Aging and disease

Long-Term Improvement in Hippocampal-Dependent Learning Ability in Healthy, Aged Individuals Following High Intensity Interval Training Daniel G. Blackmore, Mia A. Schaumberg, Maryam Ziaei, Samuel Belford, Xuan Vinh To, Imogen O’Keeffe, Anne Bernard, Jules Mitchell, Emily Hume, Grace L. Rose, Thomas Shaw, Ashley York, Markus Barth, Elizabeth J. Cooper, Tina L. Skinner, Fatima Nasrallah, Stephan Riek, Perry F. Bartlett: 2025, 16 (3): 1732-1754 | DOI: 10.14336/AD.2024.0642; PDF (1507KB)
Supplement; 1. Supplementary data.pdf (6754KB)

Visceral and Subcutaneous Abdominal Fat Predict Brain Volume Loss at Midlife in 10,001 Individuals Cyrus A Raji, Somayeh Meysami, Sam Hashemi, Saurabh Garg, Nasrin Akbari, Ahmed Gouda, Yosef Gavriel Chodakiewitz, Thanh Duc Nguyen, Kellyann Niotis, David A Merrill, Rajpaul Attariwala: 2024, 15 (4): 1831-1842 | DOI: 10.14336/AD.2023.0820; PDF (1480KB)

Age-Related Dysfunction in Balance: A Comprehensive Review of Causes, Consequences, and Interventions Jixian Wang, Yongfang Li, Guo-Yuan Yang, Kunlin Jin: 2025, 16 (2): 714-737 | DOI: 10.14336/AD.2024.0124-1; PDF (451KB)

Role and Potential Mechanisms of Nicotinamide Mononucleotide in Aging Sajid Ur Rahman, Abdul Qadeer, Ziyun Wu: 2024, 15 (2): 565-583 | DOI: 10.14336/AD.2023.0519-1; PDF (1183KB)

AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent Qiuqiong Tang, Deyong Xiao, Alexander Veviorskiy, Ying Xin, Sarah W.Y. Lok, Fadi E. Pulous, Peiran Zhang, Yunfeng Zhu, Yongming Ma, Xiao Hu, Shoulai Gu, Chenting Zong, Sabina Mukba, Mikhail Korzinkin, Frank W. Pun, Man Zhang, Alex Aliper, Lijuan Wu, Feng Ren, Li Zhang, Alex Zhavoronkov: | DOI: 10.14336/AD.2024.1492; PDF (1558KB)
Supplement; 1. Supplementary data.pdf (1198KB); 2. TNIK Senomorphic Video.mp4.mp4 (14113KB)

Molecular Mechanisms of Phase Separation and Amyloidosis of ALS/FTD-linked FUS and TDP-43 Jianxing Song: 2024, 15 (5): 2084-2112 | DOI: 10.14336/AD.2023.1118; PDF (2060KB)

The Expanding Burden of Neurodegenerative Diseases: An Unmet Medical and Social Need Shu Wang, Yin Jiang, Anchao Yang, Fangang Meng, Jianguo Zhang: 2025, 16 (5): 2937-2952 | DOI: 10.14336/AD.2024.1071; PDF (1253KB)

Alzheimer's Disease Puzzle: Delving into Pathogenesis Hypotheses Mohammad Nasb, Weichu Tao, Ning Chen: 2024, 15 (1): 43-73 | DOI: 10.14336/AD.2023.0608; PDF (1172KB)

Hallmarks of Skin Aging: Update Shifeng Jin, Kezhu Li, Xuanru Zong, Seokchan Eun, Naoki Morimoto, Shu Guo: 2023, 14 (6): 2167-2176 | DOI: 10.14336/AD.2023.0321; PDF (579KB)

Amyloid-β and Phosphorylated Tau are the Key Biomarkers and Predictors of Alzheimer’s Disease Jangampalli Adi Pradeepkiran, Javaria Baig, Md Ariful Islam, Sudhir Kshirsagar, P. Hemachandra Reddy: 2025, 16 (2): 658-682 | DOI: 10.14336/AD.2024.0286; PDF (1120KB)

Cross-Vendor Test-Retest Validation of Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS) for Evaluating Glymphatic System Function Xiaodan Liu, Giuseppe Barisano, Xingfeng Shao, Kay Jann, John M Ringman, Hanzhang Lu, Konstantinos Arfanakis, Arvind Caprihan, Charles DeCarli, Brian T Gold, Pauline Maillard, Claudia L Satizabal, Elyas Fadaee, Mohamad Habes, Lara Stables, Herpreet Singh, Bruce Fischl, Andre van der Kouwe, Kristin Schwab, Karl G Helmer, Steven M Greenberg, Danny J.J Wang, for the MarkVCID Consortium: 2024, 15 (4): 1885-1898 | DOI: 10.14336/AD.2023.0321-2; PDF (1783KB)

Responsiveness to Tocilizumab in Anti-Acetylcholine Receptor-Positive Generalized Myasthenia Gravis Dongmei Jia, Fenghe Zhang, Huining Li, Yi Shen, Zhao Jin, Fu-Dong Shi, Chao Zhang: 2024, 15 (2): 824-830 | DOI: 10.14336/AD.2023.0528; PDF (466KB)

Post-Stroke Neuropsychiatric Complications: Types, Pathogenesis, and Therapeutic Intervention Jing Zhou, Yijia Fangma, Zhong Chen, Yanrong Zheng: 2023, 14 (6): 2127-2152 | DOI: 10.14336/AD.2023.0310-2; PDF (939KB)

Consequences of Aging on Bone Lingli Zhang, Qiao Guan, Zhikun Wang, Jie Feng, Jun Zou, Bo Gao: 2024, 15 (6): 2417-2452 | DOI: 10.14336/AD.2023.1115; PDF (1209KB)

Microglia and Astrocytes in Alzheimer’s Disease: Significance and Summary of Recent Advances Qianting Deng, Chongyun Wu, Emily Parker, Timon Cheng-Yi Liu, Rui Duan, Luodan Yang: 2024, 15 (4): 1537-1564 | DOI: 10.14336/AD.2023.0907; PDF (1606KB)

State of the Science on Brain Insulin Resistance and Cognitive Decline Due to Alzheimer’s Disease Elizabeth M Rhea, Manon Leclerc, Hussein N Yassine, Ana W Capuano, Han Tong, Vladislav A Petyuk, Shannon L Macauley, Xavier Fioramonti, Owen Carmichael, Frederic Calon, Zoe Arvanitakis: 2024, 15 (4): 1688-1725 | DOI: 10.14336/AD.2023.0814; PDF (1636KB)

Arterial Aging and Cerebrovascular Function: Impact of Aerobic Exercise Training in Older Adults Tsubasa Tomoto, Rong Zhang: 2024, 15 (4): 1672-1687 | DOI: 10.14336/AD.2023.1109-1; PDF (1470KB)

Inflammatory Pathogenesis of Post-stroke Depression Xinyu Feng, Xiaojuan Ma, Juan Li, Qing Zhou, Yao Liu, Jingyi Song, Jiaqi Liu, Qingqing Situ, Lingyue Wang, Jingzhi Zhang, Facai Lin: 2025, 16 (1): 209-238 | DOI: 10.14336/AD.2024.0203; PDF (1207KB)

The Interfascicular Matrix of Energy Storing Tendons Houses Heterogenous Cell Populations Disproportionately Affected by Aging Danae E. Zamboulis, Neil Marr, Luca Lenzi, Helen L. Birch, Hazel R. C. Screen, Peter D. Clegg, Chavaunne T. Thorpe: 2024, 15 (1): 295-310 | DOI: 10.14336/AD.2023.0425-1; PDF (1364KB)
Supplement; 1. Supplementary data.pdf (1021KB)

Microbiota-Gut-Brain Axis Dysregulation in Alzheimer's Disease: Multi-Pathway Effects and Therapeutic Potential Linkai Qu, Yanwei Li, Fan Liu, Yimeng Fang, Jiaxuan He, Jiahui Ma, Ting Xu, Lei Wang, Pengyu Lei, Hao Dong, Libo Jin, Qinsi Yang, Wei Wu, Da Sun: 2024, 15 (3): 1108-1131 | DOI: 10.14336/AD.2023.0823-2; PDF (2004KB)

Cerebral Small Vessel Disease: Current and Emerging Therapeutic Strategies Yuewen Sun, Xiaoqian Song, Chenyang Jin, Yilong Peng, Jing Zhou, Xueping Zheng: | DOI: 10.14336/AD.2024.1515; PDF (493KB)

A Potential “Anti-Warburg Effect” in Circulating Tumor Cell-mediated Metastatic Progression? Zhuofeng Jiang, Jiapeng He, Binyu Zhang, Liping Wang, Chunhao Long, Boxi Zhao, Yufan Yang, Longxiang Du, Weiren Luo, Jianyang Hu, Xin Hong: | DOI: 10.14336/AD.2023.1227; PDF (1082KB)

Human APOE4 Protects High-Fat and High-Sucrose Diet Fed Targeted Replacement Mice against Fatty Liver Disease Compared to APOE3 Patricia Huebbe, Stephanie Bilke, Johanna Rueter, Anke Schloesser, Graeme Campbel, Claus-C. Glüer, Ralph Lucius, Christoph Röcken, Andreas Tholey, Gerald Rimbach: 2024, 15 (1): 259-281 | DOI: 10.14336/AD.2023.0530; PDF (1348KB)

Inhibiting MicroRNA-141-3p Improves Musculoskeletal Health in Aged Mice Sagar Vyavahare, Sandeep Kumar, Kathryn Smith, Bharati Mendhe, Roger Zhong, Marion A. Cooley, Babak Baban, Carlos M. Isales, Mark Hamrick, William D Hill, Sadanand Fulzele: 2023, 14 (6): 2303-2618 | DOI: 10.14336/AD.2023.0310-1; PDF (1103KB)
Supplement; 1. Supplementary data.pdf (125KB)

The Role of Microglia in Brain Metastases: Mechanisms and Strategies Ying Feng, Xueqing Hu, Yingru Zhang, Yan Wang: 2024, 15 (1): 169-185 | DOI: 10.14336/AD.2023.0514; PDF (826KB)

Tryptophan Metabolism in Alzheimer’s Disease with the Involvement of Microglia and Astrocyte Crosstalk and Gut-Brain Axis Lushuang Xie, Qiaofeng Wu, Kelin Li, Mohammed A. S. Khan, Andrew Zhang, Bharati Sinha, Sihui Li, Sulie L. Chang, David L. Brody, Mark W. Grinstaff, Shuanhu Zhou, Gil Alterovitz, Pinghua Liu, Xin Wang: 2024, 15 (5): 2168-2190 | DOI: 10.14336/AD.2024.0134; PDF (799KB)

Deformability of Heterogeneous Red Blood Cells in Aging and Related Pathologies Dmitry S. Prudinnik, Aigul Kussanova, Ivan A. Vorobjev, Alexander Tikhonov, Fazly I. Ataullakhanov, Natasha S. Barteneva: 2025, 16 (3): 1242-1264 | DOI: 10.14336/AD.2024.0526; PDF (1188KB)

Vascular Aging and Atherosclerosis: A Perspective on Aging Shudong Ma, Xuena Xie, Rong Yuan, Qiqi Xin, Yu Miao, Sean Xiao Leng, Keji Chen, Weihong Cong: 2025, 16 (1): 33-48 | DOI: 10.14336/AD.2024.0201-1; PDF (810KB)

Expert Consensus on the Application of Stem Cells in Psoriasis Research and Clinical Trials Ye-Hong Kuang, Wu Zhu, Ge Lin, La-Mei Cheng, Qun Qin, Zhi-Jun Huang, Yu-Ling Shi, Chun-Lei Zhang, Jin-Hua Xu, Ke-Xiang Yan, Cheng-Zhi Lv, Wei Li, Qin Han, Ilia Stambler, Lee Wei Lim, Sasanka Chakrabarti, Brun Ulfhake, Kyung-Jin Min, Georgina Ellison-Hughes, William C Cho, Kunlin Jin, Danni Yao, Chuanjian Lu, Robert Chunhua Zhao, Xiang Chen: 2025, 16 (3): 1363-1377 | DOI: 10.14336/AD.2024.0012; PDF (615KB)

Microglia Exhibit Distinct Heterogeneity Rather than M1/M2 Polarization within the Early Stage of Acute Ischemic Stroke Hongyu Ma, He Li, Yongxin Zhang, Yu Zhou, Hanchen Liu, Hongye Xu, Luojiang Zhu, Guanghao Zhang, Jing Wang, Zifu Li, Bo Hong, Wang Zhou, Pengfei Yang, Jianmin Liu: 2023, 14 (6): 2284-2302 | DOI: 10.14336/AD.2023.0505; PDF (2210KB)
Supplement; 1. Supplementary data.pdf (1726KB)

LLMs and AI Life Models for Traditional Chinese Medicine-derived Geroprotector Formulation Fedor Galkin, Feng Ren, Alex Zhavoronkov: | DOI: 10.14336/AD.2024.1697; PDF (899KB)

Causality of Aging Hallmarks Bilu Huang, Xiaowen Hu: | DOI: 10.14336/AD.2025.0541; PDF (597KB)

Involvement of Inheritance in Determining Telomere Length beyond Environmental and Lifestyle Factors Naheemat Modupeola Gold, Michael Ngozi Okeke, Yonghan He: 2024, 15 (6): 2470-2490 | DOI: 10.14336/AD.2023.1023; PDF (671KB)

Targeting Cellular Senescence in Aging and Age-Related Diseases: Challenges, Considerations, and the Emerging Role of Senolytic and Senomorphic Therapies Liyao Zheng, Shipei He, Hong Wang, Jinling Li, Yuanyuan Liu, Sijia Liu: 2024, 15 (6): 2554-2594 | DOI: 10.14336/AD.2024.0206; PDF (943KB)

The Emerging Role of Interleukin-(IL)-11/IL-11R in Bone Metabolism and Homeostasis: From Cytokine to Osteokine Bingzi Dong, Jingjing Zhu, Xian Chen, Hongyuan Jiang, Yujie Deng, Lili Xu, Yangang Wang, Shufa Li: 2023, 14 (6): 2113-2126 | DOI: 10.14336/AD.2023.0306; PDF (494KB)

Machine Learning-Based Decision-Making in Geriatrics: Aging Phenotype Calculator and Survival Prognosis Aleksandra Mamchur, Natalia Sharashkina, Veronika Erema, Daria Kashtanova, Mikhail Ivanov, Maria Bruttan, Elena Zelenova, Eva Shelly, Valentina Ostapenko, Irina Dzhumaniiazova, Lorena Matkava, Vladimir Yudin, Anna Akopyan, Irina Strazhesko, Lilit Maytesyan, Irina Tarasova, Olga Beloshevskaya, Anton Keskinov, Sergey Kraevoy, Olga Tkacheva, Sergey Yudin: 2025, 16 (1): 565-577 | DOI: 10.14336/AD.2024.0120; PDF (1073KB)
Supplement; 1. Supplementary data.pdf (684KB)

Revolutionizing Diabetic Foot Ulcer Care: The Senotherapeutic Approach Guiqin Zhang, Priyadarshani Nadeeshika Samarawickrama, Li Gui, Yuan Ma, Mei Cao, Hong Zhu, Wei Li, Honglin Yang, Kecheng Li, Yang Yang, Enfang Zhu, Wen Li, Yonghan He: 2025, 16 (2): 946-970 | DOI: 10.14336/AD.2024.0065; PDF (1049KB)