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2025
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Total 40 results are found
Long-Term Improvement in Hippocampal-Dependent Learning Ability in Healthy, Aged Individuals Following High Intensity Interval Training
Daniel G. Blackmore, Mia A. Schaumberg, Maryam Ziaei, Samuel Belford, Xuan Vinh To, Imogen O’Keeffe, Anne Bernard, Jules Mitchell, Emily Hume, Grace L. Rose, Thomas Shaw, Ashley York, Markus Barth, Elizabeth J. Cooper, Tina L. Skinner, Fatima Nasrallah, Stephan Riek, Perry F. Bartlett
2025, 16 (3): 1732-1754 | DOI: 10.14336/AD.2024.0642
Supplement

1. Supplementary data.pdf (6754KB)

Age-Related Dysfunction in Balance: A Comprehensive Review of Causes, Consequences, and Interventions
Jixian Wang, Yongfang Li, Guo-Yuan Yang, Kunlin Jin
2025, 16 (2): 714-737 | DOI: 10.14336/AD.2024.0124-1
The Expanding Burden of Neurodegenerative Diseases: An Unmet Medical and Social Need
Shu Wang, Yin Jiang, Anchao Yang, Fangang Meng, Jianguo Zhang
2025, 16 (5): 2937-2952 | DOI: 10.14336/AD.2024.1071
Cerebral Small Vessel Disease: Current and Emerging Therapeutic Strategies
Yuewen Sun, Xiaoqian Song, Chenyang Jin, Yilong Peng, Jing Zhou, Xueping Zheng
2026, 17 (1): 286-303 | DOI: 10.14336/AD.2024.1515
AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent
Qiuqiong Tang, Deyong Xiao, Alexander Veviorskiy, Ying Xin, Sarah W.Y. Lok, Fadi E. Pulous, Peiran Zhang, Yunfeng Zhu, Yongming Ma, Xiao Hu, Shoulai Gu, Chenting Zong, Sabina Mukba, Mikhail Korzinkin, Frank W. Pun, Man Zhang, Alex Aliper, Lijuan Wu, Feng Ren, Li Zhang, Alex Zhavoronkov
2026, 17 (1): 432-451 | DOI: 10.14336/AD.2024.1492
Supplement

1. Supplementary data.pdf (1198KB)

2. TNIK Senomorphic Video.mp4.mp4 (14113KB)

Peakspan: Defining, Quantifying and Extending the Boundaries of Peak Productive Lifespan
Authors: Alex Zhavoronkov, Kejun Ying, Dominika Wilczok
| DOI: 10.14336/AD.2026.0080
Molecular Mechanisms of Phase Separation and Amyloidosis of ALS/FTD-linked FUS and TDP-43
Jianxing Song
2024, 15 (5): 2084-2112 | DOI: 10.14336/AD.2023.1118
Perimenopausal Hormone Replacement Treatments as a Geroprotective Approach - Adapting Clinical Guidance
Jaron Rabinovici, Henk-Peter Oonk, Zhongwei Huang, Tashiya Mirando, Moran Zhou, Tzipora Strauss, Lia-Raluca Olari, Dominika Wilczok, Andrea B. Maier, Evelyne Bischof
| DOI: 10.14336/AD.2025.1391
Blue Zones, an Analysis of Existing Evidence through a Scoping Review
Cristina Candal-Pedreira, Julia Rey-Brandariz, Lucía Martín-Gisbert, Ana Teijeiro, Guadalupe García, Alberto Ruano-Ravina, Mónica Pérez-Ríos
2026, 17 (3): 1335-1346 | DOI: 10.14336/AD.2025.0461
Supplement

1. Supplementary data.pdf (244KB)

Amyloid-β and Phosphorylated Tau are the Key Biomarkers and Predictors of Alzheimer’s Disease
Jangampalli Adi Pradeepkiran, Javaria Baig, Md Ariful Islam, Sudhir Kshirsagar, P. Hemachandra Reddy
2025, 16 (2): 658-682 | DOI: 10.14336/AD.2024.0286
Causality of Aging Hallmarks
Bilu Huang, Xiaowen Hu
2026, 17 (3): 1236-1253 | DOI: 10.14336/AD.2025.0541
Consequences of Aging on Bone
Lingli Zhang, Qiao Guan, Zhikun Wang, Jie Feng, Jun Zou, Bo Gao
2024, 15 (6): 2417-2452 | DOI: 10.14336/AD.2023.1115
Epigenetic Clocks: Beyond Biological Age, Using the Past to Predict the Present and Future
Runyu Liang, Qiang Tang, Jia Chen, Luwen Zhu
2025, 16 (6): 3520-3545 | DOI: 10.14336/AD.2024.1495
Reduced Blood Choline in Obesity Is Associated with Metabolic and Alzheimer’s Biomarkers
Wendy Winslow, Jessica M. Judd, Savannah Tallino, Geidy E. Serrano, Thomas G. Beach, Lori R. Roust, Eleanna De Filippis, Brooke Brown, Christos Katsanos, Ramon Velazquez
| DOI: 10.14336/AD.2025.1207
Green Tea Mitigates the Hallmarks of Aging and Age-Related Multisystem Deterioration
Yusuf Yilmaz
2026, 17 (2): 712-730 | DOI: 10.14336/AD.2025.0398
Ovarian Aging: The Silent Catalyst of Age-Related Disorders in Female Body
Xingyu Liu, Yuanqu Zhao, Yanzhi Feng, Shixuan Wang, Aiyue Luo, Jinjin Zhang
2026, 17 (1): 132-158 | DOI: 10.14336/AD.2024.1468
Targeting Cellular Senescence in Aging and Age-Related Diseases: Challenges, Considerations, and the Emerging Role of Senolytic and Senomorphic Therapies
Liyao Zheng, Shipei He, Hong Wang, Jinling Li, Yuanyuan Liu, Sijia Liu
2024, 15 (6): 2554-2594 | DOI: 10.14336/AD.2024.0206
Aging-Related Sarcopenia: Metabolic Characteristics and Therapeutic Strategies
Yonglian Chen, Jinhui Wu
2025, 16 (2): 1003-1022 | DOI: 10.14336/AD.2024.0407
LLMs and AI Life Models for Traditional Chinese Medicine-derived Geroprotector Formulation
Fedor Galkin, Feng Ren, Alex Zhavoronkov
2026, 17 (2): 1155-1168 | DOI: 10.14336/AD.2024.1697
Inflammatory Pathogenesis of Post-stroke Depression
Xinyu Feng, Xiaojuan Ma, Juan Li, Qing Zhou, Yao Liu, Jingyi Song, Jiaqi Liu, Qingqing Situ, Lingyue Wang, Jingzhi Zhang, Facai Lin
2025, 16 (1): 209-238 | DOI: 10.14336/AD.2024.0203
Exercise-Induced Central Fatigue: Biomarkers and Non-Medicinal Interventions
Ying Yang, Zhi Feng, Yu-hang Luo, Jue-miao Chen, Yu Zhang, Yi-jun Liao, Hui Jiang, Yinxi Long, Bo Wei
2025, 16 (3): 1302-1315 | DOI: 10.14336/AD.2024.0567
Skin-brain axis in Alzheimer's disease - Pathologic, diagnostic, and therapeutic implications: A Hypothetical Review
Hyeon soo Kim, Haram Jung, Yong Ho Park, Su-Hak Heo, Sujin Kim, Minho Moon
2025, 16 (2): 901-916 | DOI: 10.14336/AD.2024.0406
SLC7A11 in Fibrosis: Molecular Mechanisms and Future Prospects
Juntong Chen, Yanjie He, Ru Chen, Zhiyong Yang, Xiaomeng Luo, Fan Yang
2026, 17 (2): 731-759 | DOI: 10.14336/AD.2025.0106
Aging and “Age-Related” Diseases - What Is the Relation?
Wolfgang Kopp
2025, 16 (3): 1316-1346 | DOI: 10.14336/AD.2024.0570
ROS-Induced Endothelial Dysfunction in the Pathogenesis of Atherosclerosis
Ruiyi Yan, Xiao Zhang, Wenlong Xu, Jiayao Li, Yixin Sun, Shengyan Cui, Ran Xu, Wenjing Li, Liqun Jiao, Tao Wang
2025, 16 (1): 250-268 | DOI: 10.14336/AD.2024.0309
Revolutionizing Diabetic Foot Ulcer Care: The Senotherapeutic Approach
Guiqin Zhang, Priyadarshani Nadeeshika Samarawickrama, Li Gui, Yuan Ma, Mei Cao, Hong Zhu, Wei Li, Honglin Yang, Kecheng Li, Yang Yang, Enfang Zhu, Wen Li, Yonghan He
2025, 16 (2): 946-970 | DOI: 10.14336/AD.2024.0065
Vascular Aging and Atherosclerosis: A Perspective on Aging
Shudong Ma, Xuena Xie, Rong Yuan, Qiqi Xin, Yu Miao, Sean Xiao Leng, Keji Chen, Weihong Cong
2025, 16 (1): 33-48 | DOI: 10.14336/AD.2024.0201-1
Deformability of Heterogeneous Red Blood Cells in Aging and Related Pathologies
Dmitry S. Prudinnik, Aigul Kussanova, Ivan A. Vorobjev, Alexander Tikhonov, Fazly I. Ataullakhanov, Natasha S. Barteneva
2025, 16 (3): 1242-1264 | DOI: 10.14336/AD.2024.0526
Disulfidptosis, A Novel Cell Death Pathway: Molecular Landscape and Therapeutic Implications
Qiuyang Gu, Yumei An, Mingyuan Xu, Xinqi Huang, Xueshi Chen, Xianzhe Li, Haiyan Shan, Mingyang Zhang
2025, 16 (2): 917-945 | DOI: 10.14336/AD.2024.0083
Tryptophan Metabolism in Alzheimer’s Disease with the Involvement of Microglia and Astrocyte Crosstalk and Gut-Brain Axis
Lushuang Xie, Qiaofeng Wu, Kelin Li, Mohammed A. S. Khan, Andrew Zhang, Bharati Sinha, Sihui Li, Sulie L. Chang, David L. Brody, Mark W. Grinstaff, Shuanhu Zhou, Gil Alterovitz, Pinghua Liu, Xin Wang
2024, 15 (5): 2168-2190 | DOI: 10.14336/AD.2024.0134
Senescent T Cells in Age-Related Diseases
Pei-Jie Yu, Mei Zhou, Yan Liu, Jie Du
2025, 16 (1): 321-344 | DOI: 10.14336/AD.2024.0219
The Impact of Aging on Ocular Diseases: Unveiling Complex Interactions
Luling You, Yumeng Lin, Yizhuo Zheng, Zhongyu Han, Liuzhi Zeng, Haoran Chen
2025, 16 (5): 2803-2830 | DOI: 10.14336/AD.2024.0850
Aging Gut Microbiome in Healthy and Unhealthy Aging
Yangyanqiu Wang, Zhanbo Qu, Jian Chu, Shuwen Han
2025, 16 (2): 980-1002 | DOI: 10.14336/AD.2024.0331
Cellular Aging and Senescence in Cancer: A Holistic Review of Cellular Fate Determinants
Muhammad Tufail, Yu-Qi Huang, Jia-Ju Hu, Jie Liang, Cai-Yun He, Wen-Dong Wan, Can-Hua Jiang, Hong Wu, Ning Li
2025, 16 (3): 1483-1512 | DOI: 10.14336/AD.2024.0421
Dietary Interventions for Healthy Aging: An Epigenetic Perspective
Xinyu Zhang, Ziyue Xie, Huimin Bian, Yu Li, Ruigong Zhu, Jia Sun
| DOI: 10.14336/AD.2026.0333
Type 2 Diabetes Mellitus: A Metabolic Model of Accelerated Aging - Multi-Organ Mechanisms and Intervention Approaches
Ziran Zhang, Xiaolin He, Yuxin Sun, Jitong Li, Jia Sun
2026, 17 (3): 1399-1422 | DOI: 10.14336/AD.2025.0233
Expert Consensus on the Application of Stem Cells in Psoriasis Research and Clinical Trials
Ye-Hong Kuang, Wu Zhu, Ge Lin, La-Mei Cheng, Qun Qin, Zhi-Jun Huang, Yu-Ling Shi, Chun-Lei Zhang, Jin-Hua Xu, Ke-Xiang Yan, Cheng-Zhi Lv, Wei Li, Qin Han, Ilia Stambler, Lee Wei Lim, Sasanka Chakrabarti, Brun Ulfhake, Kyung-Jin Min, Georgina Ellison-Hughes, William C Cho, Kunlin Jin, Danni Yao, Chuanjian Lu, Robert Chunhua Zhao, Xiang Chen
2025, 16 (3): 1363-1377 | DOI: 10.14336/AD.2024.0012
The Impact of Rosemary and Ginger Extracts on Aging and Healthspan in Drosophila
Ricardo Aparicio, Anna M. Salazar, Edward T. Schmid, Armen Khanbabaei, Arun Rajgopal, R. Keith Randolph, David W. Walker
2026, 17 (1): 416-431 | DOI: 10.14336/AD.2024.1558
Supplement

1. Supplementary data.pdf (378KB)

Fecal Microbiota Transplantation from Young-Trained Donors Improves Cognitive Function in Old Mice Through Modulation of the Gut-Brain Axis
Camila Cerna, Nicole Vidal-Herrera, Francisco Silva-Olivares, Daniela Álvarez, Camila González-Arancibia, Miltha Hidalgo, Pabla Aguirre, José González-Urra, Camila Astudillo-Guerrero, Michel Jara, Omar Porras, Gonzalo Cruz, Christian Hodar, Paola Llanos, Pamela Urrutia, Claudia Ibacache-Quiroga, Yulia Nevzorova, Francisco Javier Cubero, Marco Fuenzalida, Samanta Thomas-Valdés, Gonzalo Jorquera
2024, 15 (6): 3649-3670 | DOI: 10.14336/AD.2024.1089
Supplement

1. Supplementary data.pdf (902KB)

Recent Advances in Our Understanding of Age-Related Macular Degeneration: Mitochondrial Dysfunction, Redox Signaling, and the Complement System
Francesco Buonfiglio, Christina A. Korb, Bernhard Stoffelns, Norbert Pfeiffer, Adrian Gericke
2025, 16 (3): 1535-1575 | DOI: 10.14336/AD.2024.0124