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2025
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9.6

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Total 40 results are found
Cerebral Small Vessel Disease: Current and Emerging Therapeutic Strategies
Yuewen Sun, Xiaoqian Song, Chenyang Jin, Yilong Peng, Jing Zhou, Xueping Zheng
2026, 17 (1): 286-303 | DOI: 10.14336/AD.2024.1515
AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent
Qiuqiong Tang, Deyong Xiao, Alexander Veviorskiy, Ying Xin, Sarah W.Y. Lok, Fadi E. Pulous, Peiran Zhang, Yunfeng Zhu, Yongming Ma, Xiao Hu, Shoulai Gu, Chenting Zong, Sabina Mukba, Mikhail Korzinkin, Frank W. Pun, Man Zhang, Alex Aliper, Lijuan Wu, Feng Ren, Li Zhang, Alex Zhavoronkov
2026, 17 (1): 432-451 | DOI: 10.14336/AD.2024.1492
Supplement

1. Supplementary data.pdf (1198KB)

2. TNIK Senomorphic Video.mp4.mp4 (14113KB)

Peakspan: Defining, Quantifying and Extending the Boundaries of Peak Productive Lifespan
Authors: Alex Zhavoronkov, Kejun Ying, Dominika Wilczok
| DOI: 10.14336/AD.2026.0080
Perimenopausal Hormone Replacement Treatments as a Geroprotective Approach - Adapting Clinical Guidance
Jaron Rabinovici, Henk-Peter Oonk, Zhongwei Huang, Tashiya Mirando, Moran Zhou, Tzipora Strauss, Lia-Raluca Olari, Dominika Wilczok, Andrea B. Maier, Evelyne Bischof
| DOI: 10.14336/AD.2025.1391
Blue Zones, an Analysis of Existing Evidence through a Scoping Review
Cristina Candal-Pedreira, Julia Rey-Brandariz, Lucía Martín-Gisbert, Ana Teijeiro, Guadalupe García, Alberto Ruano-Ravina, Mónica Pérez-Ríos
2026, 17 (3): 1335-1346 | DOI: 10.14336/AD.2025.0461
Supplement

1. Supplementary data.pdf (244KB)

Causality of Aging Hallmarks
Bilu Huang, Xiaowen Hu
2026, 17 (3): 1236-1253 | DOI: 10.14336/AD.2025.0541
Epigenetic Clocks: Beyond Biological Age, Using the Past to Predict the Present and Future
Runyu Liang, Qiang Tang, Jia Chen, Luwen Zhu
2025, 16 (6): 3520-3545 | DOI: 10.14336/AD.2024.1495
Reduced Blood Choline in Obesity Is Associated with Metabolic and Alzheimer’s Biomarkers
Wendy Winslow, Jessica M. Judd, Savannah Tallino, Geidy E. Serrano, Thomas G. Beach, Lori R. Roust, Eleanna De Filippis, Brooke Brown, Christos Katsanos, Ramon Velazquez
| DOI: 10.14336/AD.2025.1207
Green Tea Mitigates the Hallmarks of Aging and Age-Related Multisystem Deterioration
Yusuf Yilmaz
2026, 17 (2): 712-730 | DOI: 10.14336/AD.2025.0398
Ovarian Aging: The Silent Catalyst of Age-Related Disorders in Female Body
Xingyu Liu, Yuanqu Zhao, Yanzhi Feng, Shixuan Wang, Aiyue Luo, Jinjin Zhang
2026, 17 (1): 132-158 | DOI: 10.14336/AD.2024.1468
LLMs and AI Life Models for Traditional Chinese Medicine-derived Geroprotector Formulation
Fedor Galkin, Feng Ren, Alex Zhavoronkov
2026, 17 (2): 1155-1168 | DOI: 10.14336/AD.2024.1697
SLC7A11 in Fibrosis: Molecular Mechanisms and Future Prospects
Juntong Chen, Yanjie He, Ru Chen, Zhiyong Yang, Xiaomeng Luo, Fan Yang
2026, 17 (2): 731-759 | DOI: 10.14336/AD.2025.0106
Type 2 Diabetes Mellitus: A Metabolic Model of Accelerated Aging - Multi-Organ Mechanisms and Intervention Approaches
Ziran Zhang, Xiaolin He, Yuxin Sun, Jitong Li, Jia Sun
2026, 17 (3): 1399-1422 | DOI: 10.14336/AD.2025.0233
The Impact of Rosemary and Ginger Extracts on Aging and Healthspan in Drosophila
Ricardo Aparicio, Anna M. Salazar, Edward T. Schmid, Armen Khanbabaei, Arun Rajgopal, R. Keith Randolph, David W. Walker
2026, 17 (1): 416-431 | DOI: 10.14336/AD.2024.1558
Supplement

1. Supplementary data.pdf (378KB)

Dietary Interventions for Healthy Aging: An Epigenetic Perspective
Xinyu Zhang, Ziyue Xie, Huimin Bian, Yu Li, Ruigong Zhu, Jia Sun
| DOI: 10.14336/AD.2026.0333
Towards Precision Aging Biology: Single-Cell Multi-Omics and Advanced AI-Driven Strategies
Sijia Xie, Xinwei Luo, Feitong Hong, Yijie Wei, Yuduo Hao, Xueqin Xie, Xiaolong Li, Guangbo Xie, Fuying Dao, Hao Lyu
2026, 17 (2): 907-926 | DOI: 10.14336/AD.2025.0218
A Combination of Low-Dose Δ9-THC and Celecoxib as a Therapeutic Strategy for Alzheimer’s Disease
Jian Zhang, Dexiao Zhu, Mei Hu, Mingzhe Pan, Chu Chen
| DOI: 10.14336/AD.2025.1206
Supplement

1. Supplementary data.pdf (4873KB)

A Standardized Protocol for Mouse Longevity Studies in Preclinical Drug Development
Alex Zhavoronkov, Qian Wang, Yujie Liu, Wenbin Hou, Yuelei Shen, Dominika Wilczok, Kristen Fortney, Alex Aliper, Man Zhang, Feng Ren, Richard A. Miller
2026, 17 (3): 1169-1179 | DOI: 10.14336/AD.2025.0508
Pros and Cons of Human Brain Organoids to Study Alzheimer’s Disease
Andrea Sainz, Fernando Pérez-Cerdá, Alberto Pérez-Samartín, Mitradas Panicker, Asier Ruiz, Carlos Matute
2025, 16 (6): 3483-3504 | DOI: 10.14336/AD.2024.1409
The Role of Hypoxia in Longevity
Ayesha Nisar, Sawar Khan, Yongzhang Pan, Li Hu, Pengyun Yang, Naheemat Modupeola Gold, Zhen Zhou, Shengjie Yuan, Meiting Zi, Sardar Azhar Mehmood, Yonghan He
2026, 17 (1): 62-90 | DOI: 10.14336/AD.2024.1630
Engineering the Future of Longevity R&D: The Case for AI-Driven, Integrated Biotechnology Ecosystems
Alex Zhavoronkov, Chuen Yan Leung
| DOI: 10.14336/AD.2025.1313
Capsaicin and TRPV1: A Novel Therapeutic Approach to Mitigate Vascular Aging
Xing-Yu Cui, Jun-Kun Zhan
2026, 17 (1): 256-274 | DOI: 10.14336/AD.2024.1292
Bone Health and Physical Activity - The Complex Mechanism
Alicja Nowak, Małgorzata Ogurkowska
2025, 16 (6): 3400-3420 | DOI: 10.14336/AD.2024.1316
Glucagon Like Peptide-1 Receptor Agonists for Sarcopenia and Muscle Wasting Disorders: A Systematic Review of Efficacy and Mechanisms
Abudureheman Maihemuti, Can Cui, Qianjin Wang, Reziwanguli Amuti, Wai Wang Chau, Senlin Chai, Ning Zhang, Ronald Man Yeung Wong, Ho Ko, Timothy Chi-Yui Kwok, Wing-Hoi Cheung
| DOI: 10.14336/AD.2025.1165
Supplement

1. Supplementary data.pdf (298KB)

Targeting Ferroptosis to Eliminate Senescent Cells: Mechanisms and Therapeutic Potential
Sanjay Kumar Kureel, Blake B. Rasmussen
2026, 17 (4): 1786-1808 | DOI: 10.14336/AD.2025.0141
Decoding Aging through iPSC Reprogramming: Advances and Challenges
Rui-lin Li, Yun-zeng Zou, Sheng Kang
2026, 17 (3): 1179-1189 | DOI: 10.14336/AD.2025.0438
Role of AMPK and Sirtuins in Aging Heart: Basic and Translational Aspects
Maria Luisa Barcena, Muhammad Aslam, Kristina Norman, Christiane Ott, Yury Ladilov
2025, 16 (6): 3335-3360 | DOI: 10.14336/AD.2024.1216
Exercise as a Metabolic Regulator: Targeting AMPK/mTOR-Autophagy Crosstalk to Counteract Sarcopenic Obesity
Daoqi Zhang, Congfei Lu, Kai Sang
2026, 17 (4): 1904-1915 | DOI: 10.14336/AD.2025.0419
Metabolic Dysfunction in Idiopathic Intracranial Hypertension: Current Theories and Updates
Hui Li, Lu Liu, Yifan Zhou, Huimin Jiang, Weiyue Zhang, Chenxia Zhou, Chuanjie Wu, Chen Zhou, Xunming Ji
2025, 16 (6): 3311-3334 | DOI: 10.14336/AD.2024.1147
Targeting T-cell Aging to Remodel the Aging Immune System and Revitalize Geriatric Immunotherapy
Mi Chen, Zhou Su, Jianxin Xue
2026, 17 (2): 607-624 | DOI: 10.14336/AD.2025.0061
Unraveling the ROS-Inflammation-Immune Balance: A New Perspective on Aging and Disease
Sihang Fang, Mingjun Jiang, Juan Jiao, Hongye Zhao, Dizhi Liu, Danni Gao, Tenger Wang, Ze Yang, Huiping Yuan
2026, 17 (1): 305-325 | DOI: 10.14336/AD.2024.1253
Increased Stability of Tristetraprolin mRNA Supports Bone Health and Decreases Frailty During Aging
Ramkumar Thiyagarajan, Lixia Zhang, Leticia Andrea Rojas Cortez, Kyu Hwan Kwack, Victoria Maglaras, Nanda Kumar Yellapu, Yukitomo Arao, Kenneth L. Seldeen, Perry J. Blackshear, Bruce R. Troen, Keith L. Kirkwood
| DOI: 10.14336/AD.2025.1243
Supplement

1. Supplementary data.pdf (1343KB)

NK Cell Senescence in Cancer: From Molecular Mechanisms to Therapeutic Opportunities
Zilin Qiu, Zhengrui Li, Cangang Zhang, Qun Zhao, Zaoqu Liu, Quan Cheng, Jian Zhang, Anqi Lin, Peng Luo
2026, 17 (2): 1002-1033 | DOI: 10.14336/AD.2025.0053
Gut Microbiota-Immune System Interactions in Health and Neurodegenerative Diseases: Insights into Molecular Mechanisms and Therapeutic Applications
Rengasamy Balakrishnan, Shin-Il Kang, Ji-Yeon Lee, Yang-Kook Rho, Byoung-Kook Kim, Dong-Kug Choi
2025, 16 (6): 3421-3452 | DOI: 10.14336/AD.2024.1362
Lysosomes as Dynamic Regulators of Metabolic Signaling and Organ Physiology in Aging: From Mechanism to Therapy
Yu Sun, Jin Wei, Shiyin Ma, Chang He, Liutao Sui, Xudong Pan, Xiaoyan Zhu
2026, 17 (2): 657-690 | DOI: 10.14336/AD.2025.0275
Glucose Metabolism, Lactate, Lactylation and Alzheimer’s Disease
Shuangshuang Hai, Yadan Hou, Meiyan Zhang, Xiaoyan Gao, Tuo Yang, Xiuli Shang, Xiaohong Sun
2026, 17 (4): 1850-1867 | DOI: 10.14336/AD.2025.0338
Lactylation: A Novel Epigenetic Regulator of Cellular Senescence
Caiyu Sun, Jiaxuan Li, Lei Dong, Yakui Mou, Bei Zhang, Xicheng Song
2026, 17 (2): 890-906 | DOI: 10.14336/AD.2025.0277
Immunosenescence in Sepsis: Molecular Mechanisms and Potential Therapeutic Targets
Heyang Sun, Qianya Hong, Chenning Li, Shuainan Zhu, Ying Yu, Hao Zhang, Kefang Guo
2026, 17 (2): 780-811 | DOI: 10.14336/AD.2025.0039
Lifelong Glutathione Deficiency in Mice Increased Lifespan and Delayed Age-Related Motor Declines
J. Thomas Mock, Paapa Mensah-Kane, Delaney L. Davis, Jessica M. Wong, Philip H. Vann, Michael J. Forster, Nathalie Sumien
2025, 16 (6): 3671-3689 | DOI: 10.14336/AD.2024.1077
Decoding Microglial Polarization and Metabolic Reprogramming in Neurodegenerative Diseases: Implications for Disease Progression and Therapy
Ran Gao, Ya Gao, Wenting Su, Renxi Wang
2026, 17 (1): 91-113 | DOI: 10.14336/AD.2024.1629