Zhou, Huimin Shan, Lidong Deng, Tingting Chen, Yiyan Guo, Zhijun Zhang, Guo-Yuan Yang, Yongting Wang, Yaohui Tang: 2022, 13 (3): 943-959 | DOI: 10.14336/AD.2021.1029; PDF (1915KB)
Supplement; 1. Supplementary data.pdf (888KB)

Intrinsic Capacity in Older Adults: Recent Advances Yaru Zhou, Lina Ma: 2022, 13 (2): 353-359 | DOI: 10.14336/AD.2021.0818; PDF (361KB)

Functions of Gut Microbiota Metabolites, Current Status and Future Perspectives Juan Liu, Yuzhu Tan, Hao Cheng, Dandan Zhang, Wuwen Feng, Cheng Peng: 2022, 13 (4): 1106-1126 | DOI: 10.14336/AD.2022.0104; PDF (1455KB)

SIRT6 in Vascular Diseases, from Bench to Bedside Si-Chong Ren, Xiangqi Chen, Hui Gong, Han Wang, Chuan Wu, Pei-Heng Li, Xiao-Feng Chen, Jia-Hua Qu, Xiaoqiang Tang: 2022, 13 (4): 1015-1029 | DOI: 10.14336/AD.2021.1204; PDF (1325KB)

Pathogeneses and Imaging Features of Cerebral White Matter Lesions of Vascular Origins Xiaoqin Wu, Jingyuan Ya, Da Zhou, Yuchuan Ding, Xunming Ji, Ran Meng: 2021, 12 (8): 2031-2051 | DOI: 10.14336/AD.2021.0414; PDF (1249KB)

Cellular Senescence in Cardiovascular Diseases: A Systematic Review Can Hu, Xin Zhang, Teng Teng, Zhen-Guo Ma, Qi-Zhu Tang: 2022, 13 (1): 103-128 | DOI: 10.14336/AD.2021.0927; PDF (883KB)

Vascular Calcification in Chronic Kidney Disease: An Update and Perspective Si-Chong Ren, Nan Mao, Si Yi, Xin Ma, Jia-Qiong Zou, Xiaoqiang Tang, Jun-Ming Fan: 2022, 13 (3): 673-697 | DOI: 10.14336/AD.2021.1024; PDF (1225KB)

Emerging Roles of Ceramide in Cardiovascular Diseases Hongyang Shu, Yizhong Peng, Weijian Hang, Na Li, Ning Zhou, Dao Wen Wang: 2022, 13 (1): 232-245 | DOI: 10.14336/AD.2021.0710; PDF (574KB)

Serum from Older Adults Increases Apoptosis and Molecular Aging Markers in Human Hippocampal Progenitor Cells Chiara de Lucia, Tytus Murphy, Aleksandra Maruszak, Paul Wright, Timothy R Powell, Naomi Hartopp, Simone de Jong, Michael J O'Sullivan, Gerome Breen, Jack Price, Simon Lovestone, Sandrine Thuret: 2021, 12 (8): 2151-2172 | DOI: 10.14336/AD.2021.0409; PDF (1600KB)
Supplement; 1. Supplementary data.pdf (1416KB)

Alzheimer Disease: Recent Updates on Apolipoprotein E and Gut Microbiome Mediation of Oxidative Stress, and Prospective Interventional Agents Benson OA Botchway, Favour C Okoye, Yili Chen, William E Arthur, Marong Fang: 2022, 13 (1): 87-102 | DOI: 10.14336/AD.2021.0616; PDF (535KB)
Supplement; 1. Supplementary data.pdf (157KB)

Mechanisms of Short-Chain Fatty Acids Derived from Gut Microbiota in Alzheimer's Disease Xiao-hang Qian, Ru-yan Xie, Xiao-li Liu, Sheng-di Chen, Hui-dong Tang: 2022, 13 (4): 1252-1266 | DOI: 10.14336/AD.2021.1215; PDF (642KB)

ACE2 and COVID-19 Susceptibility and Severity Ming Zheng: 2022, 13 (2): 360-372 | DOI: 10.14336/AD.2021.0805; PDF (1806KB)

Mammalian AKT, the Emerging Roles on Mitochondrial Function in Diseases Xiaoxian Xie, Ruonan Shu, Chunan Yu, Zhengwei Fu, Zezhi Li: 2022, 13 (1): 157-174 | DOI: 10.14336/AD.2021.0729; PDF (625KB)

Atrial Fibrillation Underlies Cardiomyocyte Senescence and Contributes to Deleterious Atrial Remodeling during Disease Progression Ailiya Adili, Xiyu Zhu, Hailong Cao, Xinlong Tang, Yali Wang, Junxia Wang, Jian Shi, Qing Zhou, Dongjin Wang: 2022, 13 (1): 298-312 | DOI: 10.14336/AD.2021.0619; PDF (2048KB)
Supplement; 1. Supplementary data.pdf (1003KB)

Mitochondrial Quality Control in Sarcopenia: Updated Overview of Mechanisms and Interventions Di Liu, Yi-bin Fan, Xiao-hua Tao, Wei-li Pan, Yu-xiang Wu, Xiu-hua Wang, Yu-qiong He, Wen-feng Xiao, Yu-sheng Li: 2021, 12 (8): 2016-2030 | DOI: 10.14336/AD.2021.0427; PDF (565KB)

Aquaporin-4 and Cognitive Disorders Yifan Wang, Chuyi Huang, Qihao Guo, Heling Chu: 2022, 13 (1): 61-72 | DOI: 10.14336/AD.2021.0731; PDF (742KB)

The Role of Kynurenine Pathway and NAD ⁺ Metabolism in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Mona Dehhaghi, Hamed Kazemi Shariat Panahi, Bahar Kavyani, Benjamin Heng, Vanessa Tan, Nady Braidy, Gilles J. Guillemin: 2022, 13 (3): 698-711 | DOI: 10.14336/AD.2021.0824; PDF (807KB)

The safety and efficacy of Ezetimibe Plus Statins on ASVD and Related Diseases Shuling Wan, Yuchuan Ding, Xunming Ji, Ran Meng: 2021, 12 (8): 1857-1871 | DOI: 10.14336/AD.2021.0412; PDF (604KB)

Review on Laser Technology in Intravascular Imaging and Treatment Jing Li, Ce Shang, Yao Rong, Jingxuan Sun, Yuan Cheng, Boqu He, Zihao Wang, Ming Li, Jianguo Ma, Bo Fu, Xunming Ji: 2022, 13 (1): 246-266 | DOI: 10.14336/AD.2021.0711; PDF (1067KB)

COVID-19 Pandemic and Osteoporosis in Elderly Patients Jun Tang: 2022, 13 (4): 960-969 | DOI: 10.14336/AD.2021.1201; PDF (418KB)

Recent Neurotherapeutic Strategies to Promote Healthy Brain Aging: Are we there yet? Chul-Kyu Kim, Perminder S Sachdev, Nady Braidy: 2022, 13 (1): 175-214 | DOI: 10.14336/AD.2021.0705; PDF (1495KB)

Juvenile Plasma Factors Improve Organ Function and Survival following Injury by Promoting Antioxidant Response Xiaogang Chu, Kumar Subramani, Bobby Thomas, Alvin V Terry, Sadanand Fulzele, Raghavan Pillai Raju: 2022, 13 (2): 568-582 | DOI: 10.14336/AD.2021.0830; PDF (1934KB)

Potential Effect of the Circadian Clock on Erectile Dysfunction Tao Li, Yunjin Bai, Yiting Jiang, Kehua Jiang, Ye Tian, Zhen Wang, Yong Ban, Xiangyi Liang, Guangheng Luo, Fa Sun: 2022, 13 (1): 8-23 | DOI: 10.14336/AD.2021.0728; PDF (1021KB)

Extension of the Life Span by Acarbose: Is It Mediated by the Gut Microbiota? Baiyun Wu, Jiai Yan, Ju Yang, Yanping Xia, Dan Li, Feng Zhang, Hong Cao: 2022, 13 (4): 1005-1014 | DOI: 10.14336/AD.2022.0117; PDF (535KB)

Dysfunction of the Blood-brain Barrier in Cerebral Microbleeds: from Bedside to Bench Hai-ling Wang, Chun-lin Zhang, Yan-mei Qiu, An-qi Chen, Ya-nan Li, Bo Hu: 2021, 12 (8): 1898-1919 | DOI: 10.14336/AD.2021.0514; PDF (798KB)

The Applications of Focused Ultrasound (FUS) in Alzheimer’s Disease Treatment: A Systematic Review on Both Animal and Human Studies Xiaodan Liu, S. Sta Maria Naomi, Wu Lin Sharon, E. Jacobs Russell: 2021, 12 (8): 1977-2002 | DOI: 10.14336/AD.2021.0510; PDF (751KB)

Skeletal Muscle Metabolic Alternation Develops Sarcopenia Qiumei Yang, Piu Chan: 2022, 13 (3): 801-814 | DOI: 10.14336/AD.2021.1107; PDF (698KB)

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