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2023
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Total 40 results are found
Long-Term Improvement in Hippocampal-Dependent Learning Ability in Healthy, Aged Individuals Following High Intensity Interval Training
Daniel G. Blackmore, Mia A. Schaumberg, Maryam Ziaei, Samuel Belford, Xuan Vinh To, Imogen O’Keeffe, Anne Bernard, Jules Mitchell, Emily Hume, Grace L. Rose, Thomas Shaw, Ashley York, Markus Barth, Elizabeth J. Cooper, Tina L. Skinner, Fatima Nasrallah, Stephan Riek, Perry F. Bartlett
2025, 16 (3): 1732-1754 | DOI: 10.14336/AD.2024.0642
Supplement

1. Supplementary data.pdf (6754KB)

Visceral and Subcutaneous Abdominal Fat Predict Brain Volume Loss at Midlife in 10,001 Individuals
Cyrus A Raji, Somayeh Meysami, Sam Hashemi, Saurabh Garg, Nasrin Akbari, Ahmed Gouda, Yosef Gavriel Chodakiewitz, Thanh Duc Nguyen, Kellyann Niotis, David A Merrill, Rajpaul Attariwala
2024, 15 (4): 1831-1842 | DOI: 10.14336/AD.2023.0820
Age-Related Dysfunction in Balance: A Comprehensive Review of Causes, Consequences, and Interventions
Jixian Wang, Yongfang Li, Guo-Yuan Yang, Kunlin Jin
2025, 16 (2): 714-737 | DOI: 10.14336/AD.2024.0124-1
Molecular Mechanisms of Phase Separation and Amyloidosis of ALS/FTD-linked FUS and TDP-43
Jianxing Song
2024, 15 (5): 2084-2112 | DOI: 10.14336/AD.2023.1118
AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent
Qiuqiong Tang, Deyong Xiao, Alexander Veviorskiy, Ying Xin, Sarah W.Y. Lok, Fadi E. Pulous, Peiran Zhang, Yunfeng Zhu, Yongming Ma, Xiao Hu, Shoulai Gu, Chenting Zong, Sabina Mukba, Mikhail Korzinkin, Frank W. Pun, Man Zhang, Alex Aliper, Lijuan Wu, Feng Ren, Li Zhang, Alex Zhavoronkov
| DOI: 10.14336/AD.2024.1492
Supplement

1. Supplementary data.pdf (1198KB)

2. TNIK Senomorphic Video.mp4.mp4 (14113KB)

The Expanding Burden of Neurodegenerative Diseases: An Unmet Medical and Social Need
Shu Wang, Yin Jiang, Anchao Yang, Fangang Meng, Jianguo Zhang
| DOI: 10.14336/AD.2024.1071
Cross-Vendor Test-Retest Validation of Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS) for Evaluating Glymphatic System Function
Xiaodan Liu, Giuseppe Barisano, Xingfeng Shao, Kay Jann, John M Ringman, Hanzhang Lu, Konstantinos Arfanakis, Arvind Caprihan, Charles DeCarli, Brian T Gold, Pauline Maillard, Claudia L Satizabal, Elyas Fadaee, Mohamad Habes, Lara Stables, Herpreet Singh, Bruce Fischl, Andre van der Kouwe, Kristin Schwab, Karl G Helmer, Steven M Greenberg, Danny J.J Wang, for the MarkVCID Consortium
2024, 15 (4): 1885-1898 | DOI: 10.14336/AD.2023.0321-2
Amyloid-β and Phosphorylated Tau are the Key Biomarkers and Predictors of Alzheimer’s Disease
Jangampalli Adi Pradeepkiran, Javaria Baig, Md Ariful Islam, Sudhir Kshirsagar, P. Hemachandra Reddy
2025, 16 (2): 658-682 | DOI: 10.14336/AD.2024.0286
Arterial Aging and Cerebrovascular Function: Impact of Aerobic Exercise Training in Older Adults
Tsubasa Tomoto, Rong Zhang
2024, 15 (4): 1672-1687 | DOI: 10.14336/AD.2023.1109-1
Inflammatory Pathogenesis of Post-stroke Depression
Xinyu Feng, Xiaojuan Ma, Juan Li, Qing Zhou, Yao Liu, Jingyi Song, Jiaqi Liu, Qingqing Situ, Lingyue Wang, Jingzhi Zhang, Facai Lin
2025, 16 (1): 209-238 | DOI: 10.14336/AD.2024.0203
Microglia and Astrocytes in Alzheimer’s Disease: Significance and Summary of Recent Advances
Qianting Deng, Chongyun Wu, Emily Parker, Timon Cheng-Yi Liu, Rui Duan, Luodan Yang
2024, 15 (4): 1537-1564 | DOI: 10.14336/AD.2023.0907
A Potential “Anti-Warburg Effect” in Circulating Tumor Cell-mediated Metastatic Progression?
Zhuofeng Jiang, Jiapeng He, Binyu Zhang, Liping Wang, Chunhao Long, Boxi Zhao, Yufan Yang, Longxiang Du, Weiren Luo, Jianyang Hu, Xin Hong
| DOI: 10.14336/AD.2023.1227
Consequences of Aging on Bone
Lingli Zhang, Qiao Guan, Zhikun Wang, Jie Feng, Jun Zou, Bo Gao
2024, 15 (6): 2417-2452 | DOI: 10.14336/AD.2023.1115
State of the Science on Brain Insulin Resistance and Cognitive Decline Due to Alzheimer’s Disease
Elizabeth M Rhea, Manon Leclerc, Hussein N Yassine, Ana W Capuano, Han Tong, Vladislav A Petyuk, Shannon L Macauley, Xavier Fioramonti, Owen Carmichael, Frederic Calon, Zoe Arvanitakis
2024, 15 (4): 1688-1725 | DOI: 10.14336/AD.2023.0814
Tryptophan Metabolism in Alzheimer’s Disease with the Involvement of Microglia and Astrocyte Crosstalk and Gut-Brain Axis
Lushuang Xie, Qiaofeng Wu, Kelin Li, Mohammed A. S. Khan, Andrew Zhang, Bharati Sinha, Sihui Li, Sulie L. Chang, David L. Brody, Mark W. Grinstaff, Shuanhu Zhou, Gil Alterovitz, Pinghua Liu, Xin Wang
2024, 15 (5): 2168-2190 | DOI: 10.14336/AD.2024.0134
Deformability of Heterogeneous Red Blood Cells in Aging and Related Pathologies
Dmitry S. Prudinnik, Aigul Kussanova, Ivan A. Vorobjev, Alexander Tikhonov, Fazly I. Ataullakhanov, Natasha S. Barteneva
2025, 16 (3): 1242-1264 | DOI: 10.14336/AD.2024.0526
Expert Consensus on the Application of Stem Cells in Psoriasis Research and Clinical Trials
Ye-Hong Kuang, Wu Zhu, Ge Lin, La-Mei Cheng, Qun Qin, Zhi-Jun Huang, Yu-Ling Shi, Chun-Lei Zhang, Jin-Hua Xu, Ke-Xiang Yan, Cheng-Zhi Lv, Wei Li, Qin Han, Ilia Stambler, Lee Wei Lim, Sasanka Chakrabarti, Brun Ulfhake, Kyung-Jin Min, Georgina Ellison-Hughes, William C Cho, Kunlin Jin, Danni Yao, Chuanjian Lu, Robert Chunhua Zhao, Xiang Chen
2025, 16 (3): 1363-1377 | DOI: 10.14336/AD.2024.0012
Machine Learning-Based Decision-Making in Geriatrics: Aging Phenotype Calculator and Survival Prognosis
Aleksandra Mamchur, Natalia Sharashkina, Veronika Erema, Daria Kashtanova, Mikhail Ivanov, Maria Bruttan, Elena Zelenova, Eva Shelly, Valentina Ostapenko, Irina Dzhumaniiazova, Lorena Matkava, Vladimir Yudin, Anna Akopyan, Irina Strazhesko, Lilit Maytesyan, Irina Tarasova, Olga Beloshevskaya, Anton Keskinov, Sergey Kraevoy, Olga Tkacheva, Sergey Yudin
2025, 16 (1): 565-577 | DOI: 10.14336/AD.2024.0120
Supplement

1. Supplementary data.pdf (684KB)

LLMs and AI Life Models for Traditional Chinese Medicine-derived Geroprotector Formulation
Fedor Galkin, Feng Ren, Alex Zhavoronkov
| DOI: 10.14336/AD.2024.1697
Brain Insulin Signaling is Associated with Late-Life Cognitive Decline
Han Tong, Ana W. Capuano, Owen T. Carmichael, Kathryn L. Gwizdala, David A. Bennett, Rexford S. Ahima, Steven E. Arnold, Zoe Arvanitakis
2024, 15 (5): 2205-2215 | DOI: 10.14336/AD.2023.1117
Aging and Sex Differences in Brain Volume and Cerebral Blood Flow
Hiroto Kawano, Shigeki Yamada, Yoshiyuki Watanabe, Satoshi Ii, Tomohiro Otani, Hirotaka Ito, Ko Okada, Chifumi Iseki, Motoki Tanikawa, Shigeo Wada, Marie Oshima, Mitsuhito Mase, Kazumichi Yoshida
2024, 15 (5): 2216-2229 | DOI: 10.14336/AD.2023.1122
Supplement

1. Supplementary data movie-1.mp4 (19073KB)

2. Supplementary data.pdf (181KB)

3. Supplementary data movie-2.mp4 (875KB)

Vascular Aging and Atherosclerosis: A Perspective on Aging
Shudong Ma, Xuena Xie, Rong Yuan, Qiqi Xin, Yu Miao, Sean Xiao Leng, Keji Chen, Weihong Cong
2025, 16 (1): 33-48 | DOI: 10.14336/AD.2024.0201-1
Alzheimer Disease Pathology and Neurodegeneration in Midlife Obesity: A Pilot Study
Mahsa Dolatshahi, Paul K Commean, Farzaneh Rahmani, Jingxia Liu, LaKisha Lloyd, Caitlyn Nguyen, Nancy Hantler, Maria Ly, Gary Yu, Joseph E Ippolito, Claude Sirlin, John C Morris, Tammie L.S Benzinger, Cyrus A Raji
2024, 15 (4): 1843-1854 | DOI: 10.14336/AD.2023.0707
Supplement

1. Supplementary data.pdf (178KB)

Physical Exercise Counteracts Aging-Associated White Matter Demyelination Causing Cognitive Decline
Tanya H. Butt, Makoto Tobiume, Diane B. Re, Shingo Kariya
2024, 15 (5): 2136-2148 | DOI: 10.14336/AD.2024.0216
The Role of Circadian Rhythm in Neurological Diseases: A Translational Perspective
Wanbin Huang, Jiabin Zong, Yu Zhang, Yanjie Zhou, Lily Zhang, Yajuan Wang, Zhengming Shan, Qingfang Xie, Ming Li, Songqing Pan, Zheman Xiao
2024, 15 (4): 1565-1587 | DOI: 10.14336/AD.2023.0921
Involvement of Inheritance in Determining Telomere Length beyond Environmental and Lifestyle Factors
Naheemat Modupeola Gold, Michael Ngozi Okeke, Yonghan He
2024, 15 (6): 2470-2490 | DOI: 10.14336/AD.2023.1023
Aging-Related Sarcopenia: Metabolic Characteristics and Therapeutic Strategies
Yonglian Chen, Jinhui Wu
2025, 16 (2): 1003-1022 | DOI: 10.14336/AD.2024.0407
Aging and “Age-Related” Diseases - What Is the Relation?
Wolfgang Kopp
2025, 16 (3): 1316-1346 | DOI: 10.14336/AD.2024.0570
Revolutionizing Diabetic Foot Ulcer Care: The Senotherapeutic Approach
Guiqin Zhang, Priyadarshani Nadeeshika Samarawickrama, Li Gui, Yuan Ma, Mei Cao, Hong Zhu, Wei Li, Honglin Yang, Kecheng Li, Yang Yang, Enfang Zhu, Wen Li, Yonghan He
2025, 16 (2): 946-970 | DOI: 10.14336/AD.2024.0065
ROS-Induced Endothelial Dysfunction in the Pathogenesis of Atherosclerosis
Ruiyi Yan, Xiao Zhang, Wenlong Xu, Jiayao Li, Yixin Sun, Shengyan Cui, Ran Xu, Wenjing Li, Liqun Jiao, Tao Wang
2025, 16 (1): 250-268 | DOI: 10.14336/AD.2024.0309
Senescent T Cells in Age-Related Diseases
Pei-Jie Yu, Mei Zhou, Yan Liu, Jie Du
2025, 16 (1): 321-344 | DOI: 10.14336/AD.2024.0219
Skin-brain axis in Alzheimer's disease - Pathologic, diagnostic, and therapeutic implications: A Hypothetical Review
Hyeon soo Kim, Haram Jung, Yong Ho Park, Su-Hak Heo, Sujin Kim, Minho Moon
2025, 16 (2): 901-916 | DOI: 10.14336/AD.2024.0406
Targeting Cellular Senescence in Aging and Age-Related Diseases: Challenges, Considerations, and the Emerging Role of Senolytic and Senomorphic Therapies
Liyao Zheng, Shipei He, Hong Wang, Jinling Li, Yuanyuan Liu, Sijia Liu
2024, 15 (6): 2554-2594 | DOI: 10.14336/AD.2024.0206
Adiponectin mRNA Conjugated with Lipid Nanoparticles Specifically Targets the Pathogenesis of Type 2 Diabetes
Rady E. El-Araby, Qisheng Tu, Ying Xie, Tarek Aboushousha, Zhongyu Li, Xiaoyang Xu, Zoe X. Zhu, Lily Q. Dong, Jake Chen
2025, 16 (2): 1059-1079 | DOI: 10.14336/AD.2024.0162
Supplement

1. Supplementary data.pdf (275KB)

Aging Gut Microbiome in Healthy and Unhealthy Aging
Yangyanqiu Wang, Zhanbo Qu, Jian Chu, Shuwen Han
2025, 16 (2): 980-1002 | DOI: 10.14336/AD.2024.0331
Ovariectomy and High Fat-Sugar-Salt Diet Induced Alzheimer's Disease/Vascular Dementia Features in Mice
Sahar Sweetat, Moti Ben Shabat, Paschalis Theotokis, Nir Suissa, Eleni Karafoulidou, Olga Touloumi, Rami Abu-Fanne, Oded Abramsky, Gilly Wolf, Ann Saada, Amit Lotan, Nikolaos Grigoriadis, Hanna Rosenmann
2024, 15 (5): 2284-2300 | DOI: 10.14336/AD.2024.03110
A Combination Study of Pre- and Clinical Trial: Seaweed Consumption Reduces Aging-Associated Muscle Loss!
Jimin Hyun, Sang Yeoup Lee, Bomi Ryu, You-Jin Jeon
2024, 15 (6): 2813-2827 | DOI: 10.14336/AD.2023.0927
Supplement

1. Supplementary data.pdf (765KB)

Association of Plasma Markers of Alzheimer’s Disease, Neurodegeneration, and Neuroinflammation with the Choroid Plexus Integrity in Aging
Mustapha Bouhrara, Keenan A. Walker, Joseph S. R. Alisch, Zhaoyuan Gong, Caio H. Mazucanti, Alexandria Lewis, Abhay R. Moghekar, Lisa Turek, Victoria Collingham, Nader Shehadeh, Giovanna Fantoni, Mary Kaileh, Christopher M. Bergeron, Jan Bergeron, Susan M. Resnick, Josephine M. Egan
2024, 15 (5): 2230-2240 | DOI: 10.14336/AD.2023.1226
Glial Cell Activation and Immune Responses in Glaucoma: A Systematic Review of Human Postmortem Studies of the Retina and Optic Nerve
Akanksha Salkar, Roshana Vander Wall, Devaraj Basavarajappa, Nitin Chitranshi, Gabriella E. Parilla, Mehdi Mirzaei, Peng Yan, Stuart Graham, Yuyi You
2024, 15 (5): 2069-2083 | DOI: 10.14336/AD.2024.0103
Supplement

1. Supplementary data.pdf (245KB)

Disulfidptosis, A Novel Cell Death Pathway: Molecular Landscape and Therapeutic Implications
Qiuyang Gu, Yumei An, Mingyuan Xu, Xinqi Huang, Xueshi Chen, Xianzhe Li, Haiyan Shan, Mingyang Zhang
2025, 16 (2): 917-945 | DOI: 10.14336/AD.2024.0083