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2023
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Total 40 results are found
Long-Term Improvement in Hippocampal-Dependent Learning Ability in Healthy, Aged Individuals Following High Intensity Interval Training
Daniel G. Blackmore, Mia A. Schaumberg, Maryam Ziaei, Samuel Belford, Xuan Vinh To, Imogen O’Keeffe, Anne Bernard, Jules Mitchell, Emily Hume, Grace L. Rose, Thomas Shaw, Ashley York, Markus Barth, Elizabeth J. Cooper, Tina L. Skinner, Fatima Nasrallah, Stephan Riek, Perry F. Bartlett
2025, 16 (3): 1732-1754 | DOI: 10.14336/AD.2024.0642
Supplement

1. Supplementary data.pdf (6754KB)

Visceral and Subcutaneous Abdominal Fat Predict Brain Volume Loss at Midlife in 10,001 Individuals
Cyrus A Raji, Somayeh Meysami, Sam Hashemi, Saurabh Garg, Nasrin Akbari, Ahmed Gouda, Yosef Gavriel Chodakiewitz, Thanh Duc Nguyen, Kellyann Niotis, David A Merrill, Rajpaul Attariwala
2024, 15 (4): 1831-1842 | DOI: 10.14336/AD.2023.0820
Age-Related Dysfunction in Balance: A Comprehensive Review of Causes, Consequences, and Interventions
Jixian Wang, Yongfang Li, Guo-Yuan Yang, Kunlin Jin
2025, 16 (2): 714-737 | DOI: 10.14336/AD.2024.0124-1
Role and Potential Mechanisms of Nicotinamide Mononucleotide in Aging
Sajid Ur Rahman, Abdul Qadeer, Ziyun Wu
2024, 15 (2): 565-583 | DOI: 10.14336/AD.2023.0519-1
Human Aging and Age-Related Diseases: From Underlying Mechanisms to Pro-Longevity Interventions
Piotr Paweł Chmielewski, Krzysztof Data, Bartłomiej Strzelec, Maryam Farzaneh, Amir Anbiyaiee, Uzma Zaheer, Shahab Uddin, Mohadeseh Sheykhi-Sabzehpoush, Paul Mozdziak, Maciej Zabel, Piotr Dzięgiel, Bartosz Kempisty
2025, 16 (4): 1853-1877 | DOI: 10.14336/AD.2024.0280
Molecular Mechanisms of Phase Separation and Amyloidosis of ALS/FTD-linked FUS and TDP-43
Jianxing Song
2024, 15 (5): 2084-2112 | DOI: 10.14336/AD.2023.1118
AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent
Qiuqiong Tang, Deyong Xiao, Alexander Veviorskiy, Ying Xin, Sarah W.Y. Lok, Fadi E. Pulous, Peiran Zhang, Yunfeng Zhu, Yongming Ma, Xiao Hu, Shoulai Gu, Chenting Zong, Sabina Mukba, Mikhail Korzinkin, Frank W. Pun, Man Zhang, Alex Aliper, Lijuan Wu, Feng Ren, Li Zhang, Alex Zhavoronkov
| DOI: 10.14336/AD.2024.1492
Supplement

1. Supplementary data.pdf (1198KB)

2. TNIK Senomorphic Video.mp4.mp4 (14113KB)

Cardiac System during the Aging Process
Ana Sofia Fernandes Ribeiro, Blanca Egea Zerolo, Fidel López-Espuela, Raúl Sánchez, Vítor S Fernandes
2023, 14 (4): 1105-1122 | DOI: 10.14336/AD.2023.0115
Alzheimer's Disease Puzzle: Delving into Pathogenesis Hypotheses
Mohammad Nasb, Weichu Tao, Ning Chen
2024, 15 (1): 43-73 | DOI: 10.14336/AD.2023.0608
Hallmarks of Skin Aging: Update
Shifeng Jin, Kezhu Li, Xuanru Zong, Seokchan Eun, Naoki Morimoto, Shu Guo
2023, 14 (6): 2167-2176 | DOI: 10.14336/AD.2023.0321
The Expanding Burden of Neurodegenerative Diseases: An Unmet Medical and Social Need
Shu Wang, Yin Jiang, Anchao Yang, Fangang Meng, Jianguo Zhang
| DOI: 10.14336/AD.2024.1071
Longevity-Associated Transcription Factor ATF7 Promotes Healthspan by Suppressing Cellular Senescence and Systematic Inflammation
Yaqun Huang, Ming-Xia Ge, Yu-Hong Li, Jing-Lin Li, Qin Yu, Fu-Hui Xiao, Hong-Shun Ao, Li-Qin Yang, Ji Li, Yonghan He, Qing-Peng Kong
2023, 14 (4): 1374-1389 | DOI: 10.14336/AD.2022.1217
Supplement

1. Supplementary data.pdf (633KB)

TGF-β as A Master Regulator of Aging-Associated Tissue Fibrosis
Li-Li Ren, Hua Miao, Yan-Ni Wang, Fei Liu, Ping Li, Ying-Yong Zhao
2023, 14 (5): 1633-1650 | DOI: 10.14336/AD.2023.0222
Responsiveness to Tocilizumab in Anti-Acetylcholine Receptor-Positive Generalized Myasthenia Gravis
Dongmei Jia, Fenghe Zhang, Huining Li, Yi Shen, Zhao Jin, Fu-Dong Shi, Chao Zhang
2024, 15 (2): 824-830 | DOI: 10.14336/AD.2023.0528
Cross-Vendor Test-Retest Validation of Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS) for Evaluating Glymphatic System Function
Xiaodan Liu, Giuseppe Barisano, Xingfeng Shao, Kay Jann, John M Ringman, Hanzhang Lu, Konstantinos Arfanakis, Arvind Caprihan, Charles DeCarli, Brian T Gold, Pauline Maillard, Claudia L Satizabal, Elyas Fadaee, Mohamad Habes, Lara Stables, Herpreet Singh, Bruce Fischl, Andre van der Kouwe, Kristin Schwab, Karl G Helmer, Steven M Greenberg, Danny J.J Wang, for the MarkVCID Consortium
2024, 15 (4): 1885-1898 | DOI: 10.14336/AD.2023.0321-2
Parental Alcohol Exposures Associate with Lasting Mitochondrial Dysfunction and Accelerated Aging in a Mouse Model
Alison Basel, Sanat S. Bhadsavle, Katherine Z. Scaturro, Grace K. Parkey, Matthew N. Gaytan, Jai J. Patel, Kara N. Thomas, Michael C. Golding
2025, 16 (4): 2408-2452 | DOI: 10.14336/AD.2024.0722
Supplement

1. Supplementary data.pdf (1015KB)

Amyloid-β and Phosphorylated Tau are the Key Biomarkers and Predictors of Alzheimer’s Disease
Jangampalli Adi Pradeepkiran, Javaria Baig, Md Ariful Islam, Sudhir Kshirsagar, P. Hemachandra Reddy
2025, 16 (2): 658-682 | DOI: 10.14336/AD.2024.0286
Engineered Mitochondrial Transplantation as An Anti-Aging Therapy
Rui Zhao, Chen Dong, Qian Liang, Jianlin Gao, Chi Sun, Zhifeng Gu, Yujuan Zhu
2025, 16 (4): 1918-1945 | DOI: 10.14336/AD.2024.0231
A Framework for an Effective Healthy Longevity Clinic
Sergey Mironov, Olga Borysova, Ivan Morgunov, Zhongjun Zhou, Alexey Moskalev
2025, 16 (4): 1971-1986 | DOI: 10.14336/AD.2024.0328-1
Supplement

1. Supplementary data.pdf (502KB)

Mitochondrial Dynamics: Working with the Cytoskeleton and Intracellular Organelles to Mediate Mechanotransduction
Danyuan Huang, Shuo Chen, Ding Xiong, Han Wang, Li Zhu, Yuanyuan Wei, Yuyu Li, Shujuan Zou
2023, 14 (5): 1511-1532 | DOI: 10.14336/AD.2023.0201
Arterial Aging and Cerebrovascular Function: Impact of Aerobic Exercise Training in Older Adults
Tsubasa Tomoto, Rong Zhang
2024, 15 (4): 1672-1687 | DOI: 10.14336/AD.2023.1109-1
Post-Stroke Neuropsychiatric Complications: Types, Pathogenesis, and Therapeutic Intervention
Jing Zhou, Yijia Fangma, Zhong Chen, Yanrong Zheng
2023, 14 (6): 2127-2152 | DOI: 10.14336/AD.2023.0310-2
The Interfascicular Matrix of Energy Storing Tendons Houses Heterogenous Cell Populations Disproportionately Affected by Aging
Danae E. Zamboulis, Neil Marr, Luca Lenzi, Helen L. Birch, Hazel R. C. Screen, Peter D. Clegg, Chavaunne T. Thorpe
2024, 15 (1): 295-310 | DOI: 10.14336/AD.2023.0425-1
Supplement

1. Supplementary data.pdf (1021KB)

Inhibiting MicroRNA-141-3p Improves Musculoskeletal Health in Aged Mice
Sagar Vyavahare, Sandeep Kumar, Kathryn Smith, Bharati Mendhe, Roger Zhong, Marion A. Cooley, Babak Baban, Carlos M. Isales, Mark Hamrick, William D Hill, Sadanand Fulzele
2023, 14 (6): 2303-2618 | DOI: 10.14336/AD.2023.0310-1
Supplement

1. Supplementary data.pdf (125KB)

Inflammatory Pathogenesis of Post-stroke Depression
Xinyu Feng, Xiaojuan Ma, Juan Li, Qing Zhou, Yao Liu, Jingyi Song, Jiaqi Liu, Qingqing Situ, Lingyue Wang, Jingzhi Zhang, Facai Lin
2025, 16 (1): 209-238 | DOI: 10.14336/AD.2024.0203
Human APOE4 Protects High-Fat and High-Sucrose Diet Fed Targeted Replacement Mice against Fatty Liver Disease Compared to APOE3
Patricia Huebbe, Stephanie Bilke, Johanna Rueter, Anke Schloesser, Graeme Campbel, Claus-C. Glüer, Ralph Lucius, Christoph Röcken, Andreas Tholey, Gerald Rimbach
2024, 15 (1): 259-281 | DOI: 10.14336/AD.2023.0530
A Potential “Anti-Warburg Effect” in Circulating Tumor Cell-mediated Metastatic Progression?
Zhuofeng Jiang, Jiapeng He, Binyu Zhang, Liping Wang, Chunhao Long, Boxi Zhao, Yufan Yang, Longxiang Du, Weiren Luo, Jianyang Hu, Xin Hong
| DOI: 10.14336/AD.2023.1227
Microglia and Astrocytes in Alzheimer’s Disease: Significance and Summary of Recent Advances
Qianting Deng, Chongyun Wu, Emily Parker, Timon Cheng-Yi Liu, Rui Duan, Luodan Yang
2024, 15 (4): 1537-1564 | DOI: 10.14336/AD.2023.0907
Microbiota-Gut-Brain Axis Dysregulation in Alzheimer's Disease: Multi-Pathway Effects and Therapeutic Potential
Linkai Qu, Yanwei Li, Fan Liu, Yimeng Fang, Jiaxuan He, Jiahui Ma, Ting Xu, Lei Wang, Pengyu Lei, Hao Dong, Libo Jin, Qinsi Yang, Wei Wu, Da Sun
2024, 15 (3): 1108-1131 | DOI: 10.14336/AD.2023.0823-2
State of the Science on Brain Insulin Resistance and Cognitive Decline Due to Alzheimer’s Disease
Elizabeth M Rhea, Manon Leclerc, Hussein N Yassine, Ana W Capuano, Han Tong, Vladislav A Petyuk, Shannon L Macauley, Xavier Fioramonti, Owen Carmichael, Frederic Calon, Zoe Arvanitakis
2024, 15 (4): 1688-1725 | DOI: 10.14336/AD.2023.0814
Consequences of Aging on Bone
Lingli Zhang, Qiao Guan, Zhikun Wang, Jie Feng, Jun Zou, Bo Gao
2024, 15 (6): 2417-2452 | DOI: 10.14336/AD.2023.1115
Tryptophan Metabolism in Alzheimer’s Disease with the Involvement of Microglia and Astrocyte Crosstalk and Gut-Brain Axis
Lushuang Xie, Qiaofeng Wu, Kelin Li, Mohammed A. S. Khan, Andrew Zhang, Bharati Sinha, Sihui Li, Sulie L. Chang, David L. Brody, Mark W. Grinstaff, Shuanhu Zhou, Gil Alterovitz, Pinghua Liu, Xin Wang
2024, 15 (5): 2168-2190 | DOI: 10.14336/AD.2024.0134
The Role of Microglia in Brain Metastases: Mechanisms and Strategies
Ying Feng, Xueqing Hu, Yingru Zhang, Yan Wang
2024, 15 (1): 169-185 | DOI: 10.14336/AD.2023.0514
Microglia Exhibit Distinct Heterogeneity Rather than M1/M2 Polarization within the Early Stage of Acute Ischemic Stroke
Hongyu Ma, He Li, Yongxin Zhang, Yu Zhou, Hanchen Liu, Hongye Xu, Luojiang Zhu, Guanghao Zhang, Jing Wang, Zifu Li, Bo Hong, Wang Zhou, Pengfei Yang, Jianmin Liu
2023, 14 (6): 2284-2302 | DOI: 10.14336/AD.2023.0505
Supplement

1. Supplementary data.pdf (1726KB)

Deformability of Heterogeneous Red Blood Cells in Aging and Related Pathologies
Dmitry S. Prudinnik, Aigul Kussanova, Ivan A. Vorobjev, Alexander Tikhonov, Fazly I. Ataullakhanov, Natasha S. Barteneva
2025, 16 (3): 1242-1264 | DOI: 10.14336/AD.2024.0526
Citicoline for Supporting Memory in Aging Humans
Maciej Świątkiewicz, Paweł Grieb
2023, 14 (4): 1184-1195 | DOI: 10.14336/AD.2022.0913
Expert Consensus on the Application of Stem Cells in Psoriasis Research and Clinical Trials
Ye-Hong Kuang, Wu Zhu, Ge Lin, La-Mei Cheng, Qun Qin, Zhi-Jun Huang, Yu-Ling Shi, Chun-Lei Zhang, Jin-Hua Xu, Ke-Xiang Yan, Cheng-Zhi Lv, Wei Li, Qin Han, Ilia Stambler, Lee Wei Lim, Sasanka Chakrabarti, Brun Ulfhake, Kyung-Jin Min, Georgina Ellison-Hughes, William C Cho, Kunlin Jin, Danni Yao, Chuanjian Lu, Robert Chunhua Zhao, Xiang Chen
2025, 16 (3): 1363-1377 | DOI: 10.14336/AD.2024.0012
Machine Learning-Based Decision-Making in Geriatrics: Aging Phenotype Calculator and Survival Prognosis
Aleksandra Mamchur, Natalia Sharashkina, Veronika Erema, Daria Kashtanova, Mikhail Ivanov, Maria Bruttan, Elena Zelenova, Eva Shelly, Valentina Ostapenko, Irina Dzhumaniiazova, Lorena Matkava, Vladimir Yudin, Anna Akopyan, Irina Strazhesko, Lilit Maytesyan, Irina Tarasova, Olga Beloshevskaya, Anton Keskinov, Sergey Kraevoy, Olga Tkacheva, Sergey Yudin
2025, 16 (1): 565-577 | DOI: 10.14336/AD.2024.0120
Supplement

1. Supplementary data.pdf (684KB)

Probiotic Limosilactobacillus Reuteri (Lactobacillus Reuteri) Extends the Lifespan of Drosophila Melanogaster through Insulin/IGF-1 Signaling
Hye-Yeon Lee, Ji-Hyeon Lee, Seung Hyung Kim, Su-Yeon Jo, Kyung-Jin Min
2023, 14 (4): 1407-1424 | DOI: 10.14336/AD.2023.0122
Supplement

1. Supplementary data.pdf (842KB)

Lactylation: An Innovative Approach to Disease Control
Xiaoxin Jiang, Yanyan Yang, Xiaolu Li, Tianxiang Li, Tao Yu, Xiuxiu Fu
2025, 16 (4): 2132-2150 | DOI: 10.14336/AD.2024.0918